ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts, Synovial"

  • Abstract Number: 1782 • ACR Convergence 2023

    The Stromal-cell Derived Cytokine interleukin-17D Attenuates Joint Inflammation

    Jia (Sijia) Chen1, Catherine Manning1, Nataliya Yeremenko2, Jae-Hyuck Shim3, Daniel Montoro4, Dominique Baeten5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Amsterdam University Medical Centers, Amsterdam, Netherlands, 3University of Massachusetts Chan Medical School, Worcester, MA, 4TenSixty Biosciences, Boston, MA, 5UCB Pharma, Slough, United Kingdom, 6Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: The interleukin-17 (IL-17) family of cytokines consists of 6 evolutionarily conserved cytokines, IL-17A-F. Of these, IL-17A, B, C, and F play diverse roles in…
  • Abstract Number: 1738 • ACR Convergence 2023

    Identification of Homeostatic and Inflammatory Synovial Fibroblast Signatures in Synovial Tissue Biopsies of Healthy Controls and Patients with Rheumatoid Arthritis

    Brianne Barker1, Órla Tynan2, Conor Smith3, Dumitru Anton4, Carl Orr5, Mary Canavan6, Douglas Veale7 and Ursula Fearon8, 1Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Rheumatic and Arthritic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland, 2Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 3Translational Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland, 4Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 5EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 6Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 7St.Vincent's University Hosp, Dublin, Ireland, 8Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Recent literature has identified different synovial fibroblast (FLS) populations within RA synovium with distinct inflammatory profiles. Despite current advances in classifying heterogeneity of FLS…
  • Abstract Number: 1787 • ACR Convergence 2023

    Regulatory Role of JAK-1/TYK2 Signaling on the Pannus Formation: Novel Mechanisms for JAK Inhibitors in Psoriatic Disease

    Siba Raychaudhuri1, Christine Abria2 and Smriti K Raychaudhuri2, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, Davis, CA, 2VA Sacramento Medical Center, Mather, CA

    Background/Purpose: In psoriatic arthritis (PsA) aberrant activation/migration of specific T cell subpopulations (Th17/Th9/MAIT cells) in the joint synovium induce synovial inflammation and pannus formation. Several…
  • Abstract Number: 1744 • ACR Convergence 2023

    Histological and Molecular Comparison in the Synovial Tissue of Patients with Active Rheumatoid Arthritis to Remission

    Selina Ohl1, Klaus Frommer1, Markus Rickert2, Stefan Rehart3, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 2Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 3Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which leads to local and systemic manifestations. Subsequently, the inflamed synovium drives the destruction of…
  • Abstract Number: 2135 • ACR Convergence 2023

    Synovial Fluid High-density Lipoprotein (HDL)-miR-1246 Is Enriched in Patients with Inflammatory Arthritis Compared to Osteoarthritis and Increases Synovial Fibroblast IL-6 Expression

    Olivia Posey1, Qiong Wu1, Anastasiia Phothisane1, Christine Pham2, Deborah Parks2, Antonina Akk3, Danielle Michell1, Kasey Vickers1 and Michelle Ormseth1, 1Vanderbilt University Medical Center, Nashville, TN, 2Washington University, St. Louis, MO, 3Washington University in St. Louis, St. Louis, MO

    Background/Purpose: High-density lipoprotein (HDL), known for its anti-atherogenic reverse cholesterol transport function, also transports miRNAs between cells, altering cellular function. We found that compared to…
  • Abstract Number: 1745 • ACR Convergence 2023

    Chronic Inflammation and Collagen IV Fragment Canstatin Influence Rheumatoid Arthritis Synovial Fibroblast and Endothelial Cell Interactions in Vitro and in Vivo

    Corinna Heck1, Sophie Haun1, Daria Kürsammer1, Klaus Frommer1, Mona Arnold1, Markus Rickert2, Katrin Susanne Lips3, Stefan Rehart4, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 2Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 3Justus Liebig University Gießen, Department of Experimental Trauma Surgery, Giessen, Germany, 4Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany

    Background/Purpose: In the inflamed synovium of RA patients, increased and altered angiogenesis is a pathological feature. Key players are chronically activated RA synovial fibroblasts (RASF),…
  • Abstract Number: 2426 • ACR Convergence 2023

    The Role of β-catenin in Synovial Lining Fibroblast Differentiation

    Sonia Presti1, Gerald F.M. Watts1, Junning Case1, Zhu Zhu2, Teri Bowman1, Hung Nguyen1, Gabriel Nigrovic1, Ce Gao1, Kartik Bhamidipati1, Yuhong Li1, Suppawat Kongthong1, Fan Zhang3, Anna Helena Jonsson1, Accelerating Medicines Partnership Program (AMP RA/SLE) Network4, STARS BWH1, Michael Brenner5, Shideh Kazerounian1 and Kevin Wei5, 1Brigham and Women's Hospital, Boston, MA, 210x Genomics, St. Louis, MO, 3University of Colorado, Aurora, CO, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: In healthy synovium, lining fibroblasts promote joint health by secreting proteoglycans that lubricate the joint cavity. In rheumatoid arthritis (RA), sublining fibroblasts undergo marked…
  • Abstract Number: 1749 • ACR Convergence 2023

    Fatty Acid Synthase Is a Critical Repressor of Ferroptosis in Rheumatoid Arthritis

    Qi Cheng, Mo chen, Xin chen, Yifan Xie, Yan Du and Huaxiang wu, The Second Affiliated Hospital Of Zhejiang University School Of Medicine, Hangzhou, China

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease with synovial inflammation as the main pathological feature, and can eventually lead to irreversible joint or…
  • Abstract Number: 2432 • ACR Convergence 2023

    Wnt Signaling Drives Pathogenic Stromal Inflammation in Inflammatory Arthritis

    Alisa Mueller1, Angela Zou2, Lucy-Jayne Marsh3, Samuel Kemble4, Saba Nayar3, Emily Taylor3, Triin Major3, David Gardner5, Gerald F.M. Watts1, Cassandra Murphy1, Roche Fibroblast Network Consortium6, Adam Croft3, Andrew Filer3, Christopher Buckley7, Kevin Wei8, ilya Korsunsky1, Soumya Raychaudhuri1 and Michael Brenner8, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3University of Birmingham, Birmingham, United Kingdom, 4University Birmingham, Rugeley, United Kingdom, 5University of Birmingham, Havelock North, New Zealand, 6Roche, Basel, Switzerland, 7University of Oxford, Oxford, United Kingdom, 8Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Synovial fibroblasts are a promising therapeutic target in rheumatoid arthritis (RA) where they can adopt inflammatory or destructive phenotypes and directly promote bone and…
  • Abstract Number: 1750 • ACR Convergence 2023

    Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses

    Sho Sendo1, Camilla R. L. Machado2, Robert Benschop3, Narayanan B. Perumal4, Eunice Choi5, David Boyle5, Wei Wang5 and Gary Firestein2, 1Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2University of California San Diego, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN, 4Eli Lilly and Company, San Diego, CA, 5University of California San Diego, La Jolla, CA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) contribute to the pathogenesis of rheumatoid arthritis (RA), especially cartilage damage and cytokine production. These cells display an aggressive phenotype in…
  • Abstract Number: 2438 • ACR Convergence 2023

    Synovial Tissue Single-Cell Analysis Demonstrates Differential Fibroblast Populations Between RA and PsA Which Display Distinct Function

    Órla Tynan1, Mary Canavan2, Achilleas Floudas3, Conor Smith4, Aoife O' Rourke4, Dumitru Anton5, Carl Orr6, Douglas Veale7 and Ursula Fearon8, 1Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 2Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 3Dublin City University, Dublin, Ireland, 4Translational Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland, 5Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 6EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 7St.Vincent's University Hosp, Dublin, Ireland, 8Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Synovial fibroblasts (FLS) are key contributors to joint inflammation and damage in patients with Rheumatoid (RA) and Psoriatic Arthritis (PsA). Recent studies have identified…
  • Abstract Number: 1752 • ACR Convergence 2023

    Fibroblast Expression of Neurotransmitter Receptor HTR2A Associates with Inflammation in Rheumatoid Arthritis Joint

    Chunyan Xiang1, Soomin Hong1, Bingjiao Zhao2, Hui Pi3, Fang Du4, Xingyu Lu5, Yuanjia Tang1, Nan Shen6, Chunxi Yang7 and Runci Wang8, 1Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 2Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China, 3Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China, 4Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 5Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 6Shanghai Jiao Tong University School of Medicine, Shanghai, China, 7Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 8Renji hospital, Shanghai Jiaotong University, Pudong Xinqu, China

    Background/Purpose: Peripheral neuroimmune crosstalk plays a crucial role in the inflammatory process and bone metabolism in joint. Serotonin receptor HTR2A was reported to be expressed…
  • Abstract Number: 2440 • ACR Convergence 2023

    Synovial Shaping of Skin-derived Migrating Immune Cells Determines Initiation of Inflammation in Psoriatic Arthritis

    Maria Gabriella Raimondo1, Simon Rauber2, Hashem Mohammadian3, Mario Angeli1, Cong Xu1, Aleix Rius Rigau4, Markus Luber1, Hannah Labinsky5, Alina Ramming1, Stefano Alivernini6, Jörg Distler1, Ursula Fearon7, Douglas Veale8, Michael Sticherling9, Juan D Canete10, Georg Schett11 and Andreas Ramming1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3, Rheumatology and Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 5Medical Department II, Rheumatology, University Hospital Würzburg, Würzburg, Germany, 6Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, 7Trinity College Dublin, Dublin, Ireland, 8St.Vincent's University Hosp, Dublin, Ireland, 9Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 10Hospital Clinic an IDIBAPS, Barcelona, Spain, 11Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Around 30% of the patients with psoriasis (PsO) develop psoriatic arthritis (PsA) overtime, suggesting the existence of a disease mediated skin-joint crosstalk. To date,…
  • Abstract Number: 0012 • ACR Convergence 2023

    Immune-cell Derived Cytokines Synergistically Interact to Drive Synovial Fibroblast Invasive Function and Metabolic Capacity

    Órla Tynan1, Achilleas Floudas2, Nuno Neto3, Michael Monaghan3, Siobhán Wade4, Dumitru Anton5, Carl Orr6, Douglas Veale7 and Ursula Fearon8, 1Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 2Dublin City University, Dublin, Ireland, 3Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, Dublin, Ireland, 4Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 5Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 6EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, 7St.Vincent's University Hosp, Dublin, Ireland, 8Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) encompass two of the most common forms of Inflammatory Arthritis. While common pathogenic mechanisms are involved in…
  • Abstract Number: 1753 • ACR Convergence 2023

    Acylcarnitine Enrichment Is a Characteristic of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Metabolic Fingerprint

    Georgios Vasileiadis1, Anna-Karin Hultgård Ekwall2, Reshmi Sureshkumar1, Monica Guma3, Anna Rudin4, Yuan Zhang1 and Cristina Maglio1, 1Institute of Medicine, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Kullavik, Sweden, 3San Diego VA Healthcare Service, La Jolla, CA, 4Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Several metabolic pathways have been implicated in rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) aggressive phenotype1,2. Here, we aimed to analyse the full spectrum of…
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