Abstracts tagged "fibroblasts and rheumatoid arthritis (RA)"

Abstract Number: 145 • 2018 ACR/ARHP Annual Meeting
1,25(OH)2D3 and Dexamethasone Additively Suppress Synovial Fibroblast Activation By CCR6+ T-Helper Memory Cells and Enhance the Effect of Tnfα Blockade
W Dankers¹, C González-Leal¹, N Davelaar², P Asmawidjaja³, A Otten-Mus², JMW Hazes⁴, E Colin⁵ and Erik Lubberts⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Erasmus Medical Centre, Rotterdam, Netherlands, ⁵ZGT Almelo, Deventer, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Despite improvement in treatment of rheumatoid arthritis (RA) over the past decades, insufficient treatment response and treatment resistance in many patients demonstrate the need…
Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, Amanda Kuhs¹, Rizi Ai², David L. Boyle¹, Wei Wang³ and Gary S. Firestein¹, ¹Medicine, University of California San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…
Abstract Number: 44 • 2017 ACR/ARHP Annual Meeting
Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies
Elisa Corsiero¹, Lucas Jagemann¹, Costantino Pitzalis² and Michele Bombardieri³, ¹Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: We previously showed that up to 40% of RA synovial recombinant monoclonal antibodies (RA-rmAbs) generated from germinal center-like structure (GC-LS+) RA synovium recognize citrullinated…
Abstract Number: 971 • 2017 ACR/ARHP Annual Meeting
Synovial Fibroblast CD318 Expression Mediates T Cell Adhesion and Migration in Rheumatoid Arthritis
Ray A. Ohara¹, Stephanie M. Rasmussen¹, W. Alexander Stinson¹, Huadong Cui¹, Yuxuan Du¹, Daniel P. Weber¹, M. Asif Amin¹, Phillip L. Campbell², Nora Singer³, Feng Lin⁴, David A. Fox¹ and Jeffrey H. Ruth⁵, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Ann Arbor, MI, ³Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁴Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, Cleveland, OH, ⁵Internal Medicine, Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI
Background/Purpose: CD6 is an important marker and regulator of T cells and interacts with its known ligand, CD166. Our group has previously shown that interferon…
Abstract Number: 1434 • 2017 ACR/ARHP Annual Meeting
COX-2 Inhibitor Contributes Cell Death in Rheumatoid Arthritis Fibroblast-like Synoviocytes Via PI3K/AKT/mTOR Signaling Pathway Triggered By Autophagy
Sang-Hyon Kim¹, Jihye Bang², Ji-Min Kim¹, Chang-Nam Son¹, Jin-Nyeong Chae¹ and Hye-Jin Jeong³, ¹Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, Republic of (South), ³Department of Rheumatology, Keimyung University Dongsan Medical Center, Daegu, Korea, Republic of (South)
Background/Purpose: Recently, the possibilities that autophagy regulates apoptosis resistance and hyperplasia of fibroblast-like synoviocytes (FLS) were also presented. The aim of this study is to…
Abstract Number: 2793 • 2017 ACR/ARHP Annual Meeting
Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, David L. Boyle², Rizi Ai³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³UC San Diego, La Jolla, CA, ⁴Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁵Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Aberrant epigenetic marks in RA FLS contribute to disease pathogenesis and aggressive FLS behavior. Computational data also suggest that RA FLS isolated from different…
Abstract Number: 1578 • 2016 ACR/ARHP Annual Meeting
Functional Screening of Micrornas Using the Inhibitor Library Identified Micrornas to Regulate Expression of MMP-3 and IL-6 in Rheumatoid Arthritis Synovial Fibroblasts
Fumitaka Mizoguchi, Hisanori Hasegawa and Hitoshi Kohsaka, Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They secrete proteinases and proinflammatory cytokines to damage the synovial tissues in…
Abstract Number: 2154 • 2016 ACR/ARHP Annual Meeting
Novel Pathogenic Functions of IL-11 on RA Joint Fibroblasts and Endothelial Cells
Hatem A. Elshabrawy^1,2, Abdul B. Essani^1,2, Zhenlong Chen¹, Michael Volin³, Iain B McInnes⁴, Seung-jae Kim^2,5 and Shiva Shahrara^2,6, ¹Medicine, University of Illinois at Chicago, Chicago, IL, ²Jesse Brown VA Medical Center, Chicago, IL, ³Midwestern University, Downers Grove, IL, ⁴University of Glasgow, Glasgow, Great Britain, ⁵University of Illinois at Chicago, Chicago, IL, ⁶Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 2.5 millions of Americans. Several cytokines are involved in RA pathogenesis and may serve as…
Abstract Number: 2568 • 2016 ACR/ARHP Annual Meeting
ARL15 expressed By Rheumatoid Arthritis Synovial Fibroblasts Regulates IL6 and Plays a Role in Apoptosis and Hypoxia
SUJIT KASHYAP¹, Patralika Chattopadhyaay¹, Anuj kumar Pandey¹, Uma Kumar², Chandra Shekhar Yadav³ and B.K Thelma¹, ¹DEPARTMENT OF GENETICS, UNIVERSITY OF DELHI SOUTH CAMPUS, NEW DELHI, India, ²Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India, ³Orthopaedics, All India Institute of Medical Sciences, New Delhi, India
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic, inflammatory condition that affects more than 1% population globally. Several studies suggest RA to be controlled by a…
Abstract Number: 3120 • 2016 ACR/ARHP Annual Meeting
RA Net: A Systems Biology Approach to Identify Genes Regulating Pathogenic Pathways in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Wei Wang¹, RIchard Ainsworth², Richard Stein², Rizi Ai³ and Gary Firestein⁴, ¹Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ²UC San Diego, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Medicine, UCSD, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) remains a significant unmet need despite improved therapy. Defining the interlaced nature of gene regulation and disease pathogenesis using integrative systems…
Abstract Number: 2213 • 2015 ACR/ARHP Annual Meeting
RA-Associated Autoantibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua², Aase Haj Hensvold^1,3, Khaled Amara⁴, Vivianne Malmström¹, Heidi Wähämaa¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with a more aggressive disease phenotype and bone destruction. Synovial fibroblasts (SFs) are…
Abstract Number: 2136 • 2015 ACR/ARHP Annual Meeting
Identification of Synovial Fibroblast Subsets That Define Pathology in Rheumatoid Arthritis
Fumitaka Mizoguchi¹, Kamil Slowikowski^2,3, Sook Kyung Chang¹, Deepak A. Rao⁴, Hung Nguyen¹, Erika H. Noss⁵, Brandon E. Earp⁶, Philip E. Blazar⁶, John Wright⁶, Barry P. Simmons⁶, Nir Hacohen^7,8,9, Peter A. Nigrovic^1,10, Soumya Raychaudhuri^2,3,11 and Michael B. Brenner¹, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Divison of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Broad Institute of MIT and Harvard, Cambridge, MA, ⁸Massachusetts General Hospital, Charlestown, MA, ⁹Harvard Medical School, Boston, MA, ¹⁰Division of Immunology, Boston Children's Hospital, Boston, MA, ¹¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Synovial fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). They expand as part of the pannus, mediate degradation of cartilage, amplify…
Abstract Number: 1174 • 2015 ACR/ARHP Annual Meeting
Class 3 Semaphorins Modulate the Invasive Capacity of Rheumatoid Arthritis Fibroblast-like Synoviocytes
Samuel Garcia Perez¹, Bea Malvar Fernandez¹, Simon P. Newsom², Man Wai Tang², T.R.D.J. Radstake³, Dominique Baeten², Paul P. Tak^2,4 and Kris A. Reedquist¹, ¹Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴University of Cambridge and GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: The semaphorin family is a large group of proteins initially described as axon guidance molecules that play crucial roles in the development of the…
Abstract Number: 1035 • 2014 ACR/ARHP Annual Meeting
TNF-á Modulates the Expression of Circadian Clock Genes Via Calcium Signaling in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Nao Shibanuma², Teppei Hashimoto^3,4, Yoshiko Kawasaki⁴, Naonori Hashimoto¹, Ayako Nakai¹, Kenta Kaneshiro¹, Koji Tateishi⁵, Natsuko Nakagawa⁵ and Akira Hashiramoto^1,4,6, ¹Faculty of Health Sciences, Kobe University School of Medicine, Kobe, Japan, ²Department of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ³Department of General Internal Medicine, Kobe University School of Medicine, Kobe, Japan, ⁴Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁶Clinical Immunology, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 993 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Proteins Antibodies Promote Synovial Fibroblast Migration in Rheumatoid Arthritis
Meng Sun¹, Vijay Joshua¹, Aase Haj Hensvold¹, Sergiu-Bogdan Catrina², Lars Klareskog³, Vivianne Malmström⁴, Heidi Wähämaa¹ and Anca I Catrina¹, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁴Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with aggressive disease phenotype and bone destruction. As synovial fibroblasts (SFs) are considered…