Abstracts tagged "ER Stress"

Abstract Number: 2811 • 2019 ACR/ARP Annual Meeting
The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Gautam Sule¹, Basel Abuaita ¹, Paul Steffes ¹, Kristen Gilley ¹, Andrew Fernandes ¹, Mary O’Riordan ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Immune complex (IC)-activated neutrophils appear to amplify inflammation in lupus through the release of neutrophil extracellular traps (NETosis). There is presently no consensus as…
Abstract Number: 2082 • 2018 ACR/ARHP Annual Meeting
ERAP1 Deficiency Partially Relieves HLA-B27-Induced ER Stress and IL-23 Expression, but Does Not Restore Dendritic Cell Function in Experimental Spondyloarthritis
Tri Tran¹, Vance Holt², Tejpal Gill¹, Joshua R. Bennett², Joel Taurog³ and Robert Colbert⁴, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ⁴National Institute of Arthritis and Musculuskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Preliminary results suggest that endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) deficiency partially protects HLA-B27/human b2m transgenic (B27-Tg) rats from spondyloarthritis (SpA) as evidenced by…
Abstract Number: 176 • 2017 ACR/ARHP Annual Meeting
SEC16A and Antigen Presentation Abnormalities in the Pathogenesis of Axial Spondyloarthritis
Fanxing Zeng¹, Vidya Ranganathan², Proton Rahman³, Darren O’Rielly⁴ and Nigil Haroon⁵, ¹University Health Network, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁴Memorial University, St John's, NF, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory rheumatic disease of axial skeleton. Our group recently identified a novel rare mutation of the SEC16A gene…
Abstract Number: 1910 • 2017 ACR/ARHP Annual Meeting
ERAP1 Deficiency Implicates Long Peptides in Protection from HLA-B27-Induced Experimental Spondyloarthritis
Tri Tran¹, Tejpal Gill¹, Joshua R. Bennett¹, Vance Holt¹, Sohee Hong², Joel Taurog³ and Robert Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institutes of Arthritis and Muskuloskeletal and skin diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Common endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) haplotypes influence the risk of developing axial spondyloarthritis (SpA) in HLA-B27-positive individuals, with loss-of-function and reduced expression…
Abstract Number: 176 • 2016 ACR/ARHP Annual Meeting
Endoplasmic Reticulum Stress Induces Lupus Kidney Disease By Facilitating Antigen Cross-Presentation Via the Increase of Endosomal Sec61
Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: Repeated immunization with exogenous antigen such as ovalbumin (OVA) induces SLE in mice otherwise not prone to spontaneous autoimmune diseases, in which autoantibody-inducing CD4…
Abstract Number: 3163 • 2016 ACR/ARHP Annual Meeting
SEC16A and Intracellular Trafficking Abnormalities in Axial Spondyloarthritis
Fanxing Zeng¹, Zhenbo Zhang¹, Vidya Ranganathan², Darren Orielly³, Proton Rahman⁴ and Nigil Haroon⁵, ¹Krembil research institute, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NF, Canada, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: The pathogenesis of Axial Spondyloarthritis (AxSpA) is not well understood. A rare 9 base-pair deletion of SEC16A was recently identified to be strongly associated with AxSpA in a multiplex…
Abstract Number: 2579 • 2015 ACR/ARHP Annual Meeting
Effect of Tacrolimus on Endoplasmic Reticulum Stress-Mediated Osteoclastogenesis in a Collagen-Induced Arthritis Mouse Model
Won-Seok Lee¹, Yun Jung Choi², Myong-Joo Hong³, Chang-Hoon Lee^4,5, Myeung Su Lee⁶, Young Sun Suh⁷, Sang-Il Lee⁸ and Wan-Hee Yoo⁹, ¹Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, jeonju, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, JeonJu, South Korea, ³Internal Medicine, Presbyterian Medical center, Jeonju, South Korea, ⁴Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ⁵Rheumatology, Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ⁶Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ⁹Division of Rhuematology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, Jeonju, South Korea
Background/Purpose: Although the effects of tacrolimus on T cells are well known, its direct effects on osteoclastogenesis remain unclear. We previously revealed that thapsigargin (TG)-induced…
Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting
AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis
Masaru Kato¹, Kerstin Klein², Caroline Ospelt², Christoph Kolling³, Michihito Kono¹, Shinsuke Yasuda¹, Renate E. Gay⁴, Steffen Gay⁵ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland
Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
Abstract Number: 2717 • 2015 ACR/ARHP Annual Meeting
Stf-083010, the Inhibitor of ER Stress Transducer IRE1, Suppresses Rheumatoid Synovitis
Soutarou Izumi¹, Tomoyuki Nakasa², Shigeru Miyaki³ and Mitsuo Ochi¹, ¹Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan, ²Orthopaedic Surgery, Matsuyama Redcross Hospital, Matsuyama, Japan, ³Translational Research Medical Center, Hiroshima, Japan
Background/Purpose: Endoplasmic reticulum (ER) stress is a cellular signal, which is triggered by the failure to fold newly synthesized ER proteins. ER stress plays an…
Abstract Number: 2826 • 2015 ACR/ARHP Annual Meeting
Stimulation of Autophagy Reduces Misfolded HLA-B27 in a Rat Model of Spondyloarthritis
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹ and Robert A. Colbert², ¹NIAMS/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27/human β2microglobulin transgenic rats develop spondyloarthritis (SpA) characterized by inflammation in the gut and peripheral joints by mechanisms that remain poorly defined, but do…
Abstract Number: 203 • 2015 ACR/ARHP Annual Meeting
Rescue of Copa Syndrome Cellular Phenotype By Autophagy Modifying Drugs
Levi Watkin^1,2, Briana Burns^1,2, Timothy Vece³ and Jordan S. Orange^1,2, ¹Baylor College of Medicine, Houston, TX, ²Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, ³Pulmonology, Texas Children's Hospital, Houston, TX
Background/Purpose: Autoimmunity is a diverse group of complex conditions that can include certain congenital genetic defects leading to loss of self-tolerance with subsequent imbalances of…
Abstract Number: 298 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathway Activation in the Idiopathic Inflammatory Myopathies (IIM): Skeletal Muscle Cells As a Source of Cytokines (Myokines)
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Kate E. Earl², Caroline V. Cotton², Anne McArdle¹ and Robert G. Cooper³, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a collection of autoimmune disorders, characterised by the development of debilitating symmetrical skeletal muscle weakness. IIM Patients also…
Abstract Number: 306 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathways in the Idiopathic Inflammatory Myopathies (IIM): Interrogating the Role of Micro-RNA 133a As an Important Regulator of ER Stress Activation
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Anne McArdle¹ and Robert G. Cooper^3,4, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom, ⁴MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) is a heterogeneous group of acquired autoimmune disorders, characterised by symmetrical muscle weakness. Whilst immune cells clearly play a…
Abstract Number: 2218 • 2014 ACR/ARHP Annual Meeting
Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Dysfunction and Atrophy Can be Prevented By Pharmacological Upregulation of Heat Shock Protein 70 (HSP) in Cultured Murine Myotubes
Adam P. Lightfoot, Malcolm J. Jackson, Anne McArdle and Robert G. Cooper, Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The symmetrical proximal muscle weakness typical of myositis often fails to improve completely with any treatment, due to irreversible muscle fibre degeneration. Although inflammatory…
Abstract Number: 2695 • 2013 ACR/ARHP Annual Meeting
Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger
Linda Rehaume¹, Stanislas Mondot², Daniel Aguirre de Cárcer², Jared Velasco¹, Helen Benham¹, Sumaira Hasnain³, Jaclyn Bowman¹, Merja Ruutu¹, Philip Hansbro⁴, Michael McGuckin³, Mark Morrison² and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²CSIRO Livestock Industries, Brisbane, Australia, ³Mater Medical Research Institute, Brisbane, Australia, ⁴Center for Asthma and Respiratory Disease and Hunter Medical Research Institute, Newcastle, Australia
Background/Purpose: Chronic inflammatory diseases known as spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and arthritis associated with inflammatory bowel disease, collectively affect 3%…

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