ACR Meeting Abstracts

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Abstracts tagged "endothelial cells and scleroderma"

  • Abstract Number: 808 • 2016 ACR/ARHP Annual Meeting

    Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis

    bashar kahaleh1, Nezam Altorok2, Yongqing Wang3, Shadia Nada2, Mohammed Madkhali3 and John Sun3, 1Rheumatology, University of Toledo, Toledo, OH, 2Medicine/Rheumatology, University of Toledo, Toledo, OH, 3University of Toledo, Toledo, OH

    Background/Purpose: Impaired angiogenesis in SSc is a crucial component of disease pathology that occurs in spite of upregulation of VEGF and other proangiogenic factors. MicroRNA-126…
  • Abstract Number: 824 • 2013 ACR/ARHP Annual Meeting

    Bosentan Improves Vascular Abnormalities In Endothelial Cell-Specific Fli1 Knockout Mice By Increasing The DNA Binding Ability Of Fli1 – a Possible Mechanism Explaining The Effect Of Bosentan On Scleroderma Vasculopathy

    Kaname Akamata1, Yoshihide Asano1, Takashi Taniguchi1, Takehiro Takahashi1, Yohei Ichimura1, Tetsuo Toyama1, Maria Trojanowska2 and Shinichi Sato1, 1Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Arthritis Center, Boston University, Boston, MA

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Although there…
  • Abstract Number: 668 • 2013 ACR/ARHP Annual Meeting

    Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation

    Yongqing Wang1, David R. Giovannucci2 and Bashar Kahaleh3, 1Medicine, University of Toledo, Toledo, OH, 2Neurosciences, University of Toledo, Toledo, OH, 3Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Cold exposure induces vasospasm and incites reperfusion injury in SSc. The mechanisms responsible for enhanced cold sensitivity in SSc are poorly understood. Transient receptor…
  • Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting

    Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis

    Pei-Suen Tsou1, George Zakhem2, Beatrix Balogh2, M. Asif Amin3, Phillip Campbell4, Gautam Edhayan1, Ray Ohara2, Elena Schiopu5, Dinesh Khanna6, Alisa E. Koch3,7 and David A. Fox1, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 4Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 5Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI

    Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
  • Abstract Number: 1506 • 2012 ACR/ARHP Annual Meeting

    Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis

    Pei-Suen Tsou1, Bradley J. Rabquer2, Beatrix Balogh2, Ann Kendzicky2, Bashar Kahaleh3, Elena Schiopu4, Dinesh Khanna5 and Alisa E. Koch6, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Medicine/Rheumatology, University of Toledo, Toledo, OH, 4Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 5Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 6Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Angiogenesis, the formation of new blood vessels, plays a critical role in a number of pathological processes including systemic sclerosis (scleroderma, SSc). SSc is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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