Abstracts tagged "Disease Activity"

Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting
Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity
Ladislav Senolt¹, Klara Prajzlerova¹, Hana Hulejova², David Veigl³, Karel Pavelka¹ and Jiri Vencovsky¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
Abstract Number: 666 • 2014 ACR/ARHP Annual Meeting
Approach to Discriminate Treatment Impact in Both Moderate and Severe SLE: The Atacicept Phase IIb Trial Design
Joan T. Merrill¹, Yong Li², Stephen D. Wax³ and Christopher Tehlirian⁴, ¹Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²R&D Global BioStatistics, EMD Serono, Billerica, MA, ³Global Clinical Development Center - Immunology, EMD Serono Inc, Rockland, MA, ⁴EMD Serono, Rockland, MA
Background/Purpose Increases in background treatment in SLE trials lead to high placebo group responses in patients with moderate but not those with high disease activity…
Abstract Number: 390 • 2014 ACR/ARHP Annual Meeting
Prevalence and Correlates of Patient-Physician Discordance in Early Rheumatoid Arthritis
John M. Davis III¹, Cynthia S. Crowson², Tim Bongartz¹, Clement J. Michet¹, Eric L. Matteson¹ and Sherine E. Gabriel³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose Patients with rheumatoid arthritis (RA) sometimes rate their global disease activity differently than their rheumatologists. Previous studies describing this ‘discordance’ have primarily included patients…
Abstract Number: 101 • 2014 ACR/ARHP Annual Meeting
Country of Residence and Its Wealth Determine Disease Activity Levels in RA: Results from Multi-National Study Across 17 Countries (COMORA)
Polina Putrik^1,2, Sofia Ramiro³, Andras Keszei⁴, Ihsane Hmamouchi⁵, Maxime Dougados⁶, Till Uhlig⁷, Tore K. Kvien⁷ and Annelies Boonen⁸, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Health Promotion, Maastricht University, Maastricht, Netherlands, ³Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam & Hospital Garcia de Orta, Almada, Portugal, Amsterdam, Netherlands, ⁴Medical Informatics, Uniklinik RWTH Aachen University, Aachen, Germany, ⁵Biostatistics, Epidemiology LBRCE, Mohamed V Souissi University, Rabat, Morocco, ⁶Cochin Hospital, Paris Descartes University, Paris, France, ⁷Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁸Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose Socio-economic (SE) inequalities in health persist both between and within countries and even increased in the recent years. Therefore, it is important to explore…
Abstract Number: 2989 • 2014 ACR/ARHP Annual Meeting
Lupus Impact Tracker Is Responsive to Changes in Disease Activity in Lupus
David Giangreco¹, Hervé Devilliers², Narender Annapureddy¹, Joel A. Block³ and Meenakshi Jolly¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, ³Section of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Patient reported outcomes (PRO) are important to understand, educate, manage and follow patients with systemic lupus erythematosus (SLE). Lupus Impact Tracker (LIT) is a…
Abstract Number: 2619 • 2014 ACR/ARHP Annual Meeting
Low Socioeconomic Status (SES) As Measured By Education Is (not) Associated with Worse Outcome in SLE: Data from the 1000 Canadian Faces of Lupus
Angela George¹, Christine Peschken², Earl Silverman³, Christian A. Pineau⁴, C Douglas Smith⁵, Hector Arbillaga⁶, Michel Zummer⁷, Ann Clarke⁸, Sasha Bernatsky⁹, Marie Hudson¹⁰, Carol A. Hitchon¹¹, Paul R. Fortin¹² and Janet E. Pope¹³, ¹Medicine/Rheumatology, University of Western Ontario, London, ON, Canada, ²Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ³Pediatrics/Rheumatology, Toronto Hospital for Sick Children, U of Toronto, Toronto, ON, Canada, ⁴Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁵The Arthritis Centre, TOH Riverside Campus, Ottawa, ON, Canada, ⁶Medicine/Rheumatology, Lethbridge Rheumatology practice, Lethbridge, AB, Canada, ⁷Medicine/Rheumatology, U of Montreal, Montreal, QC, Canada, ⁸Medicine/Allergy, U of Calgary, Calgary, AB, Canada, ⁹Clinical Epidemiology, McGill UHC/RVH, Montreal, QC, Canada, ¹⁰Medicine/Rheumatology, McGill University, Montreal, QC, Canada, ¹¹Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ¹²Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada, ¹³St Joseph Health Care, London, ON, Canada
Background/Purpose: To determine whether socioeconomic status, as measured by education, impacts disease activity (measured by SLAM-2, SLEDAI-2K) or disease damage (measured by SLICC SDI) in…
Abstract Number: 2404 • 2014 ACR/ARHP Annual Meeting
RA Patients with Inadequate Response to Oral MTX Maintain Satisfactory Disease Control and Durable Long-Term Response When Switched to SC MTX Monotherapy
Anthony Hammond¹ and Michael Batley², ¹Rheumatology, Maidstone and Tunbridge Wells NHS Trust, Kent TN13 2JD, United Kingdom, ²Rheumatology, Maidstone and Tunbridge Wells Hospital, Kent, United Kingdom
Background/Purpose: Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) therapy, but many patients do not achieve adequate response to oral therapy for reasons of…
Abstract Number: 1871 • 2014 ACR/ARHP Annual Meeting
Puberty and Disease Activity in JIA
Philomine A. van Pelt¹, Aike.a. Kruize², Anita C.S. Hokken-Koelega³, Radboud JEM Dolhain⁴, Johannes WJ Bijlsma⁵ and Nico M. Wulffraat⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁵Dept of Rheumatology and Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁶Paediatric Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
Background/Purpose Delayed puberty and decreased final length has been reported in chronic diseases like Crohn's disease and JIA with a disease onset at prepubertal age.…
Abstract Number: 1375 • 2014 ACR/ARHP Annual Meeting
Educational Level and Not Ethnicity an Important Determinant of Disease Progression in Patients with Rheumatoid Arthritis
Sharon Dowell¹, Gail S. Kerr², Yusuf Yazici³, Christopher Swearingen⁴, Mercedes Quinones⁵, Luis R. Espinoza⁶, Edward L. Treadwell⁷, Theresa Lawrence-Ford⁸, Yvonne Sherrer⁹, Angelia Mosley-WIlliams¹⁰, Ignacio Garcia-Valladares¹¹, Rodolfo Perez Alamino¹², Chunqiao Luo¹³, Akgun Ince¹⁴, Adrian Godoy¹ and John Amatruda¹⁵, ¹Division of Rheumatology, Howard University, Washington, DC, ²Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Pediatrics and Biostatistics, University of Arkansas, Little Rock, AR, ⁵Division of Rheumatology, Howard University Hospital, Washington, DC, ⁶Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA, ⁷Dept Medicine Div of Rheum, East Carolina University, Greenville, NC, ⁸North Georgia Rheumatology Group, PC, Lawrenceville, GA, ⁹Rheum/Immunology, Centre Rheum Immunol Arthritis, Fort Lauderdale, FL, ¹⁰Rheumatology, Detroit VAMC, Detroit, MI, ¹¹Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ¹²internal Medicine, LSUHSC, New Orleans, LA, ¹³University of Arkansas for Medical Sciences, Little Rock, AR, ¹⁴Arthitis Consultants Inc, St. Louis University, St. Louis, MO, ¹⁵Rheumatology, Howard University, Washington, DC
Background/Purpose: Formal educational level is often used as a surrogate for socioeconomic status and in patients with rheumatoid arthritis (RA), low levels have been associated…
Abstract Number: 1002 • 2014 ACR/ARHP Annual Meeting
Global Transcriptome Analysis in Osteoarthritic Cartilage Reveals Significant Differential Gene Expression and Associations with Histologic Disease Progression
Matlock A. Jeffries^1,2, Madison Donica³, Anand Annan⁴, Michael Stevenson⁵, Mary Beth Humphrey^6,7, Judith A. James^6,8 and Amr H. Sawalha⁹, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Pathol;ogy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Rheumatology/Immunology/Arthritis Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in…
Abstract Number: 622 • 2014 ACR/ARHP Annual Meeting
Gut Microbiota Variations Correlate with Disease Activity in Spondyloarthritis (SpA) and Rheumatoid Arthritis (RA)
Julien Tap^1,2, Jad Abou-Ghantous¹, Ariane Leboime³, Roula Said Nahal³, Philippe Langella¹, Henri-Jean Garchon⁴, Gilles Chiocchia⁵, Jean-Pierre Furet¹ and Maxime Breban^3,4, ¹UMR INRA-AgroParisTech 1319, Equipe ProbiHote, MICALIS Institute, National Institute for Agronomical research (INRA), Jouy-en-Josas, France, ²Metagenopolis, INRA, Jouy-en-Josas, France, ³Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁴INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Inflammatory bowel diseases (IBD) are associated with changes in microbiota which may be responsible for sustained gut inflammation and/or a consequence of it. Whether…
Abstract Number: 388 • 2014 ACR/ARHP Annual Meeting
Soluble TREM-1 Is a Biomarker of Anti-CCP-Positive, DMARD-Naive Early Rheumatoid Arthritis
Shachaf Ofer-Shiber¹, Elisheva Pokroy-Shapira², Yair Molad^3,4, Shirly Oren², Hagit Shay-Aharoni² and Ilan Babai⁵, ¹Department of Internal Medicine H, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ²Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ³Rheumatology Unit, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Teqva, Israel, ⁴Laboratory of Inflammation Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel, ⁵Laboratory of Clinical Immunology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
Background/Purpose : Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface receptor, expressed mainly on monocytes and neutrophils and involved in amplification of the inflammatory…
Abstract Number: 107 • 2014 ACR/ARHP Annual Meeting
Use of Internet in Adolescents and Young Adults with JIA
Philomine A. van Pelt¹, Constance H.C. Drossaert², Radboud JEM Dolhain³, A.a. Kruize⁴, Jaap Huisman⁵ and Nico Wulffraat⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Psychology, Health and Technology, University of Twente, Enschede, Netherlands, ³Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Pediatric Psychology, Wilhelmina's Children Hospital UMC Utrecht, Utrecht, Netherlands, ⁶Paediatric Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Internet-use is increasing since it is an efficient way to find information. Information obtained via Health Related Internet (HRI) sites, or online peer support…
Abstract Number: 2967 • 2014 ACR/ARHP Annual Meeting
Patient Reported Pain By the Paindetect Questionnaire Reveals Multimodal Elements to Pain Perception in Rheumatoid Arthritis
Saqa Ahmed¹, Tejal Magan¹, Mario Vargas¹, Abiola Harrison¹ and Nidhi Sofat², ¹Rheumatology, Mailpoint J1A, St George's, University of London, London, United Kingdom, ²Rheumatology, St. George's University of London, London, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted towards synovial joints. Inhibition of pro-inflammatory networks by disease-modifying anti-rheumatic drugs…
Abstract Number: 2615 • 2014 ACR/ARHP Annual Meeting
Preliminary Assessment of a Multi-Biomarker Disease Activity Test for Axial Spondyloarthritis
Walter P. Maksymowych¹, Stephanie Wichuk¹, P. Scott Eastman² and Eric H. Sasso³, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Crescendo Bioscience, Inc., South San Francisco, CA, ³Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose There has been limited validation of soluble biomarker measures of disease activity in patients with axial spondyloarthritis (SpA). C-reactive protein (CRP) is most commonly…

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