ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "extracellular matrix proteins"

  • Abstract Number: 583 • 2019 ACR/ARP Annual Meeting

    A Biomarker of Type VI Collagen Degradation (C6M) Is Associated with Changes in ASDAS MRI Measures of Inflammation in Patients with Axial Spondyloarthritis During TNF Inhibitor Therapy

    Signe Holm Nielsen1, Anne Bay-Jensen 2, Mikkel Østergaard 3, Anne Siebuhr 4, Morten Karsdal 5, inge Juul Sørensen 6, Ulrich Weber 7, Anne Gitte Loft 8, Gina Kollerup 9, Gorm Thamsborg 9, Ole Rintek Madsen 10, Jakob Møller 11 and Susanne Juhl Pedersen 12, 1Nordic Bioscience/Technical University of Denmark, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, 4Nordic Bioscience, Herlev, 5Nordic Bioscience, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, 7Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, 8Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, 9Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, 10Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 11Department of Radiology, Herlev and Gentofte University Hospital, Herlev, Denmark, Copenhagen, Denmark, 12Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark

    Background/Purpose: Axial spondyloarthritis (AxSpa) is characterized by inflammation in the sacroiliac joints and spine and associated with extracellular matrix (ECM) remodelling of affected tissues. Type…
  • Abstract Number: 2863 • 2019 ACR/ARP Annual Meeting

    Increased Expression of Extracellular Matrix Proteins in Human Fibroblast Synoviocytes and Lung Epithelial Cells Following Malondialdehyde-Acetaldehyde Adduct (MAA)/Citrullinated Protein Stimulation

    Matthew O'Dell1, Logan Duryee 1, Lynell Klassen 1, James O'Dell 2, Bryant England 3, Michael Duryee 1, Geoffrey Thiele 2 and Ted Mikuls 2, 1University of Nebraska Medical Center, Omaha, NE, 2VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 3VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha

    Background/Purpose: Recently we have shown that both malondialdehyde-acetaldehyde adducts (MAA) and citrullinated proteins (CIT) are co-localized in joint and lung tissues of patients with rheumatoid…
  • Abstract Number: 70 • 2018 ACR/ARHP Annual Meeting

    Colocalization of Malondialdehyde-Acetaldehyde Adducts (MAA) and Extracellular Matrix Proteins in Joint and Lung Tissues from Rheumatoid Arthritis Patients

    Geoffrey M. Thiele1, Michael J. Duryee2, Jacob D. McGowan1, Logan M. Duryee1, Lynell W. Klassen3, James R. O'Dell3, Bryant R. England4 and Ted R. Mikuls5, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Malondialdehyde-acetaldehyde adducts (MAA) are products of oxidative stress that modify self-proteins and stimulate potent cellular and humoral immune responses. We have previously demonstrated…
  • Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting

    Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis

    Yunyun Su1, Stanley Hoffman2 and Carol A. Feghali-Bostwick3, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, 2Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…
  • Abstract Number: 1106 • 2016 ACR/ARHP Annual Meeting

    Test of the Spleen Tyrosine Kinase Inhibitor Fostamatinib in a Translational Joint Tissue Model Show Significant Effect on Bone, but Not on Synovial Tissue

    Cecilie F. Kjelgaard-Petersen1,2, Anne C. Bay-Jensen3, Thorbjørn G. Christiansen4, Morten Asser Karsdal3, Per Hägglund2 and Christian S. Thudium1, 1Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, 3Rheumatology, Nordic Bioscience, Herlev, Denmark, 4Gentofte University Hospital, Orthopaedicsurgery unit, Gentofte, Denmark

    Background/Purpose: The Spleen tyrosine kinase (Syk) inhibitor fostamatinib was not approved as treatment for rheumatoid arthritis (RA) due to insufficient effect on joint structure in…
  • Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting

    Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease

    Elena Pachera1, Shervin Assassi2, Gloria Salazar2, Mojca Frank Bertoncelj1, Rucsandra Dobrota1, Matthias Brock3, Fina Kurreeman4, Jeska K. de Vries-Bouwstra4, Tobias Messemaker4, Carol Feghali-Bostwick5, Jeorg HW Distler6, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 3Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 6Internal Medicine 3, University of Erlangen, Erlangen, Germany

    Background/Purpose:  Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…
  • Abstract Number: 1151 • 2015 ACR/ARHP Annual Meeting

    The Proteomic Profile of Histological Samples Derived from a Surgical Mouse Model of Osteoarthritis Reveals an Unexpected Mode of Action for the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017

    Gianfranco Caselli1, Riccardo Chiusaroli2, Michela Visintin3, Tiziana Piepoli2, Ornella Letari2, Adriana Grotti2, Marco Lanza2, Antonella De Palma4, Dario di Silvestre4, Pierluigi Mauri4 and Lucio Claudio Rovati2, 1Pharmacology & Toxicology, Rottapharm Biotech Srl, Monza, Italy, 2Rottapharm Biotech Srl, Monza, Italy, 3Rottapharm Biotech Srl, Trieste, Italy, 4Institute for Biomedical Technologies - CNR, Segrate, Italy

    Background/Purpose : CRB0017 is a novel therapeutic monoclonal antibody that recognizes the spacer domain of aggrecanase-2, a key enzyme in the degradation of extracellular matrix…
  • Abstract Number: 1149 • 2015 ACR/ARHP Annual Meeting

    The Active Metabolite of Fostamatinib, R406, Only Decreases the Inflammation-Driven Extracellular Matrix Turnover of the Joint at High Concentrations Ex Vivo

    Cecilie F. Kjelgaard-Petersen1,2, Christian S. Thudium1, Anne Sofie Siebuhr1, Thorbjørn G. Christiansen3, Morten Asser Karsdal1, Per Hägglund2 and Anne C. Bay-Jensen4, 1Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, 3Gentofte University Hospital, Orthopaedicsurgery unit, Gentofte, Denmark, 4Biomarkers and Research, Rheumatology, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis are degenerative diseases of the whole joint.  The extracellular matrix (ECM) turnover is highly regulated in response to the…
  • Abstract Number: 654 • 2013 ACR/ARHP Annual Meeting

    Effects Of Macitentan and Its Active Metabolite In Modulating Extracellular Matrix Synthesis In Cultured Human Systemic Sclerosis and Normal Skin Fibroblasts

    Maurizio Cutolo1, Paola Montagna2, Renata Brizzolara2, Elisa Alessandri3, Pietro Paolo Tavilla4, Aurora Parodi4, Alberto Sulli5 and Stefano Soldano6, 1University of Genova, Genova, Italy, 2Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, 3Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 4Department of Endocrinologial and Medical Science, Unit of Dermatology, University of Genova, Genova, Italy, 5Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 6Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy

    Background/Purpose: Endothelin-1 (ET-1) has been shown to activate myofibroblasts and to enhance the synthesis of extracellular matrix proteins (ECM),  such as collagen type I (COL-1)…
  • Abstract Number: 48 • 2012 ACR/ARHP Annual Meeting

    Tissue Engineering for Articular Cartilage Repair, Culturing Bone Marrow Mesenchymal Stem Cells On Collagen and Heparan Sulphate Scaffolds

    Adela Helvia Martinez-Sanchez1, Clara Sanjurjo-Rodriguez1, Silvia Diaz-Prado2, Emma Muiños1, Isaac M. Fuentes2, Francisco J. De Toro2, Julia Bujan3 and Francisco J. Blanco1, 1Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC-University of A Coruña, A Coruña, Spain, 3Department of Medical Specialties. University of Alcala de Henares, Madrid, Spain

     Background/Purpose: The aim of this study was to evaluate the chondrogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) grown on type I collagen and…
  • Abstract Number: 859 • 2012 ACR/ARHP Annual Meeting

    Endothelin-1 (ET-1) Induces Extracellular Matrix Protein Production by Human Temporal Artery Derived Myointimal Cells. A Mechanism Potentially Leading to Intimal Hyperplasia and Vascular Occlusion in Giant-Cell Arteritis

    Ester Planas-Rigol1, Marc Corbera-Bellalta2, Marco A. Alba3, Itziar Tabera-Bahillo3, Sergio Prieto-Gonzalez3, Georgina espigol-Frigole3, Jose Hernandez-Rodriguez4, Ester Lozano5 and Maria C. Cid6, 1Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 2Hospital Clinic University Barcelona, Hospital Clinic University Barcelona, Barcelona, Spain, 3Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, Barcelona, Spain, 4Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 5Vasculitis research Unit, systemic autoimmune diseases department. Idibaps., Hospital Clinic University Barcelona, 6Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Background/Purpose: Endothelin-1 (ET-1) is the main isoform of the Endothelin family. It is also the most powerful vasoconstrictor identified. ET-1 is constitutively produced in blood…
  • Abstract Number: 2286 • 2012 ACR/ARHP Annual Meeting

    Dysregulated Discoidin Domain Receptor 2-Microrna 196a-Mediated Negative Feedback Against Excess Type I Collagen Expression in Scleroderma Dermal Fibroblasts

    Katsunari Makino1, Masatoshi Jinnin1, Jun Aoi1, Ikko Kajihara1, Takamitsu Makino2, Keisuke Sakai1, Satoshi Fukushima1, Yuji Inoue1 and Hironobu Ihn2, 1Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan, 2Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan

    Background/Purpose: Systemic sclerosis (SSc) is characterized by the excess deposition of collagen in the skin, due to intrinsic transforming growth factor (TGF)-β activation. The discoidin…
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