ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "DNA Methylation"

  • Abstract Number: 1727 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of Interferon-Associated Genes in CD4+ and CD8+ T Cells

    Weilin Pu1, Weifeng Ding2, Lei Wang3, Shuai Jiang4, Wenzhen Tu3, Shicheng Guo5, Qingmei Liu6, Yanyun Ma4, Sidi Chen7, Wenyu Wu6, Xiaodong Zhou8, Maureen D. Mayes9, Shervin Assassi9, John D. Reveille9, Li Jin10 and Jiucun Wang10, 1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, 2Medical Laboratory Center, Medical Laboratory Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China, Nantong, China, 3Division of Rheumatology, Division of Rheumatology, Shanghai TCM-integrated Hospital, Shanghai, China, Shanghai, China, 4Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, Shanghai, China, 5Department of Bioengineering, Department of Bioengineering, University of California at San Diego, CA, USA, San Diego, CA, 6Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China, 7State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, 8Internal Medicine-Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9University of Texas McGovern Medical School, Houston, TX, 10State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China

    Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease caused by complicated interaction between genetic, epigenetic and environmental risk factors. Evidence showed epigenetic modifications,…
  • Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting

    TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages

    Emmanuel Karouzakis1, Fangfang Sun2, Agnieszka Pajak1, Shuang Ye2, Steffen Gay1, Oliver Distler3 and Michel Neidhart1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
  • Abstract Number: 2654 • 2017 ACR/ARHP Annual Meeting

    Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus

    Juliana Imgenberg-Kreuz1,2, Jonas Carlsson Almlöf1, Dag Leonard3, Gunnel Nordmark2, Maija-Leena Eloranta3, Leonid Padyukov4, Iva Gunnarsson4, Elisabet Svenungsson4, Christopher Sjöwall5, Lars Rönnblom2, Ann-Christine Syvänen1 and Johanna K Sandling1,2, 1Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 3Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 4Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 5Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden

    Background/Purpose: DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). SLE typically requires continuous treatment to control…
  • Abstract Number: 2108 • 2016 ACR/ARHP Annual Meeting

    DNA Hypomethylation in Promoter Region of Zbtb38 Gene Ultimately Leads to Downregulated Expression of Anti-Inflammatory IL1r2 in Experiential Model of Rheumatoid Arthritis

    Timea Ocskó1, Daniel M. Tóth1, Attila Balog2, Katalin Mikecz1, Tibor T. Glant1 and Tibor A. Rauch3, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, 31735 W. Harrison Str., Rush University Medical Center, Chicago, IL

    Background/Purpose: Interleukin 1 beta (IL1B) is a multifunctional cytokine that is highly expressed in rheumatoid arthritis (RA) and drives pro-inflammatory pathways via interleukin 1 receptor…
  • Abstract Number: 2867 • 2016 ACR/ARHP Annual Meeting

    Aberrant Epigenetic Alterations at the Promoter up-Regulate cAMP Responsive Element Modulator Alpha in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

    Qing Zhang1, Huilin Zhang2, Shu Ding3, Hai Long4, Yi Zhan2, Xiangning Qiu4 and Qianjin Lu4, 1Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, 2Second Xiangya Hospital, Central South University, Changsha, China, 3Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China, 4Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China

    Background/Purpose:  Recently, accumulating studies have documented that up-regulated cAMP responsive element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays…
  • Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting

    Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)

    Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose:  The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
  • Abstract Number: 74 • 2016 ACR/ARHP Annual Meeting

    Arthritis-Associated DNA Hypermethylation Provokes Increased Antibody Expression in Mouse Model of Rheumatoid Arthritis

    Daniel M. Tóth1, Timea Ocskó1, Adrienn Markovics1, Attila Balog2, Katalin Mikecz1, Tibor T. Glant1 and Tibor A. Rauch1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary

    Background/Purpose: Although a number of epigenetic alterations have been revealed in rheumatoid arthritis (RA), it remained an open question whether these epimutations play role in…
  • Abstract Number: 1130 • 2015 ACR/ARHP Annual Meeting

    Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage

    Matlock A. Jeffries1,2, Madison Andrews3, Mary Beth Humphrey1, Judith A. James4 and Amr H. Sawalha5, 1Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Association, Oklahoma City, OK, 3Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Univers, Oklahoma City, OK

    Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability affecting a majority of individuals over age 70. Outside of cartilage, little is known regarding…
  • Abstract Number: 1242 • 2015 ACR/ARHP Annual Meeting

    Germ Line DNA Methylation Profiling Provides Novel Insights into the Parent-of-Origin Effect in Psoriatic Disease

    Remy Pollock1, Darren O'Reilly2, Proton Rahman3, Vinod Chandran4 and Dafna Gladman4, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Memorial University of Newfoundland, St. John's, NF, Canada, 3Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, 4Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Parent-of-origin effects refer to the differential risk or pathogenicity of a disease that depends on the sex of the disease-transmitting parent. Excessive paternal transmission…
  • Abstract Number: 1250 • 2015 ACR/ARHP Annual Meeting

    DNA Methylation and Its Relation to Immunological Phenotypes in Peripheral Blood: A Study of Anti-CCP Antibody Positivity from a Population-Based Pool

    Sasha Bernatsky1, Xiaojian Shao2, Marie-Michelle Simon2, Marvin J. Fritzler3, Philip Awadalla4,5, Marie Hudson6, Ines Colmegna7, Tony Kwan2 and Tomi Pastinen2, 1Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 2Department of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada, 3Medicine, University of Calgary, Calgary, AB, Canada, 4Medicine, Université de Montreal, Montreal, QC, Canada, 5Ontario Institute for Cancer Research, Toronto, ON, Canada, 6McGill University, Jewish General Hospital, Montreal, QC, Canada, 7Rheumatology, McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: DNA methylation represents an important potential mediator of environmental influences on autoimmunity, including rheumatoid arthritis (RA).  Genome-wide methylation in the context of clinical phenotypes…
  • Abstract Number: 1255 • 2015 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Patterns in CD4+ T Reveal Significant Contribution of DNA Methylation to Rheumatoid Arthritis

    Shicheng Guo1,2, Ting Jiang1,2, Rongsheng Wang1,2, Yi Shen1,2, Xiao Zhu3, Fengmin Bai1,2, Qin Ding1,2, Guangjie Chen4 and Dongyi He1,2, 1Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China, 2Arthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China, 3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China, 4Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai, China

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence showed more and more importance of the epigenetic…
  • Abstract Number: 1257 • 2015 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Signatures of Salivary Gland Inflammation in Sjögren’s Syndrome

    Michael Cole1, Diana Quach1, Hong L. Quach1, Lisa F. Barcellos1 and Lindsey A. Criswell2, 1Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, 2Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
  • Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting

    Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage

    Oscar Alvarez-Garcia1, Kathleen M. Fisch1, Ryuichiro Akagi2,3, Masahiko Saito4, Takahisa Sasho4, Andrew I. Su5 and Martin K. Lotz6, 1The Scripps Research Institute, La Jolla, CA, 2The Scripps Research Institute, San Diego, CA, 3Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, 4Orthopaedic Surgery, Chiba University, Chiba, Japan, 5Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 6Division of Arthritis, The Scripps Research Institute, La Jolla, CA

    Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
  • Abstract Number: 1264 • 2015 ACR/ARHP Annual Meeting

    Residential Proximity to Highways, DNA Methylation and Systemic Lupus Erythematosus

    Cristina Lanata1, Renuka Nayak2, Joanne Nitiham1, Kimberly Taylor3, Lisa F. Barcellos4, Sharon A. Chung5 and Lindsey A. Criswell6,7, 1Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 2Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 3University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 4Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, 5School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 6Rheumatology, UCSF, SAN FRANCISCO, CA, 7Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by autoantibody formation in which multiple genetic, epigenetic and environmental risk factors have been implicated. We…
  • Abstract Number: 1610 • 2015 ACR/ARHP Annual Meeting

    DNA Methylation Changes Observed in Rheumatoid Arthritis Joint Tissue Are Detectable in CD4+ Naive T Cells from Peripheral Blood

    Calliope Holingue1, Brooke Rhead1, Michael Cole1, Xiaorong Shao1, Hong L. Quach1, Diana Quach1, Elizabeth Sinclair2, Jonathan D. Graf3, Thomas M. Link4, Ruby Harrison5, Vladimir Chernitskiy6, Wei Wang7, Gary S. Firestein8, Lisa F. Barcellos1 and Lindsey A. Criswell5, 1Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, 2Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, 3Div Of Rheumatology, Division of Rheumatology, UCSF, San Francisco, CA, 4Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 5Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 6Rheumatology, University of California, San Francisco, San Francisco, CA, 7Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 8Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA

    Background/Purpose: Aberrant DNA methylation patterns have previously been associated with rheumatoid arthritis (RA) [MIM 180300]. Our study aimed to determine whether differentially methylated CpGs in…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology