Abstracts tagged "ER Stress"

Abstract Number: 2694 • 2013 ACR/ARHP Annual Meeting
HLA-B27 Expression Prevents Tnfα-Induced Inhibition Of Bone Formation in Vitro In IFNγ/Tnfα-Treated Osteoblasts
Eva Yang¹, Grace Kwon¹, Robert A. Colbert² and Gerlinde Layh-Schmitt¹, ¹NIAMS NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 predisposes to ankylosing spondylitis (AS), an immune-mediated inflammatory disease associated with osteitis, bone loss, and dysregulated bone formation, most notably in the axial…
Abstract Number: 629 • 2013 ACR/ARHP Annual Meeting
Altered ER Stress-Induced Autophagic Reactions Are Associated With Increased Apoptosis of T Lymphocytes in Systemic Lupus Erythematosus
Won Seok Lee¹, Myung-Soon Sung¹, Eun-Gyeong Lee¹, Chang-Hoon Lee², Myeung Su Lee³, Yun-Hong Cheon⁴, Sang-il Lee⁴, Yun Kyoung Hong⁵ and Wan-Hee Yoo⁶, ¹Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ²Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ³Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ⁵Rheumatology, Department of internal medicine, Presbyterian medical center, Jeonju, South Korea, ⁶Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea
Background/Purpose: The autophagic responses to ER stress are involved in the regulation of the maintenance of lymphocyte homeostasis and has been implicated in the pathogenesis…
Abstract Number: 539 • 2013 ACR/ARHP Annual Meeting
Effects Of ERAP1 Knockdown On HLA Class I and HLA-B27 Expression In Human Monocytic U937 Cells
Tri M. Tran, Sohee Hong and Robert A. Colbert, NIAMS/NIH, Bethesda, MD
Background/Purpose: Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with susceptibility to ankylosing spondylitis in HLA-B27 (B27) positive individuals, implying a functional interaction…

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