Abstracts tagged "Environmental factors"

Abstract Number: 2668 • ACR Convergence 2025
CD14⁺ Myeloid Cells Mediate UVB Photosensitivity in Autoimmune Skin Disease via a Spatially Resolved Inflammatory Circuit
Nazgol Haddadi¹, Khashayar Afshari¹, Yuqing Wang¹, Carolina S. Lopes¹, Chee-Huat L. Eng², Nuria Martinez-Gutierrez¹, Leah Whiteman¹, Kevin Wei³, Kirsten Frieda², Stefania Gallucci¹, Misha Rosenbach⁴, Ruth Ann Vleugels⁵, John E. Harris¹, Manuel Garber¹ and Mehdi Rashighi¹, ¹UMass Chan Medical School, Worcester, MA, ²Spatial Genomics, Inc., Pasadena, CA, ³Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Brigham and Women's Hospital, Chestnut Hill, MA
Background/Purpose: Inflammatory skin diseases vary widely in symptoms and causes. While ultraviolet (UV) light helps treat some like vitiligo and psoriasis, in conditions like cutaneous…
Abstract Number: 0159 • ACR Convergence 2025
Prenatal and Early-Life Environmental Exposures in Juvenile-Onset Systemic Autoimmune Rheumatic Diseases
Takuma Ohnishi¹, Megan Zhao¹, Min Shi², Adam Schiffenbauer³, Sharon Jackson³, Anna Jansen¹, Nastaran Bayat⁴, Payam Farhadi¹, Christine Parks², Clarice Weinberg², Frederick Miller⁵ and Lisa Rider⁶, ¹National Institutes of Health/National Institute of Environmental Health Sciences, Bethesda, MD, ²National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, NC, ³National Institute of Health/National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁴National Institutes of Health/National Institute of Environmental Health Sciences, Gaithersburg, MD, ⁵National Institutes of Health/National Institute of Environmental Health Sciences, Chapel Hill, NC, ⁶National Institute of Environmental Health Sciences/National Institutes of Health, Environmental Autoimmunity Group, Bethesda, MD
Background/Purpose: Systemic autoimmune rheumatic diseases (SARDs), including juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), and systemic sclerosis (SSc), are characterized…
Abstract Number: 2390 • ACR Convergence 2025
SLE Genetic Risk Loci in the Context of Environmental Exposure: A Gene-Based Classification and Clinical Insight
Nina Oparina¹, Holme Vestin¹, Sarah Reid¹, Ahmne Sayadi¹, Maija-Leena Eloranta¹, Martina Frodlund², Karoline Lerang³, Andreas Jönsen⁴, Øyvind Molberg³, Solbritt Rantapää-Dahlqvist⁵, Anna Rudin⁶, Chrisopher Sjöwall⁷, Anders Bengtsson⁴, Lars Rönnblom¹ and Dag Leonard¹, ¹Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Linkoping, Sweden, ³Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ⁴Department of Clinical Sciences, Lund University, Lund, Sweden, ⁵Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ⁶Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden, ⁷Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden
Background/Purpose: Growing evidence supports the role of chemical exposures as contributors to the development of Systemic lupus erythematosus (SLE)1. Several of the gene variants associated…
Abstract Number: 0156 • ACR Convergence 2025
Heat Exposure and Acute Care Utilization among Individuals with Rheumatic Conditions: A Time Series Framework for Identifying Delayed Associations
Leah Santacroce¹, Jamie Collins¹, Ana Valle², Rebecca Summit³, Paul Dellaripa⁴ and Candace Feldman¹, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Brookline, MA, ³Brigham & Women's Hospital, Boston, MA, ⁴Brigham and Womens Hospital, Boston, MA
Background/Purpose: Temperature and air pollution are increasing each year across the US. There is growing interest in studying how the effects of high temperature impact…
Abstract Number: 1905 • ACR Convergence 2025
Exploring the Association Between Environmental Quality Index and Rheumatoid Arthritis Mortality in the United States
Rohan Sharma¹, Eric Yen² and Ram Singh³, ¹UCLA, Bakersfield, CA, ²UCLA, Los Angeles, CA, ³UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Environmental factors such as smoking, pollutants, diet, and geography as well as sex, race/ethnicity, and genetics have been linked with rheumatoid arthritis (RA) pathogenesis…
Abstract Number: 0038 • ACR Convergence 2025
DNA Methylation Signatures of Smoking in Labial Salivary Gland Tissue in a Sjögren’s Disease Cohort
Priya Bhatt¹, Mary Horton², Caroline Shiboski³, Lisa Barcellos⁴ and Lindsey Criswell², ¹Mayo Clinic Alix School of Medicine, Toledo, ²NIH/NHGRI, Bethesda, MD, ³University of California San Francisco, San Francisco, CA, ⁴UC Berkeley, Berkeley
Background/Purpose: Cigarette smoking has been linked to the development of several autoimmune diseases, including Sjögren’s Disease (SjD). Since DNA methylation (DNAm) is altered by cigarette…
Abstract Number: 1903 • ACR Convergence 2025
Seasonal and Racial/Ethnic Variation in Achieving Target Uric Acid Levels in Gout Patients on Urate Lowering Therapy in US Veterans in Central California
Nidaa Rasheed¹ and Candice Reyes², ¹UCSF Fresno, Fresno, CA, ²VACCHCS, Fresno, CA
Background/Purpose: Gout is a chronic, inflammatory arthritis driven by monosodium urate (MSU) crystal deposition and elevated serum uric acid (SUA) levels, increasing the risk for…
Abstract Number: 0036 • ACR Convergence 2025
Integrated Analysis of Polygenic and Environmental Risk Scores for Late-Onset Systemic Lupus Erythematosus
Mehmet Hocaoglu¹ and Amr Sawalha², ¹University of Pittsburgh Medical Center, Piitsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Polygenic risk scores (PRS) have been constructed to summarize genetic risk but there is limited research on environment-wide analysis of risk factors for systemic…
Abstract Number: 1788 • ACR Convergence 2025
Manganese-associated Single-nucleotide Polymorphisms are Associated with Radiographic Knee Osteoarthritis: The Johnston County Osteoarthritis Project
Griffin Sonaty¹, Carolina Alvarez², Liubov Arbeeva³, Joanne Jordan¹, Brian Diekman⁴, Doug Phanstiel¹, Richard Loeser⁵ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Univesity of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵University of North Carolina, Chapel Hill, NC
Background/Purpose: Trace elements may be differentially associated with osteoarthritis (OA) risk. Single-nucleotide polymorphisms (SNPs) have been found to correlate to cumulative exposure level, free of…
Abstract Number: 1507 • ACR Convergence 2025
Temporal Trends in the Incidence of Systemic Lupus Erythematosus (SLE) in the United States (US): Holding Steady?
Sasha Bernatsky¹, Sharon Dowell², Brittany Banbury³, Jeffrey Curtis⁴, Grace Wright⁵, Emily Holladay⁶, Amy Mudano⁷, Cristiano Moura⁸ and Gail Kerr⁹, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²NEA Baptist Memorial Hospital, Jonesboro, AR, ³Mount Sinai Beth Israel, Brooklyn, NY, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Grace C Wright MD PC, New York, NY, ⁶University of Alabama at Birmingham, Edmond, OK, ⁷Foundation for Advancing Science, Technology, Education and Research (FASTER), Birmingham, AL, ⁸Research Institute of the McGill University Health Center, Montréal, Canada, ⁹Washington DC VAMC/Georgetown and Howard Universities, Washington, DC
Background/Purpose: Since SLE is associated with significant morbidity and healthcare burden, estimates of SLE incidence are needed to inform research and public health initiatives, including…
Abstract Number: 1748 • ACR Convergence 2025
Effect of Air Pollution on Disease Activity in Patients with Rheumatoid Arthritis
Sung Cheol Jung¹, Jeffrey Curtis², Seojin Yang³, Min Hyuk Lim⁴, Saram Lee⁵, Sung Ik Cho⁶, Jin Kyun Park⁷ and Eun Bong Lee⁶, ¹Seoul National University College of Medicine, Seoul, Republic of Korea, ²University of Alabama at Birmingham, Birmingham, AL, ³Seoul National University, Seoul, Republic of Korea, ⁴Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea, ⁶Seoul National University Hospital, Seoul, South Korea, ⁷Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea
Background/Purpose: While air pollution has been implicated in the pathogenesis of rheumatoid arthritis (RA), its association with RA disease activity remains insufficiently investigated (1, 2).…
Abstract Number: 1690 • ACR Convergence 2025
Environmental Heat Exposure and Risk of Systemic Lupus Erythematosus
Jennifer Woo¹, Kaitlyn Lawrence² and Dale Sandler¹, ¹National Institute of Environmental Health Sciences, Durham, NC, ²DLH, Corp., Durham, NC
Background/Purpose: Environmental heat exposures have been linked to increased morbidity and mortality. Individuals with systemic lupus erythematous (SLE) often have heat- and photo- sensitivity, which…
Abstract Number: 1264 • ACR Convergence 2025
Breaking the Veil: Preliminary Findings for a Qualitative Analysis of Rheumatoid Arthritis Patient Perspectives on Physical Activity and Mental Healt
Daniel Garcia¹, Vanessa Madrigal², Noelia Hernandez³, Alisha Akinsete⁴, Iris Navarro-Millan⁵, Ileana Vazquez Otero⁶, Ariana Gonzalez Melendez⁷, Sarah Young⁸ and Monika Safford², ¹Weill Cornell, Brooklyn, NY, ²Weill Cornell Medicine, New York, ³Weill Cornell Medicine, New York, NY, ⁴Weill Cornell Medical Center, New York, NY, ⁵Weill Cornell Medicine, Hospital for Special Surgery, Poughkeepsie, NY, ⁶Clinica Reuviva, San Juan, PR, ⁷Ponce Health Sciences, San Juan, PR, ⁸Weill Cornell Medicine, Johnson City, NY
Background/Purpose: Approximately 1.3 million Americans have rheumatoid arthritis (RA)1. Up to 83% of people with chronic pain, the hallmark symptom of RA also experience anxiety…
Abstract Number: 1059 • ACR Convergence 2025
Assessing the Relationship Between Multidimensional Area Level Indicators and Lupus Disease Activity in Children
Chelsea Reynolds¹, Natasha Ruth², Paul Nietert¹, Mileka Gilbert¹, Emily Vara¹ and Joyce Chang³, ¹Medical University of South Carolina, Charleston, SC, ²Medical University South Carolina, Charleston, SC, ³Boston Children's Hospital, Boston, MA
Background/Purpose: Recent research suggests that multidimensional area-level indicators, including the Social Vulnerability Index (SVI), Area Deprivation Index (ADI) and Childhood Opportunity Index (COI), associate with…
Abstract Number: 0594 • ACR Convergence 2025
Patients with SLE Have an Increased Bisphenol A Methylation Score Linked to SLE Risk Genes and Immune Response Pathways
Holme Vestin¹, Nina Oparina¹, Maija-Leena Eloranta¹, Martina Frodlund², Iva Gunnarsson³, Chrisopher Sjöwall², Elisabet Svenungsson⁴, Lars Rönnblom¹, Juliana Imgenberg-Kreuz¹ and Dag Leonard¹, ¹Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, ³Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Karolinska Institutet, Stockholm, Stockholms Lan, Sweden
Background/Purpose: The pathogenesis of SLE involves genetic, environmental and epigenetic factors (1). Increased levels of Bisphenol A (BPA) have been observed in the urine of…

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