Abstracts tagged "Epigenetics"

Abstract Number: 0941 • ACR Convergence 2024
DC-9476, a Novel Selective BRD4(BD2) Inhibitor, Improves Arthritis Scores in Preclinical Models of Rheumatoid Arthritis by Regulating Key Inflammatory Pathways
Michal Segal Salto¹, Rebecca Ross², Steven Ferrara³, Kelvin Chan⁴, Elvira haimov⁵, Francesco Del Galdo⁶ and Kulveer Mankia⁶, ¹DeepCure Inc., Tel Aviv, Israel, ²Medicine and Health, University of Leeds, Leeds, United Kingdom, ³DeepCure Inc., Boston, MA, ⁴DeepCure Inc., Texas, NV, ⁵DeepCure Inc., Los Angeles, CA, ⁶University of Leeds, Leeds, United Kingdom
Background/Purpose: Bromodomain and Extra-Terminal domain (BET) family proteins (BRD2, BRD3, BRD4, and BRDT) control the transcription of a wide range of proinflammatory and immunoregulatory genes.…
Abstract Number: 1653 • ACR Convergence 2024
Osteoarthritis Drives Inflammatory Imprinting of Synovial Fibroblasts, Exacerbating Gouty Arthritis Through m6A Modification of S100A4
ZIYI CHEN¹, Yinghui Hua² and Wenjuan Wang¹, ¹Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, Shanghai, China (People's Republic), ²Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, China (People's Republic)
Background/Purpose: Patients with osteoarthritis (OA) face an elevated risk of future gouty arthritis (GA). To delineate the underlying cellular and molecular mechanisms of OA-driven gout…
Abstract Number: 1654 • ACR Convergence 2024
CRTAC1 in Osteoarthritis: Implications for Disease Severity and miRNA Regulation
Aneta Prokopcová¹, Jiri Baloun², Adéla Navrátilová³, Klára Mocová², Lucia Ondrejčáková⁴, Jana Juhaszova², Tereza Kropáčková¹, Hana Storkanova⁵, Michal Tomcik⁵, Jindriska Gatterova², Olga Sleglova², Olga Ruzickova², Eva Kriegova⁶, Jiri Gallo⁷, Rastislav Ballay⁸, Petr Fulin⁹, Jiří Vencovský¹ and Ladislav Šenolt¹, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³1st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, ⁵Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁶Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Czech Republic, ⁷Department of Orthopaedics, University Hospital Olomouc, Olomouc, Czech Republic, ⁸1st Faculty of Medicine, Charles University, Prague, Czechia, Prague, Czech Republic, ⁹1st Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czechia, Prague, Czech Republic
Background/Purpose: Cartilage acidic protein1 (CRTAC1) is a potential biomarker linked to osteoarthritis (OA) and cartilage degeneration. This study aimed to compare CRTAC1 levels in the…
Abstract Number: 1806 • ACR Convergence 2024
Bisphenol a Methylation Scores Associate with SLE and ClinicalSubphenotypes
Holme Vestin¹, Nina Oparina², Maija-Leena Eloranta¹, Martina Frodlund³, Iva Gunnarsson⁴, Christopher Sjowall⁵, Elisabet Svenungsson⁶, Lars Rönnblom¹, Ann-Christine Syvänen¹, Johanna Sandling¹, Juliana Imgenberg-Kreuz¹ and Dag Leonard¹, ¹Uppsala university, Uppsala, Sweden, ²UU, Uppsala, Sweden, ³Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, ⁴Karolinska Institute, Stockholm, Sweden, ⁵Linköping University, Linköping, Sweden, ⁶Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by production of auto-antibodies, immune complex formation and an activated type I interferon system. Both genetic and environmental…
Abstract Number: 1856 • ACR Convergence 2024
Distinct Proliferative and Special Properties of Peripheral Helper T Cells in RA Synovium
Yuki Masuo¹, Akinori Murakami¹, Rinko Akamine¹, Osamu Iri¹, Koichi Murata¹, Kohei Nishitani¹, Hiromu Ito¹, Takayuki Fujii¹, Ryu Watanabe², Takeshi Iwasaki¹, Shinichiro Nakamura¹, Shinichi Kuriyama¹, Yugo Morita¹, Yasuhiro Murakawa¹, Chikashi Terao³, Yukinori Okada⁴, Motomu Hashimoto², Shuichi Matsuda⁵, Hideki Ueno¹ and Hiroyuki Yoshitomi¹, ¹Kyoto University, Kyoto, Japan, ²Osaka Metropolitan University, Osaka, Japan, ³RIKEN, Tokyo, Japan, ⁴The University of Tokyo / Osaka University / RIKEN, Tokyo, Japan, ⁵Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
Background/Purpose: Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that are frequently observed in the target tissues of chronic diseases. In patients with…
Abstract Number: 2498 • ACR Convergence 2024
The Methylome Profile of B-cells as a Biomarker of Nephritis in IgA Vasculitis
Veronica Pulito-Cueto¹, Joao Carlos Batista-Liz¹, Laura Carmen Terron², Iván Fernández Rengel³, María Sebastián Mora-Gil⁴, María Teresa Leonardo⁵, Ana Peñalba⁵, Luis Martín-Penagos⁶, Lara Belmar-Vega⁷, Cristina Gomez-Fernandez⁸, Ligia Gabrie-Rodriguez⁹, Rafael Gálvez Sánchez⁹, Luis Caminal-Montero¹⁰, Ana Turrion Nieves¹¹, Patricia Quiroga Colina¹², Esther Vicente-rabaneda¹³, Belén Sevilla-Pérez¹⁴, José Luis Callejas¹⁵, Eduardo Andrés-León², Javier Martin¹⁶, Ana María Marquez¹⁷, Santos Castañeda¹³, Ricardo Blanco-Alonso¹⁸ and Raquel Lopez-mejias¹, ¹IDIVAL, Santander, Spain, ²Unidad de Bioinformática, Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, Granada, Spain, ³Bioinformatics Unit, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, GENYO, Cen, Granada, Spain, ⁴Immunopathology Group, IDIVAL, Santander, Spain, ⁵Division of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁶Immunopathology Group, IDIVAL. Division of Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁷Immunopathology Group, IDIVAL. Division of Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, ⁸Division of Dermatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁹Immunopathology Group, IDIVAL. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹⁰Internal Medicine Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain, ¹¹Rheumatology Department, Hospital Universitario Virgen de la Vega, Salamanca, Spain, ¹²Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, ¹³Hospital Universitario de La Princesa, Madrid, Spain, ¹⁴Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, ¹⁵Systemic Autoimmune Diseases Unit, Hospital Clinico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain, ¹⁶Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Spain, Granada, Spain, ¹⁷Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, ¹⁸Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain
Background/Purpose: Nephritis is the main cause of long-term morbidity and mortality in patients with Immunoglobulin-A vasculitis (IgAV) [1, 2]. Unfortunately, sensitive, specific, and non-invasive biomarkers…
Abstract Number: 2599 • ACR Convergence 2024
Xist Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes
Claudia Lovell¹, Nikhil Jiwrajka², Hayley Amerman³, Michael Cancro⁴ and Montserrat Anguera⁵, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, ⁴Perelman School of Medicine, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, PA
Background/Purpose: Systemic lupus erythematosus (SLE) exhibits a strong female sex bias but the mechanisms underlying this bias are not well understood. Epidemiological studies demonstrate that…
Abstract Number: 0066 • ACR Convergence 2024
Association Between Gut Microbiota, Inflammation, and Epigenetics in Rheumatoid Arthritis Patients
jose Manuel Lisbona-Montañez¹, Arkaitz Mucientes², Patricia Ruiz-Limón³, Gracia María Martín-Nuñez⁴, Rocio Redondo-Rodríguez⁴, Laura Cano-García⁴, Sara Manrique-Arija⁵, Isabel Moreno-Indias², Natalia Mena Vázquez⁶ and Antonio Fernández-Nebro⁷, ¹University of Malaga, Malaga, Andalucia, Spain, ²IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, ³IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, ⁴IBIMA Plataforma Bionand, Malaga, Spain, ⁵Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, ⁶IBIMA, Málaga, Andalucia, Spain, ⁷Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain
Background/Purpose: The etiology of rheumatoid arthritis (RA) is not entirely known. Epigenetic modifications could be the link between genetic and environmental factors related to the…
Abstract Number: 0610 • ACR Convergence 2024
Clinical Evaluation on IFI44L Gene Methylation Detection for Diagnosis of Systemic Lupus Erythematosus by Methylation Sensitive High Resolution Melting (MS-HRM)
Xiaoping hong and liancheng lin, The Second Clinical Medical College of Jinan University, Shenzhen, China (People's Republic)
Background/Purpose: To evaluate the clinical effectiveness of IFI44L gene methylation detection for the diagnosis of Systemic Lupus Erythematosus (SLE) by MS-HRM, to determine the relative…
Abstract Number: 0784 • ACR Convergence 2024
RUNX1 Is Expressed in a Subpopulation of Dermal Fibroblasts and Is Increased with Systemic Sclerosis Disease Severity
Rezvan Parvizi¹, Zhiyun Gong², Helen Jarnagin², Tamar Abel², Dillon Popovich³, Madeline Morrisson⁴, Tammara Wood⁵, Sasha Shenk⁶, Monique Hinchcliff⁷, jonathan Garlick⁶, Patricia Pioli⁸ and Michael Whitfield¹, ¹Geisel School of Medicine at Dartmouth, Hanover, NH, ²Dartmouth College, Lebanon, NH, ³Dartmouth College, West Lebanon, NH, ⁴Geisel School of Medicine at Dartmouth College, Hanover, NH, ⁵Dartmouth, Hanover, NH, ⁶Tufts University, Boston, MA, ⁷Yale School of Medicine, Westport, CT, ⁸Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: Systemic Sclerosis (SSc) skin fibrosis results in complex changes in transcriptional and signaling pathways in the skin. Through transcription factor activity network analyses, the…
Abstract Number: 0863 • ACR Convergence 2024
The Development of Future Radiographic Knee Osteoarthritis Can Be Predicted by Peripheral Blood Epigenetic Models
Cindy Miranda¹, Nicholas Hannebutt², Gabby dyson³, Montana Barrett⁴, Aleksander Szymczak³ and Matlock Jeffries³, ¹Oklahoma Medical Research Foundation, Yukon, OK, ²Oklahoma Medical Research Foundation, Spencer, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴University of Oklahoma, Cement, OK
Background/Purpose: Knee osteoarthritis (OA) is a heterogeneous disease characterized by a variety of clinical and molecular phenotypes. However, we do not yet have robust biomarkers…
Abstract Number: 0897 • ACR Convergence 2024
Dynamic eQTLs from Activated Human B Cells Suggest Cell-state Dependent Effects for GWAS Risk Variants in BLK
Yao Fu, David Murphy, Richard Pelikan, Jeniffer Kelly, Kiely Grundahl, Satish Pasula, Kandice Tessneer and Patrick Gaffney, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex genetic disease in which B cells play a critical role in pathogenesis. Previous genome-wide association studies (GWAS)…
Abstract Number: 0914 • ACR Convergence 2023
Transcription Factor RFX1 Promotes M1 Macrophage Polarization in Systemic Lupus Erythematosus via Regulating APOBEC3A
shuang Yang¹, Pei Du¹, Sujie Jia² and Ming Zhao², ¹Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, China, ²Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China
Background/Purpose: Aberrant macrophage polarization is generally present in autoimmune diseases. Overwhelming M1 macrophage induces the continuous progression of inflammation, which is one of the vital…
Abstract Number: 0941 • ACR Convergence 2023
RUNX1 Expression and Binding Site Accessibility Is Associated with Increased Disease Severity in Systemic Sclerosis
Rezvan Parvizi¹, Zhiyun Gong¹, Dillon Popovich¹, Tamar Abel², Helen Jarnagin¹, Madeline Morrisson¹, Tammara Wood², Jonathan Garlick³, Monique Hinchcliff⁴, Patricia Pioli¹ and Michael Whitfield¹, ¹Geisel School of Medicine at Dartmouth, Hanover, NH, ²Dartmouth College, Hanover, NH, ³Tufts University School of Dental Medicine, Boston, MA, ⁴Yale School of Medicine, Westport, CT
Background/Purpose: Runt-related transcription factor 1 (RUNX1) is a member of the core-binding factor family that regulates proliferation, differentiation, and cell survival in multiple cell lineages.…
Abstract Number: 0960 • ACR Convergence 2023
MiR-3606-3p Alleviates Skin Fibrosis by Suppressing Fibroblast Inflammation and Migration via Inhibiting GAB1 and ITGAV
yahui chen¹, Mengkun shi¹, Wei Wang¹, Chenyi Shi¹, Xueyi Xia¹, wenyu Wu², Jiucun Wang³ and Xiangguang Shi³, ¹Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai, Shanghai, China
Background/Purpose: Systemic sclerosis (SSc) and keloid are typical skin fibrotic diseases with unclear epigenetic mechanisms and clinical targets. As an important epigenetic regulatory factor, microRNAs…

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