Abstracts tagged "Ex-vivo arthritis model and LAG-3"

Abstract Number: 782 • 2019 ACR/ARP Annual Meeting
Oligoarticular Juvenile Idiopathic Arthritis Displayed Increased Expression of Co-Inhibitory Receptors Without Signs of T-Cell Exhaustion
Erdal Sag¹, Selcan Demir ², Morten A. Nielsen ³, Malene Hvid ⁴, Egemen Turhan ⁵, Yelda Bilginer ², Seza Ozen ⁶ and Bent Deleuran ⁷, ¹Hacettepe University, Ankara, Turkey, ²Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Department of Biomedicine; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁵Department of Orthopedics and Traumatology, Hacettepe University, Ankara, Turkey, ⁶Hacettepe University Hospital, Ankara, Turkey, ⁷Department of Biomedicine; Department of Rheumatology, Aarhus University, Aarhus, Denmark
Background/Purpose: Activated T cells are involved in the pathogenesis of the synovitis in oligoarticular Juvenile Idiopathic Arthritis (o-JIA). T cell activation is counter-balanced via co-inhibitory…

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