Abstracts tagged "Disease Activity"

Abstract Number: 2675 • 2015 ACR/ARHP Annual Meeting
Has the Relationship Between Disease Activity and Disability in Rheumatoid Arthritis Changed?
Aneela Mian¹, Fowzia Ibrahim^2,3, Ian C. Scott⁴, Sardar Bahadur⁵, Maria Filkova⁶, Louise Pollard⁷, Gabrielle H. Kingsley⁸, Sophia Steer⁹, David L. Scott⁶ and James Galloway¹⁰, ¹Academic Rheumatology, King's College London, London, United Kingdom, ²Academic Rheumatology Dept, King's College, London, United Kingdom, ³Academic Rheumatology Dept, King's College London, London, United Kingdom, ⁴Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁵Guys' and St Thomas' NHS Trust, London, United Kingdom, ⁶Academic Department of Rheumatology, King´s College London, London, United Kingdom, ⁷University Hospital Lewisham, London, United Kingdom, ⁸Rheumatology, Kings College London, London, United Kingdom, ⁹Rheumatology Dept, Kings College Hospital, London, United Kingdom, ¹⁰King's College Hospital, London, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) management paradigms have changed over the last two decades. Evidence now supports aggressive immunosuppression with early use of combination disease modifying…
Abstract Number: 3080 • 2015 ACR/ARHP Annual Meeting
Histone H2AX Phosphorylation As a Measure of DNA Double Strand Breaks and a Marker of Environmental Stress and Disease Activity in Lupus
Rajaie Namas, Paul Renauer, Mikhail Ognenovski, Pei-Suen Tsou and Amr H. Sawalha, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Studies suggested that defective or inefficient DNA double strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death,…
Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting
Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months
Samuel Reade¹, Jamie C Sergeant^2,3, Matthew Sperrin⁴, David M. Schultz⁵, Karen Spencer⁶, Caroline Sanders⁶ and William G Dixon⁷, ¹The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁴Institute of Population Health, Health e-Research Centre, The University of Manchester, Manchester, United Kingdom, ⁵Faculty of Engineering and Physical Sciences, School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester, United Kingdom, ⁶Institute of Population Health, Centre for Primary Care, The University of Manchester, Manchester, United Kingdom, ⁷Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…
Abstract Number: 172 • 2015 ACR/ARHP Annual Meeting
Prospective Assessment of Carotid Intima Media Thickness in Relation to Activity of the Disease in Patients with Rheumatoid Arthritis
Bozena Targonska-Stepniak¹, Mariusz Piotrowski¹, Robert Zwolak² and Maria Majdan³, ¹Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland, Lublin, Poland, ²Rheumatologyand Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland, ³Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Poland, Lublin, Poland
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, inflammatory disease that is complicated by accelerated atherosclerosis associated with the risk of adverse cardiovascular (CV) events and…
Abstract Number: 541 • 2015 ACR/ARHP Annual Meeting
Microrna-125b Expression in PBMCs Is Associated with Disease Activity in Patients with Early Rheumatoid Arthritis
Veronika Hruskova^1,2, Romana Jandová³, Lucia Vernerova⁴, Herman F Mann⁵, Klára Prajzlerová⁴, Maria Filkova⁴, Karel Pavelka⁵, Jiri Vencovsky⁵ and Ladislav Senolt⁵, ¹Institute of Rheumatology and Department of Rheumatology; Faculty of Science Charles University, Prague, Czech Republic, ²Faculty of Science, Charles University, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression at posttranscription level and play a significant role in rheumatoid…
Abstract Number: 771 • 2015 ACR/ARHP Annual Meeting
Convergent Validity of New Disease Assessment Instruments in Systemic Lupus Erythematosus in Relation to Sledai-2K
Christopher Collins¹, W. Winn Chatham², Howard Busch³, Norman B. Gaylis⁴, Emily Hautamaki⁵ and Siva Narayanan⁶, ¹MedStar Washington Hospital Center, Washington, DC, ²Medicine/Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Science & Research Institute, Jupiter, FL, ⁴Arthritis & Rheumatic Disease Specialties, Aventura, FL, ⁵Ipsos Healthcare, Washington, DC, ⁶Global Evidence, Value and Access, Ipsos Healthcare, Washington, DC
Background/Purpose: Current validated disease assessment instruments (DAIs) in systemic lupus erythematosus (SLE) such as SLEDAI-2K and BILAG, require disease expertise and/or involve complex scoring systems,…
Abstract Number: 1579 • 2015 ACR/ARHP Annual Meeting
Association of Myocardial Abnormalities with N-Terminal Pro-Brain Natriuretic Peptide and Disease Activity in Rheumatoid Arthritis without Cardiac Symptoms, Assessed By Cardiac Magnetic Resonance Imaging
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Isamu Yokoe³, Natsumi Ikumi^4,5, Hirotake Inomata⁶, Atsuma Nishiwaki⁶, Noboru Kitamura¹, Kaita Sugiyama⁶, Hidetake Shiraiwa⁶, Masataka Nozaki⁶, Yosuke Nagasawa⁶, Yoshihiro Matsukawa⁵ and Masami Takei¹, ¹Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ²Advanced Biomedical Imaging Informatics, St.Marianna University School of Medicine, Kawasaki, Japan, ³Rheumatology, Itabashi Chuo Medical Center, Tokyo, Japan, ⁴Nihon University School of Medicine, Shinjuku, Japan, ⁵Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, ⁶Nihon University School of Medicine, Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a multi-organ inflammatory disorder associated with high cardiovascular morbidity and mortality. Cardiac involvements are typically clinically silent, only manifesting as…
Abstract Number: 2285 • 2015 ACR/ARHP Annual Meeting
Poor Quality of Sleep Is Associated with Increased Disease Activity and Fatigue in Axial Spondyloarthritis
Lana Frost¹, Jiayi Zhou², Lourdes Pena Castillo², Sean Hamilton¹, Nayef Al Ghanim¹, Proton Rahman¹ and Jennifer Burt¹, ¹Rheumatology, St. Clare's Mercy Hospital, St. John's, NF, Canada, ²Computer Science, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Sleep disturbance is a common occurrence in musculoskeletal disease including ankylosing spondylitis. The reasons for the sleep disturbance in rheumatic diseases are multifactorial. There…
Abstract Number: 2601 • 2015 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Score in a TNF Inhibitor Tapering Study in Rheumatoid Arthritis Patients: Predictive Value for Successful Tapering, Flaring and Radiographic Progression
Chantal A.M. Bouman¹, Aatke van der Maas¹, Noortje van Herwaarden¹, Eric H. Sasso², Frank H.J. van den Hoogen¹ and Alfons A. den Broeder¹, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: We evaluated the predictive value of the multi-biomarker disease activity (MBDA) score for clinical outcomes and radiographic progression in a TNFi tapering study in…
Abstract Number: 2682 • 2015 ACR/ARHP Annual Meeting
A Brief Patient-Reported Measure of Physical Function Is Sensitive to Changes in a Composite Disease Activity Measure in a Diverse Rheumatoid Arthritis Clinic Setting
Elizabeth R. Wahl^1,2, Andrew Gross², Vladimir Chernitskiy², Laura Trupin², Jinoos Yazdany³ and Patricia P. Katz², ¹Medicine/Rheumatology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, ²Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ³University of California, San Francisco, San Francisco, CA
Background/Purpose: Rheumatoid arthritis (RA) patients' physical function is a strong predictor of clinical outcomes. A brief patient-reported measure of physical function, the PROMIS PF-10a (PF-10a),…
Abstract Number: 3118 • 2015 ACR/ARHP Annual Meeting
Clinical Characteristics and Disease Outcomes in Psoriatic Arthritis Patients By Extent of Body Surface Area Affected By Psoriasis: Results from Corrona Registry
Philip J. Mease^1,2,3,4, Chitra Karki⁵, Carol J. Etzel^5,6, Arthur Kavanaugh⁷, Christopher T. Ritchlin⁸, Wendi Malley⁵, Vivian Herrera⁹, Jacqueline B. Palmer⁹ and Jeffrey D. Greenberg^5,10, ¹Swedish Medical Center and University of Washington School of Medicine, Seattle, WA, ²Seattle Rheumatology Associates, Seattle, WA, ³Rheumatology Research, Swedish Medical Center, Seattle, WA, ⁴Clinical Professor, University of Washington School of Medicine, Seattle, WA, ⁵Corrona, LLC, Southborough, MA, ⁶University of Texas M.D. Anderson Cancer Center, Houston, TX, ⁷University of California San Diego, La Jolla, CA, ⁸Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁹Novartis Pharmaceuticals Corporation, East Hanover, NJ, ¹⁰NYU School of Medicine, New York, NY
Background/Purpose: Psoriatic arthritis (PsA) is a type of inflammatory arthritis that is commonly comorbid with the skin condition, psoriasis. A major contributor to the severity…
Abstract Number: 217 • 2015 ACR/ARHP Annual Meeting
Circulating Levels of Neo-Epitopes Reflecting Connective Tissue Turnover As Biomarkers of Gout and Frequent Gout Attacks in Men
Ana Valdes¹, Tina Manon-Jensen², Wendy Jenkins³, Anne Sofie Siebuhr⁴, Morten Asser Karsdal⁴, Sally Doherty⁵, Abhishek Abhishek³, Helen Richardson³, Weiya Zhang⁶, Michael Doherty⁷ and Anne C. Bay-Jensen⁸, ¹Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ²Antibody Research Unit, Nordic Bioscience, 2370, Denmark, ³Devision of Rheumatology, University of Nottingham, NG5 1PB, England, ⁴Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁵Division of ROD, University of Nottingham, Nottingham, United Kingdom, ⁶Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁷Academic Rheumatology, City Hospital, Nottingham, United Kingdom, ⁸Biomarkers and Research, Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Recurrent flares constitute the main clinical burden of gout. The neo-epitope blood-based biomarkers, C1M and C3M, measuring matrix metalloproteinases (MMP)-mediated connective tissue degradation, have previously…
Abstract Number: 561 • 2015 ACR/ARHP Annual Meeting
Improvement in Disease Activity and the Long-Term Risk of Serious Infectious Events in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol
Jeffrey R. Curtis¹, Marc de Longueville², Cathy O'Brien² and Boulos Haraoui³, ¹University of Alabama at Birmingham, Birmingham, AL, ²UCB Pharma, Brussels, Belgium, ³Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Background/Purpose: Anti-TNF drugs are an effective treatment option for rheumatoid arthritis (RA) patients (pts) but have been associated with an increased incidence of serious infectious…
Abstract Number: 785 • 2015 ACR/ARHP Annual Meeting
Further Validation of Simple Index As a Simple Disease Activity Assessment Tool for SLE
Nisarg Gandhi¹, Meenakshi Jolly², Alana Nevares³ and Winston Sequeira¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Department of Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Internal Medicine, Cook County Hospital, Chicago, IL
Background/Purpose: An easy, quick tool, requiring minimal training or physician input for disease activity (DA) assessment in SLE, would have potentially greater uptake for routine…
Abstract Number: 1620 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Profiling of Rheumatoid Arthritis Peripheral Blood Identifies Hypermethylation of TRIM69 Promoter Region in CD4+ T Cells Associated with Disease Activity
Amanda Mok¹, Brooke Rhead¹, Calliope Holingue¹, Xiaorong Shao¹, Diana Quach¹, Hong L. Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison³, Vladimir Chernitskiy³, Wei Wang⁵, Gary S. Firestein⁶, Lisa F. Barcellos¹ and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Epigenetic modifications have been previously associated with rheumatoid arthritis (RA [MIM 180300]). This study aimed to determine whether differential DNA methylation in peripheral blood…

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