ACR Meeting Abstracts

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Abstracts tagged "Epigenetics"

  • Abstract Number: 0257 • ACR Convergence 2022

    High Density Lipoprotein Bound miR-1246 Is Enriched in Patients with Rheumatoid Arthritis and Is Proinflammatory

    Qiong Wu, Quanhu Sheng, Danielle Michell, Kasey Vickers and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: High density lipoprotein (HDL) is known for its anti-atherogenic cholesterol efflux and antioxidant functions. HDL has additional relevance to rheumatoid arthritis (RA) because of…
  • Abstract Number: 1155 • ACR Convergence 2022

    Epigenome-Wide Integrative Association Study on Spondyloarthritis and Psoriatic Arthritis

    Elena Carnero-Montoro1, Ivan Arias-de la Rosa2, Clementina Lopez-Medina3, lourdes Ladehesa-Pineda4, Rafaela Ortega-Castro2, Daniel Toro-Domínguez1, Manuel Martinez-Bueno1, Raúl López-Domínguez5, Olivia Castellini-Pérez1, Guillermo Barturen1, Nuria Barbarroja2, Eduardo Collantes2 and Marta Alarcon-Riquelme1, 1Center for Genomics and Oncological Research (GENYO), Granada, Spain, 2IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 3Reina Sofia University Hospital, Rheumatology Department, Jaén, Spain, 4Reina Sofia University Hospital/Rheumatology Department/Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain, 5University of Granada, Granada, Spain

    Background/Purpose: An important role of DNA methylation changes in Spondylitis Ankylosing has been recently demonstrated by epigenome-wide studies. However, there is a lack of genome-wide…
  • Abstract Number: 0350 • ACR Convergence 2021

    EPI-SIGN: Epigenetic SLE Indicators of Glomerular Nephritis

    Ashira Blazer1, Olusola Ayanlowo2, Will Liao3, Dzifa Dey4, Jasmin Divers5, Uyiekpen Ima-Edomwonyin6, Hakeem Olaosebikan7, Cristina Lanata8, Girish Nadkarni9, Jill Buyon1, Peter Izmirly10 and Timothy Niewold11, 1NYU School of Medicine, New York, NY, 2College of Medicine University of Lagos, New York, NY, 3New York Genome Center, New York, NY, 4University of Ghana, Accra, Ghana, 5NYU Langone Hospital - Long Island, Mineola, NY, 6Lagos State University Teaching Hospital, Lagos, Nigeria, 7Lagos University State Teaching Hospital, Lagos, Nigeria, 8University of California San Francisco, Moss Beach, CA, 9Icahn School of Medicine at Mount Sinai, New York, NY, 10New York University School of Medicine, New York, NY, 11Colton Center for Autoimmunity NYU School of Medicine, New York, NY

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is more common and severe in those of African Ancestry (AA) who, relative to Europeans, are twice as likely to…
  • Abstract Number: 0542 • ACR Convergence 2021

    Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

    Pamela Palisoc1, Leah Vaikutis1, Ellen Model1, Morgan Omara1, Dinesh Khanna1, Eliza Pei-Suen Tsou1 and Amr Sawalha2, 1University of Michigan, Ann Arbor, MI, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Glycoprotein nonmetastatic melanoma protein B (GPNMB) is widely expressed on stromal cells and immune cells. It is involved in various cell functions such as…
  • Abstract Number: 0543 • ACR Convergence 2021

    Novel Insights into Systemic Sclerosis Using a Sensitive Computational Method to Analyze Whole-genome Bisulfite Sequencing Data

    Jeffrey Yu1, Tianyuan Lu1, Kaiqiong Zhao1, Kathleen Oros Klein1, Maximilien Lora2, Ines Colmegna3, Celia MT Greenwood4 and Marie Hudson2, 1Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, 2McGill University, Montréal, QC, Canada, 3The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 4Epidemiology, Biostatistics and Occupational Health / Faculty of Medicine and Health Sciences / McGill University, Montréal, QC, Canada

    Background/Purpose: While the etiology of systemic sclerosis (SSc) remains largely unknown, epigenetic dysregulation including abnormal DNA methylation is thought to contribute to its onset and…
  • Abstract Number: 0545 • ACR Convergence 2021

    SIRT1 Modulates the Senescent Phenotype in Scleroderma Endothelial Cells

    Ellen Model, Morgan Omara, Pamela Palisoc, Dinesh Khanna and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI

    Background/Purpose: Vascular abnormalities in systemic sclerosis (SSc) are characterized by injury to vascular wall and extensive damage of the microvessels. It has been shown that…
  • Abstract Number: 0559 • ACR Convergence 2021

    Targeting NNMT as a Novel Metabolic Approach to Treat Systemic Sclerosis

    M.Asif Amin1, Bo Shi2, Pei-Suen Tsou1, Swarna Bale1, Phillip Campbell1, Mikel Gurrea-Rubio1, Mark Eckert3, Ernst Lengyel3, Johann Gudjonsson4 and Varga John1, 1University of Michigan, Ann Arbor, MI, 2Nothwestern university, Chicago, IL, 3University of chicago, Chicago, IL, 4Department of Dermatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Fibrosis, the hallmark of systemic sclerosis (SSc), is associated with metabolic and epigenetic alterations that are incompletely characterized. Our laboratory had previously implicated dysregulated…
  • Abstract Number: 1105 • ACR Convergence 2021

    Discovering Variants in Suspected Monogenic Systemic Inflammatory Disease: An Adult Case Series

    Jason An1, Madeline Couse1, Dilan Dissanayake2, Daniela Dominguez2, Ronald Laxer1, Christian Marshall1, Johannes Roth3, Robert Rottapel4 and Linda Hiraki2, 1SickKids, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada, 4St Michael's Hospital, Toronto, ON, Canada

    Background/Purpose: Monogenic systemic inflammatory diseases (MSID) are a heterogeneous group of rare conditions caused by single gene variants leading to immune dysregulation. Diagnostic yield of…
  • Abstract Number: 1263 • ACR Convergence 2021

    Treatment of Pediatric Lupus Is Associated with Significant Re-Organization of B Cell Chromatin

    Joyce Hui-Yuen1, Kaiyu Jiang2, Susan Malkiel3, Betty Diamond3 and James Jarvis4, 1North Shore LIJ Health System, Great Neck, NY, 2University at Buffalo, Buffalo, NY, 3Northwell Health, Manhasset, NY, 4University at Buffalo Jacobs School of Medicine, Buffalo, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) may be triggered by gene-environment interactions. Data remain scarce on how epigenetic variance contributes to disease risk in pediatric SLE…
  • Abstract Number: 1470 • ACR Convergence 2021

    Cartilage Epigenetic Changes Induced by Microbial DNA Amplified from Human OA Samples

    Vladislav Izda1, Christopher Dunn2, Cassandra Sturdy1, Jake Martin1, Cassandra Velasco2, Paul Jacob3 and Matlock Jeffries1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Oklahoma Joint Reconstruction Institute, Oklahoma City, OK

    Background/Purpose: Strong links between epigenetic changes, particularly alterations in DNA methylation, have been linked with the onset and progression of knee osteoarthritis (OA); however, the…
  • Abstract Number: 1480 • ACR Convergence 2021

    LncRNA XIST Alters the Balance of Peripheral Blood Immune Cells in Systemic Lupus Erythematosus by Regulating the miR-17-92/OFLM4 and CEACAM8 Axis

    Qi Cheng, Mo Chen, xin Chen, peiyu zhang, huaxiang wu and yan du, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)

    Background/Purpose: X-inactive-specific transcript (XIST) has been shown to silence linked genes on the X chromosome that may be related to the pathogenesis of systemic lupus…
  • Abstract Number: 1935 • ACR Convergence 2021

    Skewed Escape from X-inactivation: Insights into the Female Bias of Sjögren’s Syndrome

    Teressa Shaw1, Wei Zhang2, Sara McCoy3, Xueer Qiu1, Adam Pagenkopf1, Robert Hal Scofield4, Jacques Galipeau3 and Yun Liang1, 1University of Wisconsin-Madison, Madison, WI, 2University of California San Diego, La Jolla, CA, 3University of Wisconsin, Madison, WI, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Many autoimmune diseases feature increased prevalence in females, with primary Sjögren's syndrome (pSS) being the most female-predominant autoimmune disease with a female-to-male ratio of…
  • Abstract Number: 1856 • ACR Convergence 2020

    Abnormal DNA Methylation in CD4+T Cells Is Associated with Cardiovascular Risk in Psoriatic Arthritis

    Iván Arias de la Rosa1, Maria Dolores Lopez-Montilla2, Carlos Pérez-Sánchez1, Javier Rodriguez-Ubreva3, Esteban Ballestar3, Carmen Torres-Granados1, María-Carmen Abalos-Aguilera1, Ignacio Gómez-García1, Alejandra Maria Patiño-Trives1, Maria Luque-Tevar1, Eduardo Collantes-Estévez4, Chary Lopez-Pedrera5, Alejandro Escudero-Contreras4, Clementina Lopez-Medina6 and Nuria Barbarroja1, 1Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 2IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, 3Josep Carreras Institute (IJC), Badalona, Spain, 4Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 5IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 6Rheumatology Department, Cochin Hospital, Paris, Paris, France

    Background/Purpose: Cardiovascular risk factors are increased in Psoriatic Arthritis (PsA). Latest studies suggested that inflammatory and metabolic disorders may be under epigenetic control, including DNA…
  • Abstract Number: 1903 • ACR Convergence 2020

    Assessment of Global DNA Methylation in Peripheral Blood Cell Subpopulations of Patients with Axial Spondyloarthritis : Preliminary Results

    Eric Toussirot1, Sebastien Pasquereau2, Charline Vauchy3, Zeina Nehme4, Daniel Wendling5, Jean Charles Balbalnc6, Caroline Laheurte7, Marc Puyraveau8 and Georges Herbein2, 1CIC biotherapies, Besançon University Hospital, Besançon, France, 2Pathogens & Inflammation/EPILAB Laboratory, UPRES EA 4266, Besancon, France, 3INSERM CIC-1431, Besancon, France, 4Pathogens & Inflammation/EPILAB Laboratory, UPRES EA 4266, Besancon, 5CHU Besançon, department of rheumatology, Besancon, France, 6Rhumatologie, Trevenans, France, 7Plateforme de biomonitring, Besancon, France, 8uMETh & INSERM CIC 1431, Besancon, France

    Background/Purpose: Axial spondyloarthritis (ax-SpA) corresponds to a group of chronic inflammatory disease mainly affecting the axial skeleton. TNF and IL-17A have been identified as key…
  • Abstract Number: 1914 • ACR Convergence 2020

    Long Non-coding RNA HOTAIR Induces GLI2 Expression Through Notch Signalling in Systemic Sclerosis Dermal Fibroblasts

    Christopher Wasson1, Rebecca Ross1, Rebecca Wells1, Clarissa Corinaldesi1, Ioanna Georgiou2, Natalia Riobo-Del Galdo2 and Francesco Del Galdo3, 11. Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom, 22. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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