ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Experimental Arthritis"

  • Abstract Number: 0947 • ACR Convergence 2024

    REX-7117 Is a Highly Potent and Selective Oral STAT3 Inhibitor That Demonstrated Potential Efficacy and Safety Differentiation versus JAK/TYK2 Targeting in Preclinical Models of Inflammatory Arthritis

    Alexandra Gardino1, Neil Bifulco1, Jeremy Hunt2, Rishi Vaswani1, Donglim Park2, Patrick Metz2, Ksenya Cohen-Katsenelson2, Jeong-Ho Kim2, Xia Tian2, Aryan Alavi2, Ajay Nirula2, Daniel Treiber2, Brian Hodous1, Seong Kim3 and Paul Smith2, 1Recludix Pharma, Cambridge, MA, 2Recludix Pharma, San Diego, CA, 3Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA

    Background/Purpose: Inhibition of JAK family signaling has translated into clinically meaningful efficacy in rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases. However, small molecule JAK/TYK2…
  • Abstract Number: 0948 • ACR Convergence 2024

    Neuronal Intestinal Dysplasia Due to Ncx Gene Deficiency Attenuates the Severity of Experimental Arthritis in Mice

    Takayoshi Owada1, Keiko Hatanaka2, Ayae Tanaka2, Kei Ikeda3, Hirokuni Hirata1, Yasutsugu Fukushima1, Kazuhiro Kurasawa2 and Masafumi Arima2, 1Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan, 2Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan, 3Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, Tochigi, Japan

    Background/Purpose:   Loss of bacterial diversity and increases of specific bacteria in the gut microbiota have been observed in inflammatory arthritis such as rheumatoid arthritis…
  • Abstract Number: 0949 • ACR Convergence 2024

    CCN1 Is a Novel Therapeutic Target for Reducing Structural Damage in Rheumatoid Arthritis: Demonstration from 2 Preclinical Models

    Manon Lesturgie-Talarek1, Jérôme Avouac2, Virginie Gonzalez3, Anne Cauvet1, Francoise Tilotta4 and Yannick Allanore5, 1Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, 2Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, 3Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, 4UFR Odontologie, and Plateforme Imagerie du Vivant, Université Paris Cité, Montrouge, France, 5Université Paris Cité, Paris, France

    Background/Purpose: We have previously shown that the matricellular protein CCN1, characterized by angiogenic and immunomodulatory properties, is overexpressed in endothelial cells and synovial tissue of…
  • Abstract Number: 2263 • ACR Convergence 2024

    The Potential Use of Circulating Extracellular Vesicles for Improved Diagnosis and Therapy in Rheumatic Inflammatory/autoimmune Diseases: Proof of Concept Studies

    Gilad Halpert1, Ori Moskovitch2, Linoy Israel2, Eri Govrin2, Boris Gilburd2, Ori Segal2, Adi Anaki3, Tal Caller2, Daniel Yechiali2, Shlomo Segev2, Omer Gendelman4, Abdulla Watad5, Ruty Mehrian-Shai2, Rachella Popovtzer3 and Howard Amital6, 1CAHIM SHEBA MEDICAL CENTER, Tel Hashomer, Israel, 2Sheba Medical Center, Ramat-Gan, Israel, 3Bar Ilan University, Ramat-Gan, Israel, 4Sheba Medical Center, Ramat Gan, Israel, 5Tel Hashomer Medical Center, Ramat Gan, Israel, 6Sheba Medical Center, Tel-Hashomer, Israel, Ramat Gan, Israel

    Background/Purpose: Many patients with rheumatic conditions do not completely respond or are refractory to biological therapy. Therefore, there are unmet medical needs in the treatment…
  • Abstract Number: 2542 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis

    Anders Nguyen1, Miriam Bollmann1, Agnieszka Lastowska2, Anna-Karin Hultgård Ekwall1, Dietmar Zaiss3, Gary Firestein4 and Mattias Svensson5, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Goteborg, Sweden, 3University Hospital Regensburg, Regensburg, Germany, 4University of California, San Diego, San Diego, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
  • Abstract Number: 0923 • ACR Convergence 2024

    Immunization of Arthritis Prone Mice with Malondialdehyde-Acetaldehyde Modified Vimentin Induces Post-Translational Protein Modifications and Extracellular Matrix Deposition in Heart Tissues

    Kimberley Sinanan1, Wenxian Zhou2, Michael Duryee1, Nozima Aripova1, Jill Poole1, Carlos Hunter1, Amy Nelson1, Tate Johnson1, Daniel Anderson3, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Bellevue, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: Recent studies have highlighted the importance of malondialdehyde-acetaldehyde (MAA)-modified proteins and resulting immune responses in the pathogenesis of rheumatoid arthritis (RA). MAA adducts have…
  • Abstract Number: 0937 • ACR Convergence 2024

    A Novel Quantitative Method Reveals Bone-Structural Changes During Course of Inflammatory Arthritis

    Anders Nguyen1, David McBride2, Miriam Bollmann1, Agnieszka Lastowska3 and Mattias Svensson4, 1University of Gothenburg, Göteborg, Sweden, 2Calibr-Skaggs Institute for Innovative Medicines, La Jolla, CA, 3University of Gothenburg, Goteborg, Sweden, 4University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by both localized and generalized bone loss. The inhibition of Receptor Activator of Nuclear Factor…
  • Abstract Number: 0940 • ACR Convergence 2024

    Trans-endothelial Migration of Synovial Fibroblasts Promotes Arthritis Severity Through a PKD1-mediated Feedback Loop

    Jaeyeon Kim, Richard Ainsworth and Nunzio Bottini, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: The application of single cell genomic approaches to the study of rheumatoid synovium has recently enabled scientists to study the complex relationship between different…
  • Abstract Number: 0944 • ACR Convergence 2024

    Targeting Defective Macrophages to Restore Resolution of Inflammation in Rheumatoid Arthritis -Perspectives for an Autologous Secretome Therapy

    Melanie Couturier1, Francis Bonnefoy2, emilie Gaiffe3, Charline Vauchy4, Suzanne Behlke2, ERIC TOUSSIROT5 and Sylvain Perruche2, 11MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 2MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 3INSERM CIC -1431 CHU Besançon, France, Besançon, France, 4INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, 5university hospital of BESANCON, besancon, France

    Background/Purpose: Impaired macrophage efferocytosis, a key hallmark of failed inflammation resolution, is reported in many immune-mediated inflammatory diseases, including in Rheumatoid Arthritis (RA). Hence the…
  • Abstract Number: 0793 • ACR Convergence 2023

    The Dual Specificity Phosphatase 6 (DUSP6) Regulates Arthritis Severity and IL10 Production

    Teresina Laragione, Carolyn Harris, Natasha Rice and Percio Gulko, Icahn school of Medicine at Mount Sinai, New York, NY

    Background/Purpose: We have previously identified the Huntingtin-interacting protein-1 (HIP1) as a new gene implicated in the regulation of the rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS)…
  • Abstract Number: 0796 • ACR Convergence 2023

    Role of Group 2 Innate Lymphoid Cells in the Pathogenesis of Rheumatoid Arthritis

    Anders Nguyen1, Agnieszka Lastowska1, Miriam Bollmann1, Symeon Kourmoulakis1, Charlotte E. van der Plas1, Anna-Karin Hultgård Ekwall2, Dietmar M. Zaiss3, Gary S Firestein4 and Mattias N.D Svensson5, 1Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Kullavik, Sweden, 3Faculty of Medicine, Department of Immune Medicine, University of Regensburg, Regensburg, Germany, Regensburg, Germany, 4Department of Medicine, University of California San Diego, La Jolla, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Immune-cell mediated activation of joint-lining fibroblast-like synoviocytes (FLS) play a key role in joint inflammation and destruction during Rheumatoid arthritis (RA). Thus, identifying factors…
  • Abstract Number: 0797 • ACR Convergence 2023

    Innate Lymphoid Cells Enhance Development of CD4+ T-cell Driven Autoimmune Arthritis

    Agnieszka Lastowska1, Charlotte E. van der Plas1, Anders Nguyen1, Symeon Kourmoulakis1, Miriam Bollmann1 and Mattias N.D Svensson2, 1Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Innate Lymphoid cells (ILCs) are innate counterparts to T-cells that, based on their functional phenotype, can be divided into three subpopulations called Group 1…
  • Abstract Number: 0802 • ACR Convergence 2023

    Targeting Fibroblasts in Inflammatory Disease Using Engineered T Cells

    Samuel Kemble1, Christopher Mahony2, Charlotte Smith2, Joel Rurik3, Haig Aghajanian3, Jonathan Epstein3, Mark Coles4 and Adam Croft2, 1University Birmingham, Rugeley, United Kingdom, 2University of Birmingham, Birmingham, United Kingdom, 3University of Pennsylvania, Philadelphia, PA, 4University of Oxford, Oxford, United Kingdom

    Background/Purpose: Fibroblast activation protein alpha (FAPa) expressing fibroblasts orchestrate tissue inflammation and damage in rheumatoid arthritis (RA) as well as tissue immunity in primary Sjögren's…
  • Abstract Number: 1020 • ACR Convergence 2021

    Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Treatment for Experimental Arthritis

    Nathalie Burg, Ryan Malpass, Carl Blobel and Jane Salmon, Hospital for Special Surgery, New York, NY

    Background/Purpose: S1PR1 signaling plays critical roles in EC barrier function and vascular health, but until now, research on S1PR1 modulation in autoimmune rheumatic disease has…
  • Abstract Number: 0450 • ACR Convergence 2020

    In Vitro Characterization of Inflammatory Arthritis Associated with Immune Check Point Inhibition

    Anne Sofie Sørensen1, Morten Nørgaard Andersen1, Kristian Juul-Madsen2, Cæcilie Deisting Skejø1, Henrik Schmidt1, Thomas Vorup-Jensen1 and Tue Wenzel Kragstrup1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark

    Background/Purpose: During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, 2-4% of cancer patients develop inflammatory arthritis as an immune-related adverse…
  • 1
  • 2
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology