ACR Meeting Abstracts

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Abstracts tagged "drug treatment"

  • Abstract Number: 1496 • 2014 ACR/ARHP Annual Meeting

    Exposure-Response Analysis for Mavrilimumab Phase2b Study in RA Patients with Informative Dropout

    Chi-Yuan Wu1, Denise Jin1, Alex Godwood2, David Close3, Lorin Roskos4 and Bing Wang1, 1Clinical Pharmacology and DMPK, Medimmune, Mountain View, CA, 2Clinical Biostatics and Data Management, MedImmune Ltd, Cambridge, United Kingdom, 3Clinical Development, MedImmune Ltd, Cambridge, United Kingdom, 4One MedImmune Way, Medimmune, Gaithersburg, MD

    Background/Purpose: Mavrilimumab is a recombinant human monoclonal antibody which neutralizes granulocyte-macrophage colony stimulating factor (GM-CSF) activity by selectively binding to the alpha subunit of its…
  • Abstract Number: 272 • 2014 ACR/ARHP Annual Meeting

    Factors Associated with Choice of First Biologic Among Children with Juvenile Idiopathic Arthritis: A Combined Analysis from 2 UK Paediatric Biologic Registers

    Rebecca Davies1, Lianne Kearsley-Fleet1, Eileen Baildam2, Michael W. Beresford3, Helen E. Foster4, Taunton R. Southwood5, Wendy Thomson6, Kimme L. Hyrich7, on Behalf Of The BSPAR Etanercept Cohort Study1 and The Biologics for Children with Rheumatic Diseases (BCRD) study1, 1Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 2Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, 3Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, 6Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 7Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom

    Background/Purpose: The management of juvenile idiopathic arthritis (JIA) has been revolutionised by the introduction of biologics such as etanercept (ETN), approved in the UK in…
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