Abstracts tagged "Disease Activity"

Abstract Number: 1871 • 2014 ACR/ARHP Annual Meeting
Puberty and Disease Activity in JIA
Philomine A. van Pelt¹, Aike.a. Kruize², Anita C.S. Hokken-Koelega³, Radboud JEM Dolhain⁴, Johannes WJ Bijlsma⁵ and Nico M. Wulffraat⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁵Dept of Rheumatology and Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁶Paediatric Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
Background/Purpose Delayed puberty and decreased final length has been reported in chronic diseases like Crohn's disease and JIA with a disease onset at prepubertal age.…
Abstract Number: 1375 • 2014 ACR/ARHP Annual Meeting
Educational Level and Not Ethnicity an Important Determinant of Disease Progression in Patients with Rheumatoid Arthritis
Sharon Dowell¹, Gail S. Kerr², Yusuf Yazici³, Christopher Swearingen⁴, Mercedes Quinones⁵, Luis R. Espinoza⁶, Edward L. Treadwell⁷, Theresa Lawrence-Ford⁸, Yvonne Sherrer⁹, Angelia Mosley-WIlliams¹⁰, Ignacio Garcia-Valladares¹¹, Rodolfo Perez Alamino¹², Chunqiao Luo¹³, Akgun Ince¹⁴, Adrian Godoy¹ and John Amatruda¹⁵, ¹Division of Rheumatology, Howard University, Washington, DC, ²Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Pediatrics and Biostatistics, University of Arkansas, Little Rock, AR, ⁵Division of Rheumatology, Howard University Hospital, Washington, DC, ⁶Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA, ⁷Dept Medicine Div of Rheum, East Carolina University, Greenville, NC, ⁸North Georgia Rheumatology Group, PC, Lawrenceville, GA, ⁹Rheum/Immunology, Centre Rheum Immunol Arthritis, Fort Lauderdale, FL, ¹⁰Rheumatology, Detroit VAMC, Detroit, MI, ¹¹Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ¹²internal Medicine, LSUHSC, New Orleans, LA, ¹³University of Arkansas for Medical Sciences, Little Rock, AR, ¹⁴Arthitis Consultants Inc, St. Louis University, St. Louis, MO, ¹⁵Rheumatology, Howard University, Washington, DC
Background/Purpose: Formal educational level is often used as a surrogate for socioeconomic status and in patients with rheumatoid arthritis (RA), low levels have been associated…
Abstract Number: 1002 • 2014 ACR/ARHP Annual Meeting
Global Transcriptome Analysis in Osteoarthritic Cartilage Reveals Significant Differential Gene Expression and Associations with Histologic Disease Progression
Matlock A. Jeffries^1,2, Madison Donica³, Anand Annan⁴, Michael Stevenson⁵, Mary Beth Humphrey^6,7, Judith A. James^6,8 and Amr H. Sawalha⁹, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Pathol;ogy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Rheumatology/Immunology/Arthritis Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in…
Abstract Number: 622 • 2014 ACR/ARHP Annual Meeting
Gut Microbiota Variations Correlate with Disease Activity in Spondyloarthritis (SpA) and Rheumatoid Arthritis (RA)
Julien Tap^1,2, Jad Abou-Ghantous¹, Ariane Leboime³, Roula Said Nahal³, Philippe Langella¹, Henri-Jean Garchon⁴, Gilles Chiocchia⁵, Jean-Pierre Furet¹ and Maxime Breban^3,4, ¹UMR INRA-AgroParisTech 1319, Equipe ProbiHote, MICALIS Institute, National Institute for Agronomical research (INRA), Jouy-en-Josas, France, ²Metagenopolis, INRA, Jouy-en-Josas, France, ³Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁴INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Inflammatory bowel diseases (IBD) are associated with changes in microbiota which may be responsible for sustained gut inflammation and/or a consequence of it. Whether…
Abstract Number: 388 • 2014 ACR/ARHP Annual Meeting
Soluble TREM-1 Is a Biomarker of Anti-CCP-Positive, DMARD-Naive Early Rheumatoid Arthritis
Shachaf Ofer-Shiber¹, Elisheva Pokroy-Shapira², Yair Molad^3,4, Shirly Oren², Hagit Shay-Aharoni² and Ilan Babai⁵, ¹Department of Internal Medicine H, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ²Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ³Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Teqva, Israel, ⁴Laboratory of Inflammation Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ⁵Laboratory of Clinical Immunology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
Background/Purpose : Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface receptor, expressed mainly on monocytes and neutrophils and involved in amplification of the inflammatory…
Abstract Number: 107 • 2014 ACR/ARHP Annual Meeting
Use of Internet in Adolescents and Young Adults with JIA
Philomine A. van Pelt¹, Constance H.C. Drossaert², Radboud JEM Dolhain³, A.a. Kruize⁴, Jaap Huisman⁵ and Nico Wulffraat⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Psychology, Health and Technology, University of Twente, Enschede, Netherlands, ³Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Pediatric Psychology, Wilhelmina's Children Hospital UMC Utrecht, Utrecht, Netherlands, ⁶Paediatric Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Internet-use is increasing since it is an efficient way to find information. Information obtained via Health Related Internet (HRI) sites, or online peer support…
Abstract Number: 2967 • 2014 ACR/ARHP Annual Meeting
Patient Reported Pain By the Paindetect Questionnaire Reveals Multimodal Elements to Pain Perception in Rheumatoid Arthritis
Saqa Ahmed¹, Tejal Magan¹, Mario Vargas¹, Abiola Harrison¹ and Nidhi Sofat², ¹Rheumatology, Mailpoint J1A, St George's, University of London, London, United Kingdom, ²Rheumatology, St. George's University of London, London, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted towards synovial joints. Inhibition of pro-inflammatory networks by disease-modifying anti-rheumatic drugs…
Abstract Number: 2615 • 2014 ACR/ARHP Annual Meeting
Preliminary Assessment of a Multi-Biomarker Disease Activity Test for Axial Spondyloarthritis
Walter P. Maksymowych¹, Stephanie Wichuk¹, P. Scott Eastman² and Eric H. Sasso³, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Crescendo Bioscience, Inc., South San Francisco, CA, ³Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose There has been limited validation of soluble biomarker measures of disease activity in patients with axial spondyloarthritis (SpA). C-reactive protein (CRP) is most commonly…
Abstract Number: 2379 • 2014 ACR/ARHP Annual Meeting
Minimal Radiographic Progression in RA Patients Receiving Routine Care in the Espoir Early Arthritis Cohort: Similar Prognosis According to 6 Different Remission Criteria
Isabel Castrejón¹, Maxime Dougados², Bernard Combe³, Francis Guillemin⁴, Bruno Fautrel⁵ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Université Paris René Descartes and Hôpital Cochin, Paris, France, ³Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁴Nancy University Hospital, Nancy, France, ⁵Rheumatology, UPMC GRC08, Paris 06 University, Pitié Salpétrière Hospital, Paris, France
Background/Purpose Remission has become a more achievable goal in rheumatoid arthritis (RA). Several criteria for remission are available in RA, including one based on RAPID3…
Abstract Number: 1868 • 2014 ACR/ARHP Annual Meeting
Can DAS 28 at 3 Months after the 1^st Biologic Therapy Predict Subsequent Sustainable Clinical Remission in Polyarticular Juvenile Idiopathic Arthritis Patients?
Tomohiro Kubota¹, Syuji Takei², Tsuyoshi Yamatou³, Tomokazu Nagakura⁴, Hiroyuki Imanaka³, Yukiko Nonaka³, Tomoko Takezaki³, Harumi Akaike³ and Mio Matsuura⁵, ¹8-35-1 Sakuragaoka, Kagoshima University Hospital, Kagoshima City, Japan, ²School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ³Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, ⁴Department of Pediatrics, House of Meguminoseibo, Usuki, Japan, ⁵Kagoshima University, Kagoshima-Shi, Japan
Background/Purpose: To avoid the progression of joint damage, early decision making is important in JIA patients who failed to achieve sustainable clinical remission by…
Abstract Number: 1371 • 2014 ACR/ARHP Annual Meeting
Impact of Metabolic Syndrome (MetS) on Rheumatoid Arthritis Disease Activity
Federico Parra-Salcedo¹, Irazú Contreras-Yáñez², Daniel Elías-López³, Carlos A. Aguilar-Salinas³ and Virginia Pascual-Ramos⁴, ¹Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán., Mexico City, Mexico, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose The purpose of the study was to describe prevalence and components (c) of MetS in a cohort of early RA, to compare it with…
Abstract Number: 947 • 2014 ACR/ARHP Annual Meeting
Efficacy and Safety of NNC01140006, an Anti-IL-21 Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis
Juan D. Cañete¹, Piotr Leszczynski², Rikke Riisbro³ and Klaus S. Frederiksen³, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Department of Rheumatology and Rehabilitation, Poznan Medical University, Poznan, Poland, ³Novo Nordisk A/S, Søborg, Denmark
Background/Purpose A phase 2, randomised, double-blind, placebo-controlled, parallel-group trial was conducted to evaluate the efficacy and safety of NNC0114-0006 in patients with active rheumatoid arthritis…
Abstract Number: 589 • 2014 ACR/ARHP Annual Meeting
Patients with Nr-Axspa Show a Statistically Higher Disease Burden in Clinical Practice Compared with Patients with Radiographic Axial Spa
Lennart TH Jacobsson¹, Tomas Husmark², Elke Theander³, Kenneth Henriksson⁴, Katharina Büsch⁵ and Martin Johansson⁵, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Rheumatology, Falu Hospital, Falun, Sweden, ³Skane University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Rheumatology city clinic, Stockholm, Sweden, Stockholm, Sweden, ⁵AbbVie AB, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose The ASAS axial SpA classification criteria was published in 2009 but so far there has been limited research on axial SpA patients in clinical…
Abstract Number: 387 • 2014 ACR/ARHP Annual Meeting
Levels of IgG Autoantibodies to Oxidation-Associated MDA Neo-Determinants Are a Biomarker for Systemic Inflammation and Disease Activity in SLE and RA
Caroline Grönwall¹, Lelise Getu², Jeffrey D. Greenberg³, Robert M. Clancy⁴ and Gregg J. Silverman¹, ¹Medicine, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Rheumatology, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose Monitoring disease activity in patients with autoimmune rheumatic disease is an essential part of clinical care. Highly reactive malondialdehyde (MDA) arise from reactive oxygen…
Abstract Number: L17 • 2014 ACR/ARHP Annual Meeting
Bariatric Surgery Improves Rheumatoid Arthritis Disease Activity, Reduces Inflammatory Markers, and Decreases Medication Usage
Jeffrey A. Sparks¹, Florencia Halperin², Jonathan C. Karlson³, Elizabeth W. Karlson¹ and Bonnie L. Bermas¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Obesity causes a chronic inflammatory state. Increased body mass index (BMI) is associated with incident rheumatoid arthritis (RA) and may impact RA disease activity.…

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