Abstracts tagged "Early Rheumatoid Arthritis"

Abstract Number: 1662 • 2015 ACR/ARHP Annual Meeting
Treat to Target of Remission Is Effective but Not All Patients Are Always in Remission
Laura M.M. Steunebrink¹, Peter M. ten Klooster², Harald E. Vonkeman³, G.A. Versteeg¹, Arie E. van der Bijl⁴ and Mart A.F.J. van de Laar¹, ¹Rheumatology, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, ²Psychology, Health & Technology, University of Twente, Enschede, Netherlands, ³Ariensplein 1, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, ⁴Isala Klinieken, Zwolle, Netherlands
Background/Purpose: Presently the goals of rheumatoid arthritis (RA) therapy are to control symptoms, to prevent joint damage and disability. Attaining long-term clinical remission or at…
Abstract Number: 3172 • 2015 ACR/ARHP Annual Meeting
Effect of Anti Citrullinated Protein Antibodies on Periarticular and Systemic Bone Mass in Early Arthritis Patients
Irene Llorente Cubas*¹, Leticia Merino-Meléndez², Ana M. Ortiz Garcia², Eugenio Escolano³, Teresa Velasco¹, Elena García², Esther Vicente-Rabaneda², Alberto Garcia-Vadillo⁴, Rosario Garcia-Vicuña⁴, Isidoro González-Alvaro*² and Santos Castañeda*², ¹Rheumatology, H.U La Princesa, Madrid, Spain, ²Rheumatology, H.U. La Princesa, Madrid, Spain, ³Radiology Department, H.U La Princesa, Madrid, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: Recently it has been described that anti citrullinated protein antibodies (ACPA) can induce differentatiomn and activation of osteoclasts even before arthritis onset (1,2). The…
Abstract Number: 546 • 2015 ACR/ARHP Annual Meeting
Adipokines and Insulin-like Growth Factor 1 As Predictors of Clinical and Radiographic Outcomes in Early Rheumatoid Arthritis
Adrian Levitsky¹, Kerstin Brismar², Saedis Saevarsdottir³, Karen Hambardzumyan¹, Anna Andersson¹ and Ronald F. van Vollenhoven¹, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ²Department of Molecular Medicine and Surgery, Unit of Growth and Metabolism, The Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, The Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Adipokines are cytokines/hormones primarily synthesized in white adipose tissue. In rheumatoid arthritis (RA), some adipokines have been associated with worse outcomes (1-3). The aim…
Abstract Number: 1669 • 2015 ACR/ARHP Annual Meeting
Serum Survivin Predicts Responses to Treatment in Active Rheumatoid Arthritis
Adrian Levitsky¹, Malin C. Erlandsson², Ronald F. van Vollenhoven¹ and Maria I. Bokarewa², ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ²Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Survivin is an oncological biomarker. In rheumatoid arthritis (RA), elevated serum survivin is common and has been used to predict disease onset and progressive…
Abstract Number: 3242 • 2015 ACR/ARHP Annual Meeting
A Comprehensive Method for Using Sensewear MiniTM Monitors to Explore Differences in Ambulatory Activities in People Living with and without Early Rheumatoid Arthritis: Moving Beyond Measuring Total Steps
Lynne Feehan^1,2,3, Jake McIvor⁴, Ju Young Yoo³ and Linda Li^3,5, ¹University of British Columbia, Vancouver, BC, Canada, ²Rehabilitation Program, Fraser Health Authority, Surrey, BC, Canada, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Consultant, Arthritis Research Canada, Richmond, BC, Canada, ⁵Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Measures of daily steps does not allow for examination of how steps are accumulated from different type or intensity of ambulatory activity, which is…
Abstract Number: 2381 • 2014 ACR/ARHP Annual Meeting
Adherence to a Treat-to-Target (T2T) Strategy in Early Rheumatoid Arthritis. Is It Feasible in Daily Clinical Practice?
Christian A. Waimann¹, Gustavo Citera², Fernando Dal Pra³, Maria Celeste Orozco⁴, Federico Ceccatto⁵, Sergio Paira⁶, M Gauna⁷, Anastasia Secco⁷, M Mamani⁷, Lucila Marino⁸, Francisco Caeiro⁹, AC Alvarez¹⁰, Maria Haye Salinas⁹, L Encinas¹¹, Javier Rosa¹², Valeria Scaglioni¹³, Enrique R. Soriano¹⁴, Josefina Marcos¹⁵, Mercedes García¹⁵, A Salas¹⁵, Alejandro Martinez¹⁶, Rafael Chaparro del Moral¹⁷, Oscar Luis Rillo¹⁷, Horacio Berman¹⁸, Alberto Berman¹⁸, Francisco Colombres¹⁸, Edson Veloso¹⁹, Ricardo V. Juárez²⁰, Maria Elena Crespo²¹, Ana Quinteros²², M Leal²², Gabriela Salvatierra²³, C Ledesma²³, Mónica P. Sacnun²⁴, R Quintana²⁵ and Marcelo Abdala²⁶, ¹Rheumatology, Hospital Olavarria, Olavarria, Argentina, ²Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, ⁴Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁵Rheumatology, Hospital Jose María Cullen, Santa Fé, Argentina, ⁶Section of Rheumatology, Hospital Jose Maria Cullen, Santa Fe, Argentina, ⁷Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁸Rheumathology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁹Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, ¹⁰Hospital Privado Centro Médico de, Córdoba, Argentina, ¹¹Rheumatology, Hospital Privado Centro Medico De Córdoba, Cordoba, Argentina, ¹²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹³Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ¹⁴Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ¹⁵HIGA San Martín, La Plata, Argentina, ¹⁶Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹⁷Rheumatology Section, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹⁸Centro Medico Privado de Reumatologia, Tucumán, Argentina, ¹⁹Sanatorio y Universidad Adventista Del Plata, Entre Rios, Argentina, ²⁰Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, ²¹Hospital Señor Del Milagro, Salta, Argentina, ²²Centro Integral de Reumatología, Tucumán, Argentina, ²³Instituto Provincial De Rehabilitación Integral, Stgo. del Estero, Argentina, ²⁴Hospital Provincial, Rosario, Argentina, ²⁵Hospital provincial, Rosario, Argentina, ²⁶Hospital Provincial del Centenario, Santa Fe, Argentina
Background/Purpose : The treat-to-target (T2T) strategy has become the new paradigm for the treatment of Rheumatoid Arthritis (RA); however the question is whether this strategy…
Abstract Number: 1181 • 2014 ACR/ARHP Annual Meeting
Effects of Tofacitinib on Bone Marrow Edema, Synovitis, and Erosive Damage in Methotrexate-Naïve Patients with Early Active Rheumatoid Arthritis (Duration ≤2 Years): Results of an Exploratory Phase 2 MRI Study
Philip G. Conaghan¹, M. Østergaard², C. Wu³, D. van der Heijde⁴, F. Irazoque-Palazuelos⁵, P. Hrycaj⁶, Z. Xie⁷, R. Zhang⁷, B.T. Wyman⁷, J.D. Bradley⁷, K. Soma⁷ and B. Wilkinson⁷, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom, ²Copenhagen Center for Arthritis Research, Glostrup, Denmark, ³BioClinca Inc., Newark, CA, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Servicio de Reumatología, Hospital Angeles Mocel, Mexico City, Mexico, ⁶Poznan University of Medical Sciences, Poznan, Poland, ⁷Pfizer Inc, Groton, CT
Background/Purpose: Inflammation of the synovium and in particular the bone marrow, as assessed by magnetic resonance imaging (MRI), have been identified as prognostic indicators of…
Abstract Number: 371 • 2014 ACR/ARHP Annual Meeting
The Impact of Missing Anti-Citrullinated Protein Antibody (ACPA) on Outcomes in Early Rheumatoid Arthritis: From the Canadian Early Arthritis Cohort
Jenny Shu¹, Vivian P. Bykerk², Gilles Boire³, Carol A. Hitchon⁴, J. Carter Thorne⁵, Diane Tin⁶, Edward C. Keystone⁷, Boulos Haraoui⁸ and Janet E. Pope⁹, ¹Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁴Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Medicine, University of Toronto, Toronto, ON, Canada, ⁸Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁹St Joseph Health Care, London, ON, Canada
Background/Purpose: The impact of missing ACPA in early inflammatory arthritis patients was studied to determine if failure to perform ACPA testing could cause a care…
Abstract Number: 2392 • 2014 ACR/ARHP Annual Meeting
Anti-Carbamylated Antibodies (anti-CarPA) Are Associated with Long Term Disability and Increased Disease Activity in Patients with Early Inflammatory Arthritis: Results from the Norfolk Arthritis Register (NOAR)
Jenny H. Humphreys¹, Marije K Verheul², Anne Barton^3,4, Tarnya Marshall⁵, Bo Fu⁶, René E.M. Toes⁷, Deborah PM Symmons^1,4, Leendert A. Trouw⁷ and Suzanne MM Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁶Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, United Kingdom, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-CarPA have been shown to predict development of rheumatoid arthritis (RA) in patients with arthralgia. However, little is known about their association with disease…
Abstract Number: 1174 • 2014 ACR/ARHP Annual Meeting
Evaluating MRI-Detected Tenosynovitis of the Hand and Wrist in Early Arthritis
W.P. Nieuwenhuis¹, A. Krabben¹, W. Stomp², T. W. J. Huizinga¹, D. M. van der Heijde¹, J.L Bloem², M. Reijnierse³ and A.H.M. van der Helm-van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Magnetic resonance imaging (MRI) is a sensitive method to detect local inflammation in rheumatoid arthritis (RA), visualizing synovitis, bone marrow edema and tenosynovitis. The…
Abstract Number: 2368 • 2014 ACR/ARHP Annual Meeting
Impact of Physicians’ Adherence to Treat-to-Target Strategy on Outcomes in Early Rheumatoid Arthritis
Laura Kuusalo¹, Kari Puolakka², Hannu Kautiainen³, Marjatta Leirisalo-Repo⁴ and Vappu Rantalaiho⁵, ¹Department of Internal Medicine, Division of Rheumatology, Turku University Hospital, Turku, Finland, ²Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland, ³Medcare Oy, Äänekoski, Finland, ⁴Department of Medicine, Division Of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, ⁵Department of Internal Medicine, Centre for Rheumatic Diseases,, Tampere University Hospital, Tampere, Finland
Background/Purpose We have previously shown that in early rheumatoid arthritis (RA) remission targeted, intensive combination treatment, regardless of initial infliximab, results in remission in most…
Abstract Number: 1176 • 2014 ACR/ARHP Annual Meeting
Feasibility and Clinical Implication of Radiocarpal Cartilage T_1ρ MR Imaging in Rheumatoid Arthritis
Valentina Pedoia¹, Favian Su², Andrew J. Burghardt¹, Jonathan Graft³, John B. Imboden³, Mary Nakamura⁴, Ursula Heilmeier¹, Thomas M Link⁵ and Xiaojuan Li⁵, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ²Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ³Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Arthritis/Rheumatology 111-R, SFVAMC/UCSF, San Francisco, CA, ⁵Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose Rheumatoid arthritic (RA) disease progression and anti-rheumatic treatment efficacy have traditionally been monitored by evaluation of radiographs. However, MRI has emerged as a more…
Abstract Number: 2161 • 2014 ACR/ARHP Annual Meeting
Interest of Systematic Lyme Serology in Context of Recent Onset Arthritis
Dewi Guellec¹, Valérie Narbonne², Divi Cornec³, Thierry Marhadour⁴, Maxime Dougados⁵, Jean-Pierre Daures⁶, Sandrine Jousse-Joulin¹, Valerie Devauchelle⁷ and Alain Saraux⁸, ¹Rheumatology, CHU Brest, Brest, France, ²Microbiology, CHU Brest, Brest, France, ³Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, ⁴Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁵INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁶Biostatistic, INSERM, Montpellier, France, ⁷Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁸Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France
Background/Purpose Lyme arthritis is a late manifestation of a tick-transmitted spirotechal infection, mainly caused by Borrelia burdorgferi. Lyme arthritis typically presents as a mono- or…
Abstract Number: 1138 • 2014 ACR/ARHP Annual Meeting
Vasoactive Intestinal Peptide (VIP) Genetic Variants Determine VIP Serum Levels and Could be Used As a Prognosis Biomarker
Amalia Lamana¹, Iria Valino-Seoane², Luis Rodriguez-Rodriguez³, Javier Leceta², Yasmina Juarranz², Ana M. Ortiz Garcia¹, Carmen Martinez-Mora⁴, Benjamín Fernández-Gutiérrez³, Isidoro González-Alvaro⁵, Rosa P Gomariz² and Rosario Garcia-Vicuña⁵, ¹Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, ²Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ³Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ⁴Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: VIP has shown immunoregulatory properties in assays performed with human or murine cells. VIP has demonstrated a therapeutic effect in a murine model of…
Abstract Number: 2138 • 2014 ACR/ARHP Annual Meeting
Radiological Outcomes after Two Years of Remission Steered Treatment in Early Arthritis Patients
G. Akdemir¹, L. Heimans¹, K.V.C. Wevers-de Boer¹, M.K. Verheul², A.a. Schouffoer³, M. van Oosterhout⁴, J.B. Harbers⁵, C. Bijkerk⁶, G.M. Steup-Beekman⁷, L.R. Lard⁸, T. W. J. Huizinga¹, L.a. Trouw¹ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Haga Hospital, The Hague, Netherlands, ⁴Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁵Rheumatology, Franciscus Hospital, Roosendaal, Netherlands, ⁶Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, ⁷Rheumatology, Bronovo Hospital, The Hague, Netherlands, ⁸Rheumatology, MCH Antoniushove Hospital, Leidschendam, Netherlands
Background/Purpose: We investigated whether early, remission steered treatment can prevent damage progression in patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA), and aimed…

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