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Abstracts tagged "Disease-Modifying Antirheumatic Drugs (Dmards)"

  • Abstract Number: 1841 • ACR Convergence 2022

    To Combine or Not to Combine: Influence of Immunosuppressive Drug Combination in the Induction of Therapeutic Response in Non-infectious Uveitis

    María Paula Álvarez Hernández1, Alfredo Madrid-García2, Alejandro Gómez Gómez3, Lara Borrego Sanz4, Rosalía Méndez Fernández4, Pedro Arriola Villalobos4, Esperanza Pato Cour5, David Díaz Valle4 and Luis Rodriguez-Rodriguez5, 1Hospital Clínico San Carlos, Madrid, Spain, 2Instituto de Investigación Sanitaria San Carlos, Rheumatology, Madrid, Spain, Madrid, Spain, 3Hospital Infanta Sofia, Rheumatology, San Sebastián de los Reyes, Madrid, Spain, 4Instituto de Investigación Sanitaria San Carlos, Ophthalmology, Madrid, Spain, 5Instituto de Investigación Sanitaria San Carlos, Rheumatology, Madrid, Spain

    Background/Purpose: Non-infectious uveitides (NIUs) include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), prescribed…
  • Abstract Number: 2123 • ACR Convergence 2022

    Hierarchical Ranking of Biologic Disease-Modifying Antirheumatic Drugs and Targeted Systemic Therapies for Psoriatic Arthritis: A Network Meta-analysis

    Jesus Diaz1, Guillermo Quiceno2 and Adela Castro3, 1Hamilton Medical Center, Chattanooga, TN, 2UT Southwestern Medical Center, Dallas, TX, 3Hamilton Physician Group-Specialty Care, Dalton, GA

    Background/Purpose: There are an increasing number of biological and targeted DMARDs in PsA. However, challenges around treatment selection remain, given the few head-to-head studies directly…
  • Abstract Number: 0067 • ACR Convergence 2022

    Cost Per Responder in RA Patients Failing First Line Treatment

    Manuel Cardozo, Pharmalab PHL, Huixquilucan, Mexico

    Background/Purpose: The Colombian healthcare system is under economic pressure like many other systems in the world. In that sense, treatment choice involves cost in addition…
  • Abstract Number: 0289 • ACR Convergence 2022

    Real-world Data of Tofacitinib versus Tumor Necrosis Factor Inhibitors in Taiwanese Patients with Rheumatoid Arthritis from a Drug-based Registry

    Song-Chou Hsieh1, Wei-Sheng Chen2, Jui-Chieh Hu3, Wan-Yu Sung4, Wen-Chan Tsai4, Hsiang-Cheng Chen5, Chung-Ming Huang6, Edward Kuo7, James Wee8, John Woolcott9 and Yi-Hsing Chen10, 1Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 2Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 3Division of Allergy, Immunology and Rheumatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 4Department of Allergy, Immunology, and Rheumatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, 5Division of Immunology, Rheumatology, and Allergy, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan, 6Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, 7Pfizer Ltd, Taipei, Taiwan, 8Pfizer Inc, Makati City, Philippines, 9Pfizer, Inc, Collegeville, PA, 10Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA and was approved under Taiwan's National Health Insurance (NHI) reimbursement system in…
  • Abstract Number: 0414 • ACR Convergence 2022

    Efficacy and Safety of Upadacitinib in Patients with Ankylosing Spondylitis with Intolerance to And/or Lack of Efficacy of Prior Biologic Therapy: A Subgroup Analysis

    Xenofon Baraliakos1, Fabiana Ganz2, Hideto Kameda3, Jessica Walsh4, Manish Jain5, Kristin D’Silva6, Peter Wung6, Xianwei Bu6, Jayne Stigler6 and Désirée van der Heijde7, 1Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 2AbbVie, Inc., Luzern, Switzerland, 3Toho University, Tokyo, Japan, 4University of Utah, Salt Lake City, UT, 5Great Lakes Clinical Trials, Chicago, IL, 6AbbVie, Inc., North Chicago, IL, 7Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands

    Background/Purpose: Upadacitinib (UPA), an oral Janus kinase inhibitor, has been evaluated in the treatment of AS both in patients (pts) naïve to biologic DMARDs (bDMARDs)1…
  • Abstract Number: 0765 • ACR Convergence 2022

    The Impact of Immunomodulating Treatment on the Immunogenicity of COVID-19 Vaccines in Patients with Immune-mediated Inflammatory Rheumatic Diseases Compared to Healthy Controls. a Swedish Nationwide Study (COVID19-REUMA)

    Martina Frodlund1, Katerina Chatzidionysiou2, Anna Södergren3, Eva Klingberg4, Anders A Bengtsson5, Monika Hansson2, Sophie Ohlsson6, Elisa Pin7, Lars Klareskog8 and Meliha Kapetanovic9, 1Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, 2Department of Medicine, Solna, Division of Rheumatology, Karolinska University Hospital at Karolinska Institutet, Stockholm, Sweden, 3Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden and Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden, 4Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 5Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden, 6Department of Clinical Sciences, Lund, Section for Nephrology, Lund University, Lund and Skåne University Hospital, Lund, Sweden, 7Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden, 8Karolinska Institutet, Stockholm, Sweden, 9Lund University, Department for clinical sciences Lund, section of rheumatology and Lund University Hospital Lund and Malmö, Lund, Sweden

    Background/Purpose: The aim of the study was to elucidate antibody responses after vaccination with two doses of COVID-19 vaccines in patients with inflammatory rheumatic diseases…
  • Abstract Number: 0919 • ACR Convergence 2022

    Predictors of Methotrexate Monotherapy Response in Patients with Active Rheumatoid Arthritis: Results from a Multicentre, Randomized Controlled Trial

    Siddharth Jain1, Varun Dhir2, Amita Aggarwal3, Ranjan Gupta4, Bidya Laishangtham1, Aastha Khullar1, Shankar Naidu1, Veena Dhawan1, Shefali Sharma5, Aman Sharma6 and sanjay jain1, 1Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2PGIMER, CHD, INDIA, Chandigarh, India, 3Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 4All India Institute of Medical Sciences, New Delhi, India, 5PGIMER< Chandigarh, Chandigarh, India, 6PGIMER, Chandigarh, India, Chandigarh, India

    Background/Purpose: Methotrexate (MTX) is the gold standard, first-line therapy for rheumatoid arthritis (RA). However, not all patients respond to MTX, and the predictors of its…
  • Abstract Number: 1125 • ACR Convergence 2022

    Genomics of JAK-STAT Signaling in Venous Thromboembolism

    Stine R Haysen, Ane Langkilde-Lauesen Nielsen, Per Qvist and Tue Kragstrup, Aarhus University, Aarhus, Denmark

    Background/Purpose: Janus kinase inhibitors (JAKi) have been associated with an increased risk of venous thromboembolism (VTE). This concern limits the use of JAKi-based therapy. Hence,…
  • Abstract Number: 1427 • ACR Convergence 2022

    Impact of Upadacitinib versus Abatacept on Individual Disease Outcomes in Patients with Rheumatoid Arthritis and Inadequate Responses to Biologic DMARDs

    Ronald van Vollenhoven1, Andrea Rubbert-Roth2, Stephen Hall3, Ricardo Xavier4, Anna K Shmagel5, Yanna Song5, Samuel Anyanwu5 and Vibeke Strand6, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland, 3Emeritus Research and Monash University, Melbourne, Australia, 4Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, 5AbbVie, Inc., North Chicago, IL, 6Stanford University School of Medicine, Stanford, CA

    Background/Purpose: The phase 3 SELECT-CHOICE trial of patients with rheumatoid arthritis (RA) and prior inadequate response to biologic DMARD(s) (bDMARD-IR) demonstrated superiority of the JAK…
  • Abstract Number: 1843 • ACR Convergence 2022

    Trends in the Cumulative Exposure to Corticosteroids in Polymyalgia Rheumatica (PMR) Patients: A Single Academic Center Experience

    Vivekanand Tiwari1, Vishnuteja Devalla2, Emily Campbell1 and William Rigby1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Essential Health St. Joseph's-Brainerd Clinic, Brainerd, MN

    Background/Purpose: Polymyalgia rheumatica (PMR) treatment is predominantly based on long-term corticosteroids, which results in significant corticosteroid-related toxicities. Studies1,2 have shown patients with PMR are exposed…
  • Abstract Number: 2126 • ACR Convergence 2022

    Impact of Risankizumab on Enthesitis and Dactylitis: Integrated Analysis of the Phase 3, Randomized, Double-Blind KEEPsAKE 1 and 2 Trials

    Shawn Kwatra1, Saakshi Khattri2, Ahmad Amin3, Huzefa Photowala4, Ran Liu4, Byron Padilla5, Blair Kaplan4 and Dennis McGonagle6, 1John Hopkins University, Baltimore, MD, 2Mount Sinai Medical Center, New York, NY, 3Northwestern Medicine Dermatology, Chicago, IL, 4AbbVie, Inc., North Chicago, IL, 5AbbVie, Inc., Waukegan, IL, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research, Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Psoriatic arthritis (PsA) is a progressive condition with chronic inflammation and joint destruction impacting quality of life.1 Dactylitis and enthesitis are clinically relevant domains…
  • Abstract Number: 0073 • ACR Convergence 2022

    Opioid and Pain Medication Prescribing by Rheumatologists for Medicare Part D Beneficiaries from 2013 to 2019

    Erin Valley1, Connor Pedersen1, Kathryn Henry2, Ali Duarte-Garcia3, Viktoriya Sabchyshyn1 and Mike Putman4, 1Medical College of Wisconsin, Milwaukee, WI, 2Medical College of Wisconsin, Manitowoc, WI, 3Mayo Clinic, Rochester, MN, 4The Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Prescription opioid medications are highly effective in managing acute pain, but their use for chronic pain remains controversial. The objective of this study is…
  • Abstract Number: 0290 • ACR Convergence 2022

    Evaluation of Treatment Discontinuation Due to Adverse Events, and the Effect of Cardiovascular Risk Factors or Type of JAK-inhibitors: An International Collaboration of Registries of Rheumatoid Arthritis Patients (the ‘JAK-pot‘ Study)

    Kim Lauper1, Romain Aymon2, Denis Mongin2, Sytske Anne Bergstra3, Denis Choquette4, Catalin Codreanu5, Ori Elkayam6, Kimme Hyrich7, Florenzo Iannone8, Nevsun Inanc9, Lianne Kearsley-Fleet10, Tore K. kvien11, Eirik Kristianslund12, Burkhard Leeb13, Galina Lukina14, Dan Nordstrom15, Karel Pavelka16, Manuel Pombo-Suarez17, Ziga Rotar18, Maria José Santos19, Delphine Courvoisier20 and Axel Finckh21, 1Geneva University Hospitals, Genéve, Switzerland, 2Geneva University Hospitals, Geneva, Switzerland, 3LUMC, Leiden, Netherlands, 4Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, 5Center for Rheumatic Diseases, Bucharest, Romania, 6Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7The University of Manchester, Manchester, United Kingdom, 8School of Medicine University of Bari, Bari, Italy, 9Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 10Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, 11Diakonhjemmet Hospital, Oslo, Norway, 12Diakonhjemmet Hospital, Division of Rheumatology and Research, Oslo, Norway, 13Bioreg, Stockerau, Austria, 14Federal state budgetary scientific institution �Research Institute of rheumatology named after V. A. Nasonova�, Moscow, Russia, 15Helsinki University Hospital, Helsinki, Finland, 16Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 17Hospital Clinico Universitario, Santiago de Compostela, Spain, 18University Medical Centre Ljubljana, Ljubljana, Slovenia, 19Hospital Garcia de Orta, Almada, Charneca da Caparica, Portugal, 20University Hospitals of Geneva, Geneva, Switzerland, 21Geneva University Hospital, Geneve - Vesenaz, Switzerland

    Background/Purpose: The "ORAL Surveillance" study1 suggests an increased risk of serious adverse events (AEs) with tofacitinib, a JAK-inhibitor (JAKi), compared to TNF-inhibitors (TNFi). Currently, there…
  • Abstract Number: 0421 • ACR Convergence 2022

    Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis by Prior bDMARD Treatment: Analysis of a Phase 3 Trial

    Atul Deodhar1, Helena Marzo-Ortega2, Joseph Wu3, Cunshan Wang3, Oluwaseyi Dina4, Keith S Kanik3, Lara Fallon5 and Lianne Gensler6, 1Oregon Health & Science University, Portland, OR, USA, Portland, OR, 2Leeds Teaching Hospitals Trust and University of Leeds, Leeds, United Kingdom, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Montréal, QC, Canada, 6Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA

    Background/Purpose: Prior exposure to biologic (b)DMARD therapy of patients (pts) with AS may influence treatment response.1-3 Tofacitinib is an oral JAK inhibitor for the treatment…
  • Abstract Number: 0787 • ACR Convergence 2022

    Relationship Between Humoral and Cellular Immune Responses in Persons with Rheumatoid Arthritis Following a Third Dose of COVID-19 Vaccine

    Sara Tedeschi1, Daniel Solomon1, Yuezhou Chen2, Jack Ellrodt1, Mary Grace Whelan1, Jacklyn Stratton1, Keigo Hayashi3, Noah Whiteman2, Lin Chen1, Ifeoluwakiisi Adejoorin1, Kathryne Marks1, Emma Gomez-Rivas1, Deepak Rao1, Anna Jonsson1 and Duane Wesemann2, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Okayama, Japan

    Background/Purpose: DMARDs that treat RA may reduce immune responses to COVID-19 vaccination. We compared measures of humoral and cell-mediated immunity in RA patients before and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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