ACR Meeting Abstracts

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Abstracts tagged "Disease-modifying antirheumatic drugs"

  • Abstract Number: 1336 • 2019 ACR/ARP Annual Meeting

    Systematic Literature Review and Meta-Analysis of DAS28 Clinical Response Rates Among Advanced Therapies in Biologic-Naïve Patients with Rheumatoid Arthritis

    Daniel Aletaha1, Ruta Sawant 2, Patrick Zueger 3, Erin Cook 4, Fan Mu 4, Vishvas Garg 2 and Keith A. Betts 4, 1Medical University of Vienna, Vienna, Austria, 2AbbVie Inc., North Chicago, IL, 3AbbVie Inc., North Chicago, 4Analysis Group, Inc., Boston, MA

    Background/Purpose: Biologic (b) and targeted synthetic (ts) DMARDs have demonstrated efficacy for the treatment of rheumatoid arthritis (RA) in clinical trials; however, real-world evidence on…
  • Abstract Number: 1343 • 2019 ACR/ARP Annual Meeting

    Pop a Pill or Give Myself a Shot? Patient Perspectives of Disease-modifying Anti-rheumatic Drug (DMARD) Choice for Rheumatoid Arthritis (RA)

    Jasvinder Singh1, Haley Tornberg 2 and Susan Goodman 3, 1University of Alabama Medical Center, Birmingham, 2Hospital for Special Surgery, New York, NY, 3Hospital For Special Surgery/Weill Cornell Medicine, New York, NY

    Background/Purpose: Little is known about the patient perspective related to DMARD choice in RA. Our objective was to assess how patients decide whether to add…
  • Abstract Number: 1393 • 2019 ACR/ARP Annual Meeting

    Impact of Sarilumab on Unacceptable Pain and Inflammation Control in Moderately-to-Severely Active Rheumatoid Arthritis (RA) Patients in 3 Phase 3 Studies

    Vivian Bykerk1, Wenhui Wei 2, Susan Boklage 2, Toshio Kimura 2, Stefano Fiore 3 and Gregory St John 4, 1Hospital for Special Surgery, New York City, NY, 2Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 3Sanofi Genzyme, Bridgewater, NJ, 4Regeneron Pharmaceuticals, Inc., Tarrytown, NY

    Background/Purpose: Pain, a core-set domain and a troubling symptom to patients with RA, may be directly related to inflammation. Unacceptable pain (UP) levels may persist…
  • Abstract Number: 1414 • 2019 ACR/ARP Annual Meeting

    Improvement of Mental Health and Quality of Life During Therapy with Tocilizumab

    Frank Behrens1, Werner A Biewer 2, Gerd Burmester 3, Martin Feuchtenberger 4, Michael W. Hofmann 5, Peter Kästner 6, Herbert Kellner 7, Ramona König 8, Anke Liebhaber 9, Christina Luig 10, Regina Max 11, Patrizia Sternad 12, Hans-Peter Tony 13 and Christopher Amberger 14, 1Rheumatology Goethe-University Frankfurt & Fraunhofer IME-TMP, Frankfurt, Germany, 2Rheumatologische Schwerpunktpraxis Saarbrücken, Saarbrücken, Germany, 3Charité—University Medicine Berlin, Berlin, Germany, 4Rheumatologie/Klinische Immunologie, Kreiskliniken Altötting-Burghausen, Burghausen, Germany, 5Chugai Pharma Europe Ltd., Frankfurt/Main, Germany, 6MVZ Ambulantes Rheumazentrum Erfurt, Erfurt, Germany, 7Praxis Prof. Herbert Kellner, Munich, Germany, 8Justus-Liebig-Universität Giessen and Kerckhoff-Klinik-Forschungs-GmbH, Giessen, Germany, 9Internistisch-Rheumatologische Arztpraxis, Halle, Halle, Germany, 10Roche Pharma AG, Rheumatologie, Grenzach-Wyhlen, Germany, 11Universitätsklinikum Heidelberg, Heidelberg, Germany, 12Gemeinschaftspraxis, Planegg, Planegg, Germany, 13Department of Rheumatology/Clinical Immunology, University Hospital, Wuerzburg, Germany, Würzburg, Germany, 14Rheumatologische Gemeinschaftspraxis Dr. Pick/Dr. Amberger, Bad Neuenahr, Germany

    Background/Purpose: In rheumatoid arthritis (RA), the proinflammatory cytokine IL-6 is associated with mental disorders such as depression and anxiety.1 Furthermore, depression and anxiety are comorbidities…
  • Abstract Number: 2370 • 2019 ACR/ARP Annual Meeting

    Discontinuation of Disease Modifying Drugs in Patients with Incident Rheumatoid Arthritis

    pia Lois1, Zulema Rosales Rosado 1, Judit Font Urgelles 2, Cristina Vadillo Font 1, isabel Hernandez Rodriguez 1, Juan Angel Jover Jover 1 and lydia Abasolo Alcazar 1, 1HOSPITAL CLINICO SAN CARLOS, MADRID, Spain, 2HOSPITAL CLINICO SAN CARLOS, MADRID, Madrid, Spain

    Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has undergone a big change in the last two decades in strategies, objectives and therapeutic options, especially with the…
  • Abstract Number: 2387 • 2019 ACR/ARP Annual Meeting

    Management of Patients with Incident Rheumatoid Arthritis in Rheumatology Clinical Practice

    isabel Hernandez Rodriguez1, Zulema Rosales Rosado 1, pia Lois 1, Cristina Lajas 1, Judit Font Urgelles 2, Juan Angel Jover Jover 1 and lydia Abasolo Alcazar 1, 1HOSPITAL CLINICO SAN CARLOS, MADRID, Spain, 2HOSPITAL CLINICO SAN CARLOS, MADRID, Madrid, Spain

    Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has changed drastically in the last two decades in strategies and objectives, as well as in therapeutic options, especially…
  • Abstract Number: 2833 • 2019 ACR/ARP Annual Meeting

    Shared Decision Making in Routine Clinical Practice: An Assessment of Audio-recorded Consultations with Rheumatoid Arthritis Patients

    Elke Mathijssen1, Johanna Vriezekolk 2 and Bart van den Bemt 2, 1Sint Maartenskliniek, Ubbergen, Netherlands, 2Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose: International guidelines for rheumatoid arthritis (RA) treatment emphasize that all treatment decisions should be made through a shared decision making (SDM) process between clinicians…
  • Abstract Number: 507 • 2019 ACR/ARP Annual Meeting

    Inhibition of Joint Destruction in Patients with Rheumatoid Arthritis Treated with Peficitinib in Combination with Methotrexate: A Randomized, Double-Blind, Placebo-Controlled Trial in Japan

    Tsutomu Takeuchi1, Yoshiya Tanaka 2, Mitsuhiro Rokuda 3, Hiroyuki Izutsu 3, Yuichiro Kaneko 3, Musashi Fukuda 3, Daisuke Kato 3 and Désirée van der Heijde 4, 1Keio University School of Medicine, Tokyo, Japan, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Astellas Pharma, Inc., Tokyo, Japan, 4Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Peficitinib (PEF), a novel oral Janus kinase (JAK) inhibitor, has demonstrated efficacy in Phase 3 studies of patients with RA (NCT02305849).1 We report the…
  • Abstract Number: 519 • 2019 ACR/ARP Annual Meeting

    Efficacy of Biosimilar Candidate ABP 710 in a Phase 3 Study in Subjects with Moderate to Severe RA: Additional Analysis Focusing on the ACR Individual Components

    Mark Genovese1, Juan Sanchez-Burson 2, Éva Balázs 3, Andrea Everding 4, MyungShin Oh 5, Gary Fanjiang 5 and Stanley Cohen 6, 1Stanford University, Stanford, CA, 2Hospital Infanta Luisa, Sevilla, Spain, 3Dr. Bugyi István Hospital, Szentes, Hungary, 4HRF Hamburger Rheuma Forschungszentrum, Hamburg, Germany, 5Amgen, Thousand Oaks, CA, 6Metroplex Clinical Research Center, Dallas, TX

    Background/Purpose: ABP 710 is being developed as a biosimilar to infliximab. Both ABP 710 and infliximab reference product (RP) inhibit tumor necrosis factor-alpha. Following demonstration…
  • Abstract Number: 520 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety Results from a Phase 3 Study of Biosimilar Candidate ABP 710 in Subjects with Moderate to Severe RA

    Mark Genovese1, Juan Sanchez-Burson 2, Éva Balázs 3, Andrea Everding 4, MyungShin Oh 5, Gary Fanjiang 5 and Stanley Cohen 6, 1Stanford University, Stanford, CA, 2Hospital Infanta Luisa, Sevilla, Spain, 3Dr. Bugyi István Hospital, Szentes, Hungary, 4HRF Hamburger Rheuma Forschungszentrum, Hamburg, Germany, 5Amgen, Thousand Oaks, CA, 6Metroplex Clinical Research Center, Dallas, TX

    Background/Purpose: ABP 710 is being developed as a biosimilar to infliximab. Both ABP 710 and infliximab reference product (RP) inhibit tumor necrosis factor-alpha and have…
  • Abstract Number: 521 • 2019 ACR/ARP Annual Meeting

    Discontinuation of Disease Modifying Drugs Due to Inefficacy in Patients with Incident Rheumatoid Arthritis

    Zulema Rosales Rosado1, pia Lois 1, Arkaitz Mucientes Ruiz 1, Esperanza Pato Cour 1, Dalifer Freites Nuñez 2, Juan Angel Jover Jover 1, lydia Abasolo Alcazar 1 and Leticia León 3, 1HOSPITAL CLINICO SAN CARLOS, MADRID, Spain, 2Hospital Clínico San Carlos, MADRID, Spain, 3Fundación para la Investigación Biomedica, Madrid, Madrid, Spain

    Background/Purpose: The treatment of Rheumatoid Arthritis (RA) has undergone a big change in the last two decades with the Disease Modifying Drugs (DMARDs). These drugs…
  • Abstract Number: 528 • 2019 ACR/ARP Annual Meeting

    Assessment of Bone and Cartilage Turnover Markers Following Treatment with Repository Corticotropin Injection in Patients with Persistently Active Rheumatoid Arthritis

    Roy Fleischmann1, Daniel Furst 2, Erin Connolly-Strong 3, Jingyu Liu 3, Julie Zhu 3 and Richard Brasington 4, 1Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 2University of California, Los Angeles, CA, 3Mallinckrodt Pharmaceuticals, ARD, LLC, Bedminster, NJ, 4Washington University School of Medicine in St Louis, St Louis, MO

    Background/Purpose: Persistently active rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and bone loss.1 Although short-term administration of corticosteroids (CSs) is recommended…
  • Abstract Number: 849 • 2019 ACR/ARP Annual Meeting

    Risk of Malignancies Associated with Biologics in Rheumatoid Arthritis: Analysis of a National Claim Database

    Raphaèle Seror1, Alexandre Lafourcade 2, yann De Rycke 2, Bruno Fautrel 3, Xavier Mariette 4 and Florence Tubach 5, 1Université Paris Sud, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM UMR 1184, Le Kremlin-Bicêtre, France, 2Biostatistics, Public Health and Medical Information department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, Paris, France, 3Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, 5Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France

    Background/Purpose: Our objectives were to estimate and compare the incidence rate of malignancies between biologic and csDMARD-treated RA patients.Methods: We conducted an historical cohort study…
  • Abstract Number: 953 • 2019 ACR/ARP Annual Meeting

    Treatment Patterns and Persistency Following the First Biologic DMARD in Patients with Rheumatoid Arthritis: Real-World Analysis of 2012–2016 US Medicare Data

    Robin Dore1, Lawrence Chang 2, Yuanyuan Ji 3, Suying Li 3, Jenya Antonova 2 and Mark Genovese 4, 1Private practice, Tustin, CA, 2Gilead Sciences, Foster City, CA, 3Chronic Disease Research Group, Minneapolis, MN, 4Stanford University, Stanford, CA

    Background/Purpose: In RA patients not meeting treat-to-target goals despite treatment with a biologic (b)DMARD, ACR guidelines1 recommend using other targeted immunomodulators (TIM): TNF-α inhibitor (TNFi),…
  • Abstract Number: 1134 • 2019 ACR/ARP Annual Meeting

    Medicaid Spending (2013-2017) on Disease Modifying Agents Commonly Used in Rheumatoid Arthritis

    Deepan Dalal1, Tingting Zhang 2 and Theresa Shireman 2, 1Brown University, Riverside, RI, 2Brown University, Providence, RI

    Background/Purpose: The management of rheumatoid arthritis (RA) and other conditions have improved tremendously since the introduction of biologic disease modifying agents (DMARDs). However, these agents…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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