Abstracts tagged "Disease Activity"

Abstract Number: 3196 • 2016 ACR/ARHP Annual Meeting
A Natural Language Processing System Can Capture Rheumatoid Arthritis Disease Activity Measures in US Veterans Across Multiple Sites
Grant W. Cannon¹, Shobhit Mehortra², Brett South², Ted R Mikuls³, Andreas M. Reimold⁴ and Brian C Sauer², ¹Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, ²Salt Lake City VA and University of Utah, Salt Lake City, UT, ³Omaha VA and University of Nebraska Medical Center, Omaha, NE, USA, Omaha, NE, ⁴Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX
Background/Purpose: The retrieval of rheumatoid arthritis (RA) disease activity measures recorded in an electronic medical record through natural language processing (NLP) would significantly aid…
Abstract Number: 279 • 2016 ACR/ARHP Annual Meeting
Increased Heat Shock Protein 90 in Muscle Tissue and Plasma in Idiopathic Inflammatory Myopathies Correlates with Disease Activity and Skeletal Muscle Involvement
Hana Storkanova¹, Olga Krystufkova¹, Martin Klein², Herman F Mann¹, Lucia Vernerova¹, Maja Spiritovic^1,3, Josef Zámecník⁴, Karel Pavelka², Ladislav Senolt¹, Jiří Vencovský¹ and Michal Tomcik¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁴Department of Pathology and Molecular Medicine, 2nd Medical School and University Hospital Motol, Charles University, Prague, Czech Republic
Background/Purpose: Heat shock proteins (Hsps) are chaperones playing important roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. The…
Abstract Number: 559 • 2016 ACR/ARHP Annual Meeting
Comparison of Multi-Dimensional Health Assessment Questionnaire (MD-HAQ)-Based and Patient-Reported Outcomes Measurement Information System (PROMIS) 29-Based Routine Assessment of Patient Index 3 (RAPID3) for Assessing Rheumatoid Arthritis Disease Activity
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng², Jason Lyons², Anthony Fabio² and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA
Background/Purpose: Patient-reported outcomes measurement information system (PROMIS) 29 is recommended by the National Institute of Health (NIH) consensus panel as the preferred battery of…
Abstract Number: 941 • 2016 ACR/ARHP Annual Meeting
An International, Multi-Specialty Validation Study of the IgG4-Related Disease Responder Index
Zachary Wallace¹, Arezou Khosroshahi², Mollie Carruthers³, Campochiaro Corrado⁴, Hyon K. Choi⁵, Emma Culver⁶, Frank Cortazar⁷, Mikael Ebbo⁸, Ana Fernandes⁹, Luca Frulloni¹⁰, Omer Karadag¹¹, Shigeyuki Kawa¹², Mitsuhiro Kawano¹³, MH Kim¹⁴, Marco Lanzillotta¹⁵, Shoko Matsui¹⁶, Cory Perugino¹⁷, Kazuichi Okazaki¹⁸, Philip Hart¹⁹, Jay H. Ryu²⁰, Takako Saeki²¹, Nicolas Schleinitz²², Paula Tanasa²³, Hisanori Umehara²⁴, George Webster²⁵, Wen Zhang²⁶ and John H. Stone²⁷, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁴San Raffaele Scientific Institute, Milan, Italy, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Translational Gastroenterology Unit and NDM Oxford University, Translational Gastroenterology Unit and NDM Oxford University, John Radcliffe Hospital/Oxford University, Oxford, United Kingdom, ⁷Department of Nephrology, Massachusetts General Hospital, Boston, MA, ⁸Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ⁹Rheumatology Unit, Massachusetts General Hospital, Boston, MA, ¹⁰Gastroenterology, University of Verona, Verona, Italy, ¹¹Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹²Center for Health, Safety and Environmental Management, Shinshu University, Matsumoto, Japan, ¹³Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan, ¹⁴University of Ulsan College of Medicine, Seoul, Korea, The Republic of, ¹⁵Vita-Salute San Raffaele University, Milan, Italy, ¹⁶University of Toyama, Toyama, Japan, ¹⁷Rheumatology, Massachusetts General Hospital, Boston, MA, ¹⁸Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan, ¹⁹Ohio State University Wexner Medical Center, Columbus, OH, ²⁰Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, ²¹Nagaoka Red Cross Hospital, Niigata, Japan, ²²La Timone University Hospital, Marseille, France, ²³Rheumatology, Emory University, Atlanta, GA, ²⁴Kyoto University, Kyoto, Japan, ²⁵University College Hospital, London, United Kingdom, ²⁶Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ²⁷Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is an immune-mediated condition responsible for fibro-inflammatory lesions that can affect nearly any organ and lead to irreversible damage. To evaluate…
Abstract Number: 1376 • 2016 ACR/ARHP Annual Meeting
In Juvenile Dermatomyositis, Organ Damage Is Comparable after Median 13.5 and 21.5 Years Follow-up Time, Despite Sustained Disease Activity
Kristin Schjander Berntsen¹, Berit Flatø^1,2, Ivar Sjaastad^2,3 and Helga Sanner^1,4, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ²Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ³Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway
Background/Purpose: All previous studies of disease outcome in juvenile dermatomyositis (JDM) patients have been based on retrospective data or cross sectional examination. We aimed to…
Abstract Number: 1592 • 2016 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Parallel-Group, Phase III Study of Shortening the Dosing Interval of Subcutaneous Tocilizumab Monotherapy in RA Patients with an Inadequate Response to Subcutaneous Tocilizumab Every Other Week
Atsushi Ogata¹, Nobuhiro Takagi², Hiroko Miwa³ and the MRA231JP study group, ¹Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine and NTT West Osaka Hospital, Osaka, Japan, ²Chugai Pharmaceutical Co. Ltd., Tokyo, Japan, ³Chugai Pharmaceutical Co. Ltd, Tokyo, Japan
Background/Purpose: The non-inferiority of subcutaneous tocilizumab (TCZ-SC) monotherapy every 2 weeks (q2w) to intravenous TCZ monotherapy every 4 weeks was demonstrated in Japanese patients with…
Abstract Number: 1919 • 2016 ACR/ARHP Annual Meeting
Analysis of T Cell Repertoire Diversity of CD4+ Memory and NaïVe T Cells By Next Generation Sequencing and Its Association with Rheumatoid Arthritis Disease Parameters
Keiichi Sakurai¹, Hirofumi Shoda¹, Kazuyoshi Ishigaki², Yumi Tsuchida¹, Yasuo Nagafuchi¹, Shuji Sumitomo¹, Akari Suzuki², Keishi Fujio¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by peripheral polyarthritis. The importance of CD4+ T cell in the pathophysiology of RA is well-known…
Abstract Number: 2485 • 2016 ACR/ARHP Annual Meeting
Correlates of Successful Flare Management: The Role of Clinician-Driven Treatment, Home-Based Strategies, and Medication Change
Taysir G. Mahmoud¹, M Frits², Christine Iannaccone³, Vivian P. Bykerk⁴, Clifton Bingham III⁵, Michael Weinblatt³ and N A Shadick², ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Flares are a common experience in RA, often associated with worse clinical outcomes such as cardiovascular disease, lower functional status, and radiographic progression. …
Abstract Number: 2719 • 2016 ACR/ARHP Annual Meeting
Discriminating Value of Calprotectin in Disease Activity and Progression of Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
Jinxian Huang¹, Zhihua Yin², Guoxiang Song³, Shengjin Cui⁴, Jinzhao Jiang⁴ and Lijun Zhang⁴, ¹Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, ²Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ³The Third People’s Hospital of Shenzhen, Shenzhen, China, ⁴The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Background/Purpose: Due to the limitation of early diagnosis of ankylosing spondylitis (AS), updated criteria in recent years introduced the concept of axial spondyloarthritis (axSpA) and…
Abstract Number: 2862 • 2016 ACR/ARHP Annual Meeting
Whole Blood Phenotyping and Innate and Adaptive Stimulation Reveal Unique Differences in Granulocytes and Innate Pathways of African American SLE Patients with Variable Disease Activity
Samantha Slight-Webb¹, Krista M. Bean¹, Joseph Kheir¹, Bolanle Adebayo¹, Holden T. Maecker², Paul J. Utz³, Judith A. James⁴ and Joel M. Guthridge⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Medicine, Stanford University School of Medicine, Stanford, CA, ⁴Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by periods of heightened disease activity. Disease flares significantly affect quality of life and…
Abstract Number: 3228 • 2016 ACR/ARHP Annual Meeting
Specific T Cell and B Cell Distributions Characterize Subgroups of Patients with Primary Sjögren’s Syndrome and Are Associated with Disease Activity and Pro-Inflammatory Cytokine Expression
Lucas Le Lann¹, Quentin Simon¹, Christophe Jamin¹, Maria Orietta Borghi², Lorenzo Beretta³, Ricard Cervera⁴, Alain Saraux⁵, Divi Cornec¹, Rik Lories⁶, Carlo Chizzolini⁷, Marta E. Alarcon Riquelme⁸, Jacques-Olivier Pers¹ and on behalf of the PRECISESADS Consortium, ¹INSERM ERI29, EA2216, Université de Brest, Labex IGO, CHRU Morvan, Brest, France, ²University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ³Rheumatology, Milan, Italy, ⁴Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, ⁵Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ⁶Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ⁷University hospital of Geneva, Geneva, Switzerland, ⁸Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose : The goal of the IMI PRECISESADS project is to reclassify individuals affected by systemic autoimmune diseases (SADs) into clusters of molecular, instead of…
Abstract Number: 382 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor-α -308 a/G Gene Polymorphism in Children with Juvenile Idiopathic Arthritis: Relation to Disease Activity, Damage and Disability
Tamer Gheita¹, Iman El Gazzar², Hanan Fathy³, Abeer Nour El-Din⁴, Enas Abdel Rasheed⁵, Rasha Bassyouni⁶ and Sanaa Kenawy⁷, ¹Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ²Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, ³Rheumatology, Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁴Pediatric Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁵Clinical Pathology Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁶Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁷Pharmacology, Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and an important cause of disability. Its cause remains unknown, but…
Abstract Number: 578 • 2016 ACR/ARHP Annual Meeting
Do Specific Anti-Citrullinated Antibodies Predict Different Phenotype of Rheumatoid Arthritis?
Mikael Brink¹, Monika Hansson², Linda Mathsson-Alm^3,4, Johan Rönnelid⁵, Karl Skriner⁶, Guy Serre⁷, Lars Klareskog² and Solbritt Rantapää-Dahlqvist¹, ¹Rheumatology, Umeå University, Umeå, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³ThermoFisher Scientific, Uppsala, Sweden, Uppsala, Sweden, ⁴Thermo Fisher Scientific, Uppsala, Sweden, ⁵Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Humboldt University of Berlin, Berlin, Germany, ⁷Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France
Background/Purpose: Antibodies against cyclic citrullinated peptides (anti-CCP) have been suggested to identify a more severe phenotype of rheumatoid arthritis. In this study we have analysed…
Abstract Number: 945 • 2016 ACR/ARHP Annual Meeting
When and Where Musculoskeletal Ultrasound Might Replace Magnetic Resonance in the Assessment of Patients with Juvenile Idiopathic Arthritis?
Stefano Lanni¹, Francesca Magnaguagno², Erica Ricci³, Angela Pistorio⁴, Cecilia Bava¹, Alberto Martini⁵ and Clara Malattia⁶, ¹Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, ³Istituto G. Gaslini, Pediatria 2 -Reumatologia, genova, Italy, ⁴Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ⁵PRINTO-IRCCS, Genova, Italy, ⁶Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Magnetic resonance imaging (MRI) is the most attractive imaging modality for the investigation of patients with juvenile arthritis (JIA). Musculoskeletal ultrasound (MSUS) has intuitive…
Abstract Number: 1387 • 2016 ACR/ARHP Annual Meeting
Evaluation of Mild to Moderate SLE Flare in Patients with Childhood-Onset Disease
Malki Peskin¹, Dawn Wahezi^2,3, Chaim Putterman⁴, Tamar Rubinstein^5,6 and Nicole Jordan^4,7, ¹Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ²Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY, ³Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ⁶Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁷Montefiore Medical Center, New York, NY
Background/Purpose: One aspect of childhood SLE lacking understanding is the prediction of disease flares. The objective of this study is to identify predictors of mild…

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