Abstracts tagged "extraarticular manifestations"

Abstract Number: 645 • 2018 ACR/ARHP Annual Meeting
Real World Secukinumab Study in Ankylosing Spondylitis and Psoriatic Arthritis – Comorbidities and Extraarticular Manifestations: Incidence and Status throughout a Non-Interventional Study in Germany
Uta Kiltz¹, Peter Kaestner², Holger Krauel², Ilka Schwarze³, Jan Brandt-Juergens⁴, Monika Maier-Peuschel⁵, Carolin Legeler⁵, Justyna Veit⁵ and Hans-Peter Tony⁶, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology, Ambulantes Rheumazentrum, Erfurt, Germany, ³Praxis internistische Rheumatologie, Leipzig, Germany, ⁴Rheumatology, Rheumatologische Schwerpunktpraxis, Berlin, Germany, ⁵Novartis Pharma GmbH, Nürnberg, Germany, ⁶Rheumatology/Immunology, Medizinische Klinik II, Universitätsklinik, Würzburg, Germany
Background/Purpose: Patients with psoriatic arthritis (PsA) or ankylosing spondylitis (AS) may suffer from extraarticular (EA) manifestations (uveitis, psoriasis) and have higher rates of comorbidities like…
Abstract Number: 929 • 2018 ACR/ARHP Annual Meeting
Transcriptional Profiling of the Subcutaneous Rheumatoid Nodule: An Insight into Pathogenic Mechanisms and Cellular Content
Judith Marsman¹, Melanie J Millier¹, John Highton¹, Lisa K. Stamp² and Paul A Hessian¹, ¹Department of Medicine, University of Otago, Dunedin, New Zealand, ²University of Otago, Christchurch, New Zealand
Background/Purpose: Rheumatoid nodules are the most common cutaneous manifestation in patients with RA, often associated with longstanding and a more severe disease course. Paradoxically, therapy…
Abstract Number: 1593 • 2018 ACR/ARHP Annual Meeting
Extra-Articular Manifestations, Neoplasms and Cardiovascular Events in a Series of Spondyloarthritis from a Single Center
Itziar Calvo Zorrilla¹, Edurne Guerrero Basterretxea¹, Oihane Ibarguengoitia¹, David Montero¹, Maria Luz Garcia Vivar¹, Esther Ruíz Lucea², Ignacio Torre Salaberri², Olaia Begoña Fernandez Berrizbeitia², Juan Maria Blanco Madrigal², Ana Rosa Inchaurbe Pellejero¹, Clara Eugenia Perez Velasquez², Natalia Rivera-García³, Maria Jesus Allande Lopez Linares³, Iñigo Gorostiza-Hormaetxe⁴ and Eva Galíndez Agirregoikoa², ¹Rheumatology, Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ²Rheumatology Department; Basurto University Hospital, Bilbao, Spain, ³Rheumatology, University Hospital of Basurto, Bilbao, Spain, ⁴Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Spondyloarthritis(SpA) is characterized by axial, peripheral and extra-articular manifestation(EAMs). Its frequency depends on the series, being the psoriasis(Ps), uveitis and inflammatory bowel disease(IBD) the…
Abstract Number: 1631 • 2018 ACR/ARHP Annual Meeting
Incidence of Uveitis in Patients with Spondyloarthritis: The Impact of Biologics Era.a Multicenter Study Using Data from International ASAS-Comospa Study
Hernán Maldonado Ficco¹, Rodolfo Perez-Alamino², Christian A. Waimann³, José A. Maldonado-Cocco⁴, Anna Moltó⁵, Maxime Dougados⁶, Robert B.M. Landewé⁷, Désirée van der Heijde⁸ and Filip van Den Bosch⁹, ¹Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina, ²Rheumatology Department, Hospital de Clínicas Pte. Dr. Nicolás Avellaneda, Tucumán, Argentina, ³Hospital Dr. Hector Cura, Olavarria, Argentina, ⁴Buenos Aires University, University of Buenos Aires School of Medicine. Argentina, Buenos Aires, Argentina, ⁵Rheumatology Department, Hôpital Cochin, AP-HP, Paris, France, ⁶Hopital Cochin, Paris, France, ⁷Amsterdam Rheumatology & Clinical Immunology Center and Zuyderland Medical Center, Amsterdam; Heerlen, Netherlands, ⁸Leiden University Medical Center, Leiden, Leiden, Netherlands, ⁹Department of Rheumatology, University of Ghent, Ghent, Belgium, Ghent, Belgium
Background/Purpose: Uveitis is a common extra-articular manifestation in Spondyloarthritis (SpA). The purpose of this study was to analyze incidence of uveitis in SpA patients during…
Abstract Number: 1638 • 2018 ACR/ARHP Annual Meeting
Impact of Extra-Articular Manifestations on Patient-Reported Outcomes in Ankylosing Spondylitis and Psoriatic Arthritis: Interim Results from the Complete Studies
Louis Bessette¹, Majed Khraishi^2,3, Brandusa Florica⁴, Yatish Setty⁵, Michelle Teo⁶ and Valencia P. Remple⁷, ¹Centre Hospitalier de l'Université Laval, Quebec, QC, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Nexus Clinical Research, Memorial University of Newfoundland, St Johns, NF, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Grey Bruce Health Services, Owen Sound, ON, Canada, ⁶University of British Columbia, Penticton, BC, Canada, ⁷AbbVie Corporation, Montreal, QC, Canada
Background/Purpose: Extra-articular manifestations (EAMs) in rheumatic diseases have been previously found to negatively impact health outcomes including quality of life and work capacity. Even though…
Abstract Number: 2506 • 2018 ACR/ARHP Annual Meeting
The Joint Disease Burden in Patients with Secondary Sjögren’s Syndrome and RA Compared to Patients with RA Only
Evo Alemao¹, Yogesh Saini², Ying Bao¹, Aarti Rao², Christine K Iannaccone³, Michael E Weinblatt³ and Nancy A. Shadick³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is considered a poor prognostic factor in RA and is a common extra-articular manifestation of RA. We estimated prevalence of…
Abstract Number: 2520 • 2017 ACR/ARHP Annual Meeting
Incidence of Extra-Articular Manifestations in Psa and As Patients Treated with Golimumab in Canadian Real-World
Michelle Teo¹, Derek Haaland², John Kelsall³, Isabelle Fortin⁴, Pauline Boulos⁵, Raman Rai⁶, Sanjay Dixit⁷, B Haraoui⁸, Dalton Sholter⁹, Eliofotisti Psaradellis¹⁰, Emmanouil Rampakakis¹⁰, Brendan Osborne¹¹, Francois Nantel¹¹ and Allen J Lehman¹², ¹Balfour Medical Clinic, Penticton, BC, Canada, ²Rheumatology, Clinical Immunology & Allergy, McMaster University, Barrie, ON, Canada, ³Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁴Centre de Rhumatologie De l’Est du Quebec, Rimouski, QC, Canada, ⁵Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Private Practice, Hamilton, ON, Canada, ⁷Rheumatology, McMaster University Hamilton, Burlington, ON, Canada, ⁸Institut de Recherche en Rhumatologie de Montréal (IRRM), Montreal, QC, Canada, ⁹Rheumatology Associates, Edmonton, AB, Canada, ¹⁰JSS Medical Research, Montreal, QC, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹²Janssen Inc., Toronto, ON, Canada
Background/Purpose: Spondyloarthropathies (SpA) encompass a heterogeneous group of chronic inflammatory diseases affecting axial and peripheral joints. Besides articular symptoms, patients also experience extra-articular manifestations (EAMs)…
Abstract Number: 1355 • 2016 ACR/ARHP Annual Meeting
ASAH1 Gene Mutations Cause Acid Ceramidase Deficiency (Farber Disease), with Symptoms Including Arthritis and Subcutaneous Nodules. Patients Are Often Misdiagnosed with JIA, and Slowly Progressive Disease May Only be Diagnosed in Adulthood
Alexander Solyom¹, Calogera Simonaro² and Edward Schuchman³, ¹Roivant Sciences, New York, NY, ²Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, ³Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Mutations in the ASAH1 gene cause acid ceramidase deficiency, accumulation of the pro-inflammatory and pro-apoptotic lipid ceramide, and a distinct set of clinical features,…
Abstract Number: 1486 • 2016 ACR/ARHP Annual Meeting
Associations Between Heart Rate Adjusted ST Segment and Heart Rate Variability in Patients with Rheumatoid Arthritis
Ahmad Osailan^1,2, Jet JJCS Veldhuijzen van Zanten^2,3, Joan Duda¹, Sally Fenton^1,2, Peter Rouse⁴, Nikos Ntoumanis⁵, George D. Kitas^1,2 and George Metsios^2,6, ¹School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, ²Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ³School of Sport, Exercise and Rehabilitation, University of Birmingham, Dudley, United Kingdom, ⁴Department for Health, University of Bath, Bath, United Kingdom, ⁵School of Psychology & Speech Pathology, Curtin University, Perth, Australia, ⁶Department of Physical Activity Exercise and Health, University of Wolverhampton, Walsall, United Kingdom
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for myocardial infarction (MI), which is often silent. Heart rate adjusted ST segment (ST/HR index)…
Abstract Number: 1724 • 2016 ACR/ARHP Annual Meeting
The Effect of Certolizumab Pegol on Skin Manifestations of Psoriatic Arthritis over 4 Years of Treatment
Majed Khraishi¹, Alice B. Gottlieb², Bengt Hoepken³, Luke Peterson⁴ and Philip J. Mease⁵, ¹Department of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Tufts University School of Medicine, Boston, MA, ³UCB Pharma, Monheim, Germany, ⁴UCB Pharma, Raleigh, NC, ⁵Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: The majority of patients (pts) with psoriatic arthritis (PsA) experience psoriatic skin manifestations, which add to the already high burden of disease. The RAPID-PsA…
Abstract Number: 2879 • 2015 ACR/ARHP Annual Meeting
What Is the Location of Dactylitis in Ankylosing Spondylitis and Psoriatic Arthritis Patients and How Do They Respond to Anti-TNF Treatment?
Regan Arendse¹, Proton Rahman², Denis Choquette³, J Antonio Avina-Zubieta⁴, Michel Zummer⁵, Milton F. Baker⁶, Jacqueline Stewart⁷, Isabelle Fortin⁸, Michelle Teo⁹, Emmanouil Rampakakis¹⁰, Eliofotisti Psaradellis¹¹, Brendan Osborne¹², Cathy Tkaczyk¹², Karina Maslova¹³, Francois Nantel¹⁴ and Allen J Lehman¹³, ¹University of Saskatchewan, Saskatoon, SK, Canada, ²Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ³Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁴Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada, ⁵Rheumatology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada, ⁶VIHA, Victoria, BC, Canada, ⁷Penticton Regional Hospital, Penticton, BC, Canada, ⁸Centre de Rhumatologie de l'Est du Québec, Rimouski, QC, Canada, ⁹Rheumatology, Penticton Regional Hospital, Penticton, BC, Canada, ¹⁰JSS Medical Research, St-Laurent, QC, Canada, ¹¹JSS Medical Research, Montreal, QC, Canada, ¹²Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹³Janssen Inc., Toronto, ON, Canada, ¹⁴19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Dactylitis is one of the most commonly reported features in spondyloarthritis. It has been hypothesized that dactylitis is a functional enthesitis at the proximal…
Abstract Number: 1613 • 2015 ACR/ARHP Annual Meeting
Expression of the Genes Facilitating Methotrexate Action within Rheumatoid Subcutaneous Nodules
Emma Houlder¹, Melanie Millier², John Highton³, Lisa K. Stamp⁴ and Paul Hessian², ¹Medicine, University of Otago, Dunedin, New Zealand, ²Department of Medicine, University of Otago, Dunedin, New Zealand, ³Dept of Medicine, University of Otago, Dunedin, New Zealand, ⁴Medicine, University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose: Methotrexate (MTX) is the most frequently used DMARD in the treatment of rheumatoid arthritis (RA). There are known links between the use of MTX…
Abstract Number: 1590 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Related Interstitial Lung Disease (RA-ILD): Methotrexate and the Extension of Lung Disease Are Associated to Prognosis
Jorge Rojas-Serrano¹, Denisse Herrera-Bringas², Renzo Perez-Dorame³, Mayra Mejia² and Heidegger Mateos-Toledo⁴, ¹Interstitial Lung Diseases Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico, ²Interstitial Lung Diseases Unit, Insituto Nacional de Enfermedades Respiratorias, Mexico, Mexico, ³Intertitial Lung Disease Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico, ⁴Interstitial Lung Diseases Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico
Background/Purpose:Interstitial lung disease (ILD) is a severe rheumatoid arthritis manifestation with a median survival of 2.6 years. Worst survival has been associated to usual interstitial…
Abstract Number: 1566 • 2015 ACR/ARHP Annual Meeting
The Impact of Severe Extra-Articular Manifestations and Patient Reported Outcome Measures on Cardiovascular Disease in Rheumatoid Arthritis
Lisa Theander¹, Jan-Åke Nilsson¹, Minna Willim^1,2, Britt-Marie Nyhäll-Wåhlin^1,3, Lennart T.H. Jacobsson^1,4 and Carl Turesson^1,5, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, ³Department of Rheumatology, Falun Hospital, Falun, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁵Lund University, Rheumatology, Dept. of Clinical Sciences,, Malmö, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD). Disease severity, including extra-articular rheumatoid arthritis (ExRA) manifestations, has previously been demonstrated…
Abstract Number: 1562 • 2015 ACR/ARHP Annual Meeting
Clinical Correlates, Outcomes and Predictors of Episcleritis and Scleritis Associated with Rheumatoid Arthritis
Cristian Caimmi¹, Wendy M. Smith², Cynthia S. Crowson³, Eric L. Matteson⁴ and Ashima Makol⁵, ¹Unit of Rheumatology, Department of Medicine,, University of Verona, Verona, Italy, ²Department of Ophthalmology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology and Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
Background/Purpose: Inflammatory ocular disease (IOD) has traditionally been regarded as a severe extra-articular manifestation of rheumatoid arthritis (RA) with high mortality. This study aims to…