Abstracts tagged "Epidemiology"

Abstract Number: 1593 • ACR Convergence 2023
Combining Single-cell RNA Sequencing and Population-based Studies Reveals Hand Osteoarthritis-associated Chondrocyte Subpopulations and Pathways
Hui Li¹, Xiaofeng Jiang¹, Yongbing Xiao¹, Yuqing Zhang², Weiya Zhang³, Michael Doherty³, Jacquelyn Nestor⁴, Changjun Li⁵, Jing Ye¹, Tingting Sha⁶, Houchen Lyu¹, Jie Wei⁷, Chao Zeng¹ and Guanghua Lei¹, ¹Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ²Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, ³Academic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, United Kingdom, ⁴Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China, ⁶Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China, ⁷Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Hand osteoarthritis (OA) is a common heterogeneous joint disorder with differences in etiology and pathophysiology from the large weight-bearing knee or hip OA. Its…
Abstract Number: 1821 • ACR Convergence 2023
The “Weekend Effect” and Rheumatological Association in Patients with Diffuse Alveolar Haemorrhage
Shobhit Piplani¹, Shreya Gulati², Vladimir Jelic¹, Asad Ahmed³, Sung Mi Yoon¹, Donclair Brown¹, Miroslav Radulovic¹ and Beverly Johnson⁴, ¹Jacobi Medical Center/North Central Bronx, Albert Einstein College of Medicine, NYC Health and Hospitals, Bronx, NY, ²Jawahar lal Nehru Medical College, New York, NY, ³SUNY Downstate, Brooklyn, NY, ⁴Albert Einstein College of Medicine, Jacobi/NCB, New York, NY
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication commonly associated with autoimmune disorders. Limited treatment options are available for DAH, and time to…
Abstract Number: 2188 • ACR Convergence 2023
Lung Cysts in Primary SS: New Findings on an Allegedly Innocuous Iiagnosis
Regis Sewa Marques, Maria Fernanda Zacarin, Pamela Bellini, Raissa Dudienas D Pereira, Aloma Guinami Scabora, Zoraida Sachetto, Manoel Bertolo and ALISSON PUGLIESI, Universidade Estadual de Campinas, Campinas, Brazil
Background/Purpose: Lung cysts are a frequent finding in patients with SS, with previous data indicating a prevalence of approximately 30% on chest CT scans. In…
Abstract Number: 2420 • ACR Convergence 2023
Sex Differences in Giant Cell Arteritis: Data from the ARTESER Registry
Delia Fernández-Lozano¹, Marta Domínguez², Javier Narvaez³, Noemi Garrido-Puñal⁴, Eugenio De Miguel⁵, Paula V. Estrada-Alarcón⁶, Iñigo Hernández-Rodríguez⁷, Maria. T Silva-Diaz⁸, Joaquín M. Belzunegui⁹, Clara Moriano Morales¹⁰, Julio Sanchez Martin¹¹, Itziar Calvo-Zorrilla¹², Vicente Aldasoro¹³, lydia Abasolo¹⁴, Javier Loricera¹¹, Patricia Moya¹⁵, Maria J. García-Villanueva¹⁶, Carles Galisteo¹⁷, Anne Riveros-Frutos¹⁸, Francisco Ortiz-Sanjuán¹⁹, Selene Labrada-Arrabal²⁰, Margarida Rocha²¹, Carlos García-Porrúa²², Maria García-González²³, Clara Molina Almela²⁴, María Alcalde²⁵, Antonio Juan Mas²⁶, Fernando Alonso²⁷, Santos Castañeda²⁸, Ricardo Blanco²⁹ and on behalf of the Collaborative Group members³⁰, ¹Hospital de Mérida, Merida, Spain, ²Sociedad Española de Reumatología, Madrid, Spain, ³Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁵Hospital Universitario La Paz, Madrid, Spain, ⁶Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, ⁷Hospital do Meixoeiro. Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ⁸Complexo Hospitalario Universitario A Coruña, A Coruña, Spain, ⁹Hospital Universitario Donostia, Donostia, Spain, ¹⁰Rheumatology, Hospital Universitario de León, León, Spain, ¹¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹²Basurto University Hospital, Bilbao, Spain, ¹³Hospital Universitario de Navarra, Pamplona, Spain, ¹⁴Hospital Clínico San Carlos, Madrid, Spain, ¹⁵Hospital de Santa Creu i Sant Pau, Barcelona, Spain, ¹⁶Hospital Ramón y Cajal, Madrid, Spain, ¹⁷Hospital Universitario Parc Taulí, Sabadell, Spain, ¹⁸Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, ¹⁹Hospital Universitario y Politécnico La Fe, Valencia, Spain, ²⁰Hospital del Mar, Barcelona, Spain, ²¹Osakidetza, Bilbo, Spain, ²²Hospital Universitario Lucus Augusti, Lugo, Spain, ²³Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ²⁴Hospital General de Valencia, Valencia, Spain, ²⁵Hospital Severo Ochoa, Madrid, Spain, ²⁶Hospital Universitario Son Llàtzer, Mallorca, Spain, ²⁷Spanish Society of Rheumatology, Madrid, Spain, ²⁸Hospital Universitario de la Princesa, Madrid, Spain, ²⁹Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³⁰ARTESER group, Madrid, Spain
Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in North America and Western Europe. GCA is more likely to occur in women (1).…
Abstract Number: 0126 • ACR Convergence 2023
Epidemiology and Retrospective Case-Control Analysis of IIM in the US Veteran Population
Vladimir Liarski, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Idiopathic Inflammatory Myopathy (IIM) - comprising polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM) - is rare and difficult to study. We sought…
Abstract Number: 0299 • ACR Convergence 2023
Trends and Outcomes of Hospitalized Patients with Idiopathic Inflammatory Myopathy and Venous Thromboembolism: A Nationwide Inpatient Sample Analysis from US (2016-2019)
Haseeb Chaudhary¹, Biraj Shrestha², Sarah Abi Doumeth³ and Maya Mattar⁴, ¹Case Western Reserve University, Westlake, OH, ²Tower Health System, Reading, PA, ³Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Louis Stokes VA Medical Center, Cleveland, OH
Background/Purpose: Recent evidence suggests increased prevalence of venous thromboembolism (VTE) in patients with idiopathic inflammatory myopathies (IIM). The literature on the clinical implications of VTE…
Abstract Number: 0618 • ACR Convergence 2023
Incident versus Prevalent Interstitial Lung Disease in Systemic Sclerosis in the EUSTAR Database: Different Disease Phenotypes and Prognosis
liubov Petelytska¹, Arthiha Velauthapillai², Lorenzo Tofani³, Patricia Carreira⁴, Giovanna Cuomo⁵, Eric Hachulla⁶, Ivan Castellvi⁷, Radim Becvar⁸, Alexandra Balbir-Gurman⁹, Paolo Airò¹⁰, Irena Litinsky¹¹, Lesley Ann Saketkoo¹², Madelon Vonk¹³, Jeska de Vries-Bouwstra¹⁴, Anna Maria Hoffmann-Vold¹⁵, marco Matucci Cerinic¹⁶, Oliver Distler¹⁷ and Cosimo Bruni¹⁷, ¹Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, ²Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy, ⁴Hospital Universitario 12 de Octubre, Madrid, Spain, ⁵Department of Precision Medicine, “Luigi Vanvitelli” University of Campania, Naples, Italy, ⁶University of Lille, Lille, France, ⁷Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, ⁸Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Praha, Czech Republic, ⁹Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, ¹⁰Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, ¹¹Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ¹²University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, ¹³Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁴Leiden University Medical Center, Leiden, Netherlands, ¹⁵Oslo University Hospital, Department of Rheumatology, Oslo, Norway, ¹⁶Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, ¹⁷Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Background/Purpose: Although 50% of patients with systemic sclerosis (SSc) present with interstitial lung disease (ILD) at baseline, new onset of ILD can also occur later…
Abstract Number: 0974 • ACR Convergence 2023
Validation of Boolean 2.0 Criteria for Assessing Remission and Predicting Quality of Life in Korean Patients with Rheumatoid Arthritis Undergoing Targeted Therapy
Soo-Kyung Cho¹, Yeo-Jin Song¹, Jungyong Han², Hye Won Kim³, Eunwoo Nam³ and Yoon-Kyoung Sung¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Hanyang University Institute for Rheumatology Research, Seoul, South Korea
Background/Purpose: The management of rheumatoid arthritis (RA) focuses on achieving remission as a treatment goal. The updated ACR/EULAR remission definition (Boolean criteria 2.0) has raised…
Abstract Number: 1131 • ACR Convergence 2023
Clinical Phenotypes of IgG4-related Disease in a Multi-ethnic Singapore Cohort
Choon Guan Chua¹, Weida Chew¹, Jeggrey Kay Wee Kam¹, Hwee-Pin Phua¹, Chengzi Chow¹, Carol Yee-Leng Ng¹, Wei-Yen Lim¹, Ru Sin Lim¹, Jereme Yijin Gan¹, Mung-Ee Loh¹, Tianrong Yeo², David Zhiwei Law¹, Stephrene Seok Wei Chan³, Amanda Francesca Ya-Fang Cheang⁴, Yong-Howe Ho¹ and Charles Kien-Fong Vu¹, ¹Tan Tock Seng Hospital, Singapore, Singapore, ²National Neurology Institute, Singapore, Singapore, ³National University Hospital, Singapore, Singapore, ⁴Woodlands Health Campus, Singapore, Singapore
Background/Purpose: IgG4-related disease (IgG4-RD) is an immune-mediated condition that is heterogenous and can result in organ failure. To understand the disease profile of our local…
Abstract Number: 1628 • ACR Convergence 2023
The Impact of Cardiovascular and Cerebrovascular Disease on the Risk of Dementia in Rheumatoid Arthritis. a Mediation Analysis
Edward Lovering¹, Chanakya Kodishala², Rakesh Kumar¹, Cynthia Crowson¹, Ryan Lennon¹, John Davis¹ and Elena Myasoedova¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic Rochester Minnesota, Rochester, MN
Background/Purpose: Alzheimer's disease and related dementias have an immense disease burden, with predicted continuous increase in incidence and prevalence. Systemic inflammation plays a major role…
Abstract Number: 1824 • ACR Convergence 2023
Breakthrough COVID-19 and Severity After Vaccination Among Pregnant Persons with Rheumatic Diseases
Anna Sutton¹, Carolyn Hilliard², Qiuyuan Qin³, Alfred Jared Anzalone⁴, Mary Toth⁵, Rena Patel⁶ and Namrata Singh⁷, ¹Department of Epidemiology, University of Washington School of Public Health, Woodinville, WA, ²Department of Internal Medicine SSM Saint Louis University, St. Louis, MO, ³Department of Public Health, University of Rochester, Rochester, NY, ⁴Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, ⁵Nemours Foundation, Orlando, FL, ⁶Departments of Medicine and Global Health, University of Washington, Seattle, WA, ⁷University of Washington, Bellevue, WA
Background/Purpose: Acknowledgment: Contributed on behalf of the National COVID Cohort Collaborative (N3C) ConsortiumIndividuals with rheumatologic diseases (RD) are at higher risk for severe COVID-19 compared…
Abstract Number: 2199 • ACR Convergence 2023
Four-year Secukinumab Treatment Outcomes in Axial Spondyloarthritis and Psoriatic Arthritis Patients Treated in Routine Care: Results from the EuroSpA Collaboration
Marion Pons¹, Stylianos Georgiadis¹, Zohra Faizy Ahmadzay², Mikkel Østergaard³, Bente Glintborg¹, Jette Heberg¹, Sara Nysom Christiansen¹, Simon Horskjær Rasmussen¹, Isabel Castrejon⁴, Fernando Alonso⁵, Karin Laas⁶, Sigrid Vorobjov⁷, Nikita Khmelinskii⁸, Jakub Zavada⁹, Adrian Ciurea¹⁰, Michael Nissen¹¹, Brigitte Michelsen¹², Pawel Mielnik¹³, Anne Gitte Loft¹⁴, Ziga Rotar¹⁵, Katja Perdan Pirkmajer¹⁶, Gary Macfarlane¹⁷, Gareth T. Jones¹⁷, Dan Nordstrom¹⁸, Anna-Mari Hokkanen¹⁹, Irene van der Horst-Bruinsma²⁰, Johan Karlsson Wallman²¹, Bjorn Gudbjornsson²², olafur Palsson²³, Merete Hetland¹ and Lykke Ørnbjerg¹, ¹Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ²Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark, ³Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark, ⁴Hospital Universitario Gregorio Marañón, Madrid, Spain, ⁵Spanish Society of Rheumatology, Madrid, Spain, ⁶Department of Rheumatology, East-Tallinn Central Hospital, Tallinn, Estonia, ⁷National Institute for Health Development, Tallinn, Estonia, ⁸Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, ⁹Institute of Rheumatology; Charles University, Prague, Czech Republic, ¹⁰University Hospital Zurich, Zürich, Switzerland, ¹¹Geneva University Hospitals, Geneva, Switzerland, ¹²Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, ¹³Section for Rheumatology, Helse Førde, Førde, Norway, ¹⁴Aarhus University, Horsens, Denmark, ¹⁵University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹⁶University Medical Centre Ljubljana; University of Ljubljana, Ljubljana, Slovenia, ¹⁷Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ¹⁸Helsinki University Hospital, Helsinki, Finland, ¹⁹Departments of Medicine and Rheumatology, Helsinki University Hospital, Helsinki, Finland, ²⁰Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²¹Lund University and Skåne University Hospital, Lund, Sweden, ²²Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland, ²³Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Background/Purpose: Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are part of the spondylarthritis spectrum that can be treated with secukinumab, a fully human IgG1 monoclonal…
Abstract Number: 2428 • ACR Convergence 2023
Unclosing Premature Mortality Gap Among Gout Patients in the US General Population, Independent of Serum Urate and Atherosclerotic Cardiovascular Risk Factors
Natalie McCormick¹, Kehuan Lin², Chio Yokose³, Na Lu⁴, Yuqing Zhang¹ and Hyon K. Choi⁵, ¹Massachusetts General Hospital, Boston, MA, ²Channing Division of Network Medicine, Boston, MA, ³Massachusetts General Hospital, Waltham, MA, ⁴Arthritis Research Canada, Vancouver, BC, Canada, ⁵Massachusetts General Hospital and Harvard Medical School, Lexington, MA
Background/Purpose: A recent UK study reported a transient increased cardiovascular risk after gout flare episodes [Cipolletta et al. JAMA 2022], which may translate to premature…
Abstract Number: 0128 • ACR Convergence 2023
Incidence, Trends, and Determinants of Multimorbidity in Systemic Sclerosis: Data from a Population-based Cohort
Anukul Karn¹, Sara Achenbach², Alicia Hinze³, Cynthia Crowson¹ and Ashima Makol², ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, Rochester, MN, ³Mayo Clinic - Rochester, MN, Rochester, MN
Background/Purpose: To evaluate the burden, longitudinal trends, and drivers of multimorbidity (MM; the presence of ≥2 morbidities) in patients with Systemic Sclerosis (SSc) vs. age-…
Abstract Number: 0353 • ACR Convergence 2023
Validation of Claims-based Algorithms for Newly Diagnosed Juvenile Idiopathic Arthritis Using Machine Learning Methods
Patricia Hoffman¹, Lauren Parlett², Daniel Beachler², Daniel Reiff³, Sarah McGuire¹, Sonia Pothraj¹, Lakshmi Moorthy¹, Cynthia Salvant⁴, Dawn Koffman⁵, Sanika Rege⁵, Cecilia Huang⁵, Matthew Iozzio⁵, Kevin Schott², Kevin Haynes⁶, Amy Davidow⁷, Stephen Crystal⁸, Tobias Gerhard⁵, Brian Strom⁹, Carlos Rose¹⁰ and Daniel Horton⁴, ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Carelon, Wilmington, DE, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁵Rutgers Center for Pharmacoepidemiology and Treatment Science, New Brunswick, NJ, ⁶Janssen Pharmaceuticals, Raritan, NJ, ⁷New York University, New York, NY, ⁸Rutgers University, New Brunswick, NJ, ⁹Rutgers, State University of New Jersey, New Brunswick, NJ, ¹⁰Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Administrative claims databases represent important settings for studying large populations with juvenile idiopathic arthritis (JIA), but prior efforts to validate diagnostic algorithms for JIA…

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