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Abstracts tagged "Fibroblasts, Synovial"

  • Abstract Number: 0995 • ACR Convergence 2025

    Resident Memory T Cells Stimulate Pathogenic Activity in Fibroblast-like Synoviocytes

    Madison Mangin1, Yang Yang2, Yusuke Miyashita2 and Margaret Chang2, 1Boston Children's Hospital, St Simons Island, GA, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint specific memory. We previously demonstrated that joint-specific memory is mediated by CD8+ synovial resident…
  • Abstract Number: 0978 • ACR Convergence 2025

    IL-17A+ HLA-DR-CCR6+ regulatory T cells: Dual role in T cell suppression and synovial inflammation in arthritis.

    Bennie Heeswijk1, Margot Bongenaar1, Nadine Davelaar1, Pascal de Jong1, Hannah den Braanker1, Radboud Dolhain1 and Erik Lubberts2, 1Erasmus University Medical Center, Rotterdam, the Netherlands, Rotterdam, Netherlands, 2Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

    Background/Purpose: Regulatory T cells (Tregs) are essential for maintaining immune tolerance and limiting excessive immune responses. However, Tregs show high levels of heterogeneity and plasticity,…
  • Abstract Number: 0919 • ACR Convergence 2025

    Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns

    Stefanie Kurth1, Andre Tiaden1, Edveena Hanser1, Simone Häner1, Stavros Giaglis1, Florian Geier1, Dominik Burri1, Katarzyna Buczak1, Ute Heider2, Stefan Wild2, Yves Acklin1, Christian Egloff1 and Diego Kyburz3, 1University of Basel, Basel, Switzerland, 2Miltenyi Biotec, Bergisch-Gladbach, Germany, 3University Hospital Basel, Basel, Switzerland

    Background/Purpose: Extracellular vesicles (EVs) are secreted by virtually all cells and are known to carry bioactive cargo including proteins, RNA, DNA and metabolites. Analysis of…
  • Abstract Number: 0807 • ACR Convergence 2025

    Deciphering Synovitis in Systemic Sclerosis

    Celina Geiss1, Miranda Houtman1, Camino Calvo Cebrian1, Raphael Micheroli2, Melpomeni Toitou1, Yannis Djeffal3, Alexandra Khmelevskaya1, Mojca Frank-Bertoncelj1, Sam Edalat1, Thomas Rauer4, Kristina Bürki5, Chantal Pauli6, Michael Bonelli7, Thomas Karonitsch8, Oliver Distler9, Caroline Ospelt1 and Muriel Elhai10, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3INSERM, IMRB, Université Paris Est Créteil, Paris, France, 43Department of Traumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, 6Institute for Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 7Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Wien, Austria, 8Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 9Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, 10University Hospital zurich, Zürich, Switzerland

    Background/Purpose: Synovitis is a common manifestation of systemic sclerosis (SSc), driving disability and predicting disease progression and mortality. Current immunosuppressive strategies, largely extrapolated from rheumatoid…
  • Abstract Number: 0799 • ACR Convergence 2025

    Citrullination of neutrophil serine proteases enhances proteolytic activity, stability and autoantigenicity in Rheumatoid Arthritis

    Mario Navarrete Lagos, Ramiza Zaman, Jun Kim, Jeba Atkia Maisha, Hani El-Gabalawy and Liam O'Neil, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: In Rheumatoid Arthritis (RA), autoantibodies develop against endogenous proteins containing the amino acid citrulline, which results from a post-translational modification of arginine catalyzed by…
  • Abstract Number: 0797 • ACR Convergence 2025

    Spatial transcriptomics identifies density-sensing fibroblasts in synovial lining

    Sonia Presti1, Kseniia Anufrieva2, Ce Gao3, Sean Prell2, Philip Blazar2, Jeffrey Lange2, Morgan Jones2, Mihir Wechalekar4, Michael Brenner2, Ilya Korsunsky5, Shideh Kazerounian2 and Kevin Wei6, 1Standford University, Stanford, 2Mass General Brigham, Boston, 3Division of Rheumatology, Inflammation and Immunity, DOM, BWH; Harvard Medical School, Boston, MA, 4Flinders Medical Centre, Adelaide, Australia, 5Division of Rheumatology, Inflammation and Immunity, DOM, BWH; Division of Genetics, DOM, BWH; Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: The synovial lining is crucial for joint homeostasis, forming a barrier and producing lubricants through specialized fibroblasts. These fibroblasts differ from sublining fibroblasts, which…
  • Abstract Number: 0798 • ACR Convergence 2025

    Inhibition of Wnt Signaling Attenuates Inflammatory Arthritis Severity

    Alisa Mueller1, Angela Zou2, Lucy-Jayne Marsh3, Samuel Kemble3, Saba Nayar3, Gerald Watts4, Cassandra Murphy5, Emily Taylor3, Triin Major3, David Gardner6, Christopher Buckley7, Kevin Wei8, Soumya Raychaudhuri5, ilya Korsunsky5, Andrew Filer9, Adam Croft10 and Michael Brenner11, 1Stanford University and VA Palo Alto Health Care System, Stanford, CA, 2Harvard Medical School, Boston, MA, 3University of Birmingham, Birmingham, United Kingdom, 4Harvard Medical School, Brookline, MA, 5Brigham and Women's Hospital, Boston, MA, 6University of Birmingham, Havelock North, New Zealand, 7University of Oxford, Oxford, United Kingdom, 8Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 9The University of Birmingham, Birmingham, United Kingdom, 10University of Birmingham, Hagley, Stourbridge, United Kingdom, 11Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Fibroblasts are critical in promoting pathogenic synovial inflammation and bone erosion in rheumatoid arthritis (RA). Moreover, recent studies have pointed to their potential contribution…
  • Abstract Number: 0472 • ACR Convergence 2025

    Detrimental Effects of Umbilical Cord Blood-derived Mesenchymal Stem Cells Intra-articular Injections on Pannus Invasiveness

    Sung Eun Kim1, Hye Lim Kang1, Min Jung Kim2, Hyung-Sik Kim3 and Kichul Shin4, 1Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea, 2Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, 3Department of Oral Biochemistry, Pusan National University School of Dentistry, Yangsan, Republic of Korea, 4Seoul National University, Seoul, South Korea

    Background/Purpose: Studies have shown that mesenchymal stem cell (MSC) infusion ameliorates arthritis in animal models. However, the first-pass effect in the lung has directed attention…
  • Abstract Number: 2613 • ACR Convergence 2025

    Ga-FAPI-04 PET/CT reveals increased fibroblast activation in synovial and enthesial tissues of psoriasis patients with arthralgia and predicts the development of psoriatic arthritis

    Giulia Corte1, Koray Tascilar2, armin Atzinger3, Alp Temiz2, Melek Yalcin Mutlu4, Rita Noversa de Sousa5, Maria Gabriella Raimondo6, Andreas Ramming7, Sara Bayat2, Michael Sticherling8, Torsten Kuwert9, Christian Schmidkonz9, Georg Schett10 and Filippo Fagni11, 1- Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 3Department of Nuclear Medicine, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, erlangen, 5Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, 6Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 7Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) & Universitätsklinikum Erlangen, Erlangen, Germany, 8Department of Dermatology, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 9Department of Nuclear Medicine, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, 10Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, 11Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Bayern, Germany

    Background/Purpose: 68Ga-FAPI-04 PET/CT reveals fibroblast activation in vivo and is increasingly used to assess rheumatic diseases, including inflammatory arthritides. (1,2) We previously demonstrated that the…
  • Abstract Number: 0096 • ACR Convergence 2025

    GLUT1-Dependent Targeting and Enhanced Selectivity of a Glucose-Methotrexate Conjugate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    Sebastian Makuch1, Jacek Polański1 and Wojciech Tański2, 1Wrocław Medical University, Wrocław, Poland, 2Wrocław University of Science and Technology, Wrocław, Poland

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease where fibroblast-like synoviocytes (FLS) play a central role in joint inflammation and destruction. Methotrexate (MTX), a…
  • Abstract Number: 0771 • ACR Convergence 2024

    Arid5b Controls Pathologic Inflammatory versus Invasive Fibroblast Behavior

    Angela Zou1, Suppawat Kongthong2, Cassandra Murphy2, Gerald Watts3, Alisa Mueller4 and Michael Brenner5, 1Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Harvard Medical School, Brookline, MA, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Synovial fibroblasts assume both inflammatory and tissue invasive roles in rheumatoid arthritis (RA). Recent studies have shown that these inflammatory and invasive functions are…
  • Abstract Number: 0888 • ACR Convergence 2024

    Genetically Determined Peptidylglycine Alpha-amidating Monooxygenase (PAM) Mediated Amidation Regulates Tissue Damage by Rheumatoid Arthritis Synovial Fibroblasts

    Kevin Sheridan1, Emma Doris1, Maria Pimenta1, Jemma Falkov1, Matthew Fisher2, Munitta Muthana2, Denis Shields1, Richard Mains3, Betty Eipper3, Christopher Buckley4 and Anthony Wilson5, 1University College Dublin, Dublin, Ireland, 2University of Sheffield, Sheffield, United Kingdom, 3University of Connecticut, Connecticut, 4University of Oxford, Oxford, United Kingdom, 5UCD, Dublin, Dublin, Ireland

    Background/Purpose: The SNP rs26232 is associated with both risk and severity of rheumatoid arthritis (RA), with the C allele associated with the susceptibility to RA,…
  • Abstract Number: 0894 • ACR Convergence 2024

    HOXD13 Regulation of Primary Cilia in Rheumatoid Arthritis Synovial Fibroblasts: Implications for Joint-Specific Pathogenesis

    Masoumeh Mirrahimi1, Kerstin Klein2, Alexandra Khmelevskaya3, Eva Camarillo Retamosa3, Miranda Houtmen3, Oliver Distler1 and Caroline Ospelt1, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland, 2University of Bern, Bern, Switzerland, 3Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Zurich, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) follows a characteristic pattern of joint involvement. The embryonic development of limbs and joints influences certain joints' propensity to develop arthritis.…
  • Abstract Number: 0928 • ACR Convergence 2024

    In Vitro Study of Fibroblast-Like Synoviocytes and Macrophages-Like Synoviocytes Isolated from Rheumatoid Arthritis, Psoriatic Arthritis Patients and Healthy Subjects

    monia Maccaferri1, Francesco Zambianchi2, Carlo Salvarani3 and Elisa Pignatti3, 1Azienda Ospedaliero Universitaria di Modena, Modena, Italy, 2Department of Maternal, Child and Adult Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy, 3Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

    Background/Purpose: Interactions between fibroblast-like synoviocytes (FLSs) and macrophage-like synoviocytes (MLSs) are pivotal in the pathogenesis of RA and PsA. FLSs both activate and are activated…
  • Abstract Number: 0940 • ACR Convergence 2024

    Trans-endothelial Migration of Synovial Fibroblasts Promotes Arthritis Severity Through a PKD1-mediated Feedback Loop

    Jaeyeon Kim, Richard Ainsworth and Nunzio Bottini, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: The application of single cell genomic approaches to the study of rheumatoid synovium has recently enabled scientists to study the complex relationship between different…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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