Abstracts tagged "Disease Activity"

Abstract Number: 241 • 2017 ACR/ARHP Annual Meeting
Histological and Clinical Correlates of Ultrasound Measures of Joint Inflammation: Analysis of RA Tissue Obtained By Ultrasound Guided Biopsy in Phase 1 of the Accelerating Medicines Partnership RA Network
Andrew Filer¹, Arthur M. Mandelin II², Edward F. DiCarlo³, Brendan Boyce⁴, Darren Tabechian⁵, Ralf G. Thiele⁶, Stephan Kelly⁷, Ellen M. Gravallese⁸, Diane Horowitz⁹, Kevin Wei¹⁰, Deepak Rao¹¹, Vivian P. Bykerk¹² and Jennifer H. Anolik¹³, ¹Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ²Rheumatology, Northwestern University, Chicago, IL, ³Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁴University of Rochester Medical Center, Rochester, NY, ⁵Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁶Medicine, University of Rochester Medical Center, Rochester, NY, ⁷Queen Mary University of London, London, United Kingdom, ⁸Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, ⁹Division of Rheumatology, North Shore - Long Island Jewish Health System, Woodbury, NY, ¹⁰Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Spring, IN, ¹²2-005, Mt Sinai Hospital, Toronto, ON, Canada, ¹³Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: The AMP-RA network applies cutting edge technologies to the study of tissue obtained by ultrasound guided synovial biopsy from patients with rheumatoid arthritis (RA).…
Abstract Number: 713 • 2017 ACR/ARHP Annual Meeting
Long-Term Outcomes in Prolonged Low Disease Activity Are Comparable to Complete Clinical Remission in Systemic Lupus Erythematosus
Konstantinos Tselios¹, Dafna D Gladman², Zahi Touma³, Jiandong Su⁴, Nicole Anderson² and Murray Urowitz⁵, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Prolonged clinical remission is a desirable, though rare outcome in systemic lupus erythematosus (SLE). We recently showed that low disease activity (LDA) state confers…
Abstract Number: 1251 • 2017 ACR/ARHP Annual Meeting
Chinese Patient Reported Index with Rheumatoid Arthritis (CPRI-RA): Reliability, Validity and Agreement with DAS28 and HAQ
Man Han¹, Xun Gong¹, Xiao-po Tang¹, Hong-xiao Liu², Jian Liu³, Xin-chang Wang⁴, Jun-li Zhang⁵, Shi Chen⁶, Qing-chun Huang⁷, Yong-fei Fang⁸, Qing-jun Wu⁹, Dong-yi He¹⁰, Zhen-bin Li¹¹, Yue Wang¹², Hong Jiang¹³, Ming-li Gao¹⁴, Wei Liu¹⁵, Ying Liu¹⁶, Ze-guang Li¹⁷, Zhong-wen Zhao¹⁸, Cheng-wu Wang¹⁹, Wei-chao Liu²⁰, Hai-dong Wang²¹, Yu-qian Lou²², Qing-liang Meng²³, Chong-jie Ruan²⁴, Yan-ming Xie²⁵ and Quan Jiang²⁶, ¹Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ³The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Heifei, China, ⁴Rheumatology, The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, China, ⁵Rheumatology, The Fifth Hospital of Xi’an City, Xi’an, China, ⁶Rheumatology, Peking University People's Hospital, Beijing, China, ⁷Rheumatology, Guangzhou Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, ⁸Rheumatology, Southwest Hospital, Third Military Medical University, chongqing, China, ⁹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ¹⁰Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital, Shanghai, China, ¹¹Rheumatology, Bethune international peace hospital, Shi jiazhuang, China, ¹²Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China, ¹³Rheumatology, The Ninth People's Hospital of Chongqing City, Chongqing, China, ¹⁴Rheumatology, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China, ¹⁵Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, ¹⁶Rheumatology, The Affiliated Hospital of Shangdong University of Traditional Chinese Medicine, Qingdao, China, ¹⁷Rheumatology, The First Affiliated Hospital of Hei Longjiang University of Traditional Chinese Medicine, Ha Erbin, China, ¹⁸Rheumatology, The Second People's Hospital of Fujian Province, Fujian, China, ¹⁹Rheumatology, The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China, ²⁰Rheumatology, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China, ²¹Rheumatology, Gansu Provincial Hospital of Traditional Chinese Medicine, Shanxi, China, ²²Henan Rheumatism Hospital, Zhengzhou, China, ²³Rheumatology, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China, ²⁴Rheumatology and Pain Management Department, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China, ²⁵Clinical Evaluation Center, China Academy of Chinese Medical Sciences, Beijing, China, ²⁶Rheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Background/Purpose: The use of patient reported outcomes(PROs) has become increasingly popular in the chronic disease management, disease monitoring and the assessment of drug efficacy. However,…
Abstract Number: 1553 • 2017 ACR/ARHP Annual Meeting
Discontinuation of Tumor Necrosis Factor Inhibitor Therapy in US Patients with Ankylosing Spondylitis: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry
Philip J Mease¹, Désirée van der Heijde², Chitra Karki³, Mei Liu³, Yujin Park⁴ and Jeffrey D. Greenberg⁵, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Leiden University Medical Center, Leiden, Netherlands, ³Corrona, LLC, Southborough, MA, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵New York University School of Medicine, New York, NY
Background/Purpose: There is a need to better characterize patients with ankylosing spondylitis (AS) who discontinue vs continue TNF inhibitor (TNFi) therapies in real-world clinical settings.…
Abstract Number: 1849 • 2017 ACR/ARHP Annual Meeting
Urinary Epidermal Growth Factor and Monocyte Chemoattractant Protein-1 As Biomarkers of Renal Involvement in ANCA-Associated Vasculitis
Catherine E. Najem¹, Wenjun Ju², Viji Nair², David Cuthbertson³, Rennie L. Rhee¹, Laura Mariani⁴, Simon Carette⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁸, Carol A. McAlear⁹, Paul A. Monach¹⁰, Larry W. Moreland¹¹, Christian Pagnoux⁵, Philip Seo¹², Ulrich Specks¹³, Antoine G. Sreih¹, Steven R. Ytterberg¹⁴, Jeffrey Krischer¹⁵, Matthias Kretzler⁴ and Peter A. Merkel¹⁶, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²University of Michigan, Ann Arbor, MI, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, University of Utah, Salt Lake City, UT, ⁸Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Boston University School of Medicine, Boston, MA, ¹¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹²Medicine, Johns Hopkins University, Baltimore, MD, ¹³Mayo Clinic College of Medicine, Rochester, MN, ¹⁴Rheumatology, Mayo Clinic, Rochester, MN, ¹⁵University of South Florida, Tampa, FL, ¹⁶Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose :Epidermal growth factor (EGF) mediates distal tubular epithelial cell function and regeneration. Monocyte chemoattractant protein-1 (MCP-1) participates in recruitment of leukocytes to areas of…
Abstract Number: 2372 • 2017 ACR/ARHP Annual Meeting
Obesity and the Impact on Treat to Target Goals and Functional Ability in RA. Results from Two Multi-Centre UK Inception Cohorts
Elena Nikiphorou¹, Sam Norton², Patrick Kiely³ and Adam Young⁴, ¹Academic Rheumatology Department, King's College London, London, United Kingdom, ²Academic Rheumatology, King´s College London, London, United Kingdom, ³St George's Hospital, London, United Kingdom, ⁴University of Hertfordshire, Hertford, United Kingdom
Background/Purpose: The links between inflammation, obesity and joint dysfunction are well established. How these translate into clinical disease activity and functional disability in rheumatoid arthritis…
Abstract Number: 2625 • 2017 ACR/ARHP Annual Meeting
Predicting Flares in Patients with Stable Systemic Lupus Erythematosus
Jiacai Cho¹, Manjari Lahiri¹, Lay Kheng Teoh¹, Preeti Dhanasekaran^2,3, Pak Moon Peter Cheung¹ and Aisha Lateef¹, ¹Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, ²National University of Singapore, singapore, Singapore, ³National University Hospital of Singapore, Singapore, Singapore
Background/Purpose: The course of systemic lupus erythematosus (SLE) varies with periods of quiescence punctuated by flares. Predicting exacerbations allows clinicians to select patients who need…
Abstract Number: 2964 • 2017 ACR/ARHP Annual Meeting
Structural Damage in Patients with Very Early RA Is Predicted with Clinical Measures of Baseline Disease Activity: DAS28 (CRP), SDAI, M-DAS28 and RAPID3 but Not CDAI
Edward C. Keystone¹, H Ahmad², Yusuf Yazici³, X Liu² and MJ Bergman⁴, ¹University of Toronto, Toronto, ON, Canada, ²Bristol-Myers Squibb, Princeton, NJ, ³New York University School of Medicine, New York, NY, ⁴Drexel University College of Medicine, Philadelphia, PA
Background/Purpose: Clinicians rely on time-efficient, validated disease activity assessments to help accurately predict disease progression in patients with RA. The utility of the Routine Assessment…
Abstract Number: 366 • 2017 ACR/ARHP Annual Meeting
Short-Term Outcomes in Patients with Systemic-Onset Juvenile Idiopathic Arthritis Treated with Either Tocilizumab or Anakinra in a Real-World Setting in the United Kingdom
Lianne Kearsley-Fleet¹, Diederik De Cock¹, Eileen Baildam², Michael W. Beresford³, Helen E. Foster⁴, Taunton R. Southwood⁵, Wendy Thomson^6,7 and Kimme L. Hyrich^1,6, ¹Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ³Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, ⁴Institute of Cellular Medicine and Paediatric Rheumatology, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, ⁵Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, ⁶National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) comprises 7 ILAR categories, but systemic-onset JIA (sJIA) appears to be distinct in genetic background and pathogenesis from the other…
Abstract Number: 789 • 2017 ACR/ARHP Annual Meeting
Markers of Inflammation and Patient-Reported Measures As Predictors of Relapse in Giant Cell Arteritis
Tanaz A. Kermani¹, Antoine G. Sreih², Gunnar Tomasson³, David Cuthbertson⁴, Renee Borchin⁵, Simon Carette⁶, Lindsy J. Forbess⁷, Nader A. Khalidi⁸, Curry L. Koening⁹, Carol A. McAlear¹⁰, Paul A. Monach¹¹, Larry W. Moreland¹², Christian Pagnoux⁶, Philip Seo¹³, Robert F. Spiera¹⁴, Kenneth J. Warrington¹⁵, Steven R. Ytterberg¹⁵, Carol A. Langford¹⁶ and Peter A. Merkel^17,18, ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²Rheumatology, University of Pennsylvania, Philadelphia, PA, ³University of Iceland, Faculty of Medicine, Reykjavik, IS, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵University of South Florida, Tampa, FL, ⁶Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology, McMaster University, Hamilton, ON, Canada, ⁹Rheumatology, University of Utah, Salt Lake City, UT, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Boston University School of Medicine, Boston, MA, ¹²Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹³Medicine, Johns Hopkins University, Baltimore, MD, ¹⁴Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁵Rheumatology, Mayo Clinic, Rochester, MN, ¹⁶Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁸Biostatistics, Epidemiology, and Bioinformatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The significance of increasing erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in clinically asymptomatic individuals with giant cell arteritis (GCA) is controversial. Patient-reported…
Abstract Number: 1265 • 2017 ACR/ARHP Annual Meeting
Impaired Cardiac Function in Juvenile Mixed Connective Tissue Disease Compared with Controls
Birgit Nomeland Witczak¹, Siri Opsahl Hetlevik², Zoltan Barth^1,3, Thomas Schwartz^4,5, Berit Flatø^2,6, Vibke Lilleby^2,6 and Ivar Sjaastad^1,6,7, ¹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Pathophysiology and Gerontology, Medical School, University of Pècs, Pècs, Hungary, Pècs, Hungary, ⁴Oslo University Hospital and University of Oslo, Institute for Experimental Medical Research, Oslo, Norway, ⁵Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁷Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Juvenile MCTD (JMCTD) is a heterogenic autoimmune disease, with SLE-, SSc- and PM/DM and RA like manifestations. Cardiac involvement is known in juvenile SLE,…
Abstract Number: 1555 • 2017 ACR/ARHP Annual Meeting
Treatment Changes By Joint Activity and Skin Severity in Patients with Comorbid Psa and Pso
Philip J Mease¹, Carol J. Etzel², Jeffrey Lisse³, April W Armstrong⁴, William J Huster³, Sabrina Rebello², Rhiannon Dodge², Talia M Muram³, Sarah Al Sawah³, Mwangi J Murage³, Jeffrey D Greenberg² and William Malatestinic³, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Corrona, LLC, Southborough, MA, ³Eli Lilly and Company, Indianapolis, IN, ⁴Keck School of Medicine, University of Southern California, Los Angeles, CA
Background/Purpose: Treatment of both joint and skin symptoms is important for overall disease management of patients with psoriatic arthritis and comorbid psoriasis1,2. The objective of…
Abstract Number: 1879 • 2017 ACR/ARHP Annual Meeting
Majority of Rheumatoid Arthritis Patients in Clinical Remission As Defined By DAS-28, CDAI, SDAI and RAPID-3 Have No Signal on Ultrasound Power Doppler
Allen P. Anandarajah¹, Andreea Coca² and Ralf G. Thiele³, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Remission in rheumatoid arthritis (RA) is often assessed using the following indices: disease activity scores (DAS-28), clinical disease activity index (CDAI), Simplified Disease Activity…
Abstract Number: 2374 • 2017 ACR/ARHP Annual Meeting
Obesity Impacts ESR and Not Other Measures of Rheumatoid Arthritis Disease Activity
Ana Maheshwari¹, Oumoul Barry¹ and MJ Bergman², ¹Internal Medicine, Mercy Catholic Medical Center, Darby, PA, ²Medicine, Drexel University College of Medicine, Philadelphia, PA
Background/Purpose: Disease activity measurement is a cornerstone to treat to target strategy. The impact of body mass index (BMI) on disease activity in rheumatoid arthritis…
Abstract Number: 2641 • 2017 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation in Systemic Lupus Erythematosus – Novel Biomarkers of Disease Activity and Severity
Hsin-Hsuan Juo¹, Edward Chiou², Keith B. Elkon³ and Christian Lood⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Department of Medicine & Immunology, University of Washington, Seattle, WA, ⁴Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is linked to inflammation and autoimmune diseases, including systemic lupus erythematosus (SLE) where nucleic acid-containing immune complexes (ICs) drive inflammation through engagement…

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