Abstracts tagged "Eosinophilic Granulomatosus with Polyangiitis (Churg-Strauss)"

Abstract Number: 2532 • ACR Convergence 2025
Temporal arteritis revealing eosinophilic diseases: A multicenter retrospective study, literature review, and combined cluster analysis
Julie Merindol¹, Benjamin Torreau², Matthieu Groh³, Amy Klion⁴, Paolo Delvino⁵, Olivier Espitia⁶, Jean-Benoit Arlet⁷, Sarah Lechtman⁸, Jean-sébastien Allain⁹, Federica Bello¹⁰, Anaelle Boucaud¹¹, Florian Catros¹², Julien Campagne¹³, Anne Coutard¹⁴, Cecile-Audrey DUREL¹⁵, Mikael Ebbo¹⁶, Georgina Espigol-Frigole¹⁷, Giacomo Emmi¹⁸, Yanis Kouchit¹⁹, Guillaume Lefevre²⁰, François Lifermann²¹, PAUL LEGENDRE²², Eric Liozon²³, Francois Maurier²⁴, Sara Melboucy Belhkir²⁵, Sébastien Miranda²⁶, Simon Parreau²³, Paola Parronchi²⁷, Jacques Pouchot²⁸, Vincent Pestre²⁹, Sophie Rosenstingl³⁰, Jan Willem Cohen Tervaert³¹, Odile Souchaud Debouverie³², Xavier Puéchal³³ and Benjamin Terrier³⁴, ¹CHU de Nice, Nice, France, ²Internal Medicine and Immunology, CHU Tours, Tours, France, ³Hôpital Foch, paris, France, ⁴NIAID/NIH, Bethesda, MD, ⁵University of Milano-Bicocca, Monza, Monza and Brianza, Italy, ⁶CHU de Nantes, Nantes, France, ⁷APHP, Paris, ⁸CHU de Nice, Nixe, France, ⁹Scorff-Lorient Hospital, Lorient, France, ¹⁰Université de Florence, Florence, Italy, ¹¹CHU de Tours, Tours, France, ¹²CHI VAL, Ariège, France, ¹³Hopital Robert Schuman, Metz, France, ¹⁴Groupe Hospitalier de Bretagne Sud, Lorient, France, ¹⁵CHU de Lyon, Lyon, France, ¹⁶Internal Medicine, Marseille-APHM, hôpital La Timone, Marseille, France, ¹⁷Hospital Clínic de Barcelona, Barcelona, Spain, ¹⁸Department of Medical, Surgery and Health Sciences, University of Trieste, Italy and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy, Trieste, Italy, ¹⁹CH de Cannes, Cannes, France, ²⁰CHU de Lille, Lille, France, ²¹Internal Medicine, CH de Dax, Dax, France, ²²CH LE MANS, Le Mans, France, ²³CHU de Limoges, Limoges, France, ²⁴HOPITAUX PRIVES DE METZ, Vaux / Frankreich, France, ²⁵CH de Saint Quentin, Saint Quentin, France, ²⁶Internal Medicine, CHU Rouen, Rouen, France, ²⁷CHU de Florence, Florence, Italy, ²⁸AP-HP, Rueil Malmaison, France, ²⁹CH d'Avignon, Avignon, France, ³⁰CH de Compiegne, Compiegne, France, ³¹University of Alberta, Edmonton, AB, Canada, ³²CHU de Poitiers, Poitiers, France, ³³Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( ⁷⁵⁰¹⁴ ), Ile-de-France, France, ³⁴Cochin Hospital, Paris, France
Background/Purpose: Temporal arteritis (TA) classically presents as a large-vessel vasculitis in older adults with cranial ischemic symptoms. However, in younger patients or in the presence…
Abstract Number: 2514 • ACR Convergence 2025
Comparison of Demographics and Outcomes of Inpatient Hospitalization of Severe Asthma Patients with Eosinophilic Granulomatosis with Polyangitis. A Study on the National Inpatient Sample Database
Prakriti Subedi¹, Anil Regmi², Karun Shrestha³, Manoj Ghimire⁴, Sajana Poudel⁵, Kalpana Ghimire¹, Oshna Pandey¹ and Clement Tagoe⁶, ¹St. Barnabas Hospital, Bronx, NY, ²Parkview Health, Fort Wayne, IN, ³St. Barnabas Hospital Internal Medicine Residency, Bronx, NY, ⁴St Barnabas Hospital, BRONX, NY, ⁵Cook County Health, CHICAGO, NY, ⁶Albert Einstein College of Medicine, FRESH MEADOWS, NY
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis marked by asthma and eosinophilia, often leading to severe, persistent respiratory symptoms. Unlike severe asthma…
Abstract Number: 1599 • ACR Convergence 2024
Glucocorticoids versus Glucocorticoids Plus Cyclophosphamide in Eosinophilic Granulomatosis with Polyangiitis with Poor-Prognosis Factors: A Target Trial Emulation Study
Boris Sorin¹, Matthias Papo¹, Renato Alberto Sinico², Vítor Silvestre Teixeira³, Nils Venhoff⁴, Maria-Letizia Urban⁵, Michele Iudici⁶, Juliane Mahrhold⁷, Francesco Locatelli⁸, Giulia Cassone⁹, Franco Schiavon¹⁰, Benjamin Seeliger¹¹, Thomas Neumann¹², Claudia Feder¹³, Claus Kroegel¹⁴, Matthieu Groh¹⁵, Chiara Marvisi¹⁶, Maxime Samson¹⁷, Thomas Barba¹⁸, David Jayne¹⁹, Arianna Troilo²⁰, Jens Thiel²⁰, Bernhard Hellmich²¹, Sara Monti²², Carlomaurizio Montecucco²³, Carlo Salvarani²⁴, Jean-Emmanuel Kahn²⁵, Bernard Bonnotte²⁶, Cécile-Audrey Durel²⁷, Xavier Puéchal²⁸, Luc Mouthon²⁹, Loïc Guillevin³⁰, Giacomo Emmi³¹, Augusto Vaglio³², Raphael Porcher³³ and Benjamin Terrier³⁴, and the French Vasculitis Study Group (FVSG) and the European EGPA Study Group (EESG), ¹Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West, Paris Cité University, Assistance Publique – Hôpitaux de Paris, Paris, France, ²Nephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Milan, Italy, ³Department of Rheumatology, Faro Hospital, Algarve, Portugal, ⁴Medical Center - University of Freiburg, Internal Medicine, Department of Rheumatology and Clinical Immunology, Freiburg, Germany, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West, Paris Cité University, Assistance Publique – Hôpitaux de Paris and Division of rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland, Paris, France, ⁷Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabtologyy and Immunology, ERN-RITA Reference Center, Vasculitis-Center Tübingen-Kirchheim, Medius Kliniken Kirchheim, University of Tübingen, Kirchheim-Teck, Germany, ⁸Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, ⁹Clinical and Experimental Medicine PhD Program, Azienda USL-IRCCS di Reggio Emilia and Universita di Modena and Reggio Emilia, Modena, Italy, ¹⁰Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, ¹¹Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, ¹²Department of Rheumatology, Clinic of Internal Medicine III, Jena University Hospital, Jena, Germany and Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St Gallen, St Gallen, Switzerland, Jena, Germany, ¹³Department of Rheumatology, Clinic of Internal Medicine III, Jena University Hospital, Jena, Germany, ¹⁴Department of Pneumology and Allergology, Clinic of Internal Medicine I, Jena University Hospital, Jena, Germany, ¹⁵Foch, Suresnes, France, ¹⁶Rheumatology Unit Universita di Modena and Reggio Emilia, Modena, Italy, ¹⁷Department of Internal Medicine and Clinical Immunology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, Dijon, France, ¹⁸Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France, ¹⁹University of Cambridge, Cambridge, United Kingdom, ²⁰Department of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany, ²¹Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius Kliniken, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, ²²IRCCS Istituto Auxologico Italiano, Milan, Italy, ²³IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, ²⁴Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy, Reggio Emilia, Italy, ²⁵Department of Internal Medicine, Ambroise Paré Hospital, Assistance Publique - Hôpitaux de Paris, Université de Versailles Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France, Boulogne Billancourt, France, ²⁶Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France., Dijon, France, ²⁷Edouard Herriot University Hospital, Lyon, France, ²⁸National Referral Center For Rare Systemic Autoimmune Diseases, Paris, France, ²⁹Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l'Est et de l'Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, ³⁰National Referral Center For Rare Systemic Autoimmune Diseases, Paris, Ile-de-France, France, ³¹Department of Medical, Surgery and Health Sciences, University of Trieste, and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy, ³²Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Florence, Italy, ³³Department of Rheumatology, Bicêtre AP-HP Hôpital, Université Paris-Saclay, Paris, Ile-de-France, France, ³⁴Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel necrotizing vasculitis characterized by asthma, blood and tissue eosinophilia and vasculitis affecting multiple organs. According to…
Abstract Number: 1600 • ACR Convergence 2024
Glucocorticoids versus Glucocorticoids Plus Cyclophosphamide in Eosinophilic Granulomatosis with Polyangiitis Without Poor-Prognosis Factors: A Target Trial Emulation Study
Boris Sorin¹, Matthias Papo¹, Renato Alberto Sinico², Vítor Silvestre Teixeira³, Nils Venhoff⁴, Maria-Letizia Urban⁵, Michele Iudici⁶, Juliane Mahrhold⁷, Francesco Locatelli⁸, Giulia Cassone⁹, Franco Schiavon¹⁰, Benjamin Seeliger¹¹, Thomas Neumann¹², Claudia Feder¹³, Claus Kroegel¹⁴, Matthieu Groh¹⁵, Chiara Marvisi¹⁶, Maxime Samson¹⁷, Thomas Barba¹⁸, David Jayne¹⁹, Arianna Troilo²⁰, Jens Thiel²⁰, Bernhard Hellmich²¹, Sara Monti²², Carlomaurizio Montecucco²³, Carlo Salvarani²⁴, Jean-Emmanuel Kahn²⁵, Bernard Bonnotte²⁶, Cécile-Audrey Durel²⁷, Xavier Puéchal²⁸, Luc Mouthon²⁹, Loïc Guillevin³⁰, Giacomo Emmi³¹, Augusto Vaglio³², Raphael Porcher³³ and Benjamin Terrier³⁴, and the French Vasculitis Study Group (FVSG) and the European EGPA Study Group (EESG), ¹Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West, Paris Cité University, Assistance Publique – Hôpitaux de Paris, Paris, France, ²Nephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Milan, Italy, ³Department of Rheumatology, Faro Hospital, Algarve, Portugal, ⁴Medical Center - University of Freiburg, Internal Medicine, Department of Rheumatology and Clinical Immunology, Freiburg, Germany, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West, Paris Cité University, Assistance Publique – Hôpitaux de Paris and Division of rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland, Paris, France, ⁷Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabtologyy and Immunology, ERN-RITA Reference Center, Vasculitis-Center Tübingen-Kirchheim, Medius Kliniken Kirchheim, University of Tübingen, Kirchheim-Teck, Germany, ⁸Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, ⁹Clinical and Experimental Medicine PhD Program, Azienda USL-IRCCS di Reggio Emilia and Universita di Modena and Reggio Emilia, Modena, Italy, ¹⁰Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, ¹¹Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, ¹²Department of Rheumatology, Clinic of Internal Medicine III, Jena University Hospital, Jena, Germany and Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St Gallen, St Gallen, Switzerland, Jena, Germany, ¹³Department of Rheumatology, Clinic of Internal Medicine III, Jena University Hospital, Jena, Germany, ¹⁴Department of Pneumology and Allergology, Clinic of Internal Medicine I, Jena University Hospital, Jena, Germany, ¹⁵Foch, Suresnes, France, ¹⁶Rheumatology Unit Universita di Modena and Reggio Emilia, Modena, Italy, ¹⁷Department of Internal Medicine and Clinical Immunology, François-Mitterrand Teaching Hospital, University of Bourgogne-Franche-Comté, Dijon, France, ¹⁸Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France, ¹⁹University of Cambridge, Cambridge, United Kingdom, ²⁰Department of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany, ²¹Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius Kliniken, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, ²²IRCCS Istituto Auxologico Italiano, Milan, Italy, ²³IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, ²⁴Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy, Reggio Emilia, Italy, ²⁵Department of Internal Medicine, Ambroise Paré Hospital, Assistance Publique - Hôpitaux de Paris, Université de Versailles Saint-Quentin-en-Yvelines, Boulogne-Billancourt, France, Boulogne Billancourt, France, ²⁶Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France., Dijon, France, ²⁷Edouard Herriot University Hospital, Lyon, France, ²⁸National Referral Center For Rare Systemic Autoimmune Diseases, Paris, France, ²⁹Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l'Est et de l'Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, ³⁰National Referral Center For Rare Systemic Autoimmune Diseases, Paris, Ile-de-France, France, ³¹Department of Medical, Surgery and Health Sciences, University of Trieste, and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy, ³²Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Florence, Italy, ³³Department of Rheumatology, Bicêtre AP-HP Hôpital, Université Paris-Saclay, Paris, Ile-de-France, France, ³⁴Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel vasculitis characterized by asthma, blood and tissue eosinophilia and vasculitis affecting multiple organs. According to the…
Abstract Number: 1601 • ACR Convergence 2024
Changing Spectrum of Systemic Therapies for Eosinophilic Granulomatosis with Polyangiitis from 2006-2023
Lynn Fussner¹, Christian Pagnoux², David Cuthbertson³, Thomas Corbridge⁴, Nader Khalidi⁵, Curry Koening⁶, Carol Langford⁷, Carol McAlear⁸, Paul Monach⁹, Larry Moreland¹⁰, Rennie Rhee⁸, Philip Seo¹¹, Anat Shavit¹², Jared Silver¹³, Ulrich Specks¹⁴, Kenneth Warrington¹⁴, Michael Wechsler¹⁵ and Peter Merkel⁸, and for the Vasculitis Clinical Research Consortium, ¹The Ohio State University, Columbus, OH, ²Mount Sinai Hospital, Toronto, ON, Canada, ³University of South Florida, Tampa, FL, ⁴US Value Evidence and Outcomes, GSK, Durham, NC, ⁵McMaster University, Hamilton, ON, Canada, ⁶University of Texas Dell Medical School, Austin, TX, ⁷Cleveland Clinic, Moreland Hills, OH, ⁸University of Pennsylvania, Philadelphia, PA, ⁹VA Boston Healthcare System, Boston, MA, ¹⁰University of Colorado, Denver, CO, ¹¹Johns Hopkins University, Baltimore, MD, ¹²BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, ¹³US Medical Affairs - Respiratory, GSK, Durham, ¹⁴Mayo Clinic, Rochester, MN, ¹⁵National Jewish Health, Denver, CO
Background/Purpose: The emergence of biologic therapies targeting eosinophils via the IL-5 pathway provided new options for treatment in eosinophilic granulomatosis with polyangiitis (EGPA). There has…
Abstract Number: 1604 • ACR Convergence 2024
Utilizing Machine Learning with Claims Data to Diagnose and Quantify the Prevalence of Eosinophilic Granulomatosis with Polyangiitis
Peter Merkel¹, Peter Baudy², Donna Carstens², Benjamin North³, Mahvish Danka³, Stephanie Roy³, Hanna Marshall³ and Geoffrey Chupp⁴, ¹University of Pennsylvania, Philadelphia, PA, ²Respiratory & Immunology US Medical, AstraZeneca, Wilmington, ³IQVIA, Philadelphia, ⁴School of Medicine, Yale University, New Haven
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis that can present indolently. This can lead to a delay in diagnosis and treatment. This study…
Abstract Number: 1605 • ACR Convergence 2024
Characteristics of Relapses in Patients with Eosinophilic Granulomatosis with Polyangiitis
Peter Merkel¹, David Jayne², Ulrich Specks³, Christian Pagnoux⁴, Parameswaran Nair⁵, Nader Khalidi⁵, Arnaud Bourdin⁶, Lena Börjesson Sjö⁷, Sofia Necander⁷, Anat Shavit⁸, Claire Walton⁹ and Michael Wechsler¹⁰, ¹University of Pennsylvania, Philadelphia, PA, ²University of Cambridge, Cambridge, United Kingdom, ³Mayo Clinic, Rochester, MN, ⁴Mount Sinai Hospital, Toronto, ON, Canada, ⁵McMaster University and St Joseph’s Healthcare, Hamilton, ON, Canada, ⁶Department of Respiratory Diseases, University of Montpellier, CHU Montpellier, PhyMedExp, INSERM, CNRS, Montpellier, France, ⁷Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, ⁸BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, ⁹Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, ¹⁰National Jewish Health, Denver, CO
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterized by asthma, eosinophilia, and small-to-medium size vessel vasculitis. In the Phase 3, double-blind,…
Abstract Number: 1606 • ACR Convergence 2024
Demographic and Treatment Patterns in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Cohort Analysis of US Claims and Clinical Data
Paul Dolin¹, Anat Shavit¹, Karina A. Keogh², Jennifer Rowell³, Chris Edmonds⁴, James M. Eudicone⁵, Amanda M. Moore⁶, Melissa Wilson⁷, Kinwei A. Chan⁶, Thomas Peer⁸ and Stephanie Y. Chen⁹, ¹BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, ²Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic,, Rochester, MN, ³Market Access and Pricing, AstraZeneca, Cambridge, England, United Kingdom, ⁴Market Access and Pricing, AstraZeneca, Gaithersburg, MD, ⁵Real World Science and Analytics, BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, ⁶TriNetX, Cambridge, MA, ⁷TriNetX, Durham, NC, ⁸TriNetX, Farmington, NY, ⁹BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterized by chronic necrotizing vasculitis. Conventional therapy (oral glucocorticoids [OGC] ± immunosuppressants), mepolizumab, and…
Abstract Number: 1607 • ACR Convergence 2024
Low Concentrations of Anti-C5a Complement Receptor Antibodies Are Associated with Relapse in Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Sebastian Klapa¹, Sabrina Arnold², Antje Müller², Andreas Koch³, Anja Staehle⁴, Wataru Kähler³, Harry Heidecke⁵, Gabriela Riemekasten² and Peter Lamprecht², ¹University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, ²University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, ³Christian-Albrechts-University Kiel, Institute of Experimental Medicine, Kiel, Germany, ⁴University of Lübeck, Department of Rheumatology and Immunology, Lübeck, Germany, ⁵CellTrend GmbH, Luckenwalde, Germany
Background/Purpose: Complement activation has been shown to play an important role in the pathogenesis of the two major anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) variants,…
Abstract Number: 1608 • ACR Convergence 2024
Interstitial Lung Disease in ANCA-associated Vasculitis: A Retrospective Study of Clinical Characteristics, Radiographic Features, and Outcomes
Janelle Castellino¹, Matas Orentas², Joshua Moran³, Joshlean Fair¹, Yanyu Zhang⁴ and Aleksandra Bukiej⁵, ¹Rush University Medical Center, Chicago, IL, ²RUMC, Chicago, IL, ³Rush University Medical Center - IM Residency, Chicago, IL, ⁴Rush University Medical Center, Chicago, ⁵Rush University Medical Center, River Forest, IL
Background/Purpose: Interstitial lung disease (ILD) is a significant manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and…
Abstract Number: 1611 • ACR Convergence 2024
Impact of Mepolizumab on Patient-reported Outcomes in Eosinophilic Granulomatosis with Polyangiitis by Using the ANCA-associated Vasculitis Patient-reported Outcomes (AAV-PRO) Questionnaire: A European Multicentre Prospective Study
Paolo Delvino¹, Luca Quartuccio², Joanna Robson³, Federico Alberici⁴, Diego Bagnasco⁵, Alvise Berti⁶, Marco Caminati⁷, Marta Camoni⁸, Maria Cid⁹, Edoardo Conticini¹⁰, Giulia Costanzo¹¹, Claire de Moreuil¹², Stefano Del Giacco¹¹, Georgina Espigol-Frigole¹³, Virginia V Ferretti¹⁴, Franco Franceschini¹⁵, Luca Iorio¹⁶, Anna Kernder¹⁷, Catherine Klersy¹⁴, Alberto Lo Gullo¹⁸, Laura Losappio¹⁹, Elena Manna²⁰, Matteo Maule²¹, Carlomaurizio Montecucco²², Negrini Simone²³, Roberto Padoan²⁴, Francesca Regola²⁵, Luisa Ricciardi²⁶, Jan Schroeder¹⁹, Benjamin Terrier²⁷, Paola Toniati²⁸, Elena Treppo², Maria-Letizia Urban²⁹, Augusto Vaglio³⁰, Giacomo Emmi³¹ and Sara Monti³², and European EGPA Study Group, ¹University of Milano-Bicocca, Milan, Milan, Italy, ²Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, ³UWE Bristol, Bristol, United Kingdom, ⁴Nephrology Unit, University of Brescia, ASST Spedali Civili, University of Brescia, Brescia, Italy, Brescia, Italy, ⁵Allergy and Respiratory Diseases, Department of Internal Medicine (DIMI), IRCCS Policlinico San Martino, Genoa, Italy, ⁶University of Trento, Rochester, Italy, ⁷Department of Medicine, Asthma, Allergy and Clinical Immunology Section, University of Verona, Verona, Italy, ⁸Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy, ⁹Hospital Clinic Barcelona. University of Barcelona, Barcelona, Spain, ¹⁰University of Siena, Siena, Siena, Italy, ¹¹Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy, ¹²Service de médecine interne, CHU de Brest, Brest, France, ¹³Hospital Clinic de Barcelona, Barcelona, Spain, ¹⁴Biostatistcs & Clinical Trial Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy, ¹⁵Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, ¹⁶Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy, Padova, Italy, ¹⁷HHU Dusseldorf, Dusseldorf, Germany, ¹⁸Rheumatology Unit, Papardo Hospital, Messina, Italy, ¹⁹Division of Allergy and Clinical Immunology, ASST GOM Niguarda, Milan, Milan, Italy, ²⁰Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy, ²¹Asthma Center and Allergy Unit, Verona Integrated University Hospital, Verona, Verona, Italy, ²²IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, ²³Department of Internal Medicine (DIMI), University of Genoa, Genoa, Genoa, Italy, ²⁴Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, ²⁵Unit of Rheumatology and Clinical Immunology, ASST Spedali Civili Brescia and University of Brescia, Brescia, Italy, ²⁶Allergy and Immunology Unit, Department of Clinical and Experimental Medicine, G. Martino Teaching Hospital, University of Messina, Messina, Messina, Italy, ²⁷Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, ²⁸Spedali civili, 25123, Italy, ²⁹Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ³⁰Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Florence, Italy, ³¹University of Trieste, Trieste, Italy, ³²IRCCS Istituto Auxologico Italiano, Milan, Italy
Background/Purpose: Mepolizumab (MEPO) proved its efficacy in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) in the randomized controlled MIRRA trial. The ANCA-associated vasculitis patient-reported…
Abstract Number: 0827 • ACR Convergence 2024
Oral Corticosteroid-Sparing Effects of Mepolizumab in Eosinophilic Granulomatosis with Polyangiitis (EGPA): Results up to 7.4 Years from the Long-Term Access Programme
Paneez Khoury¹, Jared Silver², Gerhard Wolff³, Robert Price⁴, Rejina Verghis⁵, Emmeline Igboekwe² and Michael E Wechsler⁶, ¹National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²US Medical Affairs-Respiratory, GSK, Durham, ³Clinical Development-Respiratory, GSK, Collegeville, ⁴Biostatistics, GSK, Stevenage, United Kingdom, ⁵Biostatistics, Development Respiratory, GSK, Brentford, United Kingdom, ⁶Department of Medicine, National Jewish Health, Denver, CO
Background/Purpose: EGPA is a severe, rare, relapsing/remitting inflammatory disease, in which chronic or high oral corticosteroid (OCS) doses lead to adverse effects, adding to disease…
Abstract Number: 2000 • ACR Convergence 2024
Induction of Systemic Inflammatory Diseases with Dupilumab Therapy
Jeanne Tisseau des Escotais¹, Camille Taille², Julie Merindol³, Matthieu Groh⁴, Perrine SMETS⁵, Amel Boudjemaa⁶, Alexandra Audemard⁷, Nabil Belfeki⁸, Philippe Bonniaud⁹, Chloe Comarmond¹⁰, Isabelle DELACROIX¹¹, Charlotte Descours¹², Lucile Grange¹³, Paul Legendre¹⁴, Nihal Martis¹⁵, Thomas Moulinet¹⁶, Béatrice Walls¹⁷, Laurent Chouchana¹ and Benjamin Terrier¹⁸, ¹Cochin, Paris, France, ²Bichat Hospital, Paris, France, ³Internal Medicine Department, University Hospital of Nice, Côte d'Azur University, Nice, Provence-Alpes-Côte d'Azur, France., Nice, France, ⁴Foch, Suresnes, France, ⁵Clermont Ferrand University Hospital - National reference center for autoimmune disease, Internal Medicine, Clermont-Ferrand, France, ⁶CHU créteil, Créteil, France, ⁷Tours, Tours, France, ⁸CH Melun, Melun, France, ⁹Centre de Référence Constitutif des Maladies Pulmonaires Rares de l'Adulte, Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalo-Universitaire de Dijon-Bourgogne, Dijon, France, ¹⁰Lariboisière University Hospital, Paris, France, ¹¹CHI créteil, Créteil, France, ¹²CH Tours, Tours, France, ¹³CH Saint-Etienne, Saint-Etienne, France, ¹⁴Service Médecine Interne et Polyvalente, Centre Hospitaliers Le Mans, Le Mans, France, ¹⁵CH Nice, Nice, France, ¹⁶CHRU de Nancy, Vandœuvre-lès-Nancy, France, ¹⁷Paris, Paris, France, ¹⁸Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France
Background/Purpose: Dupilumab is a monoclonal antibody directed against the alpha subunit of the interleukin (IL)-4 receptor, blocking interleukin (IL)-4 and IL-13 signaling. It is approved…
Abstract Number: 0828 • ACR Convergence 2024
Efficacy of Eosinophil-Targeting Therapies on Specific Disease Manifestations of Eosinophilic Granulomatosis with Polyangiitis in the Phase 3 MANDARA Trial
Peter Merkel¹, David Jayne², Ulrich Specks³, Christian Pagnoux⁴, Benjamin Terrier⁵, Bernhard Hellmich⁶, Sofia Necander⁷, Anat Shavit⁸, Claire Walton⁹ and Michael Wechsler¹⁰, ¹University of Pennsylvania, Philadelphia, PA, ²University of Cambridge, Cambridge, United Kingdom, ³Mayo Clinic, Rochester, MN, ⁴Mount Sinai Hospital, Toronto, ON, Canada, ⁵Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, ⁶Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, Medius Kliniken, Akademisches Lehrkrankenhaus der Universität Tübingen, Kirchheim unter Teck, Germany, ⁷Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, ⁸BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom, ⁹Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, ¹⁰National Jewish Health, Denver, CO
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterized by small- to medium-vessel vasculitis, asthma and eosinophilia. In the head-to-head MANDARA trial…
Abstract Number: 2479 • ACR Convergence 2024
Mepolizumab Treatment Decreased Oral Corticosteroid Use and Improved Clinical Response, Control Status, and Remission in Patients with Eosinophilic Granulomatosis with Polyangiitis: Results up to 24 Months from a Large Network of US Allergy Practices
Michael E Wechsler¹, Anna Kovalszki², Jared Silver³, Brian Stone⁴, Lior Seluk⁵, Lynn Huynh⁶, Wilson da Costa Junior⁶, Mingchen Ye⁶, Jeremiah Hwee⁷, Mei Sheng Duh⁶, William McCann⁴ and Amy G. Edgecomb⁸, ¹Department of Medicine, National Jewish Health, Denver, CO, ²Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ³US Medical Affairs - Respiratory, GSK, Durham, ⁴Allergy Partners, Asheville, NC, ⁵Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, ⁶Analysis Group, Boston, MA, ⁷Value Evidence and Outcomes, GSK, Mississauga, Canada, ⁸US Value, Evidence, & Outcomes, Anti-Infectives and Respiratory, GSK, Philadelphia
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a severe rare systemic inflammatory disease characterized by elevated blood eosinophil counts ≥1000 cells/µL and vasculitis of small-…

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