Abstract Number: 2811 • 2019 ACR/ARP Annual Meeting
The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Background/Purpose: Immune complex (IC)-activated neutrophils appear to amplify inflammation in lupus through the release of neutrophil extracellular traps (NETosis). There is presently no consensus as…Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…Abstract Number: 176 • 2017 ACR/ARHP Annual Meeting
SEC16A and Antigen Presentation Abnormalities in the Pathogenesis of Axial Spondyloarthritis
Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory rheumatic disease of axial skeleton. Our group recently identified a novel rare mutation of the SEC16A gene…Abstract Number: 1910 • 2017 ACR/ARHP Annual Meeting
ERAP1 Deficiency Implicates Long Peptides in Protection from HLA-B27-Induced Experimental Spondyloarthritis
Background/Purpose: Common endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) haplotypes influence the risk of developing axial spondyloarthritis (SpA) in HLA-B27-positive individuals, with loss-of-function and reduced expression…Abstract Number: 176 • 2016 ACR/ARHP Annual Meeting
Endoplasmic Reticulum Stress Induces Lupus Kidney Disease By Facilitating Antigen Cross-Presentation Via the Increase of Endosomal Sec61
Background/Purpose: Repeated immunization with exogenous antigen such as ovalbumin (OVA) induces SLE in mice otherwise not prone to spontaneous autoimmune diseases, in which autoantibody-inducing CD4…Abstract Number: 3163 • 2016 ACR/ARHP Annual Meeting
SEC16A and Intracellular Trafficking Abnormalities in Axial Spondyloarthritis
Background/Purpose: The pathogenesis of Axial Spondyloarthritis (AxSpA) is not well understood. A rare 9 base-pair deletion of SEC16A was recently identified to be strongly associated with AxSpA in a multiplex…Abstract Number: 203 • 2015 ACR/ARHP Annual Meeting
Rescue of Copa Syndrome Cellular Phenotype By Autophagy Modifying Drugs
Background/Purpose: Autoimmunity is a diverse group of complex conditions that can include certain congenital genetic defects leading to loss of self-tolerance with subsequent imbalances of…Abstract Number: 298 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathway Activation in the Idiopathic Inflammatory Myopathies (IIM): Skeletal Muscle Cells As a Source of Cytokines (Myokines)
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a collection of autoimmune disorders, characterised by the development of debilitating symmetrical skeletal muscle weakness. IIM Patients also…Abstract Number: 306 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathways in the Idiopathic Inflammatory Myopathies (IIM): Interrogating the Role of Micro-RNA 133a As an Important Regulator of ER Stress Activation
Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) is a heterogeneous group of acquired autoimmune disorders, characterised by symmetrical muscle weakness. Whilst immune cells clearly play a…Abstract Number: 2579 • 2015 ACR/ARHP Annual Meeting
Effect of Tacrolimus on Endoplasmic Reticulum Stress-Mediated Osteoclastogenesis in a Collagen-Induced Arthritis Mouse Model
Background/Purpose: Although the effects of tacrolimus on T cells are well known, its direct effects on osteoclastogenesis remain unclear. We previously revealed that thapsigargin (TG)-induced…Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting
AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis
Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…Abstract Number: 2717 • 2015 ACR/ARHP Annual Meeting
Stf-083010, the Inhibitor of ER Stress Transducer IRE1, Suppresses Rheumatoid Synovitis
Background/Purpose: Endoplasmic reticulum (ER) stress is a cellular signal, which is triggered by the failure to fold newly synthesized ER proteins. ER stress plays an…Abstract Number: 2826 • 2015 ACR/ARHP Annual Meeting
Stimulation of Autophagy Reduces Misfolded HLA-B27 in a Rat Model of Spondyloarthritis
Background/Purpose: HLA-B27/human β2microglobulin transgenic rats develop spondyloarthritis (SpA) characterized by inflammation in the gut and peripheral joints by mechanisms that remain poorly defined, but do…Abstract Number: 2218 • 2014 ACR/ARHP Annual Meeting
Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Dysfunction and Atrophy Can be Prevented By Pharmacological Upregulation of Heat Shock Protein 70 (HSP) in Cultured Murine Myotubes
Background/Purpose: The symmetrical proximal muscle weakness typical of myositis often fails to improve completely with any treatment, due to irreversible muscle fibre degeneration. Although inflammatory…Abstract Number: 2695 • 2013 ACR/ARHP Annual Meeting
Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger
Background/Purpose: Chronic inflammatory diseases known as spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and arthritis associated with inflammatory bowel disease, collectively affect 3%…