Abstracts tagged "Diagnostic Tests"

Abstract Number: 014 • 2020 Pediatric Rheumatology Symposium
Successful Validation of a Rapid Point-of-care Test for Serum Calprotectin (MRP8/14) as Biomarker in Juvenile Idiopathic Arthritis
Dirk Foell¹, Carolin Park ², Linda Ziegler ², Dirk Holziner ³, Kirsten Minden ⁴, Renato Cotti ⁵ and Jakob Weber ⁵, ¹University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany, ²University of Muenster, Muenster, Germany, ³University of Essen, Essen, Germany, ⁴Berlin, Germany, ⁵Buehlmann Laboratories, Schoenenbuch, Switzerland
Background/Purpose: Treat-to-target strategies are established for the therapeutic approach to patients suffering from juvenile idiopathic arthritis (JIA). Another proposed therapeutic concept in pediatric rheumatology involves…
Abstract Number: 2127 • 2019 ACR/ARP Annual Meeting
Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics
Judit Morello ¹, Sara M. Teixeira ¹, João Rodrigues ², Sara Maia ³, Atlas Sardoo ⁴, Rita Pinheiro Torres ⁵, Sofia A. Pereira ⁴, Jaime Branco ⁶, Alexandra Antunes ⁷ and Fernando Pimentel-Santos⁴, ¹Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa, Lisboa, Portugal, ²Clarify Analytical, Évora, Portugal, ³CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, ⁴Centro de Estudos de Doenças Crónicas (CEDOC), Nova Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal, lisboa, Portugal, ⁵Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, ⁶CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ⁷Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa,, Lisboa, Portugal
Background/Purpose: Early diagnosis of inflammatory rheumatic diseases (IRD), as axial Spondyloarthritis (axSpA), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) represents in our days a…
Abstract Number: 2263 • 2019 ACR/ARP Annual Meeting
A Qualitative Study Evaluating Near-Patient Tools Including a Mobile Application for Earlier RA Referral; Potential to Reduce Chronic Disease Burden
Norma Biln ¹, Simran Chahal¹, Bruce Clarke ² and Alison Warner ², ¹Augurex Life Sciences Corp, Vancouver, Canada, ²B2 Consulting, Kelowna, Canada
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, debilitative autoimmune disease. Patients who are treated with disease modifying therapy within 6-12 weeks of symptom onset have…
Abstract Number: 131 • 2019 ACR/ARP Annual Meeting
Anti-Phosphatidylserine Prothrombin Antibodies as a Predictor of the LAC in an All-Comer Population
Michael Pham¹, Giovanni Orsolini ², Cynthia Crowson ³, Melissa Snyder ¹, Rajiv Pruthi ⁴ and Kevin Moder ⁵, ¹Mayo Clinic, Rochester, MN, ²University of Verona, Verona, Italy, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic, Rochester, ⁵Mayo Clinic Rochester, rochester, MN
Background/Purpose: Anti-phosphatidylserine prothrombin antibodies (aPS-PT) are reported to be highly associated with the LAC. Some have suggested a clinically useful role for aPS-PT as a…
Abstract Number: 483 • 2019 ACR/ARP Annual Meeting
Can a Single Question on Functional Impairments Facilitate the Diagnosis of Early Inflammatory Arthritis? A Cross-Sectional Derivation and Validation Study in Two Early Arthritis Recognition Clinics
Bastiaan van Dijk¹, Hanna van Steenbergen ¹, Ellis Niemantsverdriet ¹ and Annette van der Helm-van Mil ², ¹Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Early treatment initiation in RA is associated with improved outcomes but requires early identification of synovitis. Joint swelling in early inflammatory arthritis (IA) may…
Abstract Number: 1634 • 2019 ACR/ARP Annual Meeting
Comparison of Different Pulmonary Hypertension Screening Algorithms in Patients with Systemic Sclerosis
Mustafa Erdogan¹, Burcak Kilickiran Avci ², Yagmur Ersoy ³, Cansu Ebren ², Zeki Ongen ², Gul Ongen ⁴, Vedat Hamuryudan ⁵ and Gulen Hatemi ⁶, ¹Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheuma, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey, ⁴Istanbul University, Cerrahpasa Medical Faculty, Department of Chest Diseases, Istanbul, Turkey, ⁵Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University – Cerrahpasa, Behçet’s Disease Research Center, Istanbul, Turkey, Istanbul, Turkey, ⁶Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Behcet's Disease Research Center, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Pulmonary hypertension (PH) is an important cause of morbidity and mortality in patients with systemic sclerosis (SSc). Different screening algorithms have been proposed for…
Abstract Number: 1829 • 2019 ACR/ARP Annual Meeting
Ability of Inflammatory and Regulatory Soluble Mediators to Forecast Impending Clinical Disease Flare and Inform a Refined Lupus Flare Prediction Index in a Confirmatory Cohort of SLE Patients
Melissa E. Munroe¹, Sarah Kleckner ¹, Wade DeJager ¹, Susan R. Macwana ¹, Joel Guthridge ², Eldon Jupe ³, Mohan Purushothaman ³, Sanjiv Sharma ³, Nancy Redinger ¹, Teresa Aberle ¹, Stan Kamp ¹, Cristina Arriens ², Eliza F. Chakravarty ², Joan T. Merrill ⁴ and Judith James ², ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Progentec Diagnostics, Inc., Oklahoma City, OK, ⁴Okalahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is marked by altered immune regulation linked to waxing and waning clinical disease activity. This study seeks to verify the alteration of inflammatory…
Abstract Number: 683 • 2018 ACR/ARHP Annual Meeting
Spanish Validation of the Gepard Questionnaire for the Detection of Psoriatic Arthritis in Argentinean Patients with Psoriasis
María Victoria Martire¹, María Paula Girard Bosch¹, Santiago Scarafia², Vanesa Laura Cosentino³, María Janina Tapia⁴, Eduardo Kerzberg³, Natalia Estrella⁵, Cristian Troitiño⁶, Josefina Marin⁷, Fernando Andres Sommerfleck⁸, Hernán Maldonado Ficco⁹, Erika Catay¹⁰, Mariana Benegas¹¹ and Enrique R Soriano¹², ¹Rheumatology, Instituto Médico Platense, La Plata, Argentina, ²Rheumatology, Instituto de Asistencia Reumatológica Integral, Buenos Aires, Argentina, ³Ramos Mejía Hospital, Buenos Aires, Argentina, ⁴Reumatology, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, ⁵Consultorio Privado, Buenos Aires, Argentina, ⁶Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ⁷Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁹section of Rheumatology, Clinica Regional Del Sud, Rio Cuarto, Argentina, ¹⁰Consultorios Moreno, Formosa, Argentina, ¹¹Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, ¹²Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina
Background/Purpose: Psoriatic Arthritis (PSA) is preceded by the presence of cutaneous psoriasis (PS) in approximately 80% of the cases. We consider relevant to have tools…
Abstract Number: 1229 • 2018 ACR/ARHP Annual Meeting
Diagnosing Prosthetic Joint Infections in Patients with Inflammatory Arthritis
Serene Z. Mirza¹, Shawn Richardson², Cynthia Kahlenberg², Jason Blevins², Michelle Demetres³, Lily Martin³, Jackie Szymonifka², Peter K. Sculco⁴, Mark P. Figgie⁵ and Susan M. Goodman², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Weill Cornell Medicine, New York, NY, ⁴Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: Patients with inflammatory arthritis (IA) are at increased risk of prosthetic joint infections, yet differentiating between septic and aseptic failure is a challenge in…
Abstract Number: 1441 • 2018 ACR/ARHP Annual Meeting
Diagnostic Performances of Antibodies Against Carbamylated Proteins in US Based Populations with Rheumatoid Arthritis and Other Autoimmune Rheumatic Diseases
Jing Shi¹, Jay Milo², Kelley Bradey¹, Chelsea Bentow², John Conklin¹, Tyler O'Malley¹, Armida Sace¹, Rowena Lafon¹, Duncan Poling¹, Claudia Ibarra¹, Michael Mahler² and Thierry Dervieux¹, ¹Exagen Diagnostics, Inc., Vista, CA, ²Research and Development, Inova Diagnostics, San Diego, CA
Background/Purpose: Recently, antibodies directed against carbamylated antigens (anti-CarP antibodies) were identified in rheumatoid arthritis (RA). Studies have established the predictive and prognostic value of this…
Abstract Number: 1482 • 2018 ACR/ARHP Annual Meeting
Is 14.3.3η a Predictor of Development of Rheumatoid Arthritis in Patients with Early Undifferentiated Arthritis?
Karen Marie Carlsen¹, Nina Schmidt², Anne Duer³, Kim Hørslev-Petersen⁴, Cecilie Heegaard Brahe⁵, Merete Lund Hetland², Norma K Biln⁶, Michelle L Zaharik⁷, Bo Jannik Ejbjerg⁸, Lene Bak⁹, Michael Sejer Hansen¹⁰, Julia Sidenius Johansen¹¹, Hanne Merete Lindegaard¹², Jakob M. Møller¹³ and Mikkel Østergaard¹⁴, ¹Center for Rheumatology and Spine Diseases,, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Hillerød, Denmark, Hillerød, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ³Department of Radiology, Rigshospitalet Glostrup, Denmark, Glostrup, Denmark, ⁴King Christian the Xth Hospital for Rheumatic Diseases, Denmark, Graasten, Denmark, ⁵Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ⁶Augurex Life Sciences Corp, Vancouver, BC, Canada, ⁷Augurex Life Sciences Corp, Vancouver, DC, Canada, ⁸Rheumatology, Department of Rheumatology, Køge Hospital, Denmark, Køge, Denmark, ⁹Department of Radiology, Odense University Hospital, Denmark, Odense, Denmark, ¹⁰Reuma-Klinik Roskilde, Denmark, Roskilde, Denmark, ¹¹Dept. of Oncology, Department of Oncology, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark, ¹²Dept. of Rheumatology, Department of Rheumatology, Odense University Hospital, Denmark, Odense, Denmark, ¹³Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, ¹⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark
Background/Purpose: Optimal management of rheumatoid arthritis (RA) requires early diagnosis and therefore sensitive methods for early identification of RA to prevent joint damage and disability.…
Abstract Number: 1484 • 2018 ACR/ARHP Annual Meeting
Value of Anti-RA33 Isotypes in an European Rheumatoid Arthritis Patient Cohort
Maresa Grundhuber¹, Daniela Sieghart², Günter Steiner², Maryam Poorafshar³ and Sascha Swiniarski¹, ¹Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, ²Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, ³Thermo Fisher Scientific, Uppsala, Sweden, Uppsala, Sweden
Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) leading to effective treatment is essential to improve prognosis and to prevent disease progression. Anti-cyclic citrullinated peptide (CCP)…
Abstract Number: 1485 • 2018 ACR/ARHP Annual Meeting
Survivin Measurements Improve Prediction of Rheumatoid Arthritis Among Patients with Unexplained Arthralgia
Malin C Erlandsson^1,2, Minna Turkkila³, Rille Pullerits^2,3,4 and Maria I Bokarewa^2,3, ¹Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, ²Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Rheumatology, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, ⁴Department of Clinical immunology and transfusion medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Background/Purpose: Early recognition of rheumatoid arthritis (RA) is believed to be the key to successful treatment of this disease. Symptoms of arthralgia often predate development…
Abstract Number: 1693 • 2018 ACR/ARHP Annual Meeting
Innate, Adaptive, and TNF-Superfamily Immune Pathways Inform a Lupus Disease Activity Immune Index That Characterizes Disease Activity in SLE
Melissa E. Munroe^1,2, Joel M. Guthridge¹, Rufei Lu^1,3, Joseph M. Kheir¹, Bolanle Adebayo¹, Susan R. Macwana¹, Hua Chen¹, Virginia C. Roberts¹, Mohan Purushothaman², Sanjiv Sharma², Teresa Aberle¹, Stan Kamp¹, Cristina Arriens¹, Eliza Chakravarty¹, Katherine Thanou¹, Joan T. Merrill¹ and Judith A. James^4,5, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Progentec Diagnostics, Inc., Oklahoma City, OK, ³Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by immune dysregulation. A comprehensive but cost-effective tool to track relevant mediators of altered…
Abstract Number: 1858 • 2018 ACR/ARHP Annual Meeting
An Assay Panel Combining Anti-Protein Arginine Deiminase 4 with Rheumatoid Factor Isotypes Distinguishes Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis
Thierry Dervieux¹, Laura Martinez Prat², John Conklin¹, Claudia Ibarra¹, Michael Mahler², Michael E Weinblatt³ and Joel Kremer⁴, ¹Exagen Diagnostics, Inc., Vista, CA, ²Research and Development, Inova Diagnostics, San Diego, CA, ³Brigham and Women's Hospital, Boston, MA, ⁴Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Anti-citrullinated peptide antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) but lack sensitivity. We evaluated autoantibodies to protein-arginine deiminase 4 (anti-PAD4) in distinguishing…

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