Abstracts tagged "DNA Methylation"

Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting
TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages
Emmanuel Karouzakis¹, Fangfang Sun², Agnieszka Pajak¹, Shuang Ye², Steffen Gay¹, Oliver Distler³ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 2654 • 2017 ACR/ARHP Annual Meeting
Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus
Juliana Imgenberg-Kreuz^1,2, Jonas Carlsson Almlöf¹, Dag Leonard³, Gunnel Nordmark², Maija-Leena Eloranta³, Leonid Padyukov⁴, Iva Gunnarsson⁴, Elisabet Svenungsson⁴, Christopher Sjöwall⁵, Lars Rönnblom², Ann-Christine Syvänen¹ and Johanna K Sandling^1,2, ¹Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ⁴Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁵Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden
Background/Purpose: DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). SLE typically requires continuous treatment to control…
Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells: Identification of Epigenetically Affected Key Genes and Pathways
Shadia Nada¹, Ibtissam Gad², Ali Alqahtani³, Ahmad Assaly², Sadik Khuder⁴, Yongqing Wang⁵, Bashar Kahaleh¹ and Nezam Altorok¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²University of Toledo, Toledo, OH, ³Internal Medicine, University of Toledo, Toledo, OH, ⁴Department of Medicine, University of Toledo, Toledo, OH, ⁵Medicine, University of Toledo, Toledo, OH
Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
Abstract Number: 74 • 2016 ACR/ARHP Annual Meeting
Arthritis-Associated DNA Hypermethylation Provokes Increased Antibody Expression in Mouse Model of Rheumatoid Arthritis
Daniel M. Tóth¹, Timea Ocskó¹, Adrienn Markovics¹, Attila Balog², Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary
Background/Purpose: Although a number of epigenetic alterations have been revealed in rheumatoid arthritis (RA), it remained an open question whether these epimutations play role in…
Abstract Number: 2108 • 2016 ACR/ARHP Annual Meeting
DNA Hypomethylation in Promoter Region of Zbtb38 Gene Ultimately Leads to Downregulated Expression of Anti-Inflammatory IL1r2 in Experiential Model of Rheumatoid Arthritis
Timea Ocskó¹, Daniel M. Tóth¹, Attila Balog², Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch³, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, ³1735 W. Harrison Str., Rush University Medical Center, Chicago, IL
Background/Purpose: Interleukin 1 beta (IL1B) is a multifunctional cytokine that is highly expressed in rheumatoid arthritis (RA) and drives pro-inflammatory pathways via interleukin 1 receptor…
Abstract Number: 2867 • 2016 ACR/ARHP Annual Meeting
Aberrant Epigenetic Alterations at the Promoter up-Regulate cAMP Responsive Element Modulator Alpha in CD4+ T Cells from Patients with Systemic Lupus Erythematosus
Qing Zhang¹, Huilin Zhang², Shu Ding³, Hai Long⁴, Yi Zhan², Xiangning Qiu⁴ and Qianjin Lu⁴, ¹Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, ²Second Xiangya Hospital, Central South University, Changsha, China, ³Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Recently, accumulating studies have documented that up-regulated cAMP responsive element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays…
Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting
Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)
Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
Abstract Number: 1257 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Signatures of Salivary Gland Inflammation in Sjögren’s Syndrome
Michael Cole¹, Diana Quach¹, Hong L. Quach¹, Lisa F. Barcellos¹ and Lindsey A. Criswell², ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage
Oscar Alvarez-Garcia¹, Kathleen M. Fisch¹, Ryuichiro Akagi^2,3, Masahiko Saito⁴, Takahisa Sasho⁴, Andrew I. Su⁵ and Martin K. Lotz⁶, ¹The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, ⁴Orthopaedic Surgery, Chiba University, Chiba, Japan, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
Abstract Number: 1264 • 2015 ACR/ARHP Annual Meeting
Residential Proximity to Highways, DNA Methylation and Systemic Lupus Erythematosus
Cristina Lanata¹, Renuka Nayak², Joanne Nitiham¹, Kimberly Taylor³, Lisa F. Barcellos⁴, Sharon A. Chung⁵ and Lindsey A. Criswell^6,7, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ⁵School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁶Rheumatology, UCSF, SAN FRANCISCO, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by autoantibody formation in which multiple genetic, epigenetic and environmental risk factors have been implicated. We…
Abstract Number: 1610 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Changes Observed in Rheumatoid Arthritis Joint Tissue Are Detectable in CD4+ Naive T Cells from Peripheral Blood
Calliope Holingue¹, Brooke Rhead¹, Michael Cole¹, Xiaorong Shao¹, Hong L. Quach¹, Diana Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison⁵, Vladimir Chernitskiy⁶, Wei Wang⁷, Gary S. Firestein⁸, Lisa F. Barcellos¹ and Lindsey A. Criswell⁵, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Div Of Rheumatology, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁵Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁶Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁸Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Aberrant DNA methylation patterns have previously been associated with rheumatoid arthritis (RA) [MIM 180300]. Our study aimed to determine whether differentially methylated CpGs in…
Abstract Number: 1620 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Profiling of Rheumatoid Arthritis Peripheral Blood Identifies Hypermethylation of TRIM69 Promoter Region in CD4+ T Cells Associated with Disease Activity
Amanda Mok¹, Brooke Rhead¹, Calliope Holingue¹, Xiaorong Shao¹, Diana Quach¹, Hong L. Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison³, Vladimir Chernitskiy³, Wei Wang⁵, Gary S. Firestein⁶, Lisa F. Barcellos¹ and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Epigenetic modifications have been previously associated with rheumatoid arthritis (RA [MIM 180300]). This study aimed to determine whether differential DNA methylation in peripheral blood…
Abstract Number: 1623 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of DNA Methylation in Th1 and Th17 Cells in Rheumatoid Arthritis
Katharina Stutzer¹, Fausto Pirronello¹, Simone Wahl², Hendrik Schulze-Koops¹, Alla Skapenko¹ and Jan Leipe³, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany, ³Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by systemic inflammation. Although the understanding of the pathogenesis is incomplete, there is substantial evidence…
Abstract Number: 2017 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Governs the Ability of Apoptotic Cells to Suppress Inflammatory Arthritis Via Reciprocal Regulation of IL-6 and TGF-Beta
Clare Notley¹, Christine Jordan², Jenny McGovern², Mark Brown² and Michael R. Ehrenstein³, ¹Rheumatology, UCL, London, United Kingdom, ²UCL, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Apoptotic cells (AC) have potent anti-inflammatory effects. Injection of apoptotic dendritic cells into mice suppresses the severity of antigen-induced arthritis through increased TGFβ production…
Abstract Number: 2100 • 2015 ACR/ARHP Annual Meeting
Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjögren’s Syndrome
Juliana Imgenberg-Kreuz¹, Johanna K Sandling^1,2, Jonas Carlsson Almlöf¹, Jessica Nordlund¹, Linnea Signér², Katrine B Norheim³, Roald Omdal³, Majia-Leena Eloranta², Lars Rönnblom², Ann-Christine Syvänen¹ and Gunnel Nordmark², ¹Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Epigenetic modifications have emerged as important contributing factors in the pathogenesis of autoimmune diseases, including primary Sjögren’s syndrome (pSS), and may act as a…

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