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Abstracts tagged "etanercept and rheumatoid arthritis (RA)"

  • Abstract Number: 102 • 2014 ACR/ARHP Annual Meeting

    Real-World Utilization, Patient Characteristics and Persistency of Certolizumab Pegol Vs Other Anti-TNFs for the Treatment of Rheumatoid Arthritis in the United Kingdom

    Frances Humby1, Stephen Kelly1, Angela V. Bedenbaugh2, Nawab Qizilbash3,4, Jochen Dunkel5, Belén SanJose3, Ignacio Mendez3, Jennifer Timoshanko6 and Jeyanesh Tambiah2, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 2UCB Pharma, Smyrna, GA, 3OXON Epidemiology, London, United Kingdom, 4Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom, 5UCB Pharma, Monheim, Germany, 6UCB Pharma, Slough, United Kingdom

    Background/Purpose Several anti-TNFs are currently approved in Europe for RA treatment including certolizumab pegol (CZP), adalimumab (ADA), etanercept (ETN), golimumab and infliximab. UK NICE guidance…
  • Abstract Number: 2924 • 2014 ACR/ARHP Annual Meeting

    Clinical Utility of Random Anti-TNF Drug Level Testing and Measurement of Anti-Drug Antibodies on Long-Term Treatment Response in Rheumatoid Arthritis

    Meghna Jani1, Hector Chinoy1,2, Richard B. Warren3, Christopher E.M Griffiths3, Ann W. Morgan4, Anthony G. Wilson5, Kimme L. Hyrich1, John Isaacs6, Darren Plant1,2 and Anne Barton1,7, 1Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, 3Dermatology Centre, University of Manchester, Manchester, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland, 6Institute of Cellular Medicine, University of Newcastle, Newcastle, United Kingdom, 7NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose Up to 40% of RA patients on anti-TNF treatment fail to respond either due to primary inefficacy or loss of response. One explanation is…
  • Abstract Number: 2418 • 2014 ACR/ARHP Annual Meeting

    Treatment Pattern and Direct Cost of Biologics for Rheumatoid Arthritis Patients: A Real-World Analysis of Nationwide Japanese Claims Data

    Naonobu Sugiyama M.D., Ph.D1, Tatsunori Murata, M.S.2, Yosuke Morishima3, Yuri Fukuma4, Yoshiyuki Shibasaki4 and Lisa Marshall5, 1Medical Affairs, Pfizer Japan Inc. RA & Inflammation Area Medical Affairs Department, Tokyo, Japan, 2Health Economics Research Group, CRECON Research and Consulting Inc., Tokyo, Japan, 3RA & Inflammation Area Medical Affairs Department, Pfizer Japan Inc. RA & Inflammation Area Medical Affairs Department, Tokyo, Japan, 4Pfizer Japan Inc. RA & Inflammation Area Medical Affairs Department, Tokyo, Japan, 5Inflammation Immunology Disease Group, Pfizer Inc. Inflammation Immunology Disease Group, Collegeville, PA

    Background/Purpose Biologics such as etanercept (ETN), adalimumab (ADA), infliximab (IFX) and tocilizumab (TCZ) have led dramatic improvement in the treatment of rheumatoid arthritis (RA), but…
  • Abstract Number: 1843 • 2014 ACR/ARHP Annual Meeting

    Randomised Controlled Non-Inferiority Study of Dose Reduction and Withdrawal of Adalimumab and Etanercept in Rheumatoid Arthritis

    Noortje van Herwaarden1, Aatke van der Maas1, Michiel Minten1, Frank H.J. van den Hoogen2, Ronald F. van Vollenhoven3, Johannes W.J. Bijlsma4, Bart van den Bemt5 and Alfons A. den Broeder1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 3Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose TNF inhibitors (TNFi) have proven to be effective in the treatment of rheumatoid arthritis (RA). They are however associated with side effects and high…
  • Abstract Number: 500 • 2014 ACR/ARHP Annual Meeting

    Prediction of Successful Dose Reduction or Discontinuation of Adalimumab or Etanercept Using Serum Drug Levels and Antidrug Antibody Measurement

    Noortje van Herwaarden1, Chantal Bouman2, Aatke van der Maas3, Ronald F. van Vollenhoven4, Johannes W.J. Bijlsma5, Frank H.J. van den Hoogen6, Alfons A. den Broeder1 and Bart van den Bemt7, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Sint Maartenskliniek, Nijmegen, Netherlands, 3Hengstdal 3, Sint Maartenskliniek, Nijmegen, Netherlands, 4Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, 5Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 6Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 7Pharmacy, Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose Dose reduction and discontinuation of TNF inhibitors (TNFi) is feasible in many rheumatoid arthritis (RA) patients, but leads to (temporary) worsening of disease activity…
  • Abstract Number: 2360 • 2013 ACR/ARHP Annual Meeting

    Incidence Of Diabetes and Effect Of Etanercept and Adalimumab On HbA1c Over 1 Year: Data From a Randomised Trial In Patients With Rheumatoid Arthritis

    Paola de Pablo1, Fiona M. Maggs2, David Carruthers3, Abdul A. Faizal4, Mark T. Pugh5 and Paresh Jobanputra6, 1Rheumatology, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, University of Birmingham, College of Medical & Dental Sciences, Queen Elizabeth Hospital Birmingham, UK, Birmingham, United Kingdom, 2Department of Rheumatology, Queen Elizabeth Hospital Birmingham, UK, Birmingham, United Kingdom, 3Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, UK, Birmingham, United Kingdom, 4Department of Rheumatology, Solihull Hospital, Heart of England NHS Foundation Trust, UK, Solihull, United Kingdom, 5Department of Rheumatology, Saint Mary's Hospital, UK, Isle of Wight, United Kingdom, 6Department of Rheumatology, Queen Elizabeth Hospital Birmingham, UK., Birmingham, United Kingdom

    Background/Purpose:  Inflammation such as that which occurs in rheumatoid arthritis (RA) is associated with insulin resistance and risk of diabetes mellitus (DM). Some DMARDs including…
  • Abstract Number: 1886 • 2013 ACR/ARHP Annual Meeting

    Differential Methylation Related To Response To Etanercept In Patients With Rheumatoid Arthritis

    Amy Webster1, Darren Plant2, Mark Lunt3, Stephen Eyre4, Edward Flynn4, Paul Martin5, A. G. Wilson6, A. W. Morgan7, John Isaacs8, Jane Worthington1,9 and Anne Barton2,4, 1Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 4Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 5Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 6Genomic Medicine, The University of Sheffield, Sheffield, United Kingdom, 7Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, 8National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom, 9The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The introduction of biologic drug therapies targeting specific components of the inflammatory response represents a huge advance in the treatment of rheumatoid arthritis (RA).…
  • Abstract Number: 1476 • 2013 ACR/ARHP Annual Meeting

    Effectiveness Of Etanercept In Elderly Patients With Rheumatoid Arthritis: A Single Center Retrospective Study

    Arthur N. Lau1, Alpesh Shah2, Melissa Deamude3, Cynthia Mech4, Robert Bensen5 and William G. Bensen6, 1Rheumatology and Clinical Epidemiology, Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 2Epidemiology and Biostatistics, University of Western Ontario, MSc in Clinical Epidemiology, University of Western Ontario, London, ON, Canada, 3Dr. William G. Bensen, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, 4Dr. William G. Bensen, Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, 5Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, 6Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada

    Background/Purpose: Biological drugs have dramatically improved the prognosis of rheumatoid arthritis (RA), especially in those with early disease. These patientsare often in younger age with fewer…
  • Abstract Number: 1058 • 2013 ACR/ARHP Annual Meeting

    Concomitant Methotrexate Use and The Risk Of Drug Discontinuation For Adalimumab Compared With Etanercept In Anti-TNF-Naïve Rheumatoid Arthritis Patients: A Nationwide Population-Based Cohort Study

    Hsin-Hua Chen1,2, Der-Yuan Chen1, Chao-Hsiung Tang3, Ya-Wen Yang4, Chi-Hui Fang4 and Nicole Huang5, 1Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, 2nstitute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan, 3Taipei Medical University, Taipei, Taiwan, 4Pfizer Limited, Taipei, Taiwan, 5Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan

    Background/Purpose: To evaluate possible interaction effect by concomitant methotrexate (MTX) use on the risk of drug discontinuation for adalimumab (ADA) compared with etanercept (ETN) in…
  • Abstract Number: 999 • 2013 ACR/ARHP Annual Meeting

    Cost Consideration For Biologics For Patients With Rheumatoid Arthritis In a Pharmacy Benefit Management Setting

    Ning Wu1, Yuan-Chi Lee2, Neel Shah3 and David J. Harrison3, 1Economic Analysis and Solutions, United BioSource Corporation, Lexington, MA, 2United BioSource Corporation, Lexington, MA, 3Amgen Inc., Thousand Oaks, CA

    Background/Purpose: Of the seven biologics FDA-approved for the treatment of moderate to severe rheumatoid arthritis (RA) as of August 2011, etanercept, adalimumab, certolizumab, and golimumab…
  • Abstract Number: 1001 • 2013 ACR/ARHP Annual Meeting

    Long-Term Effectiveness and Cost Per Effectively Treated Patient With Biologics Used In Rheumatoid Arthritis

    Vernon F. Schabert1, Jason Yeaw2, Jonathan Korn1, Caroleen Quach3, David J. Harrison4, Huifeng Yun5, George Joseph6, David H. Collier4 and Jeffrey R. Curtis7, 1IMS Health, Alexandria, VA, 2IMS Consulting Group, Alexandria, VA, 3Public Health Policy and Management, University of North Carolina at Chapel Hill, Gillings School of Public Health, Chapel Hill, NC, 4Amgen Inc., Thousand Oaks, CA, 5Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 6Former Amgen Employee, Thousand Oaks, CA, 7Epidemiology, University of Alabama at Birmingham, School of Public Health, Birmingham, AL

    Background/Purpose: Previous work compared one-year cost per effectively treated patient with biologics for rheumatoid arthritis (RA) using a published, claims-based algorithm.1 Longer term comparisons are…
  • Abstract Number: 487 • 2013 ACR/ARHP Annual Meeting

    The Cost Savings Associated With a Departmental Etanercept Dose Reduction Pathway For Patients With Rheumatic Diseases and Maintained Low Disease Activity

    Richard CJ Campbell1, Emma Sanders1, Francesca Leone1, Emma Gilgeours1, Margaret Sibley1 and Patrick D. Kiely2, 1Rheumatology, St George's Hospital, London, United Kingdom, 2Rheumatology Dept, St George's Hospital, London, United Kingdom

    Background/Purpose: Clinical trials have previously demonstrated that it is safe and effective for some rheumatoid arthritis (RA) patients with low disease activity on full dose…
  • Abstract Number: 489 • 2013 ACR/ARHP Annual Meeting

    Combining Methotrexate To Etanercept Does Not Improve Its Retention Rate In Rheumatoid Arthritis Patients When Compared To Etanercept Monotherapy. A Report From The Rhumadata® Clinical Data Base and Registry

    Denis Choquette1, Louis Bessette2, Boulos Haraoui1, Diane Sauvageau3, Jean Pierre Pelletier1, Jean-Pierre Raynauld3, Edith Villeneuve3 and Louis Coupal1, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, 3Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada

    Background/Purpose: Etanercept (ETA) has demonstrated good retention in both mono and combination therapy in clinical trials of rheumatoid arthritis patients followed over short observation periods…
  • Abstract Number: L10 • 2012 ACR/ARHP Annual Meeting

    In Rheumatoid Arthritis Patients with Stable Low Disease Activity On Methotrexate Plus Etanercept, Continuation of Etanercept 50 Mg Weekly or 25 Mg Weekly Are Both Clinically Superior to Discontinuation: Results From a Randomized, 3-Armed, Double-Blind Clinical Trial

    R.F. van Vollenhoven1, Mikkel Østergaard2, Marjatta Leirisalo-Repo3, Till Uhlig4, Marita Jansson5, Åsa Klackenberg5, Katherine Hutchinson6 and Karin Franck-Larsson5, 1Clinical Trials Unit Department of Rheumatology, The Karolinska Institute, Stockholm, Sweden, 2Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 3Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, 4Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Speciality Care Nordic Medical Affairs, Pfizer Nordic, Sollentuna, Sweden, 6Quanticate, Hitchin, United Kingdom

    Background/Purpose: The efficacy of etanercept (ETN) in combination with methotrexate (MTX) in the treatment of rheumatoid arthritis (RA) is well established, and long-term trials1 and…
  • Abstract Number: 484 • 2012 ACR/ARHP Annual Meeting

    Comparison of Rheumatoid Arthritis-Related Health Care Resource Use and Comorbidities Among Patients with Rheumatoid Arthritis Treated with Adalimumab Vs. Etanercept

    Jipan Xie1, Arijit Ganguli2, Hongbo Yang1, Kejal Parikh1, Eric Q. Wu1 and Mary Cifaldi3, 1Analysis Group Inc., Boston, MA, 2AbbVie, North Chicago, IL, 3Abbott Laboratories, Abbott Park, IL

    Background/Purpose: Adalimumab (ADA) and etanercept (ETN) are two commonly used tumor necrosis factor (TNF)-α antagonists for the treatment of rheumatoid arthritis (RA).  The study is…
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