Abstracts tagged "Environmental factors"

Abstract Number: 0980 • ACR Convergence 2024
Ambient Air Pollution and Initiation of bDMARDs in Newly Diagnosed Rheumatoid Arthritis: A Nested Case-Control Study of NIH All of Us Cohort
Jiayi Zheng¹, Nevena Barjaktarovic² and Liangjing lu³, ¹Washington University School of Medicine, St. Louis, MO, ²The Wright Center for Community Health, South Abington Township, PA, ³Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic)
Background/Purpose: Ambient air pollution is a mixture of solid particles and gaseous pollutants derived from fossil fuel combustion and vehicle exhaust. Previous research has linked…
Abstract Number: 0994 • ACR Convergence 2024
Association Between Cardiovascular Risk Factors and the Onset of Giant Cell Arteritis: A Systematic Review and Meta-analysis
François Barde¹, Lucas Pacoureau², Alexis Elbaz², Raphaele Seror³ and Yann Nguyen⁴, ¹Inserm, CESP, Paris, France, ²Inserm, CESP, Villejuif, France, ³Service de Rhumatologie, Hôpital Bicêtre, AP-HP, le Kremlin Bicetre, Ile-de-France, France, ⁴Université Paris Saclay, Clichy, Ile-de-France, France
Background/Purpose: Giant cell arteritis (GCA) predominantly affects people over 50 years of age, with a female predominance. Its pathophysiological mechanism is currently under debate. In…
Abstract Number: 0995 • ACR Convergence 2024
What Is the Carbon Footprint of Adalimumab Originator and Its Various Biosimilar Drugs?
Ines Moninot¹, ROLAND CHAPURLAT², Elodie FEURER¹, Pierre-Jean Cottinet³, Minh-Quyen Le³ and Aurélie Fontana¹, ¹Hospices Civils Lyon, Lyon, France, ²INSERM 1033, LYON, France, ³INSA Lyon, Lyon, France
Background/Purpose: In developed countries, the impact of healthcare systems on the environment is sizeable (roughly 8% of the carbon footprint). So, it is essential to…
Abstract Number: 0997 • ACR Convergence 2024
Geographic and Lifestyle Exposures in Systemic Lupus Erythematosus
Zoe Reed¹, Janis Campbell², Xana Howard¹, Teresa Aberle¹, Bridget Parrish¹, Wade DeJager³, Cristina Arriens¹, Joan Merrill⁴ and Judith James¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, ⁴Oklahoma Medical Research Foundation, Oklahoma City 73104, OK
Background/Purpose: Systemic lupus erythematosus (SLE) has a complex etiology with genetic predispositions interacting with environmental factors. Extensive environmental exposure information is now publicly available based…
Abstract Number: 1138 • ACR Convergence 2024
Association Between Long-Term Exposure to Fine Particles and Its Components and the Onset of Systemic Autoimmune Rheumatic Diseases in Quebec
Mareva geslin¹, Julien Vachon², Naizhuo Zhao³, Elhadji Anassour Laouan Sidi², Sonia Jean⁴, audrey smargiassi² and Sasha Bernatsky⁵, ¹Universite de Montreal, Montreal, QC, Canada, ²Université de Montréal, Montreal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Institut national de santé publique du Québec, Montreal, QC, Canada, ⁵Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Exposure to fine particles (PM2.5) has been associated with numerous health effects including with autoimmune rheumatic diseases (SARDs). While PM2.5 are composed of various…
Abstract Number: 1806 • ACR Convergence 2024
Bisphenol a Methylation Scores Associate with SLE and ClinicalSubphenotypes
Holme Vestin¹, Nina Oparina², Maija-Leena Eloranta¹, Martina Frodlund³, Iva Gunnarsson⁴, Christopher Sjowall⁵, Elisabet Svenungsson⁶, Lars Rönnblom¹, Ann-Christine Syvänen¹, Johanna Sandling¹, Juliana Imgenberg-Kreuz¹ and Dag Leonard¹, ¹Uppsala university, Uppsala, Sweden, ²UU, Uppsala, Sweden, ³Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, ⁴Karolinska Institute, Stockholm, Sweden, ⁵Linköping University, Linköping, Sweden, ⁶Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by production of auto-antibodies, immune complex formation and an activated type I interferon system. Both genetic and environmental…
Abstract Number: 1875 • ACR Convergence 2024
Assessing the PULSAR (Program to Understand the Longterm Outcomes in Spondyloarthritis) Registry for Environmental Determinants of Heath Research
Liya Stolyar¹, Diane Mar², Yuhan Liu³, Esther Velasquez⁴, orr Sharpe⁵, Michael Weisman⁶, Liron Caplan⁷ and suzanne Tamang⁸, ¹Palo Alto VA Medical Center/Stanford, Stanford, CA, ²Palo Alto VA Medical Center/Stanford University Medical Center, Palo Alto, CA, ³Stanford Medicine Quantitative Sciences Unit, Palo Alto, CA, ⁴Stanford Center for Population Health Sciences, Palo Alto, CA, ⁵Department of Immunology and Rheumatology, Stanford University, Stanford, CA, ⁶Stanford University, Los Angeles, CA, ⁷Univ of Colorado School of Medicine/Rocky Mtn Regional Veterans Affairs Medical Center, Aurora, CO, ⁸Stanford University, Atherton, CA
Background/Purpose: Acute exposure to air pollution has been associated with flares of psoriasis and chronic inflammatory arthritides in prior studies. However, the impact of air pollution,…
Abstract Number: 2590 • ACR Convergence 2024
Pesticide Use and Incident Rheumatoid Arthritis Among Spouses in the Agricultural Health Study: An Updated Analysis
Christine Parks¹, Karen Costenbader², Laura Beane Freeman³, Jonathan Hofmann³ and Dale Sandler⁴, ¹National Institute of Environmental Health Sciences, Epidemiology Branch, Rese, ²Brigham and Women's Hospital/ Harvard Medical School, Boston, MA, ³National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, ⁴Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC
Background/Purpose: Systemic autoimmune rheumatic diseases have been associated with farming exposures, but the role of pesticides has not been well studied. The Agricultural Health Study…
Abstract Number: 0681 • ACR Convergence 2024
Influence of Occupational Exposure to Pollutants on Clinical and Serological Phenotypes in Systemic Sclerosis
Martina Sanahuja i Sanz¹, Irene Carrión-Barberà², Laura Tío³, Laura Triginer³, María Lee³, Alfredo Guillén-del Castillo⁴, Anna Ribes³, Lidia Valencia Muntalà⁵, Jordi Monfort², Tarek Carlos Salman Monte:⁶, Javier Narvaez-García⁷, Carmen PIlar Simeón-Aznar⁴ and Anna Pros², ¹Universitat Pompeu Fabra, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Hospital del Mar Research Institute, Barcelona, Spain, ⁴Hospital Vall d'Hebron, Barcelona, Spain, ⁵Hospital de Bellvitge, Barcelona, Spain, ⁶Hospital del Mar/Parc de Salut Mar-IMIM, Barcelona, Spain, ⁷Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Environmental factors have been proposed as a trigger for systemic sclerosis (SSc) in genetically predisposed individuals. This study aimed to investigate the association between…
Abstract Number: 0978 • ACR Convergence 2024
Associations of Fire Smoke and Other Pollutants with Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
Vanessa Kronzer¹, Yangyuna Yang², Punyasha Roul³, James Crooks⁴, Cynthia Crowson¹, John Davis¹, Jeffrey Sparks⁵, Jeffrey Pierce⁶, Katelyn O'Dell⁷, Sauer brian⁸, grant Cannon⁹, Joshua Baker¹⁰, Ted Mikuls² and Bryant England², ¹Mayo Clinic, Rochester, MN, ²University of Nebraska Medical Center, Omaha, NE, ³UNMC, Omaha, NE, ⁴National Jewish Health, Denver, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ⁶Colorado State University, Fort Collins, ⁷George Washington University, Washington DC, ⁸Salt Lake City VA/University of Utah, Salt Lake City, UT, ⁹University of Utah and Salt Lake City VA, Salt Lake City, UT, ¹⁰Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA

Background/Purpose: Wildfires have burned increasing acreage in the United States (US) since the 1980s, releasing record and alarming levels of particulate matter smaller than 2.5…
Abstract Number: 0972 • ACR Convergence 2023
Increased Incidence of Inflammatory Arthritis After COVID-19 in a Colombian Population
Juan Marin¹, Enrique Mazenett¹, Mauricio Sarmiento¹, Rosalbina Perez¹, Claudia Morales¹, Jorge Dominguez¹, Juan Salazar² and Juan-Manuel Anaya³, ¹Coosalud, EPS, Cartagena, Colombia, ²Universidad Nacional, Medellin, Colombia, ³Coosalud, EPS, Bogotá, Colombia
Background/Purpose: An increase in the incidence of autoimmune diseases after COVID-19 has been reported. Since many diseases exhibit population-specific causal effect sizes, we aimed to…
Abstract Number: 0982 • ACR Convergence 2023
Systemic Autoimmune Rheumatic Diseases (SARD) in the Agricultural Health Study Cohort: Rates of Rheumatoid Arthritis (RA) and Other SARD Among Medicare-linked Participants
Christine Parks¹, Karen Costenbader², Laura Beane Freeman³, Jonathan Hofmann³ and Dale Sandler⁴, ¹Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, ⁴Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC
Background/Purpose: Some systemic autoimmune rheumatic diseases (SARD), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), have been associated with farming, specific pesticides, and…
Abstract Number: 1146 • ACR Convergence 2023
Gene X Environment Paradigm: Exemplified by Selected Cases of Autoinflammatory Diseases
Qingping Yao and Peter Gorevic, Stony Brook University, Stony Brook, NY
Background/Purpose: The current scientific opinion holds that gene and environment (G X E) interactions contribute to certain human diseases. Systemic autoinflammatory diseases (SAIDs) are usually…
Abstract Number: 1814 • ACR Convergence 2023
Silica and Other Exposures from Jobs and Hobbies Are Associated with Myositis Phenotype in a National Myositis Registry
Christine Parks¹, Jesse Wilkerson², Payam Noroozi Farhad³, Nastaran Bayat⁴, Adam Schiffenbauer⁵, Hermine Brunner⁶, Robert Goldberg⁷, Frederick Miller⁸ and Lisa Rider⁵, ¹Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, ²NIEHS/NIH, Durham, NC, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ⁴Social Scientific Systems, DLH Holdings Corp, Silver Spring, MD, ⁵NIEHS, NIH, Bethesda, MD, ⁶Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ⁷Myositis Foundation, Alexandria, VA, ⁸NIH, NIEHS, Chapel Hill, NC
Background/Purpose: Growing evidence suggests that environmental factors may contribute to disease phenotype among patients diagnosed with the idiopathic inflammatory myopathies (IIM), dermatomyositis (DM), polymyositis (PM),…
Abstract Number: 1817 • ACR Convergence 2023
Geographic Variability of Inflammatory Bowel Disease Related Mortality, 1999-2019; CDC WONDER
Saleha Aziz¹, Anum Akhlaq¹, Sana Gurz² and Yousaf Zafar¹, ¹University of Mississippi Medical Center, Jackson, MS, ²University of Nevada, Las Vegas, NV
Background/Purpose: The United States makes a significant contribution to Inflammatory Bowel Disease (IBD) related disease burden worldwide. However, data on geographic variability of IBD related…

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