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Abstracts tagged "Fibroblasts, Synovial"

  • Abstract Number: 0068 • ACR Convergence 2025

    Unique Fibroblast-like Synoviocyte Phenotype with Elevated MCSF Expression Induced by TLR5 Activation in Rheumatoid Arthritis

    Aryan Patel1, Osama Al Zoubi2 and Shiva Shahrara3, 1University of Illinois at Chicago, Chicago, 2University of Illinois at Chicago, Chicago, IL, 3University of Illinois, Chicago, IL

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1% of the global population, causing significant morbidity and disability. Fibroblast-like synoviocytes (FLS) are…
  • Abstract Number: 1150 • ACR Convergence 2025

    Impact of IL-17A on synovial fibroblast from subacromial bursae

    Andre Ramon1, Hélène Greigert2, baptiste lamarthée3, Corentin Richard4, claudie Cladière3, Noemie Klopfenstein3, Ludovic Labattut5, Alice Bordet5, Sylvain Audia6, Romain boidot4, jean-francis Maillefert1, Bernard Bonnotte7 and Maxime Samson8, 1Rheumatology, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France, 2Vascular Medicine, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France, 3Marie et Louis Pasteur University, EFS, INSERM, UMR RIGHT, Besançon, France, Dijon, France, 4Molecular Biology Unit, Georges-François Leclerc Cancer Center, UNICANCER, Dijon, France, Dijon, France, 5Orthopedic Surgery, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France, 6Internal Medicine and Clinical Immunology, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France, 7Internal medicine and clinical immunology, Université Bourgogne Europe , CHU Dijon Bourgogne, Dijon, France, 8CHU Dijon Bourgogne, Dijon, France

    Background/Purpose: Polymyalgia rheumatica (PMR) is characterized by increases in serum IL-6 and the proportion of Th17 cells in circulating blood. During PMR, IL-6 may originate…
  • Abstract Number: 0063 • ACR Convergence 2025

    Effect of alpha-ketoglutarate on Synovial Fibroblasts-Mediated Inflammation in Arthritis

    Surabhi Gautam, Vinay Devulapalli, Akash Sathiyamurthi, Jayla Whittaker and Pallavi Bhattaram, Emory University, Atlanta, GA

    Background/Purpose: Rheumatoid arthritis (RA) and related autoimmune joint disease patients exhibit cyclic episodes of resolution and exacerbation of joint inflammation, referred to as flares. Fibroblast-like…
  • Abstract Number: 1005 • ACR Convergence 2025

    CD49a Contributes to Binding and Survival of Synovial Resident Memory T cells

    Yusuke Miyashita1, Yang Yang2, Madison Mangin3, Maryrose Hahn2 and Margaret Chang2, 1Boston Children's Hospital, Brookline, MA, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, St Simons Island, GA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease featured with recurrent inflammation in the same joints, a characteristic termed joint-specific memory. We previously demonstrated…
  • Abstract Number: 0061 • ACR Convergence 2025

    IL-22 Contributes to Autoantibody-induced Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Inflamed Synovium of a Murine Model

    Shinjiro Kaieda1, Suzuna Sugi1, Takuma Koga2, Takashi Kinoshita1 and Tomoaki Hoshino1, 1Kurume university School of Medicine, Kurume, Japan, 2Kurume Universty School of Medicine, Kurume, Japan

    Background/Purpose: IL-22 is a key cytokine involved in modulating tissue responses during inflammation and is markedly upregulated in inflammatory diseases, such as psoriasis, inflammatory bowel…
  • Abstract Number: 0995 • ACR Convergence 2025

    Resident Memory T Cells Stimulate Pathogenic Activity in Fibroblast-like Synoviocytes

    Madison Mangin1, Yang Yang2, Yusuke Miyashita2 and Margaret Chang2, 1Boston Children's Hospital, St Simons Island, GA, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint specific memory. We previously demonstrated that joint-specific memory is mediated by CD8+ synovial resident…
  • Abstract Number: 0978 • ACR Convergence 2025

    IL-17A+ HLA-DR-CCR6+ regulatory T cells: Dual role in T cell suppression and synovial inflammation in arthritis.

    Bennie Heeswijk1, Margot Bongenaar1, Nadine Davelaar1, Pascal de Jong1, Hannah den Braanker1, Radboud Dolhain1 and Erik Lubberts2, 1Erasmus University Medical Center, Rotterdam, the Netherlands, Rotterdam, Netherlands, 2Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

    Background/Purpose: Regulatory T cells (Tregs) are essential for maintaining immune tolerance and limiting excessive immune responses. However, Tregs show high levels of heterogeneity and plasticity,…
  • Abstract Number: 0919 • ACR Convergence 2025

    Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns

    Stefanie Kurth1, Andre Tiaden1, Edveena Hanser1, Simone Häner1, Stavros Giaglis1, Florian Geier1, Dominik Burri1, Katarzyna Buczak1, Ute Heider2, Stefan Wild2, Yves Acklin1, Christian Egloff1 and Diego Kyburz3, 1University of Basel, Basel, Switzerland, 2Miltenyi Biotec, Bergisch-Gladbach, Germany, 3University Hospital Basel, Basel, Switzerland

    Background/Purpose: Extracellular vesicles (EVs) are secreted by virtually all cells and are known to carry bioactive cargo including proteins, RNA, DNA and metabolites. Analysis of…
  • Abstract Number: 0807 • ACR Convergence 2025

    Deciphering Synovitis in Systemic Sclerosis

    Celina Geiss1, Miranda Houtman1, Camino Calvo Cebrian1, Raphael Micheroli2, Melpomeni Toitou1, Yannis Djeffal3, Alexandra Khmelevskaya1, Mojca Frank-Bertoncelj1, Sam Edalat1, Thomas Rauer4, Kristina Bürki5, Chantal Pauli6, Michael Bonelli7, Thomas Karonitsch8, Oliver Distler9, Caroline Ospelt1 and Muriel Elhai10, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3INSERM, IMRB, Université Paris Est Créteil, Paris, France, 43Department of Traumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, 6Institute for Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 7Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Wien, Austria, 8Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 9Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, 10University Hospital zurich, Zürich, Switzerland

    Background/Purpose: Synovitis is a common manifestation of systemic sclerosis (SSc), driving disability and predicting disease progression and mortality. Current immunosuppressive strategies, largely extrapolated from rheumatoid…
  • Abstract Number: 0799 • ACR Convergence 2025

    Citrullination of neutrophil serine proteases enhances proteolytic activity, stability and autoantigenicity in Rheumatoid Arthritis

    Mario Navarrete Lagos, Ramiza Zaman, Jun Kim, Jeba Atkia Maisha, Hani El-Gabalawy and Liam O'Neil, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: In Rheumatoid Arthritis (RA), autoantibodies develop against endogenous proteins containing the amino acid citrulline, which results from a post-translational modification of arginine catalyzed by…
  • Abstract Number: 2542 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis

    Anders Nguyen1, Miriam Bollmann1, Agnieszka Lastowska2, Anna-Karin Hultgård Ekwall1, Dietmar Zaiss3, Gary Firestein4 and Mattias Svensson5, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Goteborg, Sweden, 3University Hospital Regensburg, Regensburg, Germany, 4University of California, San Diego, San Diego, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
  • Abstract Number: 0026 • ACR Convergence 2024

    Conserved Pro-Fibrotic Fibroblast Signatures in Osteoarthritis Synovium and Systemic Sclerosis Skin

    Michael Newton1, Aanya Mohan2, Tareq Hanna3, Dana Orange4, John Varga2 and Tristan Maerz2, 1University of Michigan, South Lyon, MI, 2University of Michigan, Ann Arbor, MI, 3Wayne State University, Detroit, MI, 4The Rockefeller University, New York, NY

    Background/Purpose: Synovial fibrosis is a hallmark of osteoarthritis (OA) and a clinical correlate to joint pain. Fibrosis of skin, lungs and other organs is the…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0036 • ACR Convergence 2024

    Deep Topic Modeling Deconvolves Cell States in Spatial Transcriptomic Profiles of Rheumatoid Arthritis Synovial Tissue

    Preethi Periyakoil1, Melanie Smith2, Meghana Kshirsagar3, Daniel Ramirez4, Edward Dicarlo5, Susan Goodman6, Laura Donlin2 and Christina Leslie7, 1Weill Cornell Medical College, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Microsoft AI for Good, Seattle, 4Hospital for Special Surgery, Cartago, Costa Rica, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 6Hospital for Special Surgery, New York 10025, NY, 7Memorial Sloan Kettering Cancer Center, New York, NY

    Background/Purpose: Recent single-cell RNA sequencing (scRNA-seq) studies of the rheumatoid arthritis (RA) synovium have highlighted the heterogeneity of cell states present during active disease. It…
  • Abstract Number: 2595 • ACR Convergence 2024

    TGF-β Activated Kinase 1 (TAK1) Inhibition Suppresses Synovial Inflammation and Tissue Destruction Mediated by Activated Juvenile Idiopathic Arthritis Synovial Fibroblasts

    Meena Afroze Shanta1, Paul Panipinto2, Anil Singh3, Peter Nigrovic4, Lauren Henderson5 and Salahuddin Ahmed3, 1College of Pharmacy and Pharmaceutical Science, Washington State University, Spokane, WA, 2Washington State University College of Pharmaceutical Science and Molecular Medicine, Spokane, WA, 3Washington State university, Spokane, WA, 4Boston Children's Hospital, Brookline, MA, 5Boston Children's Hospital, Watertown, MA

    Background/Purpose: Synovial inflammation is a common manifestation of juvenile idiopathic arthritis (JIA), often accompanied by debilitating synovial hyperplasia. The current study aims to characterize the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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