ACR Meeting Abstracts

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Abstracts tagged "Disease Activity"

  • Abstract Number: 1380 • ACR Convergence 2022

    Development of Core and Expanded Datasets to Align Registries and Advance International Collaborative Research for Childhood-onset Systemic Lupus Erythematosus

    Rebecca Sadun1, Laura Lewandowski2, Alexandre Belot3, Eve Smith4 and Jennifer Cooper5, 1Duke University, Durham, NC, 2NIAMS, NIH, Bethesda, MD, 3Hospices Civils de Lyon, Collonges au mont d'or, France, 4University of Liverpool, Liverpool, United Kingdom, 5University of Colorado/Children's Hospital Colorado, Denver, CO

    Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) occurs in approximately 20% of all SLE cases. cSLE is has a worse prognosis than adult-onset SLE, often requiring…
  • Abstract Number: 1508 • ACR Convergence 2022

    Enthesitis a Dominant Pathology in Psoriatic Arthritis: Identification and Quantification of Enthesitis Burden by 18F-FDG Total-Body PET/CT Imaging

    Siba Raychaudhuri1, Yasser Abdelhafez2, Dario Mazza3, Smriti Raychaudhuri4 and Abhijit Chaudhari3, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, 2University of California Davis, Sacramento, CA, 3UC Davis, School of Medicine, Sacramento, CA, 4VA Medical Center, Sacramento, CA

    Background/Purpose: The enthesitis can be the earliest/primary inflammatory event in psoriatic arthritis (PsA). Clinically most of the entheses are not accessible and can't be assessed;…
  • Abstract Number: 1833 • ACR Convergence 2022

    Intraarticular Morphine in Knee-arthritis – Results of a Randomized Placebo-controlled Trial

    Hildrun Haibel1, Joachim Sieper1, Denis Poddubnyy2, valeria Rios-Rodriguez3, Fabian Proft2, Mikhail Protopopov4, Judith Rademacher4, Sabrina Igel5, Peter Martus6 and Christoph Stein5, 1Charité - Universitätsmedizin, Berlin, Berlin, Germany, 2Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Charité-Universitätsmedizin Berlin, Berlin, Germany, 4Charité Universitätsmedizin Berlin, Berlin, Germany, 5Charité University Medicine Berlin, Berlin, Germany, 6University Hospital Tübingen, Tübingen, Germany

    Background/Purpose: The current standard of intraarticular therapy in patients with inflammatory arthritis (e.g. rheumatoid arthritis; RA) or inflammatory exacerbations of osteoarthritis (OA) is the injection…
  • Abstract Number: 2090 • ACR Convergence 2022

    Evaluation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) vs. SLEDAI-2K Glucocorticoids (SLEDAI-2KG) on Patient Health-Related Quality of Life (HRQoL) in Systemic Lupus Erythematosus (SLE)

    Alan Cheng1, Vibeke Strand2, Jiandong Su3, Nicole Anderson3, Lee S Simon4 and Zahi Touma3, 1Michael G. DeGroote School of Medicine, McMaster University, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 2Stanford University School of Medicine, Stanford, CA, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 4SDG LLC, West Newton, MA

    Background/Purpose: Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) Glucocorticoid Index (SLEDAI-2KG) is a novel valid index able to measure disease activity while accounting for prednisone…
  • Abstract Number: 0016 • ACR Convergence 2022

    Distinct Transcriptomic and Epigenetic Profiles Mediated by Disease Activity in SLE

    Yusho Ishii, James Rose, Kevin Cashman, Sakeenah Hicks, Tsuneo Deguchi, Christopher Scharer, Scott Jenks, Jeremy Boss and Iñaki Sanz, Emory University, Atlanta, GA

    Background/Purpose: SLE is an autoimmune disease heterogenous for symptoms, disease severity and therapeutic response. This heterogeneity makes stratifying patients difficult. B cells from SLE patients…
  • Abstract Number: 0393 • ACR Convergence 2022

    Are We Meeting Patients’ Treatment Goals with Guideline-Based Therapy for Psoriatic Arthritis?

    Christeen Samuel1, Laura Prichett1, Thomas Grader-Beck1, Uzma Haque1, John Miller1, Suzanne Grieb2 and Ana-Maria Orbai3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine and School of Public Health, Baltimore, MD, 3Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Treatment success from the patients' perspective has not been defined in psoriatic arthritis (PsA). The objective was to determine prevalence and associations of patient-reported…
  • Abstract Number: 0850 • ACR Convergence 2022

    Outcomes of Patients with Juvenile Idiopathic Arthritis Following Failure of Initial Tumor Necrosis Factor Inhibitor Medication in the Childhood Arthritis and Rheumatology Research Alliance Registry

    Melissa Mannion1, Shahla Amin2, Stephen Balevic3, Colleen Correll4, Timothy Beukelman1 and , for the CARRA Registry Investigators5, 1University of Alabama at Birmingham, Birmingham, AL, 2Childhood Arthritis and Rheumatology Research Alliance, Washington, DC, 3Duke University, Durham, NC, 4University of Minnesota, Minneapolis, MN, 5CARRA, Washington, DC

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are the most commonly used first biologics to treat juvenile idiopathic arthritis (JIA), but it is unknown what subsequent…
  • Abstract Number: 1023 • ACR Convergence 2022

    Are We Treating-to-target in Spondyloarthritis (SpA)? A Cross Sectional Analysis from the Asia Pacific League of Associations for Rheumatology (APLAR) SpA Registry

    Isaac Cheng1, Ying Ying Leung2, Ho SO1, Praveena Chiowchanwisawakit3, Stanley Angkodjojo4, Muhammad Saeed5, Kichul Shin6, Han Joo Baek7, Mohit Goyal8, Muhammad Haroon9, Eman Satti10, Nallasivan Subramanian11, Fariz Yahya12, Soosan Soroosh13, ASAL ADNAN RIDHA14, Ho Yin Chung15, James Cheng-Chung WEI16, Kishimoto Mitsumasa17 and Lai-shan Tam1, 1The Chinese University of Hong Kong, Hong Kong, China, 2Rheumatology Department, Singapore General Hospital, Singapore, Singapore, 3Mahidol University, Bangkok, Thailand, 4Sengkang General Hospital / Singhealth, Singapore, Singapore, 5Central Park Medical College, Lahore, Pakistan, 6Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 7Gachon University College of Medicine, Inchon, Republic of Korea, 8CARE Pain & Arthritis Centre, Udaipur, India, 9Doctor, Tralee, Ireland, 10Hamad Medical Corporation, Doha, Qatar, 11Velammal Medical College Hospital, Velammal, India, 12University of Malaya, Kuala Lumpur, Malaysia, 13Army University for Medical School, Tehran, Iran, 14Baghdad Teaching Hospital, Baghdad, Iraq, 15Chiron Medical, Hong Kong, Hong Kong, 16Chung Shan Medical University Hospital, Taichung, Taiwan, 17Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Data on the extent to which internationally agreed treat-to-target (T2T) recommendations were applied in clinical practice in patients with SpA across the Asia-Pacific region…
  • Abstract Number: 1390 • ACR Convergence 2022

    Distinct Patterns of Multimorbidity Are Associated with Longitudinal Disease Activity and Functional Status in a Multicenter, Prospective Rheumatoid Arthritis Cohort

    Sarah Dutt1, Punyasha Roul2, Yangyuna Yang3, Kaleb Michaud3, Brian Sauer4, Grant Cannon5, Joshua Baker6, Jeffrey Curtis7, Ted Mikuls8 and Bryant England3, 1University of Nebraska Medical Center, Omaha, 2UNMC, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5Salt Lake City VA, Salt Lake city, 6University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, 7Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 8Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) predisposes to the development of other chronic conditions such as osteoporosis, cardiovascular disease, and lung disease. Previously, we used unsupervised machine…
  • Abstract Number: 1515 • ACR Convergence 2022

    Assessing the Difference Between Radiographic Axial Spondylorthritis and Non-radiographic Axial Spondylorthritis in a Two-center Descriptive Study with Mexican Patients: The Influence of Clinical, Demographic, Laboratory and Clinimetric Features

    John Londono1, Gustavo Rodriguez-Salas2, Igor Rueda-Cardenas3, Ana Maria Santos1, Marta Mantilla1, Juan Camilo Santacruz2, Cesar Pachecho4, Gilberto Vargas-Alarcon5 and Ruben Burgos vargas6, 1Spondyloarthropathies study group - Universidad de La Sabana - Hospital Militar Central, Bogotá, Colombia, 2Spondyloathropathies study group Universidad de La Sabana Hospital Militar Central, Bogotá, Colombia, 3Spondyloarthropathies study group - Universidad de LA Sabana - Hospital Militar Central, Colombia, Colombia, 4Universidad Autónoma de chihuahua, Chihuahua, Mexico, 5Insituto Nacional de Cardiología Ignacio Chavez, Ciudad de México, Mexico, 6hospital general de mexico, Ciudad de México, Mexico

    Background/Purpose: Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases that have some key features in common. According to ASAS, this condition is classified into…
  • Abstract Number: 1877 • ACR Convergence 2022

    Nailfold Videocapillaroscopic Abnormalities Correlate with Disease Activity Measures and Cutaneous Damage in Patients with Idiopathic Inflammatory Myopathies

    Diane Zisa1, Aliza Bloostein1, Deanna Jannat-Khah, DrPH, MSPH1, Maurizio Cutolo2, Vanessa Smith3 and David Fernandez1, 1Hospital for Special Surgery, New York, NY, 2Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genova, Italy, 3Department of Rheumatology, Ghent University Hospital – Department of Internal Medicine, Ghent University, Belgium – Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Gent, Belgium

    Background/Purpose: Nailfold videocapillaroscopy (NVC) is a non-invasive tool used to evaluate the microcirculation of patients with connective tissue diseases (CTDs). A specific combination of NVC…
  • Abstract Number: 2095 • ACR Convergence 2022

    Validation Analysis of the Physician Global Assessment (PGA) Scale in Patients with Systemic Lupus Erythematosus Included in RELESSER-PROS Registry

    Laura Cáceres1, Iñigo Rúa-Figueroa1, Norman Jimenez2, María Galindo-Izquierdo3, Jaime Calvo4, Raul Menor Almagro5, Antonio Fernandez-Nebro6, Julia Martinez-Barrio7, Esther Rodriguez Almaraz3, Esther Uriarte Isacelaya8, Elena Aurrecoechea9, Natalia Mena Vazquez6, José Miguel Senabre10, José Antonio Bernal11, Ana Pérez12, Vicente Torrente13, F. Javier Narváez14, Clara Sangüesa15, Marta Arévalo16, Mercedes Freire17, Clara Moriano18, Carlota Iñiguez19, Eva Tomero Muriel20, José Luis Andreu21, Mª Jesús García22, Tatiana Cobo23, Gema Bonilla24, Nuria Lozano25, Loreto Horcada26, Carlos Montilla27, Lorena Expósito28, María Esther Ruiz29, José Eloy Oller30, Ángela Pecondón31, Javier Loricera32, Francisco Javier Novoa33, Eva Salgado34, Tarek Carlos Salman-Monte35, Alejandro Muñoz36, Jorge J Fragío Gil37 and Jose M Pego-Reigosa38, 1Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain, 2IRIDIS Group, Vigo, Spain, 3Hospital Universitario 12 de Octubre, Madrid, Spain, 4Hospital Universitario de Araba, Vitoria, Spain, 5Hospital Jerez de la Frontera, Cádiz, Spain, 6Regional University Hospital of Málaga, Málaga, Spain, 7Hospital General Universitario Gregorio Marañón, Madrid, Spain, 8Hospital Universitario Donostia, Donostia, Spain, 9Hospital de Sierrallana, Torrelavega, Spain, 10Hospital Marina Baixa, Villajoyosa, Spain, 11Hospital Marina Baixa (Villajoyosa), Alicante, Spain, 12University Hospital Príncipe de Asturias, Immune System Diseases-Rheumatology Service, Alcalá de Henares, Madrid, Spain, 13Hospital de Sant Joan Despí Moisès Broggi/Consorci Sanitari Integral (CSI), Sant Joan Despí, Spain, 14Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, 15Hospital Universitario Severo Ochoa, Madrid, Spain, 16Parc Tauli Hospital Universitari, Sabadell, Catalonia, Spain, 17Complejo H. Universitario de A Coruña, A Coruña, Spain, 18Complejo Asistencial Universitario de León, León, Spain, 19Hospital Universitario Lucus Augusti, Division of Rheumatology, Lugo, Spain, 20Hospital Universitario La Princesa, Madrid, Spain, 21Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 22Hospital Universitario Ramón y Cajal, Madrid, Spain, 23Hospital Infanta Sofía, San Sebastián de los Reyes, Spain, 24Hospital Universitario La Paz, Madrid, Spain, 25Hospital Virgen de la Arrixaca, Murcia, Spain, 26Complejo Hospitalario de Navarra, Pamplona, Spain, 27Complejo asistencial Universitario de Salamanca, Salamanca, Spain, 28Hospital Universitario de Canarias, La Laguna, Spain, 29Hospital Universitario de Basurto, Bilbao, Spain, 30Hospital Universitario Dr. Peset, València, Spain, 31Hospital Universitario Miguel Servet, Zaragoza, Spain, 32Hospital Universitario Marqués de Valdecilla, Santander, Spain, 33Complejo Hospitalario Universitario Insular de Gran Canarias, Las Palmas de Gran Canaria, Spain, 34Complejo Hospitalario De Orense, Ourense, Spain, 35Hospital del Mar/Parc de Salut Mar-IMIM/UEC-AIS, Barcelona, Spain, 36Hospital Universitario Virgen del Rocío, Sevilla, Spain, 37Rheumatology Department. Hospital Universitario y Politécnico La Fe, València, Comunidad Valenciana, Spain, 38Hospital Meixoeiro, Vigo, Spain

    Background/Purpose: There is currently no agreement on which scale should be used to evaluate SLE disease activity. The aim of this study was to analyze…
  • Abstract Number: 0098 • ACR Convergence 2022

    Delays in Access to Specialized Care and Diagnosis in Patients with Systemic Lupus Erythematosus

    Alain Sanchez-Rodriguez1, Jose A Meade-Aguilar2, Jeffrey X. Yang2, Gabriel Figueroa Parra2, Shirley-Ann Osei-Onomah2, Rachel Giblon3, Hannah Langenfeld4, Alanna Chamberlain2, Cynthia Crowson5 and Ali Duarte-Garcia2, 1Division of Rheumatology, Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN, 3Mayo Clinic, Rochester, MN, Rochester, MN, 4Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 5Mayo Clinic, Eyota, MN

    Background/Purpose: Delays in access to specialized care and diagnosis of systemic lupus erythematosus (SLE) are associated with poor outcomes. Prior studies rely mostly on cross-sectional…
  • Abstract Number: 0395 • ACR Convergence 2022

    How Does Body Mass Index Affect Secukinumab Treatment Outcomes and Safety in Patients with Psoriatic Arthritis? – Real World Data from a German Observational Study

    Uta Kiltz1, Jan Brandt-Juergens2, Peter Kästner3, Elke Riechers4, Daniel Peterlik5, Christina Budden5 and Hans-Peter Tony6, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumatologische Schwerpunktpraxis, Berlin, Germany, 3Ambulantes Rheumazentrum, Medizinisches Versorgungszentrum, Erfurt, Germany, 4Medizinische Hochschule Hannover, Hannover, Germany, 5Novartis Pharma GmbH, Nürnberg, Germany, 6Medizinische Klinik II - Rheumatologie/Immunologie, Universitätsklinikum Würzburg, Würzburg, Germany

    Background/Purpose: There is a higher prevalence of obesity in patients (pts) with psoriatic disease1. The German non-interventional study AQUILA provides real-world data on the influence…
  • Abstract Number: 0855 • ACR Convergence 2022

    Change in Short Term Outcomes Following Tolerated Disease Activity Level for Individuals with Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry

    Melissa Mannion1, Fenglong Xie1, Timothy Beukelman1, Jeffrey Curtis2 and , for the CARRA Registry Investigators3, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Hoover, AL, 3CARRA, Washington, DC

    Background/Purpose: Current recommendations suggest treatment escalation for juvenile idiopathic arthritis (JIA) until the disease activity target is reached, ideally inactive or low disease activity. Our…
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