Abstracts tagged "Enthesitis"

Abstract Number: 1559 • 2014 ACR/ARHP Annual Meeting
Long Term Improvements in Physical Function Are Associated with Improvements in Dactylitis, Enthesitis, Tender and Swollen Joint Counts, and Psoriasis Skin Involvement: Results from a Phase 3 Study of Ustekinumab in Psoriatic Arthritis Patients
Arthur Kavanaugh¹, Lluís Puig Sanz², Alice B. Gottlieb³, Christopher T. Ritchlin⁴, Shu Li⁵, Yin You⁵, Alan M. Mendelsohn⁶, Michael Song⁵, Proton Rahman⁷ and Iain B. McInnes⁸, ¹University of California San Diego, La Jolla, CA, ²Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ³Tufts Medical Center, Boston, MA, ⁴Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Janssen Research & Development, LLC., Spring House, PA, ⁶Immunology, Janssen Research & Development, LLC., Spring House, PA, ⁷Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁸Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: To evaluate the association of improvements in tender and swollen joint counts (TJC, SJC), psoriasis skin involvement, and dactylitis/enthesitis (in patients affected at baseline)…
Abstract Number: 1558 • 2014 ACR/ARHP Annual Meeting
Evaluation of Extreme Enthesitis and/or Patient-Related Outcome Score As Potential Surrogates for Fibromyalgia and As Potential Confounding Factors of Anti-TNF Response
M Dougados¹, H Jones², A Szumski³, I Logeart⁴ and J Coindreau⁵, ¹Université Paris René Descartes and Hôpital Cochin, Paris, France, ²Inflammation & Immunology, Pfizer Inc., Collegeville, PA, ³Pfizer Inc., Collegeville, PA, ⁴Pfizer, Paris, France, ⁵Pfizer Inc., New York, NY
Background/Purpose: Differentiating between pain related to spondyloarthritis (in particular polyenthesitis) and pain related to fibromyalgia can be challenging, both in daily practice and in clinical…
Abstract Number: 308 • 2014 ACR/ARHP Annual Meeting
Tenascin-C, a TLR4 Ligand Levels in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis: Cross-Sectional and Longitudinal Study
Anuj Shukla¹, Priyanka Gaur² and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose Tenascin-C (TNC) is an extracellular matrix glycoprotein, which binds to TLR4 and leads to its activation. Monocytes of children with Enthesitis related arthritis (ERA)…
Abstract Number: 1714 • 2013 ACR/ARHP Annual Meeting
Grey-Scale and Power Doppler Findings Of Lower Extremity Entheses In Healthy Children
Clara Lin¹ and Diana Milojevic², ¹Pediatric Rheumatology, University of California-San Francisco, San Francisco, CA, ²Dept of Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: The aim of our study is to describe the grey-scale and Power Doppler findings in lower extremity entheses in healthy children ages 5-18 years.…
Abstract Number: 1715 • 2013 ACR/ARHP Annual Meeting
Detection Of Enthesitis In Children With Enthesitis-Related Arthritis: Dolorimeter Examination Compared To Ultrasonography
Pamela F. Weiss¹, Nancy Chauvin², Andrew J. Klink³, Russell A. Localio⁴, Chris Feudtner⁵, Diego Jaramillo², Robert A. Colbert⁶, David D. Sherry⁷ and Ron Keren³, ¹Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Radiology, Children's Hospital of Philadelphia, PHILADELPHIA, PA, ³Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵Division of General Pediatrics, Children's Hospital of Philadelphia; University of Pennsylvania Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, ⁶NIAMS/NIH, Bethesda, MD, ⁷Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: To evaluate the distribution of enthesitis and accuracy of physical examination (PE) for the detection of enthesitis in children, using ultrasound with power Doppler…
Abstract Number: 345 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Peri-Articular Manifestations (Enthesitis and Dactylitis) and Disease Activity In Psoriatic Arthritis Patients: Impact Of Treatment With TNF Inhibitors In a Real-World Canadian Population
Proton Rahman¹, Denis Choquette², William G. Bensen³, Majed M. Khraishi⁴, Isabelle Fortin⁵, Andrew Chow⁶, Maqbool K. Sheriff⁷, Julie Vaillancourt⁸, John S. Sampalis⁸, Susan M. Otawa⁹, Allen J. Lehman⁹ and May Shawi¹⁰, ¹Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ³Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, ⁴Nexus Clinical Research, St John's, NF, Canada, ⁵Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada, ⁶University of Toronto, McMaster University, Credit Valley Rheumatology, Mississauga, ON, Canada, ⁷Nanaimo Regional General Hospital, Nanaimo, BC, Canada, ⁸JSS Medical Research, Montreal, QC, Canada, ⁹Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹⁰Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada
Background/Purpose: To determine the point prevalence of peri-articular manifestations (PAMs) in psoriatic arthritis (PsA) patients treated with anti-TNF in a real-world, Canadian, routine clinical practice…
Abstract Number: 2000 • 2012 ACR/ARHP Annual Meeting
Whole Body Magnetic Resonance Imaging in Evaluation of Enthesitis in Spondyloarthropathy
Hemalatha Srinivasalu¹, Suvimol C. Hill², Gina A. Montealegre Sanchez³, April D. Brundidge³, Michael M. Ward⁴ and Robert A. Colbert³, ¹Rheumatology, NIAMS NIH, Bethesda, MD, ²Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, ³NIAMS NIH, Bethesda, MD, ⁴Bldg 10 CRC Rm 4-1339, NIAMS NIH, Bethesda, MD
Background/Purpose: Enthesitis is a characteristic feature of spondyloarthritis (SpA). Tenderness at enthesial points constitutes clinical enthesitis. However, this may not always correlate with actual inflammation…
Abstract Number: 1680 • 2012 ACR/ARHP Annual Meeting
Diagnostic Value of the Assessment of Spondyloarthropathy International Society (ASAS) Criteria for Children with Enthesitis Related Arthritis (ERA): A Single Center Study of 124 Patients
Mehul Jariwala¹, Manjari Agarwal¹ and Sujata Sawhney², ¹Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India, ²Paediatric rheumatology, Sir Ganga Ram Hospital, New Delhi, India
Background/Purpose: Enthesitis Related Arthritis (ERA) is a common subtype (36%) of Juvenile Idiopathic Arthritis (JIA) seen in India 1. These criteria do not distinguish between…
Abstract Number: 1351 • 2012 ACR/ARHP Annual Meeting
Ultrasonographic Entheseal Abnormalities Among Patients with Psoriatic Arthritis, Psoriasis Alone and Healthy Individuals and Their Correlation with Disease-Related Variables
Lihi Eder¹, Jai Jayakar², Arane Thavaneswaran³, Amir Haddad³, Daniel Pereira³, Sutharshini Shanmugarajah³, David Salonen⁴, Cheryl Rosen⁵, Vinod Chandran⁶ and Dafna D. Gladman⁷, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, University of Western Ontario, London, ON, Canada, ³Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Department of Medical Imaging, University Health Network, Toronto, ON, Canada, ⁵Division of Dermatology, University of Toronto, Toronto western Hospital, Toronto, ON, Canada, ⁶Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁷Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Enthesitis is an important manifestation of psoriatic arthritis (PsA). We aimed to compare the frequency of ultrasonographic (US) entheseal abnormalities between patients with PsA,…
Abstract Number: 725 • 2012 ACR/ARHP Annual Meeting
The Role of Interleukin-23 in Spondyloarthropathy
Jonathan Sherlock¹, Barbara Joyce-Shaikh¹, Scott Turner¹, Cheng-Chi Chao², Manjiri Sathe¹, Jeff Grein¹, Dan Gorman¹, Eddie P. Bowman², Terrill McClanahan¹, Jennifer Yearley¹, Gerard Eberl³, Christopher D. Buckley⁴, Robert Kastelein¹, Robert Pierce¹, Drake LaFace¹ and Daniel Cua⁵, ¹Merck, Palo Alto, CA, ²Drug Discovery, Merck, Palo Alto, CA, ³Institut Pasteur, Paris, France, ⁴Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁵Discovery Research, Merck Research Laboratory, Palo Alto, CA
Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone. Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…
Abstract Number: 116 • 2012 ACR/ARHP Annual Meeting
Correlation Between Clinical and Ultrasonographic Examination of the Calcaneal Enthesis in Patients with Ankylosing Spondylitis: A Controlled Study
Suellen Narimatsu¹, Rita N.V. Furtado¹, Andre Rosenfeld², Germana. B. Q. Estrela¹, Jorge E. P. Proglhof² and Jamil Natour³, ¹Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil, ²Radiology, Universidade Federal de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: 1 – To compare US findings of calcaneal entheses between AS patients and healthy subjects; 2 - To assess the calcaneal entheses by US…

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