Abstracts tagged "Epidemiology"

Abstract Number: 1952 • ACR Convergence 2022
Burden of Disease in Refractory Rheumatoid Arthritis
Kristin Wipfler¹, Bobby Kwanghoon Han², Urbano Sbarigia³, Federico Zazzetti⁴, Anna Sheahan⁵, Iris Lin⁶, Patricia Katz⁷, Evo Alemao⁸ and Kaleb Michaud⁹, ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Johnson & Johnson, Beerse, Belgium, ⁴Janssen Medical Affairs Global Services, LLC, Buenos Aires, Argentina, ⁵Janssen Research and Development, Chapel Hill, NC, ⁶Janssen, Horsham, PA, ⁷UCSF, San Rafael, CA, ⁸Janssen, Princeton, NJ, ⁹University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Despite major advances in RA treatment and the improved outcomes that have been associated with the expanding number of advanced therapies available, a substantial…
Abstract Number: 0136 • ACR Convergence 2022
Sarcoidosis Incidence After mTOR Inhibitor Treatment
Matthew Baker¹, Emese Vágó², Yuhan Liu¹, Rong Lu¹, Suzanne Tamang³, Erzsébet Horváth-Puhó² and Henrik Sørensen², ¹Stanford University, Stanford, CA, ²Aarhus University Hospital, Aarhus, Denmark, ³Stanford Center for Population Health Sciences, Redwood City, CA
Background/Purpose: Mechanistic target of rapamycin (mTOR) inhibitors are effective in animal models of granulomatous disease, but their benefit in patients with sarcoidosis is unknown. We…
Abstract Number: 0550 • ACR Convergence 2022
Improving the Accuracy of Automated Gout Flare Ascertainment Using Natural Language Processing of Medical Records and Linked Medicare Claims Data for Real-world Comparative Effectiveness Research
Kazuki Yoshida, Tianrun Cai, Lily G Bessette, Erin Kim, Su Been Lee, Luke E Zabotka, Alec Sun, Julianna M. Mastrorilli, Theresa A. Oduol, Jun Liu, Daniel Solomon, Katherine Liao and Seoyoung Kim, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Gout flares are challenging to study using large real-world data because flares are episodic with varying severity and clinical manifestations. Furthermore, there is no…
Abstract Number: 0732 • ACR Convergence 2022
Application of Natural Language Processing to Identify Varicella Zoster Infection in Clinical Notes
Austin Ho¹, Zara Izadi², Gabriela Schmajuk³, Jinoos Yazdany⁴, Suzanne Tamang⁵ and Milena Gianfrancesco⁶, ¹University of California, Berkeley, Berkeley, CA, ²University of California San Francisco, San Francisco, CA, ³UCSF / SFVA, San Francisco, CA, ⁴UCSF, San Francisco, CA, ⁵Stanford Center for Population Health Sciences, Redwood City, CA, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Varicella zoster virus (VZV) infection can be associated with significant morbidity in immunosuppressed individuals. However, infections of VZV are often documented in unstructured fields…
Abstract Number: 1143 • ACR Convergence 2022
Epigenome-wide Analysis of Osteoarthritis in the Multicenter Osteoarthritis Study
Michelle S. Yau¹, Paul C. Okoro², Ida K. Haugen³, John A. Lynch⁴, Michael Nevitt⁵, Cora E. Lewis⁶, James Torner⁷ and David Felson⁸, ¹Hebrew SeniorLife, Harvard Medical School, Boston, MA, ²Hebrew SeniorLife, Boston, MA, ³Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ⁴UCSF, San Francisco, CA, ⁵University of California at San Francisco, Orinda, CA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA, ⁸Boston University, Boston, MA
Background/Purpose: Epigenetic mechanisms like DNA methylation may play a role in OA. For example, expression of GDF5, a well-known OA gene, is modulated by demethylation…
Abstract Number: 1223 • ACR Convergence 2022
Autoimmune Thyroid Disease Associates with Hand Pain in Older Adults in the Third National Health and Nutrition Examination Survey
Clement Tagoe¹ and Wanyi Wang², ¹Albert Einstein College of Medicine, Bronx, NY, ²Elite Research, LLC, Irving, TX
Background/Purpose: Chronic hand pain is a prominent symptom of many forms of arthritis and autoimmune disease. It is often the initial presentation of diseases marked…
Abstract Number: 1593 • ACR Convergence 2022
Epidemiology and Outcomes of Infection-related Hospitalizations in Young Adults with SLE: Data from National Inpatient Sample
Rashmi Dhital¹, Monica Guma², Dilli Poudel³ and Kenneth Kalunian⁴, ¹UC San Diego, San Diego, CA, ²UCSD, La Jolla, CA, ³Indiana Regional Medical Center, Indiana, PA, ⁴University of California San Diego, La Jolla, CA
Background/Purpose: Infection is the leading cause of hospitalization and mortality in SLE. Care of young adults (YA) with SLE is particularly challenging, with higher mortality…
Abstract Number: 1770 • ACR Convergence 2022
Prevalence and Incidence of Depression in Patients with Rheumatoid Arthritis: A Systematic Review
John E Oghene¹, Griffin Reed², Ian Saldanha³, Pooja Reddy⁴, Ahmed Elshazly⁵, Yuvaraj Singh⁶ and Deepan Dalal⁷, ¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Rhode island hospital, Brown University Warren Alpert School of Medicine, Providence, RI, ³Brown University School of Public Health, Providence, RI, ⁴Rhode island hospital, Brown University Warren Alpert School of Medicine, Seekonk, MA, ⁵Westerly Hospital, Yale New Haven Health, Westerly, RI, ⁶Saint Vincent Hospital, Worcester, MA, ⁷Brown University School of Medicine, Providence, RI
Background/Purpose: Depression is a common co-morbidity that has been shown to worsen symptoms such as pain, fatigue, decreased functional status, decreased disease remission, and response…
Abstract Number: 1959 • ACR Convergence 2022
Increased Mortality in Patients with RA-Associated Interstitial Lung Disease: Data from a French Administrative Healthcare Database
Pierre-Antoine Juge¹, Lidwine Wemeau², Sebastien Ottaviani³, guillaume desjeux⁴, Joe Zhuo⁵, Virginie Vannier-Moreau⁶, René-Marc Flipo⁷, Bruno Crestani⁸ and Philippe Dieude⁹, ¹Rheumatology department, Bichat Hospital, Paris, France, ²Pulmonology department, Lille University hospital, Lille, France, ³Hopital Bichat-Claude Bernard, Paris, France, ⁴e-Health Services Sanoia, Gemenos, France, ⁵BMS, Lawrenceville, NJ, ⁶BMS, Rueil-Malmaison, ⁷Hôpital Roger Salengro, Lille, France, ⁸Hopital Bichat, Paris University, Paris, France, ⁹Université Paris Cité, Paris, France
Background/Purpose: Interstitial lung disease (ILD) is a common extra-articular manifestation of RA. Studies have shown variability in the prevalence and mortality rate of patients with…
Abstract Number: 0231 • ACR Convergence 2022
Primary Care Physician’s Perspective and Needs on Early Rheumatoid Arthritis Diagnosis: REUCARE Program for Early Referral
Camille Bourgeois¹, Jorge Olmedo Galindo², Juan Molina¹, Gema Fernandez-Plana², Julia Martinez-Barrio¹, Javier Rivera³ and Isabel Castrejon⁴, ¹Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²Gerencia Asistencial Atención Primaria, Comunidad de Madrid, Madrid, Spain, ³Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Hospital Universitario Gregorio Marañón, Madrid, Spain
Background/Purpose: Primary care physicians (PCPs) play a crucial role in early recognition and rapid referral of patients with inflammatory arthritis to improve early management and…
Abstract Number: 0552 • ACR Convergence 2022
Identifying Subgroups of Patients Undergoing Knee Replacement
Brooke McGinley¹, Gabriela Rabasa², Tuhina Neogi³, David Felson² and Michael LaValley⁴, ¹Boston University School of Public Health, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Boston University School of Public Health, Arlington, MA
Background/Purpose: Knee replacement surgery (KR) is prevalent in the US with estimated lifetime risk from age 25 of 7% for males and 9.5% for females,…
Abstract Number: 0756 • ACR Convergence 2022
Rheumatic Toxicities of Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and the Effect of Pre-existing Autoimmune and Non-immune Mediated Rheumatic Conditions
Alana Bruce¹, Georgina V Long², Alexander M Menzies², Brian Fernandes³ and Fredrick Joshua⁴, ¹Macquarie University, Balaclava, Victoria, Australia, ²Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia, ⁴Macquarie University, Integrated Specialist Medical Care, Sydney, Australia
Background/Purpose: To estimate the frequency of rheumatic toxicities of immune checkpoint inhibitors (ICI) presenting as de novo or exacerbations of pre-existing rheumatic disease in patients…
Abstract Number: 1186 • ACR Convergence 2022
The Trajectory of Multimorbidity in Patients with Systemic Lupus Erythematosus in the United States
Ali Duarte-Garcia¹, Maria Stevens², Herbert Heien², Gabriel Figueroa Parra¹, Jose A Meade-Aguilar¹, Molly M. Jeffery², Uma Thanarajasingam¹, Cynthia Crowson³ and Rozalina McCoy², ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, ³Mayo Clinic, Eyota, MN
Background/Purpose: The presence of multiple chronic conditions (multimorbidity) is associated with disability and premature death. We determined the trajectory of multimorbidity in SLE compared to…
Abstract Number: 1278 • ACR Convergence 2022
ANA Testing Practices in the United States: A Population-Based Study Between 2000 and 2019
Mehmet Hocaoglu¹, Alain Sanchez-Rodriguez², Hannah Langenfeld³, Cynthia Crowson⁴ and Ali Duarte-Garcia⁵, ¹University of Maryland Medical Center, Midtown Campus, Baltimore, MD, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Eyota, MN, ⁵Mayo Clinic, Rochester, MN
Background/Purpose: Inappropriate laboratory testing accounts for an important part of avoidable healthcare costs. Anti-nuclear antibody (ANA) is a commonly used laboratory test in rheumatology with…
Abstract Number: 1612 • ACR Convergence 2022
Prediction of Psoriatic Arthritis Tool (PRESTO): Development and Performance of a New Scoring System for Psoriatic Arthritis Risk
Lihi Eder¹, Ker-Ai Lee², Vinod Chandran³, Jessica Widdifield⁴, Aaron Drucker⁴, Christopher Ritchlin⁵, Cheryl F Rosen⁴, Richard Cook² and Dafna Gladman⁶, ¹Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, ⁶Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada
Background/Purpose: A simple, scalable tool that identifies psoriasis patients at high risk for developing PsA could improve early detection and facilitate early intervention. Our overall…

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