ACR Meeting Abstracts

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Abstracts tagged "Disease Activity"

  • Abstract Number: 1026 • ACR Convergence 2022

    Responsiveness and Minimal Clinically Important Difference in Patient-Reported Outcome Measures Among Patients with Psoriatic Arthritis

    Paras Karmacharya1, Courtney Stull2, Alisa Stephens-Shields3, M. Elaine Husni4, Jose Scher5, Ethan Craig6, Robert Fitzsimmons3, Soumya Reddy7, Marina Magrey8, Alexis Ogdie9 and Jessica Walsh10, 1Vanderbilt University, Nashville, TN, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pennsylvania, Philadelphia, 4Cleveland Clinic, Cleveland, OH, 5New York University School of Medicine, New York, NY, 6University of Pennsylvania, Wallingford, PA, 7NYU School of Medicine, New York, NY, 8Case Western Reserve University, University Hospitals, Richfield, OH, 9Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 10University of Utah, Salt Lake City, UT

    Background/Purpose: Despite significant heterogeneity in psoriatic arthritis (PsA), randomized controlled trials (RCTs) generally enroll a homogenous subgroup of PsA patients (polyarticular similar to rheumatoid arthritis).…
  • Abstract Number: 1392 • ACR Convergence 2022

    Comparing Data on Rheumatoid Arthritis (RA) Disease Status Using Patient Reported Outcome Measures (PROMS) RAID/RAPID-3/Self-Reported DAS28 in Remote Electronic Monitoring During the COVID-19 Pandemic with Face-To-Face Clinical Evaluation (DAS28-CRP) Performed Pre-Pandemic

    Maria Mirza1, Kaiyang Song1, Madiha Ashraf2, Anushka Soni3, John Jackman3 and Raashid Luqmani1, 1Oxford University Hospital, Oxford, United Kingdom, 2Oxford Universtiy Hospital, Oxford, United Kingdom, 3Oxford University Hospital, Oxford, England, United Kingdom

    Background/Purpose: During the COVID-19 pandemic, asynchronous consultations were introduced due to the significant backlog of patients with Rheumatoid arthritis awaiting clinical review. PROMs including Self-Reported…
  • Abstract Number: 1516 • ACR Convergence 2022

    How Disease Activity Can Affect Workability in Spondyloarthropaties: A Monocentric Cohort Analysis

    Federico Fattorini1, Cosimo Cigolini2, Gabriele Marchetti3, Andrea Delle Sedie4, Linda Carli5 and Marta Mosca5, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, 3University of Pisa, Pisa, Toscana, Italy, 4University of Pisa, Pisa, Pisa, Italy, 5Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy

    Background/Purpose: Spondyloarthropathies (SpA) may compromise the working ability (WA) of patients, often affected by the disease during their productive life. The Work Productivity and Activity…
  • Abstract Number: 1971 • ACR Convergence 2022

    Cumulative Joint Inflammation Is Associated with Local Joint Damage Progression in Rheumatoid Arthritis Despite Long-Term Targeted Treatment

    Sascha Heckert1, Sytske Anne Bergstra2, Yvonne Goekoop-Ruiterman3, Melek Guler-Yuksel4, Willem Lems5, Xanthe Matthijssen6, Maikel Van Oosterhout7, Tom Huizinga6 and CF Allaart6, 1Leiden University Medical Centre, Leiden, Netherlands, 2LUMC, Leiden, Netherlands, 3HagaZiekenhuis, The Hague, Netherlands, 4Maasstad ziekenhuis, Rotterdam, Netherlands, 5Amsterdam University Medical Centers, Amsterdam, Netherlands, 6Leiden University Medical Center, Leiden, Netherlands, 7Groene Hart Ziekenhuis, Gouda, Netherlands

    Background/Purpose: In Rheumatoid Arthritis (RA), both systemic and local disease activity have been shown to be associated with joint damage progression. Earlier we showed that…
  • Abstract Number: 2096 • ACR Convergence 2022

    Role of Cell-Bound Complement Fragments as Biomarkers to Determine Disease Activity in Patients with Systemic Lupus Erythematosus

    Marcela Muñoz Urbano1, Diana C. Quintero-González1, Mauricio Rojas2, Joaquín Rodelo1, Alba Luz León Álvarez1, Luis Gonzalez1 and Gloria Vásquez3, 1Universidad de Antioquia, Medellín, Colombia, 2Grupo de Inmunología Celular e Inmunogenética, GICIG, and Unidad de citometría de flujo, Sede de Investigación Universitaria, Universidad de Antioquia, Medellín, Colombia, 3Grupo de Inmunología Celular e Inmunogenética, GICIG and Grupo de Reumatología, Universidad de Antioquía, Medellín, Colombia

    Background/Purpose: The prompt identification of patients with systemic lupus erythematosus (SLE) at risk of or in flare strongly influences the prognosis of the disease. Cell-bound…
  • Abstract Number: 0173 • ACR Convergence 2022

    Cutaneous Manifestations, Clinical Trials, Safety Efficacy and Safety of Lenabasum in the Phase 3 DeterMine Trial in Dermatomyositis

    Victoria Werth1, Barbara White2, Josef Concha3, Josh Dan1, Nancy Dgetluck2, Kathleen Hally2, Scott Constantine2, Rohit Aggarwal4, David Fiorentino5, Ingrid Lundberg6 and Chester Oddis7, 1Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 2Corbus Pharmaceuticals, Norwood, MA, 3Universiity of Pennsylvania/Dermatology, Philadelphia, PA, 4University of Pittsburgh, Division of Rheumatology, Pittsburgh, PA, 5Stanford university/Department of Dermatology, Palo Alto, CA, 6Karolinska Institute, Stockholm, Sweden, 7University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Safe and effective treatments are of significant unmet need in DM. Lenabasum, a CB2 agonist that activates resolution of inflammation, improved skin disease, patient-reported…
  • Abstract Number: 0421 • ACR Convergence 2022

    Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis by Prior bDMARD Treatment: Analysis of a Phase 3 Trial

    Atul Deodhar1, Helena Marzo-Ortega2, Joseph Wu3, Cunshan Wang3, Oluwaseyi Dina4, Keith S Kanik3, Lara Fallon5 and Lianne Gensler6, 1Oregon Health & Science University, Portland, OR, USA, Portland, OR, 2Leeds Teaching Hospitals Trust and University of Leeds, Leeds, United Kingdom, 3Pfizer Inc, Groton, CT, 4Pfizer Inc, New York, NY, 5Pfizer Inc, Montréal, QC, Canada, 6Department of Medicine, Division of Rheumatology, University of California San Francisco, San Francisco, CA

    Background/Purpose: Prior exposure to biologic (b)DMARD therapy of patients (pts) with AS may influence treatment response.1-3 Tofacitinib is an oral JAK inhibitor for the treatment…
  • Abstract Number: 0858 • ACR Convergence 2022

    Predicting the Occurrence of Drug-Free Inactive Disease Two Years After Diagnosis of Non-Systemic Juvenile Idiopathic Arthritis

    Melissa Mannion1, Chen Chen2, Olha Halyabar3, Susan Paetkau4, Tingting Qiu5 and Bin Huang6, 1University of Alabama at Birmingham, Birmingham, AL, 2Cincinnati Children's Hospital Medical Center, Taipei, Taiwan, 3Children's Hospital/Boston Medical Center, Boston, MA, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Cinciannati, OH

    Background/Purpose: The goal of treatment for juvenile idiopathic arthritis (JIA) is inactive disease (ID), but the optimal treatment for each patient to maximize ID and…
  • Abstract Number: 1033 • ACR Convergence 2022

    Risk of Mood Disorders in SpA Patients and Correlations with Disease Activity, Quality of Life and Working Ability: Analysis of a Monocentric Cohort

    Cosimo Cigolini1, Federico Fattorini1, Linda Carli2, Andrea Delle Sedie3, Marta Mosca2 and Gabriele Marchetti4, 1Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, 2Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy, 3University of Pisa, Pisa, Pisa, Italy, 4University of Pisa, Pisa, Toscana, Italy

    Background/Purpose: Spondyloarthropathies (SpA) are chronic inflammatory arthritides, characterized by both peripheral and axial skeletal involvement and some typical extra-articular marks; they tend to associate with…
  • Abstract Number: 1401 • ACR Convergence 2022

    Relationship Between Disease Activity and Adverse Events of Interest in Patients with RA on Tofacitinib or TNF Inhibitors: Post Hoc Analysis of a Phase 3b/4 Randomized Safety Study

    George A Karpouzas1, Zoltan Szekanecz2, Eva Baecklund3, Ted Mikuls4, Deepak L Bhatt5, Harry Shi6, Cunshan Wang7, Gosford A Sawyerr8, Yan Chen6, Sujatha Menon7, Carol A Connell7, Steven R Ytterberg9 and Mahta Mortezavi8, 1Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Division of Rheumatology, Faculty of Medicine, Debrecen, Hungary, 3Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Department of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 6Pfizer, Inc, Collegeville, PA, 7Pfizer Inc, Groton, CT, 8Pfizer Inc, New York, NY, 9Division of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Uncontrolled RA activity and acute disease flares are associated with higher risk of adverse outcomes, such as cardiovascular (CV) disease, venous thromboembolism (VTE), malignancy,…
  • Abstract Number: 1544 • ACR Convergence 2022

    Is It Possible to Evaluate Polymyalgia Rheumatica Without C-reactive Protein? Concordance and Agreement Between Different PMR Activity Scores in Polymyalgia Rheumatica

    Justine D'agostino1, Valerie Devauchelle1, Guillermo CARVAJAL ALEGRIA2, Emmanuelle Dernis3, Christophe Richez4, Marie Truchetet5, Daniel Wendling6, ERIC TOUSSIROT7, aleth Perdriger8, jacques-eric gottenberg9, Renaud FELTEN10, Bruno Fautrel11, laurent chiche12, Pascal HILLIQUIN13, Catherine Le Henaff14, Benjamin Dervieux15, Guillaume Direz16, Isabelle Chary-Valckenaere17, Divi CORNEC18, Dewi Guellec19, Thierry MARHADOUR20, Aghiles Souki19, Emmanule Nowak19 and Alain Saraux21, 1Université de Bretagne Occidentale, Brest, France, 2CHRU de Tours, Tours, France, 3LE MANS general hospital, LE MANS, France, 4Université de Bordeaux, Bordeaux, France, 5Bordeaux University Hospital, Bordeaux, France, 6CHU, University Teaching Hospital, Besançon, France, 7CHU de Besançon, Besançon, France, 8Rennes University, Rennes, France, 9Strasbourg University Hospital, Strasbourg, France, 10Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 11Pitié Salpêtrière Hospital, Paris, France, 12hopital europeen, Marseille, France, 13Centre Hospitalier Sud-Francilien, Corbeil-Essonnes, France, 14Morlaix Hospital, Morlaix, France, 15Mulhouse Hospital, Mulhouse, France, 16Le Mans Hospital, Le Mans, France, 17Nancy University Hospital, Vandoeuvre, France, 18CHRU Brest, Brest, France, 19Brest University Hospital, Brest, France, 20CHU Cavale Blanche, Brest, France, 21CHU Brest, Brest, France

    Background/Purpose: Today, the only disease activity score developed specifically for polymylagia rheumatica is the PMR-AS. It is a composite index built as an algebraic sum…
  • Abstract Number: 1986 • ACR Convergence 2022

    Early-stage Rheumatoid Arthritis Patients with High Levels of Type III Collagen Are Less Likely to Respond to Anti-IL6R Treatment

    Sofie Falkenløve Madsen1, Dovile Sinkeviciute2, Christian Thudium2, Morten Karsdal2 and Anne-Christine Bay-Jensen2, 1University of Copenhagen / Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune disease, which normally is characterized by inflammation and thickening of the synovial membrane leading to swollen and…
  • Abstract Number: 2109 • ACR Convergence 2022

    Domains Contributing to Minimal Disease Activity Non-Achievement in Patients with Psoriatic Arthritis Receiving Golimumab: Post Hoc Analysis of a Phase 3, Randomized, Double-blind, Placebo-controlled Study

    Arthur Kavanaugh1, Gordon Lam2, Lai-shan Tam3, Natalie Shiff4, Youngja Lee5, Ana-Maria Bravo Perdomo6, May Shawi7, Elizabeth Hsia8, Emmanouil Rampakakis9 and Carlos Enrique Toro Gutiérrez10, 1University of California San Diego, La Jolla, CA, 2Arthritis and Osteoporosis Consultants of the Carolinas; Clinical Affiliate, Atrium Health and the Wake Forest School of Medicine, Cornelius, NC, 3The Chinese University of Hong Kong, Hong Kong, China, 4Janssen Scientific Affairs, LLC, Horsham, PA, USA/ Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada, Philadelphia, PA, 5Immunology Medical Affairs, Janssen Asia Pacific, Yongsan-gu, Seoul, Republic of Korea, 6Immunology Medical Affairs, Janssen Latin America, Columbia, Colombia, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8Janssen Research and Development, LLC; University of Pennsylvania School of Medicine, Kennett Square, PA, 9McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 10Internal Medicine and Rheumatology, Reference Center for Osteoporosis, Rheumatology & Dermatology. Pontificia Javeriana University, Calí, Colombia

    Background/Purpose: Sustained minimal disease activity (MDA) is only achieved by a small portion of PsA patients (pts). Levels of disease activity consistent with MDA may…
  • Abstract Number: 0243 • ACR Convergence 2022

    Real World Evidence of Treatment Effectiveness and Unfavorable Clinical Events for Elderly-onset Early Rheumatoid Arthritis in Japan: Results from the IORRA Study

    Naohiro Sugitani1, Eiichi Tanaka1, Eisuke Inoue2, Kotaro Watanabe3, Mai Abe3, Eri Sugano3, Kumiko Saka3, Moeko Ochiai3, Rei Yamaguchi3, Katsunori Ikari4 and Masayoshi Harigai1, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Research Administration Center, Showa University, Shinagawa-ku, Japan, 3Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Shinjuku-ku, Japan, 4Department of Orthopedic Surgery, Tokyo Women’s Medial University School of Medicine, Shinjuku, Japan

    Background/Purpose: The number of elderly patients with rheumatoid arthritis (RA) has been constantly increasing. As of December 2021, 50.3% of the patients with RA who…
  • Abstract Number: 0424 • ACR Convergence 2022

    The Efficacy and Safety of CT-P13 as First-line and Subsequent-line Therapy in Patients with Ankylosing Spondylitis: Real-life Data from TURKBIO Cohort

    Sadettin Uslu1, Semih Gulle1, Gercek Can2, Soner Senel3, Sedat Capar4, Huseyin ediz dalkilic5, Servet Akar6, Suleyman Serdar Koca7, Abdurrahman Tufan8, Ayten Yazici9, Sema Yilmaz10, Nevsun Inanc11, Merih Birlik1, Dilek Solmaz12, Ayse Cefle9, Berna Goker13, Servet Yolbas14, Niels Steen Krough15, Neslihan Yilmaz16, Sukran Erten17, Cemal Bes18, Ozgul Soysal19, Mehmet Akif Ozturk13, Seminur Haznedaroglu13, Sule Yavuz16, Haner Direskeneli20, Fatoş Onen21 and Ismail Sari22, 1Dokuz Eylul University School of Medicine Division of Rheumatology, Izmir, Turkey, 2Dokuz Eylul University School of Medicine Division of Rheumatology, Istanbul, Turkey, 3Erciyes University School of Medicine Division of Rheumatology, Kayseri, Turkey, 4Dokuz Eylul University Faculty of Science Department of Statistics, Izmir, Turkey, 5Uludag University School of Medicine Division of Rheumatology, Bursa, Turkey, 6Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 7Firat University School of Medicine Division of Rheumatology, Elazıg, Turkey, 8Gazi University Medical Faculty Hospital, Istanbul, Turkey, 9Kocaeli University School of Medicine Division of Rheumatology, Kocaeli, Turkey, 10Selcuk University School of Medicine Division of Rheumatology, Konya, Turkey, 11Marmara University School of Medicine, Division of Rheumatology, Istanbul, Turkey, 12Kâtip Celebi University School of Medicine Division of Rheumatology, Izmir, Turkey, 13Gazi University School of Medicine Division of Rheumatology, Ankara, Turkey, 14Inonu University School of Medicine Division of Rheumatology, Malatya, Turkey, 15Zitelab Aps, Kopenhag, Denmark, 16Demiroglu Bilim University School of Medicine Division of Rheumatology, Istanbul, Turkey, 17Yildirim Beyazit University School of Medicine Division of Rheumatology, Ankara, Turkey, 18Basaksehir Cam and Sakura ospital, Division of Rheumatology, Istanbul, Turkey, 19Celal Bayar University, School of Medicine Division of Rheumatology, Manisa, Turkey, 20Marmara University School of Medicine Division of Rheumatology, Istanbul, Turkey, 21Dokuz Eylul University, Faculty of Medicine, Rheumatology, İzmir, Turkey, 22Dokuz Eylul University School of Medicine Division of Rheumatology, İzmir, Turkey

    Background/Purpose: In this study, it was aimed to evaluate the long-term drug survival, efficacy and safety of infliximab biosimilar CT-P13 in Turkish patients diagnosed with…
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