ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts, Synovial"

  • Abstract Number: 0940 • ACR Convergence 2024

    Trans-endothelial Migration of Synovial Fibroblasts Promotes Arthritis Severity Through a PKD1-mediated Feedback Loop

    Jaeyeon Kim, Richard Ainsworth and Nunzio Bottini, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: The application of single cell genomic approaches to the study of rheumatoid synovium has recently enabled scientists to study the complex relationship between different…
  • Abstract Number: 1653 • ACR Convergence 2024

    Osteoarthritis Drives Inflammatory Imprinting of Synovial Fibroblasts, Exacerbating Gouty Arthritis Through m6A Modification of S100A4

    ZIYI CHEN1, Yinghui Hua2 and Wenjuan Wang1, 1Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, Shanghai, China (People's Republic), 2Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, China (People's Republic)

    Background/Purpose: Patients with osteoarthritis (OA) face an elevated risk of future gouty arthritis (GA). To delineate the underlying cellular and molecular mechanisms of OA-driven gout…
  • Abstract Number: 1661 • ACR Convergence 2024

    Rheumatoid Arthritis Synovial Fibroblast Modulation of T Cell Activation

    Melissa Romoff1, Daniel Ramirez2, Edward Dicarlo3, Susan Goodman4, Alexander Rudenska5, Laura Donlin1 and Melanie Smith1, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, Cartago, Costa Rica, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Hospital for Special Surgery, New York 10025, NY, 5Memorial Sloan Kettering Cancer Center, New York, NY

    Background/Purpose: In the rheumatoid arthritis (RA) joint, resident synovial fibroblasts (FLS) interact with infiltrating leukocytes. We previously identified a population of sublining FLS responsive to…
  • Abstract Number: 1663 • ACR Convergence 2024

    Notch—mediated Fibrogenic Activation Is a Spatial Determinant of RA Treatment Response

    Kartik Bhamidipati1, Ce Gao1, Ksenia Anufrieva2, Shideh Kazerounian3, Roopa Madhu4, Miles Tran1, Vikram Khedgikar1, Sonia Presti1, Anna Helena Jonsson5, ilya Korsunsky1 and Kevin Wei6, 1Brigham and Women's Hospital, Boston, MA, 2BWH, Cambridge, MA, 3Brigham & Women's Hospital, Boston, MA, 4Brigham and Women's Hospital, Brookline, MA, 5University of Colorado School of Medicine, Aurora, CO, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: In RA, poor treatment response has been linked to a fibroid synovial tissue phenotype, characterized by lack of immune cell infiltration and an expansion…
  • Abstract Number: 1840 • ACR Convergence 2024

    Synovial Resident Memory T Cell Formation During Inflammation Requires Cell Contact with Fibroblast-Like Synoviocytes

    Yusuke Miyashita1, Yang Yang1, Madison Mangin1, Maryrose Hahn2, Kevin Wei3, Peter Nigrovic4 and Margaret Chang1, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Georgetown, MA, 3Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 4Boston Children's Hospital, Brookline, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by recurrent inflammation in the same joints, a feature termed joint-specific memory. We previously demonstrated…
  • Abstract Number: 1856 • ACR Convergence 2024

    Distinct Proliferative and Special Properties of Peripheral Helper T Cells in RA Synovium

    Yuki Masuo1, Akinori Murakami1, Rinko Akamine1, Osamu Iri1, Koichi Murata1, Kohei Nishitani1, Hiromu Ito1, Takayuki Fujii1, Ryu Watanabe2, Takeshi Iwasaki1, Shinichiro Nakamura1, Shinichi Kuriyama1, Yugo Morita1, Yasuhiro Murakawa1, Chikashi Terao3, Yukinori Okada4, Motomu Hashimoto2, Shuichi Matsuda5, Hideki Ueno1 and Hiroyuki Yoshitomi1, 1Kyoto University, Kyoto, Japan, 2Osaka Metropolitan University, Osaka, Japan, 3RIKEN, Tokyo, Japan, 4The University of Tokyo / Osaka University / RIKEN, Tokyo, Japan, 5Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan

    Background/Purpose: Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that are frequently observed in the target tissues of chronic diseases. In patients with…
  • Abstract Number: 2531 • ACR Convergence 2024

    CRISPR Deletion Screen in Fibroblasts Identifies Novel Regulators of Inflammation

    Alisa Mueller1, Suppawat Kongthong2, Angela Zou3, Gerald Watts4, Cassandra Murphy2, Hung Nguyen2, Jacqueline Perrigoue5, Mathew Chamberlain5, Kevin Wei6, Soumya Raychaudhuri2 and Michael Brenner7, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Harvard Medical School, Boston, MA, 4Harvard Medical School, Brookline, MA, 5Johnson & Johnson, Spring House, PA, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 7Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts adopt an inflammatory phenotype that catalyzes pathogenic synovial hyperplasia and ultimately bone and cartilage destruction. However, identifying therapeutic…
  • Abstract Number: 2539 • ACR Convergence 2024

    Telocytes Integrated into Mast Cells and Joint-Draining Lymphatic Vessels Potentially Regulate Lymphatic Clearance

    Yue Peng1, H. Mark Kenney2, Karen Bentley1, Lianping Xing3, Benjamin Korman4, Christopher Ritchlin5 and Edward Schwarz1, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Henrietta, NY, 3University of Rochester School of Medicine and Dentistry, Webster, NY, 4University of Rochester, Rochester, NY, 5Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Rheumatoid arthritis (RA) patients and TNF-transgenic mice have lymphatic dysfunction (1). Recently, we showed mast cells involvement, as genetic ablation and drug inhibition decreased…
  • Abstract Number: 2542 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis

    Anders Nguyen1, Miriam Bollmann1, Agnieszka Lastowska2, Anna-Karin Hultgård Ekwall1, Dietmar Zaiss3, Gary Firestein4 and Mattias Svensson5, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Goteborg, Sweden, 3University Hospital Regensburg, Regensburg, Germany, 4University of California, San Diego, San Diego, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
  • Abstract Number: 0026 • ACR Convergence 2024

    Conserved Pro-Fibrotic Fibroblast Signatures in Osteoarthritis Synovium and Systemic Sclerosis Skin

    Michael Newton1, Aanya Mohan2, Tareq Hanna3, Dana Orange4, John Varga2 and Tristan Maerz2, 1University of Michigan, South Lyon, MI, 2University of Michigan, Ann Arbor, MI, 3Wayne State University, Detroit, MI, 4The Rockefeller University, New York, NY

    Background/Purpose: Synovial fibrosis is a hallmark of osteoarthritis (OA) and a clinical correlate to joint pain. Fibrosis of skin, lungs and other organs is the…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0036 • ACR Convergence 2024

    Deep Topic Modeling Deconvolves Cell States in Spatial Transcriptomic Profiles of Rheumatoid Arthritis Synovial Tissue

    Preethi Periyakoil1, Melanie Smith2, Meghana Kshirsagar3, Daniel Ramirez4, Edward Dicarlo5, Susan Goodman6, Laura Donlin2 and Christina Leslie7, 1Weill Cornell Medical College, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Microsoft AI for Good, Seattle, 4Hospital for Special Surgery, Cartago, Costa Rica, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 6Hospital for Special Surgery, New York 10025, NY, 7Memorial Sloan Kettering Cancer Center, New York, NY

    Background/Purpose: Recent single-cell RNA sequencing (scRNA-seq) studies of the rheumatoid arthritis (RA) synovium have highlighted the heterogeneity of cell states present during active disease. It…
  • Abstract Number: 2595 • ACR Convergence 2024

    TGF-β Activated Kinase 1 (TAK1) Inhibition Suppresses Synovial Inflammation and Tissue Destruction Mediated by Activated Juvenile Idiopathic Arthritis Synovial Fibroblasts

    Meena Afroze Shanta1, Paul Panipinto2, Anil Singh3, Peter Nigrovic4, Lauren Henderson5 and Salahuddin Ahmed3, 1College of Pharmacy and Pharmaceutical Science, Washington State University, Spokane, WA, 2Washington State University College of Pharmaceutical Science and Molecular Medicine, Spokane, WA, 3Washington State university, Spokane, WA, 4Boston Children's Hospital, Brookline, MA, 5Boston Children's Hospital, Watertown, MA

    Background/Purpose: Synovial inflammation is a common manifestation of juvenile idiopathic arthritis (JIA), often accompanied by debilitating synovial hyperplasia. The current study aims to characterize the…
  • Abstract Number: 0042 • ACR Convergence 2024

    Modulating Inflammation and Angiogenesis in an Advanced 3D Rheumatoid Arthritis Synovial Tissue Model

    Eva Philippon1, Jan Piet van Hamburg1, Lisanne van Rooijen1, Gary Sims2, Conny Van der Laken3 and Sander Tas4, 1Amsterdam UMC, Amsterdam, Netherlands, 2Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 3Amsterdam UMC - location VUMC, Amsterdam, Netherlands, 4Amsterdam UMC, locatie AMC, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid Arthritis (RA) is a progressive and systemic autoimmune disorder characterized by chronic and destructive joint inflammation. Key features of RA include synovial cell…
  • Abstract Number: 0771 • ACR Convergence 2024

    Arid5b Controls Pathologic Inflammatory versus Invasive Fibroblast Behavior

    Angela Zou1, Suppawat Kongthong2, Cassandra Murphy2, Gerald Watts3, Alisa Mueller4 and Michael Brenner5, 1Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Harvard Medical School, Brookline, MA, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: Synovial fibroblasts assume both inflammatory and tissue invasive roles in rheumatoid arthritis (RA). Recent studies have shown that these inflammatory and invasive functions are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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