Abstracts tagged "DNA Methylation"

Abstract Number: 1620 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Profiling of Rheumatoid Arthritis Peripheral Blood Identifies Hypermethylation of TRIM69 Promoter Region in CD4+ T Cells Associated with Disease Activity
Amanda Mok¹, Brooke Rhead¹, Calliope Holingue¹, Xiaorong Shao¹, Diana Quach¹, Hong L. Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison³, Vladimir Chernitskiy³, Wei Wang⁵, Gary S. Firestein⁶, Lisa F. Barcellos¹ and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Epigenetic modifications have been previously associated with rheumatoid arthritis (RA [MIM 180300]). This study aimed to determine whether differential DNA methylation in peripheral blood…
Abstract Number: 1623 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of DNA Methylation in Th1 and Th17 Cells in Rheumatoid Arthritis
Katharina Stutzer¹, Fausto Pirronello¹, Simone Wahl², Hendrik Schulze-Koops¹, Alla Skapenko¹ and Jan Leipe³, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany, ³Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by systemic inflammation. Although the understanding of the pathogenesis is incomplete, there is substantial evidence…
Abstract Number: 2017 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Governs the Ability of Apoptotic Cells to Suppress Inflammatory Arthritis Via Reciprocal Regulation of IL-6 and TGF-Beta
Clare Notley¹, Christine Jordan², Jenny McGovern², Mark Brown² and Michael R. Ehrenstein³, ¹Rheumatology, UCL, London, United Kingdom, ²UCL, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Apoptotic cells (AC) have potent anti-inflammatory effects. Injection of apoptotic dendritic cells into mice suppresses the severity of antigen-induced arthritis through increased TGFβ production…
Abstract Number: 2100 • 2015 ACR/ARHP Annual Meeting
Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjögren’s Syndrome
Juliana Imgenberg-Kreuz¹, Johanna K Sandling^1,2, Jonas Carlsson Almlöf¹, Jessica Nordlund¹, Linnea Signér², Katrine B Norheim³, Roald Omdal³, Majia-Leena Eloranta², Lars Rönnblom², Ann-Christine Syvänen¹ and Gunnel Nordmark², ¹Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Epigenetic modifications have emerged as important contributing factors in the pathogenesis of autoimmune diseases, including primary Sjögren’s syndrome (pSS), and may act as a…
Abstract Number: 2174 • 2015 ACR/ARHP Annual Meeting
Neutrophils in Primary Antiphospholipid Syndrome Are Characterized By a Prominent Activated Phenotype and Uniquely Remodeled Chromatin Architecture
Patrick Coit, Srilakshmi Yalavarthi, Jason S. Knight and Amr H. Sawalha, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombotic events, pregnancy complications, and the presence of antiphospholipid antibodies. The pathogenesis of…
Abstract Number: 3104 • 2015 ACR/ARHP Annual Meeting
Abnormal DNA Methylation in a Novel PTPN11 Enhancer Increases Destructive Potential of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) and Joint Inflammation
Keisuke Maeshima¹, Stephanie M. Stanford², Deepa Hammaker¹, Cristiano Sacchetti², Rizi Ai³, Vida Zhang⁴, David L. Boyle⁵, Lifan Zeng⁶, German Muench⁷, Gen-Sheng Feng⁸, John Whitaker⁹, Zhong-Yin Zhang⁶, Wei Wang¹⁰, Nunzio Bottini² and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁵Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁶Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁷La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁸Pathology and Division of Biological Sciences, UC San Diego, La Jolla, CA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) mediate disease pathogenesis by invading the joint extracellular matrix. The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed…
Abstract Number: 95 • 2015 ACR/ARHP Annual Meeting
Validation of Differential Methylation in Paternally Versus Maternally Transmitted Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Amanda Dohey², Dianne Codner², Vinod Chandran³, Dafna Gladman³ and Proton Rahman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Several studies have demonstrated excessive paternal transmission of psoriasis and psoriatic arthritis (PsA). This phenomenon is thought to be mediated by genomic imprinting. We…
Abstract Number: 3128 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Blood and Dermal Fibroblasts from Twin Pairs Discordant for Systemic Sclerosis
Paula S. Ramos¹, Thomas A. Medsger Jr.² and Carol A. Feghali-Bostwick¹, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The etiology and mechanisms underlying the wide variation in disease heterogeneity and severity in systemic sclerosis (SSc) remain unknown. To assess the role of…
Abstract Number: 1074 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Patterns in Naïve CD4+ T Cells Identify Epigenetic Susceptibility Loci for Malar Rash and Discoid Rash in Systemic Lupus Erythematosus
Paul Renauer¹, Patrick Coit¹, Matlock A. Jeffries², Joan T. Merrill³, W Joseph McCune⁴, Kathleen Maksimowicz-McKinnon⁵ and Amr H. Sawalha⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁵Rheumatology, Henry Ford Hospital, Detroit, MI, ⁶Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneous clinical manifestations, autoantibody production, and epigenetic dysregulation in T cells. We sought…
Abstract Number: 2685 • 2014 ACR/ARHP Annual Meeting
Ten-Eleven Translocation 2 Protein Down-Regulates DNA Methylation of Interleukin-17A Promoter and Induces Its Expression in CD4⁺t Cells of Patients with Systemic Lupus Erythematosus
Duo Li, Qian Tang, Lina Tan, Ming Zhao, Gongping Liang, Yang Yang and Qianjin Lu, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Recent evidence indicates that IL-17A plays a key role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). SLE patients have…
Abstract Number: 2680 • 2014 ACR/ARHP Annual Meeting
DNA Hydroxymethylation Changes in CD4+T Cells from Patients with Systemic Lupus Erythematosus
Ming Zhao, Wei Liao, Bochen Zhu, Ruifang Wu and Qianjin Lu, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose Recent studies have uncovered 5-hydroxymethylcytosine (5hmC) as the sixth base of the genome, and that the Ten-eleven translocation (TET) family proteins is responsible for…
Abstract Number: 2447 • 2014 ACR/ARHP Annual Meeting
The Role of TET3-Mediated DNA Demethylation By Pro-Inflammatory Cytokines in Rheumatoid Arthritis
Kazuhisa Nakano¹, Kunihiro Yamaoka¹, Akira Kurozumi², Akio Kawabe², Kaoru Yamagata² and Yoshiya Tanaka³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The first department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose In the pathogenesis of Rheumatoid arthritis (RA) RA fibroblast-like synoviocytes (RA FLS) exhibit a unique aggressive phenotype that contributes to the cytokine milieu and…
Abstract Number: 1887 • 2014 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis of Twin Pairs Discordant for Systemic Sclerosis Reveals Distinct Signatures in Blood and Dermal Fibroblasts
Paula S. Ramos¹, Rick Jordan², James Lyons-Weiler², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is a chronic, multisystem, autoimmune inflammatory disease with genetic and non-genetic contributions to risk. The etiology of SSc, including the reasons…
Abstract Number: 1884 • 2014 ACR/ARHP Annual Meeting
Differential DNA Methylation Associated with Rheumatoid Arthritis in Disease Discordant Monozygotic Twins
Amy Webster¹, Flore Zufferey², Darren Plant³, Anne Barton^4,5, Frances Williams² and Jane Worthington^1,6, ¹Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²Dept Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁵NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous epigenetic studies of rheumatoid arthritis (RA) using prevalent cases and unrelated controls have indicated that DNA methylation is altered in patients with RA.…
Abstract Number: 1121 • 2014 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence the DNA Methylome of Articular Chondrocytes
Ignacio Rego-Perez¹, Juan Fernández-Tajes¹, Mercedes Fernandez Moreno¹, Angel Soto-Hermida¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Maria Tamayo², Sara Relaño-Fernandez¹, Alejandro Mosquera², Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹, Jose Luis Fernandez² and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Departamento de Genética. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose Mitochondria and DNA methylation play a main role in the development of Osteoarthritis. The aim of this work is to analyze the influence of…

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