Abstracts tagged "DNA Methylation"

Abstract Number: 1074 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Patterns in Naïve CD4+ T Cells Identify Epigenetic Susceptibility Loci for Malar Rash and Discoid Rash in Systemic Lupus Erythematosus
Paul Renauer¹, Patrick Coit¹, Matlock A. Jeffries², Joan T. Merrill³, W Joseph McCune⁴, Kathleen Maksimowicz-McKinnon⁵ and Amr H. Sawalha⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁵Rheumatology, Henry Ford Hospital, Detroit, MI, ⁶Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneous clinical manifestations, autoantibody production, and epigenetic dysregulation in T cells. We sought…
Abstract Number: 1130 • 2015 ACR/ARHP Annual Meeting
Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage
Matlock A. Jeffries^1,2, Madison Andrews³, Mary Beth Humphrey¹, Judith A. James⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Association, Oklahoma City, OK, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Univers, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability affecting a majority of individuals over age 70. Outside of cartilage, little is known regarding…
Abstract Number: 1242 • 2015 ACR/ARHP Annual Meeting
Germ Line DNA Methylation Profiling Provides Novel Insights into the Parent-of-Origin Effect in Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Proton Rahman³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Parent-of-origin effects refer to the differential risk or pathogenicity of a disease that depends on the sex of the disease-transmitting parent. Excessive paternal transmission…
Abstract Number: 1250 • 2015 ACR/ARHP Annual Meeting
DNA Methylation and Its Relation to Immunological Phenotypes in Peripheral Blood: A Study of Anti-CCP Antibody Positivity from a Population-Based Pool
Sasha Bernatsky¹, Xiaojian Shao², Marie-Michelle Simon², Marvin J. Fritzler³, Philip Awadalla^4,5, Marie Hudson⁶, Ines Colmegna⁷, Tony Kwan² and Tomi Pastinen², ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Department of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada, ⁴Medicine, Université de Montreal, Montreal, QC, Canada, ⁵Ontario Institute for Cancer Research, Toronto, ON, Canada, ⁶McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁷Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: DNA methylation represents an important potential mediator of environmental influences on autoimmunity, including rheumatoid arthritis (RA). Genome-wide methylation in the context of clinical phenotypes…
Abstract Number: 1255 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns in CD4+ T Reveal Significant Contribution of DNA Methylation to Rheumatoid Arthritis
Shicheng Guo^1,2, Ting Jiang^1,2, Rongsheng Wang^1,2, Yi Shen^1,2, Xiao Zhu³, Fengmin Bai^1,2, Qin Ding^1,2, Guangjie Chen⁴ and Dongyi He^1,2, ¹Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China, ²Arthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China, ³Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China, ⁴Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai, China
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence showed more and more importance of the epigenetic…
Abstract Number: 1257 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Signatures of Salivary Gland Inflammation in Sjögren’s Syndrome
Michael Cole¹, Diana Quach¹, Hong L. Quach¹, Lisa F. Barcellos¹ and Lindsey A. Criswell², ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage
Oscar Alvarez-Garcia¹, Kathleen M. Fisch¹, Ryuichiro Akagi^2,3, Masahiko Saito⁴, Takahisa Sasho⁴, Andrew I. Su⁵ and Martin K. Lotz⁶, ¹The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, ⁴Orthopaedic Surgery, Chiba University, Chiba, Japan, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
Abstract Number: 1264 • 2015 ACR/ARHP Annual Meeting
Residential Proximity to Highways, DNA Methylation and Systemic Lupus Erythematosus
Cristina Lanata¹, Renuka Nayak², Joanne Nitiham¹, Kimberly Taylor³, Lisa F. Barcellos⁴, Sharon A. Chung⁵ and Lindsey A. Criswell^6,7, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ⁵School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁶Rheumatology, UCSF, SAN FRANCISCO, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by autoantibody formation in which multiple genetic, epigenetic and environmental risk factors have been implicated. We…
Abstract Number: 1610 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Changes Observed in Rheumatoid Arthritis Joint Tissue Are Detectable in CD4+ Naive T Cells from Peripheral Blood
Calliope Holingue¹, Brooke Rhead¹, Michael Cole¹, Xiaorong Shao¹, Hong L. Quach¹, Diana Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison⁵, Vladimir Chernitskiy⁶, Wei Wang⁷, Gary S. Firestein⁸, Lisa F. Barcellos¹ and Lindsey A. Criswell⁵, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Div Of Rheumatology, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁵Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁶Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁸Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Aberrant DNA methylation patterns have previously been associated with rheumatoid arthritis (RA) [MIM 180300]. Our study aimed to determine whether differentially methylated CpGs in…
Abstract Number: 1121 • 2014 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence the DNA Methylome of Articular Chondrocytes
Ignacio Rego-Perez¹, Juan Fernández-Tajes¹, Mercedes Fernandez Moreno¹, Angel Soto-Hermida¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Maria Tamayo², Sara Relaño-Fernandez¹, Alejandro Mosquera², Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹, Jose Luis Fernandez² and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Departamento de Genética. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose Mitochondria and DNA methylation play a main role in the development of Osteoarthritis. The aim of this work is to analyze the influence of…
Abstract Number: 881 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis
Patrick S. Coit¹, Lindsey B. De Lott², Bin Nan³, Victor M. Elner⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Department of Ophthalmology and Visual Sciences & Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: Giant cell arteritis (GCA) is a systemic large vessel vasculitis of unknown etiology. A hallmark of GCA is the presence of granulomatous inflammation of…
Abstract Number: 868 • 2014 ACR/ARHP Annual Meeting
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 524 • 2014 ACR/ARHP Annual Meeting
Distinct Patterns of DNA Methylation in Labial Salivary Gland Tissue Based on Sjögren’s Syndrome Disease Status
Michael Cole¹, Xiaorong Shao¹, Diana Quach², Hong L. Quach², Lisa F. Barcellos² and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, ²Epidemiology, University of California, Berkeley, Berkeley, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 77 • 2014 ACR/ARHP Annual Meeting
Epigenome Profiling Reveals Robust Hypomethylation of Interferon Signature Genes in Lupus Neutrophils
Patrick Coit¹, Sri Yalavarthi¹, Wenpu Zhao², Mariana J. Kaplan² and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Lupus neutrophils play an important role in tissue damage (including glomerulonephritis and lupus skin involvement), as well as endothelial damage in lupus patients. Several…
Abstract Number: L8 • 2014 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Lupus Nephritis
Renuka Nayak¹, Sharon A. Chung², Joanne Nitiham³ and Lindsey A. Criswell³, ¹Rheumatology, University of California - San Francisco, San Francisco, CA, ²School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose: Genetic and epigenetic factors contribute to the progression of systemic lupus erythematosus (SLE). We now have technologies that allow us to identify these factors…

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