Abstracts tagged "Experimental Arthritis"

Abstract Number: 1739 • ACR Convergence 2025
Acute Transcriptomic Response of Synovium and Dorsal Root Ganglia to Joint Injury
Michael Newton¹, Lai Wang², Anne-Marie Malfait³, Rachel Miller² and Tristan Maerz⁴, ¹University of Michigan, South Lyon, MI, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴University of Michigan, Ann Arbor, MI
Background/Purpose: In arthritic synovium, emerging clinical evidence suggests crosstalk between synovial cells and dorsal root ganglion (DRG) neurons drives nerve sprouting and pain sensitization [Bai+…
Abstract Number: 1724 • ACR Convergence 2025
Pathogenic role of Mucosal-Associated Invariant T cells in Rheumatoid Arthritis.
Manon LESTURGIE-TALAREK¹, Virginie Gonzalez², Anne Cauvet², Lucie Beaudoin³, Fiona Oudart⁴, Adrien Schvartz⁵, Francesco Carbone⁵, Mickael Menager⁵, Noémie Sénot³, Francoise Tilotta⁶, Yannick Allanore⁷, Agnes Lehuen⁸ and Jérôme AVOUAC⁹, ¹Paris University, Paris, France, ²INSERMU¹⁰¹⁶, Paris, France, ³Institut Cochin, Paris, ⁴APHP - Cochin hospital, Paris, France, ⁵Institut Imagine, Paris, ⁶Université Paris Cité, Montrouge, France, ⁷Université Paris Cité, Paris, France, ⁸Hôpital Cochin, Paris, France, ⁹Rheumatology department, Cochin hospital, Paris, France
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that produce cytokines and cytotoxic molecules. Reduced frequencies and altered phenotypes of MAIT cells have been…
Abstract Number: 0798 • ACR Convergence 2025
Inhibition of Wnt Signaling Attenuates Inflammatory Arthritis Severity
Alisa Mueller¹, Angela Zou², Lucy-Jayne Marsh³, Samuel Kemble³, Saba Nayar³, Gerald Watts⁴, Cassandra Murphy⁵, Emily Taylor³, Triin Major³, David Gardner⁶, Christopher Buckley⁷, Kevin Wei⁸, Soumya Raychaudhuri⁵, ilya Korsunsky⁵, Andrew Filer⁹, Adam Croft¹⁰ and Michael Brenner¹¹, ¹Stanford University and VA Palo Alto Health Care System, Stanford, CA, ²Harvard Medical School, Boston, MA, ³University of Birmingham, Birmingham, United Kingdom, ⁴Harvard Medical School, Brookline, MA, ⁵Brigham and Women's Hospital, Boston, MA, ⁶University of Birmingham, Havelock North, New Zealand, ⁷University of Oxford, Oxford, United Kingdom, ⁸Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁹The University of Birmingham, Birmingham, United Kingdom, ¹⁰University of Birmingham, Hagley, Stourbridge, United Kingdom, ¹¹Brigham and Women's Hospital, Harvard Medical School, Newton, MA
Background/Purpose: Fibroblasts are critical in promoting pathogenic synovial inflammation and bone erosion in rheumatoid arthritis (RA). Moreover, recent studies have pointed to their potential contribution…
Abstract Number: 0066 • ACR Convergence 2025
RA-required synovial tissue-resident monocyte lineage cells are comprised of three distinct subpopulations.
Yidan Wang¹, Samuel Dowling², Jessica Maciuch², Vanessa Manada De Lobos², Meghan Mayer², Kainat Mian¹, Tyler Therron³, Hadijat Makinde¹, Carla Marie Cuda¹, Deborah Rachelle Winter⁴ and Harris R Perlman¹, ¹Northwestern University, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University, Skokie, IL
Background/Purpose: Tissue-resident monocyte-lineage cell (TRMC) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis.…
Abstract Number: 0063 • ACR Convergence 2025
Effect of alpha-ketoglutarate on Synovial Fibroblasts-Mediated Inflammation in Arthritis
Surabhi Gautam, Vinay Devulapalli, Akash Sathiyamurthi, Jayla Whittaker and Pallavi Bhattaram, Emory University, Atlanta, GA
Background/Purpose: Rheumatoid arthritis (RA) and related autoimmune joint disease patients exhibit cyclic episodes of resolution and exacerbation of joint inflammation, referred to as flares. Fibroblast-like…
Abstract Number: 0058 • ACR Convergence 2025
Training for increased inflammatory arthritis in mice is not modulated by type 1 interferon
Richard Bell¹, Mary Huang¹, Claire Weigert², Ruoxi Yuan², Toolika Singh², Seda Seren² and Lionel Ivashkiv¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York
Background/Purpose: Disease flares, or episodic escalating inflammation, is a hallmark of autoimmune diseases, like Rheumatoid Arthritis (RA). They are particularly hard to predict and treat…
Abstract Number: 0053 • ACR Convergence 2025
The Integrin Inhibitor Cilengitide Targets CCN1-Mediated Angiogenesis and Reduces Disease Severity in a Preclinical Rheumatoid Arthritis Model
Jérôme Avouac¹, manon lesturgie², Virginie Gonzalez³, Sujeeba Arulananthan², Anne Cauvet³, Francoise Tilotta⁴ and Yannick Allanore⁵, ¹Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, ²INSERM U¹⁰¹⁶, Paris, France, ³INSERMU¹⁰¹⁶, Paris, France, ⁴Université Paris Cité, Montrouge, France, ⁵Université Paris Cité, Paris, France
Background/Purpose: CCN1, a matricellular protein with angiogenic and immunomodulatory properties, is overexpressed in endothelial and synovial tissues of rheumatoid arthritis (RA) patients. Previous findings demonstrated…
Abstract Number: 0947 • ACR Convergence 2024
REX-7117 Is a Highly Potent and Selective Oral STAT3 Inhibitor That Demonstrated Potential Efficacy and Safety Differentiation versus JAK/TYK2 Targeting in Preclinical Models of Inflammatory Arthritis
Alexandra Gardino¹, Neil Bifulco¹, Jeremy Hunt², Rishi Vaswani¹, Donglim Park², Patrick Metz², Ksenya Cohen-Katsenelson², Jeong-Ho Kim², Xia Tian², Aryan Alavi², Ajay Nirula², Daniel Treiber², Brian Hodous¹, Seong Kim³ and Paul Smith², ¹Recludix Pharma, Cambridge, MA, ²Recludix Pharma, San Diego, CA, ³Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA
Background/Purpose: Inhibition of JAK family signaling has translated into clinically meaningful efficacy in rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases. However, small molecule JAK/TYK2…
Abstract Number: 0948 • ACR Convergence 2024
Neuronal Intestinal Dysplasia Due to Ncx Gene Deficiency Attenuates the Severity of Experimental Arthritis in Mice
Takayoshi Owada¹, Keiko Hatanaka², Ayae Tanaka², Kei Ikeda³, Hirokuni Hirata¹, Yasutsugu Fukushima¹, Kazuhiro Kurasawa² and Masafumi Arima², ¹Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan, ²Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan, ³Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, Tochigi, Japan
Background/Purpose: Loss of bacterial diversity and increases of specific bacteria in the gut microbiota have been observed in inflammatory arthritis such as rheumatoid arthritis…
Abstract Number: 0949 • ACR Convergence 2024
CCN1 Is a Novel Therapeutic Target for Reducing Structural Damage in Rheumatoid Arthritis: Demonstration from 2 Preclinical Models
Manon Lesturgie-Talarek¹, Jérôme Avouac², Virginie Gonzalez³, Anne Cauvet¹, Francoise Tilotta⁴ and Yannick Allanore⁵, ¹Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, ²Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, ³Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, ⁴UFR Odontologie, and Plateforme Imagerie du Vivant, Université Paris Cité, Montrouge, France, ⁵Université Paris Cité, Paris, France
Background/Purpose: We have previously shown that the matricellular protein CCN1, characterized by angiogenic and immunomodulatory properties, is overexpressed in endothelial cells and synovial tissue of…
Abstract Number: 2263 • ACR Convergence 2024
The Potential Use of Circulating Extracellular Vesicles for Improved Diagnosis and Therapy in Rheumatic Inflammatory/autoimmune Diseases: Proof of Concept Studies
Gilad Halpert¹, Ori Moskovitch², Linoy Israel², Eri Govrin², Boris Gilburd², Ori Segal², Adi Anaki³, Tal Caller², Daniel Yechiali², Shlomo Segev², Omer Gendelman⁴, Abdulla Watad⁵, Ruty Mehrian-Shai², Rachella Popovtzer³ and Howard Amital⁶, ¹CAHIM SHEBA MEDICAL CENTER, Tel Hashomer, Israel, ²Sheba Medical Center, Ramat-Gan, Israel, ³Bar Ilan University, Ramat-Gan, Israel, ⁴Sheba Medical Center, Ramat Gan, Israel, ⁵Tel Hashomer Medical Center, Ramat Gan, Israel, ⁶Sheba Medical Center, Tel-Hashomer, Israel, Ramat Gan, Israel
Background/Purpose: Many patients with rheumatic conditions do not completely respond or are refractory to biological therapy. Therefore, there are unmet medical needs in the treatment…
Abstract Number: 2542 • ACR Convergence 2024
Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis
Anders Nguyen¹, Miriam Bollmann¹, Agnieszka Lastowska², Anna-Karin Hultgård Ekwall¹, Dietmar Zaiss³, Gary Firestein⁴ and Mattias Svensson⁵, ¹University of Gothenburg, Göteborg, Sweden, ²University of Gothenburg, Goteborg, Sweden, ³University Hospital Regensburg, Regensburg, Germany, ⁴University of California, San Diego, San Diego, CA, ⁵University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
Abstract Number: 0923 • ACR Convergence 2024
Immunization of Arthritis Prone Mice with Malondialdehyde-Acetaldehyde Modified Vimentin Induces Post-Translational Protein Modifications and Extracellular Matrix Deposition in Heart Tissues
Kimberley Sinanan¹, Wenxian Zhou², Michael Duryee¹, Nozima Aripova¹, Jill Poole¹, Carlos Hunter¹, Amy Nelson¹, Tate Johnson¹, Daniel Anderson³, Ted Mikuls¹ and Geoffrey Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Bellevue, NE, ³University of Nebraska Medical Center, Durham, NC
Background/Purpose: Recent studies have highlighted the importance of malondialdehyde-acetaldehyde (MAA)-modified proteins and resulting immune responses in the pathogenesis of rheumatoid arthritis (RA). MAA adducts have…
Abstract Number: 0937 • ACR Convergence 2024
A Novel Quantitative Method Reveals Bone-Structural Changes During Course of Inflammatory Arthritis
Anders Nguyen¹, David McBride², Miriam Bollmann¹, Agnieszka Lastowska³ and Mattias Svensson⁴, ¹University of Gothenburg, Göteborg, Sweden, ²Calibr-Skaggs Institute for Innovative Medicines, La Jolla, CA, ³University of Gothenburg, Goteborg, Sweden, ⁴University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by both localized and generalized bone loss. The inhibition of Receptor Activator of Nuclear Factor…
Abstract Number: 0940 • ACR Convergence 2024
Trans-endothelial Migration of Synovial Fibroblasts Promotes Arthritis Severity Through a PKD1-mediated Feedback Loop
Jaeyeon Kim, Richard Ainsworth and Nunzio Bottini, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: The application of single cell genomic approaches to the study of rheumatoid synovium has recently enabled scientists to study the complex relationship between different…

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