ACR Meeting Abstracts

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Abstracts tagged "Disease Activity"

  • Abstract Number: 1550 • 2013 ACR/ARHP Annual Meeting

    Validation Of The Ankylosing Spondylitis Disease Activity Score and Effectiveness Of Infliximab In The Treatment Of Ankylosing Spondylitis Over 4 Years: The Canadian Experience

    Proton Rahman1, Denis Choquette2, Majed M. Khraishi3, William G. Bensen4, Saeed A. Shaikh5, Dalton E. Sholter6, Maqbool K. Sheriff7, Emmanouil Rampakakis8, John S. Sampalis8, Francois Nantel9, Susan M. Otawa10, Allen J. Lehman10 and May Shawi11, 1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 2Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 3Nexus Clinical Research, St John's, NF, Canada, 4Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 5Medicine, McMaster University, St Catharines, ON, Canada, 6Rheumatology Associates, Edmonton, AB, Canada, 7Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 8JSS Medical Research, Montreal, QC, Canada, 9Janssen Inc., Toronto, ON, Canada, 10Medical Affairs, Janssen Inc., Toronto, ON, Canada, 11Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: The efficacy of anti-TNF in the management of Ankylosing Spondylitis (AS) has been demonstrated in numerous controlled clinical trials. The objective of this study…
  • Abstract Number: 1322 • 2013 ACR/ARHP Annual Meeting

    Osteoprotegerin and TNF-Related Apoptosis Inducing Ligand Are Respectively Predictive Factors Of Remission and Erosion In Early Rheumatoid Arthritis Patients Included In The French Cohort Espoir

    Rachel Audo1, Laura Papon1, Claire I. Daien1,2, Cédric Lukas3, Bernard Combe2, Olivier Vittecoq4, Michael Hahne1 and Jacques Morel5, 1IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 2Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 3Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, 4Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, 5Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France

    Background/Purpose: TNF-Related Apoptosis Inducing Ligand (TRAIL) is a member of the TNF familly. Its soluble receptor Osteoprotegerin (OPG) also inhibits Receptor activator of nuclear factor…
  • Abstract Number: 665 • 2013 ACR/ARHP Annual Meeting

    DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis

    Yaoyao Wang1, Ye Shu2, Qing Wang1, Ming Zhao1, Gongping Liang1, Qianjin Lu1 and Rong Xiao1, 1Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, 2Department of Dermatology, Hunan Children's Hospital, Changsha, China

    Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of which the etiology and pathogenesis remains complex and poorly understood.  Attention has recently been directed…
  • Abstract Number: 25 • 2013 ACR/ARHP Annual Meeting

    SLE Flares Are Characterized By Generalized Polyclonal Expansions Of Antibody Secreting Cells Without Preference For Autoimmune Responses

    H. Travis Ichikawa, Medicine, Emory University, Atlanta, GA

    Background/Purpose: Increased circulating antibody secreting cells (ASC), including both CD138- plasmablasts and CD138+ plasma cells (PB/PC), correlate with SLE activity and are prominent during Lupus…
  • Abstract Number: 2837 • 2013 ACR/ARHP Annual Meeting

    Higher Disease Activity Leads To More Damage In The Early Phases Of Ankylosing Spondylitis: 12-Year Data From The OASIS Cohort

    Sofia Ramiro1, A.M. van Tubergen2, Désirée van der Heijde3, Carmen Stolwijk4, Maxime Dougados5, Filip Van den Bosch6 and Robert Landewé7, 1Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 5Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 6Ghent University Hospital, Ghent, Belgium, 7Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands

    Background/Purpose: For years, it was unclear if inflammation and radiographic progression were related in ankylosing spondylitis (AS), but studies were only of short follow-up and…
  • Abstract Number: 2449 • 2013 ACR/ARHP Annual Meeting

    Patient-Reported Disease Activity and Outcome In Male Versus Female Patients Of The Groningen Leeuwarden Axial Spondyloarthritis (GLAS) Cohort

    Suzanne Arends1,2, Fiona Maas1, Eveline van der Veer3, Reinhard Bos2, Monique Efde2, Martha K. Leijsma1, Hendrika Bootsma1, Elisabeth Brouwer1 and Anneke Spoorenberg1, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, 3Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose:  Ankylosing Spondylitis (AS) occurs more often in males than in females. Most women tend to have milder disease and may therefore be underdiagnosed. Male…
  • Abstract Number: 2071 • 2013 ACR/ARHP Annual Meeting

    Adipokines Contribute To The Inflammatory Response In Adult and Juvenile Myositis

    Molly S. Hein1, Cynthia S. Crowson2, Helen Khun2, Consuelo Lopez de Padilla3, Erik J. Peterson4, Emily Baechler5 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Rheumatology/Immunology Research, Mayo Clinic, Rochester, MN, 4Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: Recently adipokines have been implicated for their role in regulating immune and inflammatory responses in autoimmune disease. To test the hypothesis that adipokines are…
  • Abstract Number: 1528 • 2013 ACR/ARHP Annual Meeting

    Patient-Tailored Dose Reduction Of Tumor Necrosis Factor-Alpha Blocking Agents In Ankylosing Spondylitis Patients With Stable Low Disease Activity

    Suzanne Arends1,2, Eveline van der Veer3, Fleur B.S. Kamps4, Monique Efde2, Martha K. Leijsma4, Hendrika Bootsma1, Elisabeth Brouwer5 and Anneke Spoorenberg2,4, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, 3Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, 4Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 5Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose:  Tumor necrosis factor-alpha (TNF-α) blocking agents are very effective in controlling inflammation and improving clinical assessments in patients with ankylosing spondylitis (AS). In view…
  • Abstract Number: 1323 • 2013 ACR/ARHP Annual Meeting

    Plasma Leucine-Rich Alpha-2 Glycoprotein Is a Useful Disease Activity Biomarker In Rheumatoid Arthritis

    Jung-Soo Song1, You-Jung Ha2, Eun-Jin Kang3, Kwang-Hoon Lee4, Sang-Won Lee5, Yong-Beom Park6, Soo-Kon Lee6 and Sang Tae Choi1, 1Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 3Rheumatology, Busan Medical Center, Busan, South Korea, 4Dongguk University Ilsan Hospital, Goyang, South Korea, 5Department of Internal Medicine, Yonsei University College of Medicine, Seoul, NV, South Korea, 6Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Background/Purpose: Leucine-rich a2-glycoprotein (LRG) is a plasma protein which contains leucine-rich repeats (LRRs). Though physiological functions of LRG have not been clarified yet, it has…
  • Abstract Number: 625 • 2013 ACR/ARHP Annual Meeting

    Smoking and Secondhand Smoke Exposure Among Patients With Systemic Lupus Erythematosus and Controls: Associations With Disease and Disease Damage

    Samantha J. Minkin, Stephanie N. Slan, Gary S. Gilkeson and Diane L. Kamen, Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Previous reports suggest smoking may be a risk factor for developing systemic lupus erythematosus (SLE), however the significance of this relationship varies among studies.…
  • Abstract Number: 2840 • 2013 ACR/ARHP Annual Meeting

    Predictors Of Spinal Mobility Progression In A Multi-ethnic Cohort Of Patients With Ankylosing Spondylitis

    Roozbeh Sharif1, Trisha M. Parekh2, Lianne S. Gensler3, MinJae Lee4, Mohammad Rahbar5, Laura A. Diekman6, Michael H. Weisman7, Michael M. Ward8, Shervin Assassi9 and John D. Reveille9, 1Graduate School of Biomedical Science, University of Texas Medical Branch, Galveston, TX, 2Internal Medicine, University of Texas Medical Branch, Galveston, TX, 3Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 4Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, 5The University of Texas Health Science Center at Houston, Houston, TX, 6Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, 7Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 8Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, 9Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: Clinicians utilize several different clinical measurements (metrology) in patients with Ankylosing Spondylitis (AS) to assess the spinal mobility.  We aimed to examine the pattern…
  • Abstract Number: 2356 • 2013 ACR/ARHP Annual Meeting

    Soluble Interleukin-2 Receptor Levels and The CD4/CD8 Ratio As Predictors Of The Efficacy Of Abatacept In Biologics-naïve Rheumatoid Arthritis Patients

    Hajime Sano1, Masahiro Sekiguchi1, Masayasu Kitano1, Naoto Azuma1, Shinichiro Tsunoda1, Kiyoshi Matsui1 and Tsuyoshi Iwasaki2, 1Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, 2Department of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan

    Background/Purpose: Abatacept (ABT) is a recombinant fusion protein consisting of the extracellular domain of human CTLA-4, binding to CD80/86 on antigen presenting cells and thereby…
  • Abstract Number: 2083 • 2013 ACR/ARHP Annual Meeting

    Environmental Factors Associated With Disease Flare In Juvenile and Adult Dermatomyositis

    Gulnara Mamyrova1, Lisa G. Rider2, Olcay Jones3, Alison Ehrlich4, Lauren M. Pachman5, Robert Nickeson6, Lisa G. Criscione-Schreiber7, Frederick W. Miller2, Lawrence K. Jung8 and James D. Katz1, 1Rheumatology, George Washington University, Washington, DC, 2Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 3Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 4Dermatology, The George Washington University, Washington, DC, 5Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Pediatrics, All Children's Hospital, St Petersburg, FL, 7Dept of Med/Rheum Div, Duke University School of Medicine, Durham, NC, 8Pediatric Rheumatology, Children's National Medical Center, Washington, DC

    Background/Purpose: To assess environmental factors in relationship to increased disease activity (flare) in juvenile and adult dermatomyositis (DM). Methods: An online survey was conducted for…
  • Abstract Number: 1510 • 2013 ACR/ARHP Annual Meeting

    Disease Activity In Male Smokers Has A >10-Fold Amplified Effect On Radiographic Damage In Comparison With Female NON-Smokers In Ankylosing Spondylitis

    Sofia Ramiro1,2, A.M. van Tubergen3, Robert Landewé4, Carmen Stolwijk5, Maxime Dougados6, Filip Van den Bosch7 and Désirée van der Heijde8, 1Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Rheumatology, Hospital Garcia de Orta, Almada, Portugal, 3Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 4Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands, 5Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 6Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 7Ghent University Hospital, Ghent, Belgium, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: We have shown that disease activity has an effect on radiographic progression over the long-term and that gender and symptom duration are effect modifiers.…
  • Abstract Number: 1329 • 2013 ACR/ARHP Annual Meeting

    Physician Global Assessment At Three Months Is Strongly Predictive Of Remission At 12 Months In Early Rheumatoid Arthritis. Results From The Canadian Early Arthritis Cohort

    Tommy Choy1, Vivian P. Bykerk2, Gilles Boire3, Boulos Haraoui4, Carol A. Hitchon5, J. Carter Thorne6, Edward C. Keystone7 and Janet E. Pope8, 1Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, 2Divison of Rheumatology, Hospital for Special Surgery, New York, NY, 3Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 4Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 5Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 6Southlake Regional Health Centre, Newmarket, ON, Canada, 7Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 8Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Background/Purpose: To determine predictors of 1-year remission in early rheumatoid arthritis (ERA) using baseline and 3 months data. Methods: The Canadian Early Arthritis Cohort (CATCH)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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