Abstracts tagged "fibroblasts and rheumatoid arthritis (RA)"

Abstract Number: 2736 • 2013 ACR/ARHP Annual Meeting
High Density Microarray Analysis Identifies Novel Differentially Expressed Long Noncoding RNAs In Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴ and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression. Recently, several new susceptibility loci were identified for rheumatoid arthritis (RA), mapping…
Abstract Number: 2712 • 2013 ACR/ARHP Annual Meeting
Increased Soluble PD-1: A Link Between Generation Of Immunological Memory and Risk Of Disease Flare In Early RA
Stinne Greisen¹, Tue W. Kragstrup², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Malene Hvid⁶ and Bent Deleuran², ¹Dept of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Arhus University Hospital, Aarhus, Denmark, ⁴Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ⁵Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, ⁶Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Disturbances in the regulatory mechanisms of the immune system play a major role in rheumatoid arthritis (RA). Programmed Death 1 (PD-1) on lymphocytes negatively…
Abstract Number: 1853 • 2013 ACR/ARHP Annual Meeting
Functions Of Aminopeptidase N/CD13 In Vitro On Rheumatoid Arthritis Synovial Cells
Rachel Morgan¹, Nilofar Behbahani-Nejad², Judith Endres³ and David A. Fox⁴, ¹Immunology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Rheumatology/Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Aminopeptidase N (CD13, EC 3.4.11.2) is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS) that is also found in soluble form…
Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Adelheid Korb-Pap¹, Jan Hillen¹, Marianne Heitzmann¹, Catherine S. Chew², Stefan Butz³, Dietmar Vestweber⁴, Hermann Pavenstädt⁵ and Thomas Pap¹, ¹Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ³Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁴Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
Abstract Number: 1183 • 2012 ACR/ARHP Annual Meeting
Podoplanin-Mediated Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Platelets Modulates IL-8 Expression
Manuel J. Del Rey¹, Elena Izquierdo¹, Regina Faré¹, Alicia Usategui¹, Vanessa Miranda¹, Gabriel Criado², J. D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Unitat d'Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona,, Barcelona, Spain
Background/Purpose: Synovial fibroblasts (SF) are the most abundant resident stromal cells in the synovium. In rheumatoid arthritis (RA), SF expand and undergo phenotypic changes that…
Abstract Number: 902 • 2012 ACR/ARHP Annual Meeting
Activation of NF-Kb Via Poly(I:C)-Induced Monocyte-Derived Microparticles Decreases TRAIL-Induced Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Blaz Rozman², Beat A. Michel³, Renate E. Gay¹, David S. Pisetsky⁴, Oliver Distler⁵, Steffen Gay⁶ and Astrid Juengel⁷, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Medicine, Duke University Medical Center, Durham, NC, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, CH-8091, Switzerland, ⁷Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland
Background/Purpose: Decreased sensitivity of rheumatoid arthritis (RA) synovial fibroblasts (SF) to apoptosis leads to synovial hyperplasia and destruction of joints in RA. Activation of NF-kB…
Abstract Number: 435 • 2012 ACR/ARHP Annual Meeting
CIP2A Facilitates Apoptotic Resistance of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis Independent of c-Myc Expression
Jaejoon Lee¹, Jiwon Hwang¹, Jinseok Kim², Joong Kyong Ahn³, Hoon-Suk Cha¹ and Eun-Mi Koh⁴, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Jeju National University Hospital, Jeju, South Korea, ³Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea
Background/Purpose: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that leads to cellular proliferation in cancer cells by stabilizing c-Myc protein.…

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