Abstracts tagged "DNA Methylation"

Abstract Number: 1884 • 2014 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Rheumatoid Arthritis in Disease Discordant Monozygotic Twins
Amy Webster¹, Flore Zufferey², Darren Plant³, Anne Barton^4,5, Frances Williams² and Jane Worthington^1,6, ¹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²Dept Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁵NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous epigenetic studies of rheumatoid arthritis (RA) using prevalent cases and unrelated controls have indicated that DNA methylation is altered in patients with RA.…
Abstract Number: 1121 • 2014 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence the DNA Methylome of Articular Chondrocytes
Ignacio Rego-Perez¹, Juan Fernández-Tajes¹, Mercedes Fernandez Moreno¹, Angel Soto-Hermida¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Maria Tamayo², Sara Relaño-Fernandez¹, Alejandro Mosquera², Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹, Jose Luis Fernandez² and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Departamento de Genética. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose Mitochondria and DNA methylation play a main role in the development of Osteoarthritis. The aim of this work is to analyze the influence of…
Abstract Number: 881 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis
Patrick S. Coit¹, Lindsey B. De Lott², Bin Nan³, Victor M. Elner⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Department of Ophthalmology and Visual Sciences & Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: Giant cell arteritis (GCA) is a systemic large vessel vasculitis of unknown etiology. A hallmark of GCA is the presence of granulomatous inflammation of…
Abstract Number: 868 • 2014 ACR/ARHP Annual Meeting
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 524 • 2014 ACR/ARHP Annual Meeting
Distinct Patterns of DNA Methylation in Labial Salivary Gland Tissue Based on Sjögren’s Syndrome Disease Status
Michael Cole¹, Xiaorong Shao¹, Diana Quach², Hong L. Quach², Lisa F. Barcellos² and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, ²Epidemiology, University of California, Berkeley, Berkeley, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 1893 • 2013 ACR/ARHP Annual Meeting
Altered DNA Methylation Profiles In Individuals With Osteoarthritis
Kathryn A Bailey¹, Daniel Rojas², Nikhil Umesh¹, Lisa Smeester¹, Tristan De Buysscher³, Jordan B. Renner⁴, Joanne M. Jordan⁵ and Rebecca C. Fry¹, ¹Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Medicine, Curriculum in Toxicology, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, ³Center for Bioinformatics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina Department of Radiology, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Major risk factors associated with osteoarthritis (OA) development include age, joint stress/injury, obesity, and genetic predisposition. In recent years, the role epigenetic processes that…
Abstract Number: 1874 • 2013 ACR/ARHP Annual Meeting
Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals
John Glossop^1,2, Nicola Nixon², Richard Emes³, Kim Haworth¹, Jonathon Packham², Peter Dawes², Anthony Fryer¹, Derek Mattey^1,2 and William Farrell¹, ¹Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, United Kingdom, ²Rheumatology, Haywood Rheumatology Centre, Stoke-on-Trent, United Kingdom, ³School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonnington, United Kingdom
Background/Purpose: Multiple reports now describe changes to the DNA methylome in a variety of autoimmune disorders, such as rheumatoid arthritis. In many cases, these studies…
Abstract Number: 1886 • 2013 ACR/ARHP Annual Meeting
Differential Methylation Related To Response To Etanercept In Patients With Rheumatoid Arthritis
Amy Webster¹, Darren Plant², Mark Lunt³, Stephen Eyre⁴, Edward Flynn⁴, Paul Martin⁵, A. G. Wilson⁶, A. W. Morgan⁷, John Isaacs⁸, Jane Worthington^1,9 and Anne Barton^2,4, ¹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁶Genomic Medicine, The University of Sheffield, Sheffield, United Kingdom, ⁷Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, ⁸National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom, ⁹The University of Manchester, Manchester, United Kingdom
Background/Purpose: The introduction of biologic drug therapies targeting specific components of the inflammatory response represents a huge advance in the treatment of rheumatoid arthritis (RA).…
Abstract Number: 1623 • 2013 ACR/ARHP Annual Meeting
Differential Methylation Of Interferon-Related Genes Is Associated With Anti-dsDNA Autoantibody Production In Systemic Lupus Erythematosus
Sharon A. Chung¹, Joanne Nititham², Kimberly E. Taylor¹, Emon Elboudwarej³, Hong L. Quach³, Lisa F. Barcellos³ and Lindsey A. Criswell², ¹University of California, San Francisco, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ³Epidemiology, University of California, Berkeley, Berkeley, CA
Background/Purpose: DNA methylation studies in systemic lupus erythematosus (SLE) have shown that SLE patients have less methylation in genes regulating the immune response compared to…
Abstract Number: 715 • 2013 ACR/ARHP Annual Meeting
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression In CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 665 • 2013 ACR/ARHP Annual Meeting
DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of which the etiology and pathogenesis remains complex and poorly understood. Attention has recently been directed…
Abstract Number: 655 • 2013 ACR/ARHP Annual Meeting
DNA Methylation and Systemic Sclerosis
Gloria Salazar¹, Khurshida Begum², Xinjian Guo³, Minghua Wu¹, Shervin Assassi¹, Maureen D. Mayes¹, John D. Reveille¹ and Xiaodong Zhou¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Baylor College of Medicine, Houston, TX, ³Rheumatology, The University of Texas Medical School at Houston, Houston, TX
DNA Methylation and Systemic SclerosisBackground/Purpose: Epigenetic modiﬁcations are stable and heritable alterations in gene expression and cellular function that do not involve changes to the…
Abstract Number: 2905 • 2013 ACR/ARHP Annual Meeting
Demethylation of ITGAL (CD11a) regulatory sequences in CD4+T lymphocytes of Systemic Sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease epitomized numerous cellular and humoral immunological abnormalities. The immune system undoubtedly plays a pivotal…
Abstract Number: 2773 • 2013 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns In naïve CD4+ T Cells From Patients With Primary Sjögren’s Syndrome
Nezam I. Altorok¹, Patrick S. Coit², Travis Hughes², Kristi A. Koelsch³, R. Hal Scofield⁴, Kathy L. Sivils⁵, A. Darise Farris⁶ and Amr H. Sawalha², ¹Internal Medicine and Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK
Background/Purpose: Primary Sjögren’s syndrome (PSS) is a systemic autoimmune disease characterized by inflammation of the lacrimal and salivary glands and dryness of the eyes and mouth.…
Abstract Number: 2734 • 2013 ACR/ARHP Annual Meeting
Epigenetic Control Of a Gene Regulatory Network Associated With Experimental Autoimmune Arthritis and Rheumatoid Arthritis
Andras Vida¹, Janos Gal², Gyorgyi Soos², Attila Balog³, Laszlo G. Puskas⁴, Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, ⁴Laboratory of Functional Genomics, Biological Research Center, Szeged, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that mainly affects the synovial joints, leading to destruction of articular cartilage and bone. There is…

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