Abstracts tagged "Early Rheumatoid Arthritis"

Abstract Number: 1181 • 2014 ACR/ARHP Annual Meeting
Effects of Tofacitinib on Bone Marrow Edema, Synovitis, and Erosive Damage in Methotrexate-Naïve Patients with Early Active Rheumatoid Arthritis (Duration ≤2 Years): Results of an Exploratory Phase 2 MRI Study
Philip G. Conaghan¹, M. Østergaard², C. Wu³, D. van der Heijde⁴, F. Irazoque-Palazuelos⁵, P. Hrycaj⁶, Z. Xie⁷, R. Zhang⁷, B.T. Wyman⁷, J.D. Bradley⁷, K. Soma⁷ and B. Wilkinson⁷, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom, ²Copenhagen Center for Arthritis Research, Glostrup, Denmark, ³BioClinca Inc., Newark, CA, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Servicio de Reumatología, Hospital Angeles Mocel, Mexico City, Mexico, ⁶Poznan University of Medical Sciences, Poznan, Poland, ⁷Pfizer Inc, Groton, CT
Background/Purpose: Inflammation of the synovium and in particular the bone marrow, as assessed by magnetic resonance imaging (MRI), have been identified as prognostic indicators of…
Abstract Number: 371 • 2014 ACR/ARHP Annual Meeting
The Impact of Missing Anti-Citrullinated Protein Antibody (ACPA) on Outcomes in Early Rheumatoid Arthritis: From the Canadian Early Arthritis Cohort
Jenny Shu¹, Vivian P. Bykerk², Gilles Boire³, Carol A. Hitchon⁴, J. Carter Thorne⁵, Diane Tin⁶, Edward C. Keystone⁷, Boulos Haraoui⁸ and Janet E. Pope⁹, ¹Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁴Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Medicine, University of Toronto, Toronto, ON, Canada, ⁸Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁹St Joseph Health Care, London, ON, Canada
Background/Purpose: The impact of missing ACPA in early inflammatory arthritis patients was studied to determine if failure to perform ACPA testing could cause a care…
Abstract Number: 2392 • 2014 ACR/ARHP Annual Meeting
Anti-Carbamylated Antibodies (anti-CarPA) Are Associated with Long Term Disability and Increased Disease Activity in Patients with Early Inflammatory Arthritis: Results from the Norfolk Arthritis Register (NOAR)
Jenny H. Humphreys¹, Marije K Verheul², Anne Barton^3,4, Tarnya Marshall⁵, Bo Fu⁶, René E.M. Toes⁷, Deborah PM Symmons^1,4, Leendert A. Trouw⁷ and Suzanne MM Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁶Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, United Kingdom, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-CarPA have been shown to predict development of rheumatoid arthritis (RA) in patients with arthralgia. However, little is known about their association with disease…
Abstract Number: 1174 • 2014 ACR/ARHP Annual Meeting
Evaluating MRI-Detected Tenosynovitis of the Hand and Wrist in Early Arthritis
W.P. Nieuwenhuis¹, A. Krabben¹, W. Stomp², T. W. J. Huizinga¹, D. M. van der Heijde¹, J.L Bloem², M. Reijnierse³ and A.H.M. van der Helm-van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Magnetic resonance imaging (MRI) is a sensitive method to detect local inflammation in rheumatoid arthritis (RA), visualizing synovitis, bone marrow edema and tenosynovitis. The…
Abstract Number: 2368 • 2014 ACR/ARHP Annual Meeting
Impact of Physicians’ Adherence to Treat-to-Target Strategy on Outcomes in Early Rheumatoid Arthritis
Laura Kuusalo¹, Kari Puolakka², Hannu Kautiainen³, Marjatta Leirisalo-Repo⁴ and Vappu Rantalaiho⁵, ¹Department of Internal Medicine, Division of Rheumatology, Turku University Hospital, Turku, Finland, ²Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland, ³Medcare Oy, Äänekoski, Finland, ⁴Department of Medicine, Division Of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, ⁵Department of Internal Medicine, Centre for Rheumatic Diseases,, Tampere University Hospital, Tampere, Finland
Background/Purpose We have previously shown that in early rheumatoid arthritis (RA) remission targeted, intensive combination treatment, regardless of initial infliximab, results in remission in most…
Abstract Number: 1176 • 2014 ACR/ARHP Annual Meeting
Feasibility and Clinical Implication of Radiocarpal Cartilage T_1ρ MR Imaging in Rheumatoid Arthritis
Valentina Pedoia¹, Favian Su², Andrew J. Burghardt¹, Jonathan Graft³, John B. Imboden³, Mary Nakamura⁴, Ursula Heilmeier¹, Thomas M Link⁵ and Xiaojuan Li⁵, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ²Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ³Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Arthritis/Rheumatology 111-R, SFVAMC/UCSF, San Francisco, CA, ⁵Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose Rheumatoid arthritic (RA) disease progression and anti-rheumatic treatment efficacy have traditionally been monitored by evaluation of radiographs. However, MRI has emerged as a more…
Abstract Number: 2161 • 2014 ACR/ARHP Annual Meeting
Interest of Systematic Lyme Serology in Context of Recent Onset Arthritis
Dewi Guellec¹, Valérie Narbonne², Divi Cornec³, Thierry Marhadour⁴, Maxime Dougados⁵, Jean-Pierre Daures⁶, Sandrine Jousse-Joulin¹, Valerie Devauchelle⁷ and Alain Saraux⁸, ¹Rheumatology, CHU Brest, Brest, France, ²Microbiology, CHU Brest, Brest, France, ³Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, ⁴Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁵INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁶Biostatistic, INSERM, Montpellier, France, ⁷Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁸Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France
Background/Purpose Lyme arthritis is a late manifestation of a tick-transmitted spirotechal infection, mainly caused by Borrelia burdorgferi. Lyme arthritis typically presents as a mono- or…
Abstract Number: 1138 • 2014 ACR/ARHP Annual Meeting
Vasoactive Intestinal Peptide (VIP) Genetic Variants Determine VIP Serum Levels and Could be Used As a Prognosis Biomarker
Amalia Lamana¹, Iria Valino-Seoane², Luis Rodriguez-Rodriguez³, Javier Leceta², Yasmina Juarranz², Ana M. Ortiz Garcia¹, Carmen Martinez-Mora⁴, Benjamín Fernández-Gutiérrez³, Isidoro González-Alvaro⁵, Rosa P Gomariz² and Rosario Garcia-Vicuña⁵, ¹Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, ²Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ³Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ⁴Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: VIP has shown immunoregulatory properties in assays performed with human or murine cells. VIP has demonstrated a therapeutic effect in a murine model of…
Abstract Number: 2138 • 2014 ACR/ARHP Annual Meeting
Radiological Outcomes after Two Years of Remission Steered Treatment in Early Arthritis Patients
G. Akdemir¹, L. Heimans¹, K.V.C. Wevers-de Boer¹, M.K. Verheul², A.a. Schouffoer³, M. van Oosterhout⁴, J.B. Harbers⁵, C. Bijkerk⁶, G.M. Steup-Beekman⁷, L.R. Lard⁸, T. W. J. Huizinga¹, L.a. Trouw¹ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Haga Hospital, The Hague, Netherlands, ⁴Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁵Rheumatology, Franciscus Hospital, Roosendaal, Netherlands, ⁶Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, ⁷Rheumatology, Bronovo Hospital, The Hague, Netherlands, ⁸Rheumatology, MCH Antoniushove Hospital, Leidschendam, Netherlands
Background/Purpose: We investigated whether early, remission steered treatment can prevent damage progression in patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA), and aimed…
Abstract Number: 904 • 2014 ACR/ARHP Annual Meeting
Ultrasound Synovitis Reflects Synovial Inflammation at a Histopathological Level
Nora Ng, Stephen Kelly, Frances Humby, Maria DiCicco, Vidalba Rocher, Rebecca Hands, Michele Bombardieri and Costantino Pitzalis, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Ultrasound (US) is widely used by rheumatologists to assess inflammatory burden on patients with inflammatory arthritis. Some studies have shown that US measures of…
Abstract Number: 2144 • 2014 ACR/ARHP Annual Meeting
Cuantification of Hand Bone Mineral Density By Radiogrammetry and Dual X-Ray Absorptiometry in Early Arthritis Patients
Irene Llorente Cubas*¹, Leticia Merino-Meléndez*¹, Saturnino González Ortega², Ana M. Ortiz-García¹, Eugenio Escolano², Esther Vicente-Rabaneda¹, Rosario Garcia-Vicuña³, Isidoro González-Alvaro³ and Santos Castañeda-Sanz⁴, ¹Rheumatology Department, Hospital Universitario de La Princesa, Madrid, Spain, ²Radiology Department, Hospital Universitario de la Princesa, Madrid, Spain, ³Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain
Background/Purpose: The evaluation of cortical bone mineral density (BMD) on metacarpal bones by digital radiogrammetry (DXR) has been proven to be a simple, reliable and…
Abstract Number: 423 • 2014 ACR/ARHP Annual Meeting
Circulating Anti-Citrullinated Peptide Antibodies and Cytokines As Biomarkers of Response to Disease-Modifying Antirheumatic Drugs Therapy in Early Rheumatoid Arthritis
Mahmood MTM Ally¹, Pieter Meyer², Bridget Hodkinson³, Eustasius Musenge⁴, Gregory Tintinger², Mohammed Tikly⁵ and Ronald Anderson¹, ¹University of Pretoria, Pretoria, South Africa, ²university of pretoria, pretoria, South Africa, ³Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ⁴University of Witwatersrand, Johannesburg, South Africa, ⁵Rheumatology Wits University, C H Baragwanath Hospital, Johannesburg, South Africa
Background/Purpose Serial measurement of circulating anti-citrullinated peptide antibodies (ACPA) and cytokines is of potential importance in the management of patients with rheumatoid arthritis (RA). However,…
Abstract Number: 3016 • 2014 ACR/ARHP Annual Meeting
Measuring the Impact of an Early RA Support and Education Program Using a Program Evaluation with Patient Identified Outcomes
Adena Batterman¹, Kathryn Klingenstein¹, Roberta Horton¹, Linda Leff², Theodore R. Fields³ and Vivian P. Bykerk⁴, ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Nursing, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose The Early RA Support and Education Program addresses the unique psycho-educational needs of people recently diagnosed (
Abstract Number: 1960 • 2014 ACR/ARHP Annual Meeting
NF-κB-Inducing Kinase (NIK) Is Expressed in Synovial Endothelial Cells in Early Arthritis Patients and Correlates with Local Disease Activity and Systemic Markers of Inflammation
Karen I. Maijer¹, Ae-Ri Noort², Maria J. H. de Hair¹, Christiaan van der Leij³, Katinka P.M. van Zoest⁴, Danielle M. Gerlag^5,6, Mario Maas³, Paul-Peter Tak^1,7,8 and Sander W. Tas², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁶GlaxoSmithKline, Cambridge, United Kingdom, ⁷University of Cambridge, Cambridge, United Kingdom, ⁸GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose The NF-κB family of transcription factors is strongly involved in synovial inflammation. We have previously shown that NF-κB-inducing kinase (NIK) is a key regulator…
Abstract Number: 408 • 2014 ACR/ARHP Annual Meeting
14-3-3η Auto-Antibody Positivity Informs Better Clinical Outcomes in RA
D. van Schaardenburg¹, Mairead Murphy², Samina Turk³, Walter P. Maksymowych⁴ and Anthony Marotta⁵, ¹Jan van Breemen Research Institute, Amsterdam, Netherlands, ²Augurex Life Sciences Corp., North Vancouver, BC, Canada, ³Reade, Amsterdam, Netherlands, ⁴University of Alberta, Edmonton, AB, Canada, ⁵1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose We have previously reported pilot data that patients who are only positive for 14-3-3η auto-antibodies (AAb) and negative for the 14-3-3η protein have a…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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