Abstracts tagged "Environmental factors"

Abstract Number: 1788 • ACR Convergence 2025
Manganese-associated Single-nucleotide Polymorphisms are Associated with Radiographic Knee Osteoarthritis: The Johnston County Osteoarthritis Project
Griffin Sonaty¹, Carolina Alvarez², Liubov Arbeeva³, Joanne Jordan¹, Brian Diekman⁴, Doug Phanstiel¹, Richard Loeser⁵ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Univesity of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵University of North Carolina, Chapel Hill, NC
Background/Purpose: Trace elements may be differentially associated with osteoarthritis (OA) risk. Single-nucleotide polymorphisms (SNPs) have been found to correlate to cumulative exposure level, free of…
Abstract Number: 1507 • ACR Convergence 2025
Temporal Trends in the Incidence of Systemic Lupus Erythematosus (SLE) in the United States (US): Holding Steady?
Sasha Bernatsky¹, Sharon Dowell², Brittany Banbury³, Jeffrey Curtis⁴, Grace Wright⁵, Emily Holladay⁶, Amy Mudano⁷, Cristiano Moura⁸ and Gail Kerr⁹, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²NEA Baptist Memorial Hospital, Jonesboro, AR, ³Mount Sinai Beth Israel, Brooklyn, NY, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Grace C Wright MD PC, New York, NY, ⁶University of Alabama at Birmingham, Edmond, OK, ⁷Foundation for Advancing Science, Technology, Education and Research (FASTER), Birmingham, AL, ⁸Research Institute of the McGill University Health Center, Montréal, Canada, ⁹Washington DC VAMC/Georgetown and Howard Universities, Washington, DC
Background/Purpose: Since SLE is associated with significant morbidity and healthcare burden, estimates of SLE incidence are needed to inform research and public health initiatives, including…
Abstract Number: 1748 • ACR Convergence 2025
Effect of Air Pollution on Disease Activity in Patients with Rheumatoid Arthritis
Sung Cheol Jung¹, Jeffrey Curtis², Seojin Yang³, Min Hyuk Lim⁴, Saram Lee⁵, Sung Ik Cho⁶, Jin Kyun Park⁷ and Eun Bong Lee⁶, ¹Seoul National University College of Medicine, Seoul, Republic of Korea, ²University of Alabama at Birmingham, Birmingham, AL, ³Seoul National University, Seoul, Republic of Korea, ⁴Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea, ⁶Seoul National University Hospital, Seoul, South Korea, ⁷Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea
Background/Purpose: While air pollution has been implicated in the pathogenesis of rheumatoid arthritis (RA), its association with RA disease activity remains insufficiently investigated (1, 2).…
Abstract Number: 1690 • ACR Convergence 2025
Environmental Heat Exposure and Risk of Systemic Lupus Erythematosus
Jennifer Woo¹, Kaitlyn Lawrence² and Dale Sandler¹, ¹National Institute of Environmental Health Sciences, Durham, NC, ²DLH, Corp., Durham, NC
Background/Purpose: Environmental heat exposures have been linked to increased morbidity and mortality. Individuals with systemic lupus erythematous (SLE) often have heat- and photo- sensitivity, which…
Abstract Number: 1264 • ACR Convergence 2025
Breaking the Veil: Preliminary Findings for a Qualitative Analysis of Rheumatoid Arthritis Patient Perspectives on Physical Activity and Mental Healt
Daniel Garcia¹, Vanessa Madrigal², Noelia Hernandez³, Alisha Akinsete⁴, Iris Navarro-Millan⁵, Ileana Vazquez Otero⁶, Ariana Gonzalez Melendez⁷, Sarah Young⁸ and Monika Safford², ¹Weill Cornell, Brooklyn, NY, ²Weill Cornell Medicine, New York, ³Weill Cornell Medicine, New York, NY, ⁴Weill Cornell Medical Center, New York, NY, ⁵Weill Cornell Medicine, Hospital for Special Surgery, Poughkeepsie, NY, ⁶Clinica Reuviva, San Juan, PR, ⁷Ponce Health Sciences, San Juan, PR, ⁸Weill Cornell Medicine, Johnson City, NY
Background/Purpose: Approximately 1.3 million Americans have rheumatoid arthritis (RA)1. Up to 83% of people with chronic pain, the hallmark symptom of RA also experience anxiety…
Abstract Number: 1059 • ACR Convergence 2025
Assessing the Relationship Between Multidimensional Area Level Indicators and Lupus Disease Activity in Children
Chelsea Reynolds¹, Natasha Ruth², Paul Nietert¹, Mileka Gilbert¹, Emily Vara¹ and Joyce Chang³, ¹Medical University of South Carolina, Charleston, SC, ²Medical University South Carolina, Charleston, SC, ³Boston Children's Hospital, Boston, MA
Background/Purpose: Recent research suggests that multidimensional area-level indicators, including the Social Vulnerability Index (SVI), Area Deprivation Index (ADI) and Childhood Opportunity Index (COI), associate with…
Abstract Number: 0594 • ACR Convergence 2025
Patients with SLE Have an Increased Bisphenol A Methylation Score Linked to SLE Risk Genes and Immune Response Pathways
Holme Vestin¹, Nina Oparina¹, Maija-Leena Eloranta¹, Martina Frodlund², Iva Gunnarsson³, Chrisopher Sjöwall², Elisabet Svenungsson⁴, Lars Rönnblom¹, Juliana Imgenberg-Kreuz¹ and Dag Leonard¹, ¹Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, ³Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Karolinska Institutet, Stockholm, Stockholms Lan, Sweden
Background/Purpose: The pathogenesis of SLE involves genetic, environmental and epigenetic factors (1). Increased levels of Bisphenol A (BPA) have been observed in the urine of…
Abstract Number: 0754 • ACR Convergence 2025
Is There a Seasonal Pattern in Giant Cell Arteritis? Revisiting the Evidence in a Large Monocentric Cohort of 1203 patients
Milena Bond¹, Philipp Bosch², Aaron Juche³, Hans Bastian³ and Wolfgang Schmidt⁴, ¹South Tyrol Health Trust and Teaching Hospital of the Paracelsus Medical University, Brunico, Italy, ²Medical University of Graz, Graz, Austria, ³Rheumaklinik Berlin-Buch, Berlin, Germany, ⁴Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch; Waldfriede Hospital, Rheumatology, Berlin, Germany
Background/Purpose: Whether the disease onset in giant cell arteritis (GCA) exhibits a seasonal pattern remains unclear. Previous studies have yielded conflicting evidence: some report no…
Abstract Number: 0354 • ACR Convergence 2025
Greater Neighborhood Walkability is Associated with Lower Incidence of Hip Fracture in Older, Community-dwelling Women in the United States: The Cardiovascular Health Study
Rachel Elam¹, Petra Buzkova², Howard Fink³, Joshua Barzilay⁴, Eric Roseen⁵, Jane Cauley⁶, John Robbins⁷, Laura Carbone¹, Gina Lovasi⁸ and Kenneth Mukamal⁹, ¹Augusta University, Augusta, GA, ²University of Washingon, Seattle, WA, ³University of Minnesota, Minneapolis, MN, ⁴Kaiser Permanente of Georgia, Atlanta, GA, ⁵Boston University, Boston, MA, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of California Davis, Davis, CA, ⁸Drexel University, Philadelphia, PA, ⁹Beth Israel Deaconess Medical Center, Brookline, MA
Background/Purpose: Higher physical activity is linked to reduced fracture risk in older adults, especially for hip fractures. Emerging evidence demonstrates a potential role for the…
Abstract Number: 0321 • ACR Convergence 2025
Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Lisa Rokoff², Bing Lu³, Timothy McAlington⁴, Charles Eaton⁵, Mary Roberts⁶, Diana Mathes⁷, Colleen Lestician⁷, Zhijin Carrie Xu⁷, Zhihua Tina Fan⁷, Shawn O'Leary⁷ and Abby Fleisch⁸, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME, ³UConn Health Center, Newton, MA, ⁴UMass Chan School of Medicine, Arlington, MA, ⁵Brown University, Pawtucket, RI, ⁶Center for Primary Care and Prevention, Kent Hospital, Pawtucket, RI, ⁷Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing, NJ, ⁸Maine Medical Center; ². Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME
Background/Purpose: The prevalence of hand osteoarthritis (OA) has doubled in the United States over the past half century – a finding that cannot be solely…
Abstract Number: 0174 • ACR Convergence 2025
Genetic and Environmental Risk Factors and Incident Rheumatoid Arthritis
Xuesen Zhao¹, Puran Nepa², Hui Yu³, Laura Daniel², Vivian Kawai⁴, Michael Stein⁵, Yan Guo³ and Cecilia Chung³, ¹University of Miami, Miami, FL, ²University of Miami, Research Service, Miami VA Healthcare System, Miami, FL, ³University of Miami, Miami, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: While some studies have linked air pollution to risk for rheumatoid arthritis (RA), U.S.-based studies utilizing nationwide exposure data remain limited and often exclude…
Abstract Number: 0171 • ACR Convergence 2025
The Association Between Short-Term Trajectory Of Atmospheric Particulate Matter 10 (PM10) Concentration And Hyperuricemia
Sunggun Lee¹, Minyoung Her¹, Seong-HO Kim¹, Yong-Gil Kim² and Ji Seon Oh², ¹Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, Seoul, Republic of Korea
Background/Purpose: The association between high atmospheric particulate matter concentration and gout flare has been reported1, but the causality and mechanism of this association remain unknown.…
Abstract Number: 0166 • ACR Convergence 2025
Effect of Air Pollution on Prevalence and Disease Activity of Rheumatoid Arthritis in the German Middle-aged Population from the NAKO Baseline Examination
Tim Filla¹, Gamal Chehab¹, Jutta Richter², Jörg Distler³ and Oliver Sander¹, ¹Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University., Düsseldorf, Germany, ²Clinic for Rheumatology and Hiller Research Unit, Heinrich-Heine-University Duesseldorf, Medical Faculty, Duesseldorf, Germany, Düsseldorf, Germany, ³University Hospital Duesseldorf and HHU, Duesseldorf, Germany
Background/Purpose: Environmental influences affect the human body throughout life, from conception to old age. The influence of air pollution and fine dust particles on systemic…
Abstract Number: 2668 • ACR Convergence 2025
CD14⁺ Myeloid Cells Mediate UVB Photosensitivity in Autoimmune Skin Disease via a Spatially Resolved Inflammatory Circuit
Nazgol Haddadi¹, Khashayar Afshari¹, Yuqing Wang¹, Carolina S. Lopes¹, Chee-Huat L. Eng², Nuria Martinez-Gutierrez¹, Leah Whiteman¹, Kevin Wei³, Kirsten Frieda², Stefania Gallucci¹, Misha Rosenbach⁴, Ruth Ann Vleugels⁵, John E. Harris¹, Manuel Garber¹ and Mehdi Rashighi¹, ¹UMass Chan Medical School, Worcester, MA, ²Spatial Genomics, Inc., Pasadena, CA, ³Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Brigham and Women's Hospital, Chestnut Hill, MA
Background/Purpose: Inflammatory skin diseases vary widely in symptoms and causes. While ultraviolet (UV) light helps treat some like vitiligo and psoriasis, in conditions like cutaneous…
Abstract Number: 0159 • ACR Convergence 2025
Prenatal and Early-Life Environmental Exposures in Juvenile-Onset Systemic Autoimmune Rheumatic Diseases
Takuma Ohnishi¹, Megan Zhao¹, Min Shi², Adam Schiffenbauer³, Sharon Jackson³, Anna Jansen¹, Nastaran Bayat⁴, Payam Farhadi¹, Christine Parks², Clarice Weinberg², Frederick Miller⁵ and Lisa Rider⁶, ¹National Institutes of Health/National Institute of Environmental Health Sciences, Bethesda, MD, ²National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, NC, ³National Institute of Health/National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁴National Institutes of Health/National Institute of Environmental Health Sciences, Gaithersburg, MD, ⁵National Institutes of Health/National Institute of Environmental Health Sciences, Chapel Hill, NC, ⁶National Institute of Environmental Health Sciences/National Institutes of Health, Environmental Autoimmunity Group, Bethesda, MD
Background/Purpose: Systemic autoimmune rheumatic diseases (SARDs), including juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), and systemic sclerosis (SSc), are characterized…

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