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Abstracts tagged "Diagnostic Tests"

  • Abstract Number: 014 • 2020 Pediatric Rheumatology Symposium

    Successful Validation of a Rapid Point-of-care Test for Serum Calprotectin (MRP8/14) as Biomarker in Juvenile Idiopathic Arthritis

    Dirk Foell1, Carolin Park 2, Linda Ziegler 2, Dirk Holziner 3, Kirsten Minden 4, Renato Cotti 5 and Jakob Weber 5, 1University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany, 2University of Muenster, Muenster, Germany, 3University of Essen, Essen, Germany, 4Berlin, Germany, 5Buehlmann Laboratories, Schoenenbuch, Switzerland

    Background/Purpose: Treat-to-target strategies are established for the therapeutic approach to patients suffering from juvenile idiopathic arthritis (JIA). Another proposed therapeutic concept in pediatric rheumatology involves…
  • Abstract Number: 131 • 2019 ACR/ARP Annual Meeting

    Anti-Phosphatidylserine Prothrombin Antibodies as a Predictor of the LAC in an All-Comer Population

    Michael Pham1, Giovanni Orsolini 2, Cynthia Crowson 3, Melissa Snyder 1, Rajiv Pruthi 4 and Kevin Moder 5, 1Mayo Clinic, Rochester, MN, 2University of Verona, Verona, Italy, 3Mayo Clinic Rochester, Rochester, 4Mayo Clinic, Rochester, 5Mayo Clinic Rochester, rochester, MN

    Background/Purpose: Anti-phosphatidylserine prothrombin antibodies (aPS-PT) are reported to be highly associated with the LAC.  Some have suggested a clinically useful role for aPS-PT as a…
  • Abstract Number: 483 • 2019 ACR/ARP Annual Meeting

    Can a Single Question on Functional Impairments Facilitate the Diagnosis of Early Inflammatory Arthritis? A Cross-Sectional Derivation and Validation Study in Two Early Arthritis Recognition Clinics

    Bastiaan van Dijk1, Hanna van Steenbergen 1, Ellis Niemantsverdriet 1 and Annette van der Helm-van Mil 2, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: Early treatment initiation in RA is associated with improved outcomes but requires early identification of synovitis. Joint swelling in early inflammatory arthritis (IA) may…
  • Abstract Number: 1634 • 2019 ACR/ARP Annual Meeting

    Comparison of Different Pulmonary Hypertension Screening Algorithms in Patients with Systemic Sclerosis

    Mustafa Erdogan1, Burcak Kilickiran Avci 2, Yagmur Ersoy 3, Cansu Ebren 2, Zeki Ongen 2, Gul Ongen 4, Vedat Hamuryudan 5 and Gulen Hatemi 6, 1Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheuma, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey, 3Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey, 4Istanbul University, Cerrahpasa Medical Faculty, Department of Chest Diseases, Istanbul, Turkey, 5Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University – Cerrahpasa, Behçet’s Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, 6Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Behcet's Disease Research Center, Istanbul, Turkey, Istanbul, Turkey

    Background/Purpose: Pulmonary hypertension (PH) is an important cause of morbidity and mortality in patients with systemic sclerosis (SSc). Different screening algorithms have been proposed for…
  • Abstract Number: 1829 • 2019 ACR/ARP Annual Meeting

    Ability of Inflammatory and Regulatory Soluble Mediators to Forecast Impending Clinical Disease Flare and Inform a Refined Lupus Flare Prediction Index in a Confirmatory Cohort of SLE Patients

    Melissa E. Munroe1, Sarah Kleckner 1, Wade DeJager 1, Susan R. Macwana 1, Joel Guthridge 2, Eldon Jupe 3, Mohan Purushothaman 3, Sanjiv Sharma 3, Nancy Redinger 1, Teresa Aberle 1, Stan Kamp 1, Cristina Arriens 2, Eliza F. Chakravarty 2, Joan T. Merrill 4 and Judith James 2, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Progentec Diagnostics, Inc., Oklahoma City, OK, 4Okalahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: SLE is marked by altered immune regulation linked to waxing and waning clinical disease activity. This study seeks to verify the alteration of inflammatory…
  • Abstract Number: 2127 • 2019 ACR/ARP Annual Meeting

    Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics

    Judit Morello 1, Sara M. Teixeira 1, João Rodrigues 2, Sara Maia 3, Atlas Sardoo 4, Rita Pinheiro Torres 5, Sofia A. Pereira 4, Jaime Branco 6, Alexandra Antunes 7 and Fernando Pimentel-Santos4, 1Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa, Lisboa, Portugal, 2Clarify Analytical, Évora, Portugal, 3CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, 4Centro de Estudos de Doenças Crónicas (CEDOC), Nova Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal, lisboa, Portugal, 5Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, 6CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, 7Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa,, Lisboa, Portugal

    Background/Purpose: Early diagnosis of inflammatory rheumatic diseases (IRD), as axial Spondyloarthritis (axSpA), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) represents in our days a…
  • Abstract Number: 2263 • 2019 ACR/ARP Annual Meeting

    A Qualitative Study Evaluating Near-Patient Tools Including a Mobile Application for Earlier RA Referral; Potential to Reduce Chronic Disease Burden

    Norma Biln 1, Simran Chahal1, Bruce Clarke 2 and Alison Warner 2, 1Augurex Life Sciences Corp, Vancouver, Canada, 2B2 Consulting, Kelowna, Canada

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, debilitative autoimmune disease. Patients who are treated with disease modifying therapy within 6-12 weeks of symptom onset have…
  • Abstract Number: 1859 • 2018 ACR/ARHP Annual Meeting

    The Prognostic Value of Autoantibody Isotypes for Predicting Therapeutic Responses to Methotrexate in Patients with Rheumatoid Arthritis

    Daniela Sieghart1, Alexander Platzer2, Farideh Alasti2, Paul Studenic3, Maresa Grundhuber4, Sascha Swiniarski4, Stephan Blüml2, Helmuth Haslacher5, Josef S. Smolen6 and Günter Steiner1, 1Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, 2Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Vienna, Austria, 3Division of Rheumatology, Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 5Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria, 6Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are the most specific diagnostic markers of rheumatoid arthritis (RA). Lately we showed that the determination…
  • Abstract Number: 2184 • 2018 ACR/ARHP Annual Meeting

    An Economic Evaluation on the Impact of Earlier Systemic Lupus Erythematosus (SLE) Diagnosis Using Complement C4d Activation Products in a Multivariate Assay Panel (MAP)

    Ann E. Clarke1, Tom Goss2, Andrew Piscitello3, Tarun Chandra3, Tyler O'Malley4, Thierry Dervieux4 and Tami Powell5, 1Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 2Health Economics Outcomes Research, Boston Healthcare, Boston, MA, 3EmpiriQA LLC, Long Grove, IL, 4Exagen Diagnostics, Inc., Vista, CA, 5Corporate Payer Strategy & Reimbursement, Exagen Diagnostics, Inc., vista, CA

    Background/Purpose: Diagnosis (dx) of systemic lupus erythematosus (SLE) is made via a combination of clinical and laboratory examinations; the sensitivity and specificity (S&S) of standard…
  • Abstract Number: 2402 • 2018 ACR/ARHP Annual Meeting

    Acoustic Emissions Generated By the Temporomandibular Joint of Patients with Juvenile Idiopathic Arthritis and Their Implication on Patient Assessment and Screening: A Pilot Study

    Daniel Whittingslow1,2, Hyeon Ki Jeong3, Talia Gergely4, Lori Ponder4, Sampath Prahalad5, Omer Inan3 and Shelly Abramowicz6, 1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 4Emory University, Atlanta, GA, 5Pediatrics, Emory University, Atlanta, GA, 6Surgery, Emory University/Children's Healthcare of Atlanta, Atlanta, GA

    Background/Purpose: The temperomandibular joint (TMJ) is one of the most commonly affected joints in juvenile idiopathic arthritis (JIA) (up to 45% of cases). There is a discrepancy between…
  • Abstract Number: 2833 • 2018 ACR/ARHP Annual Meeting

    Complement Activation Is a Feature of Diseases in the Lupus Spectrum

    Rosalind Ramsey-Goldman1, Roberta Alexander2, Elena Massarotti3, Daniel J. Wallace4, Sonali Narain5, Cristina Arriens6, Christopher E. Collins7, Amit Saxena8, Chaim Putterman9, Kenneth C. Kalunian10, Armida Sace2, Rowena Lafon2, Tyler O'Malley2, JoAnne Ligayon2, Claudia Ibarra2, John Conklin2, Thierry Dervieux2 and Arthur Weinstein7, 1FSM, Northwestern University, Chicago, IL, 2Exagen Diagnostics, Inc., Vista, CA, 3Brigham and Women's Hospital, Boston, MA, 4Cedars-Sinai Medical Center, Los Angeles, CA, 5Northwell Health, Great Neck, NY, 6Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, 8NYU Langone Health, New York, NY, 9Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 10Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: We showed previously that complement activation - cell-bound complement activation products (CB-CAPS) or multi-analyte assay panel (MAP) - is a sensitive and specific biomarker…
  • Abstract Number: 683 • 2018 ACR/ARHP Annual Meeting

    Spanish Validation of the Gepard Questionnaire for the Detection of Psoriatic Arthritis in Argentinean Patients with Psoriasis

    María Victoria Martire1, María Paula Girard Bosch1, Santiago Scarafia2, Vanesa Laura Cosentino3, María Janina Tapia4, Eduardo Kerzberg3, Natalia Estrella5, Cristian Troitiño6, Josefina Marin7, Fernando Andres Sommerfleck8, Hernán Maldonado Ficco9, Erika Catay10, Mariana Benegas11 and Enrique R Soriano12, 1Rheumatology, Instituto Médico Platense, La Plata, Argentina, 2Rheumatology, Instituto de Asistencia Reumatológica Integral, Buenos Aires, Argentina, 3Ramos Mejía Hospital, Buenos Aires, Argentina, 4Reumatology, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, 5Consultorio Privado, Buenos Aires, Argentina, 6Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, 7Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 8Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 9section of Rheumatology, Clinica Regional Del Sud, Rio Cuarto, Argentina, 10Consultorios Moreno, Formosa, Argentina, 11Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, 12Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina

    Background/Purpose: Psoriatic Arthritis (PSA) is preceded by the presence of cutaneous psoriasis (PS) in approximately 80% of the cases. We consider relevant to have tools…
  • Abstract Number: 1229 • 2018 ACR/ARHP Annual Meeting

    Diagnosing Prosthetic Joint Infections in Patients with Inflammatory Arthritis

    Serene Z. Mirza1, Shawn Richardson2, Cynthia Kahlenberg2, Jason Blevins2, Michelle Demetres3, Lily Martin3, Jackie Szymonifka2, Peter K. Sculco4, Mark P. Figgie5 and Susan M. Goodman2, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Weill Cornell Medicine, New York, NY, 4Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY

    Background/Purpose: Patients with inflammatory arthritis (IA) are at increased risk of prosthetic joint infections, yet differentiating between septic and aseptic failure is a  challenge in…
  • Abstract Number: 1441 • 2018 ACR/ARHP Annual Meeting

    Diagnostic Performances of Antibodies Against Carbamylated Proteins in US Based Populations with Rheumatoid Arthritis and Other Autoimmune Rheumatic Diseases

    Jing Shi1, Jay Milo2, Kelley Bradey1, Chelsea Bentow2, John Conklin1, Tyler O'Malley1, Armida Sace1, Rowena Lafon1, Duncan Poling1, Claudia Ibarra1, Michael Mahler2 and Thierry Dervieux1, 1Exagen Diagnostics, Inc., Vista, CA, 2Research and Development, Inova Diagnostics, San Diego, CA

    Background/Purpose: Recently, antibodies directed against carbamylated antigens (anti-CarP antibodies) were identified in rheumatoid arthritis (RA). Studies have established the predictive and prognostic value of this…
  • Abstract Number: 1482 • 2018 ACR/ARHP Annual Meeting

    Is 14.3.3η a Predictor of Development of Rheumatoid Arthritis in Patients with Early Undifferentiated Arthritis?

    Karen Marie Carlsen1, Nina Schmidt2, Anne Duer3, Kim Hørslev-Petersen4, Cecilie Heegaard Brahe5, Merete Lund Hetland2, Norma K Biln6, Michelle L Zaharik7, Bo Jannik Ejbjerg8, Lene Bak9, Michael Sejer Hansen10, Julia Sidenius Johansen11, Hanne Merete Lindegaard12, Jakob M. Møller13 and Mikkel Østergaard14, 1Center for Rheumatology and Spine Diseases,, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Hillerød, Denmark, Hillerød, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, 3Department of Radiology, Rigshospitalet Glostrup, Denmark, Glostrup, Denmark, 4King Christian the Xth Hospital for Rheumatic Diseases, Denmark, Graasten, Denmark, 5Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 6Augurex Life Sciences Corp, Vancouver, BC, Canada, 7Augurex Life Sciences Corp, Vancouver, DC, Canada, 8Rheumatology, Department of Rheumatology, Køge Hospital, Denmark, Køge, Denmark, 9Department of Radiology, Odense University Hospital, Denmark, Odense, Denmark, 10Reuma-Klinik Roskilde, Denmark, Roskilde, Denmark, 11Dept. of Oncology, Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark, 12Dept. of Rheumatology, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Denmark, 13Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark

    Background/Purpose: Optimal management of rheumatoid arthritis (RA) requires early diagnosis and therefore sensitive methods for early identification of RA to prevent joint damage and disability.…
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