Abstracts tagged "diagnosis"

Abstract Number: 107 • 2013 ACR/ARHP Annual Meeting
Duration Of Symptoms Before Diagnosis In Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Merete Lund Hetland^1,2 and Jan Sørensen³, ¹The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, ²Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ³Center for Applied Health Services Research, University of South Denmark, Odensen, Denmark
Background/Purpose: Early diagnosis is important for the treatment of many rheumatic diseases. Little is known about the duration of symptoms before establishment of diagnosis, and if the…
Abstract Number: L13 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Marks RA Development in Arthralgia and Radiographic Progression in Early RA Patients
D. van Schaardenburg¹, Marian van Beers-Tas², Karin Britsemmer², Mairead Murphy³, Walter P. Maksymowych⁴, Maarten Boers⁵ and Anthony Marotta⁶, ¹Jan van Breemen Research Institute, Amsterdam, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁶Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: The focus of RA management is increasingly towards early detection and treatment. While newly-diagnosed patients will benefit from treatment decisions based on more robust…
Abstract Number: 2756 • 2013 ACR/ARHP Annual Meeting
Serum Periostin Is Associated With Prevalent Knee Osteoarthritis and Predicts Disease Progression In Women: The Ofely Study
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Cindy Bertholon¹, Patrick Garnero² and Roland Chapurlat³, ¹INSERM UMR 1033, Lyon, France, ²INSERM, UMR 1033, Lyon and Cisbio Bioassays, Bagnols/Cèze, France, ³Service de Rhumatologie et Pathologie Osseuse, INSERM UMR 1033 and Université de Lyon, Hôpital Edouard Herriot, Lyon, France
Background/Purpose: Periostin (POSTN) is a secreted vitamin K-dependent (Gla-containing) protein produced by osteoblasts and chondrocytes. The aim of this study was to investigate the relationships…
Abstract Number: 2584 • 2013 ACR/ARHP Annual Meeting
Screening and Diagnostic Modalities For Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Systematic Review
Heather Gladue¹, Nezam I. Altorok², Whitney Townsend¹, Vallerie McLaughlin³ and Dinesh Khanna⁴, ¹University of Michigan, Ann Arbor, MI, ²Internal Medicine and Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Pulmonary arterial hypertension (PAH) affects patients with connective tissue diseases (CTD), especially systemic sclerosis (SSc) and MCTD. Despite this, there continues to be delay…
Abstract Number: 1189 • 2012 ACR/ARHP Annual Meeting
Stromal Cell Markers in the Synovial Tissue of Patients with Early Arthritis and Preclinical Rheumatoid Arthritis
Yuen Kei Choi¹, Olga N. Karpus², Paul Peter Tak³, Jörg Hamann⁴, Christopher D. Buckley⁵, Andrew Filer⁶ and Danielle M. Gerlag⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²1Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ³Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁶Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Stromal cells in synovial tissue (ST) of patients with arthritis may have an important role in the initiation and persistence of the inflammatory infiltrate.…
Abstract Number: 977 • 2012 ACR/ARHP Annual Meeting
14-3-3 Eta Is a Novel Citrullination Target in Rheumatoid Arthritis That Enhances Diagnostic Utility in Anti-CCP Negative Patients
Walter P. Maksymowych¹, Vivian P. Bykerk², Désirée van der Heijde³, R. Landewe⁴ and Anthony Marotta⁵, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: 14-3-3 eta is normally an intracellular protein and only in the disease state is it released into the extracellular space. We have previously presented…
Abstract Number: 948 • 2012 ACR/ARHP Annual Meeting
Antibody-Based Prediction Rules for Connective Tissue Disease: Analysis of 12,555 Patients with Antinuclear Antibody Testing
Ryo Rokutanda¹, Mitsumasa Kishimoto¹, Yasuharu Tokuda², Ken-ichi Yamaguchi¹, Hisanori Shimizu¹, Yasuhiro Suyama¹, Yuri Ohara¹, Yoichiro Haji¹, Chisun Min¹, Akira Takeda¹, Yukio Matsui³ and Masato Okada¹, ¹Division of Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, ²Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan, ³Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan
Background/Purpose: Antinuclear antibody (ANA) is widely used as a screening test for connective tissue diseases (CTDs). The sensitivity of this test is high in 3…
Abstract Number: 926 • 2012 ACR/ARHP Annual Meeting
Accuracy of Canadian Health Administrative Databases in Identifying Patients with Rheumatoid Arthritis Using a Random Sample of 7500 Patients Seen in Primary Care
Jessica Widdifield¹, Claire Bombardier², Sasha Bernatsky³, J. Michael Paterson⁴, Jacqueline Young⁴, Diane Green⁴, J. Carter Thorne⁵, Noah Ivers¹, Debra Butt⁴, R. Liisa Jaakkimainen⁶, Myra Wang⁴, Vandana Ahluwalia⁷, George A. Tomlinson⁸ and Karen Tu⁴, ¹University of Toronto, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto, ON, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada, ⁴Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Preventive Med and Biostatisti, University of Toronto, Toronto, ON, Canada, ⁷William Osler Health Center, Brampton, ON, Canada, ⁸Dept of Medicine/Rheumatology, Toronto General Hospital, Toronto, ON, Canada
Background/Purpose: The use of population-based health administrative databases in rheumatology research is well established, but there are ongoing concerns about validity. To date, previous validation…
Abstract Number: 804 • 2012 ACR/ARHP Annual Meeting
A Comparison of the Nociceptive Flexion Reflex, Pressure Algometry and Summated Widespread Pain in the Diagnosis of Fibromyalgia
Robert M. Bennett¹, Kim D. Jones² and Janice Hoffman³, ¹Medicine & Nursing, Oregon Health & Science Univ, Portland, OR, ²Research & Develop, Oregon Health Sciences University, Portland, OR, ³Office of Research Development & Support, Oregon Health & Science University, Portland, OR
Background/Purpose: To reevaluate the usefulness of the nociceptive flexion reflex (NFR) in distinguishing between FM patients and healthy controls, compared to computerized algometry and a…
Abstract Number: 778 • 2012 ACR/ARHP Annual Meeting
Spinal MRI Has Little Incremental Diagnostic Value Compared with MRI of the Sacroiliac Joints Alone in Early Spondyloarthritis
Ulrich Weber¹, Veronika Zubler², Zheng Zhao³, Robert GW Lambert⁴, Stanley Chan⁵, Susanne Juhl Pedersen⁶, Mikkel Ostergaard⁷ and Walter P. Maksymowych⁸, ¹Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ²Radiology, Balgrist University Hospital, Zurich, Switzerland, ³Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Division of Ophthalmology, University of Alberta, Edmonton, AB, Canada, ⁶Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁷Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The definition of a positive MRI as major criterion in the Assessment of SpondyloArthritis classification criteria for axial spondyloarthritis (SpA) is based on MRI…
Abstract Number: 548 • 2012 ACR/ARHP Annual Meeting
Assessment of the T1-Weighted Sequence Is Essential in Defining a Positive MRI Scan of the Sacroiliac Joints in Spondyloarthritis
Ulrich Weber¹, Veronika Zubler², Susanne Juhl Pedersen³, Kaspar Rufibach⁴, Robert GW Lambert⁵, Stanley Chan⁶, Mikkel Ostergaard⁷ and Walter P. Maksymowych⁸, ¹Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ²Radiology, Balgrist University Hospital, Zurich, Switzerland, ³Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁴Institute for Social and Preventive Medicine, Division of Biostatistics, University of Zurich, Zurich, Switzerland, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Division of Ophthalmology, University of Alberta, Edmonton, AB, Canada, ⁷Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Inflammation on MRI of the sacroiliac joints (SIJ) in patients with spondyloarthritis (SpA) is a major criterion in the Assessment of SpondyloArthritis (ASAS) classification…
Abstract Number: 192 • 2012 ACR/ARHP Annual Meeting
Clinical and Laboratory Findings in A Cohort of Italian Patients with Adult Onset Still’S Disease: The Role of IL-18 As A Disease Biomarker
Roberta Priori¹, Serena Colafrancesco², Carlo Perricone², Antonina Minniti², Cristiano Alessandri², Giancarlo Iaiani³ and Guido Valesini², ¹Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ²Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ³Department of Infectious Diseases and Tropical Medicine, Sapienza University of Rome, Rome, Italy
Background/Purpose: Adult Onset Still's Disease (AOSD) is a systemic inflammatory syndrome driven by interleukin (IL)-18. Since differential diagnosis between AOSD, sepsis and other inflammatory conditions…
Abstract Number: 2579 • 2012 ACR/ARHP Annual Meeting
Novel Autoantibodies to 14-3-3 Eta Are Highly Specific for Rheumatoid Arthritis
Walter P. Maksymowych¹, Désirée van der Heijde², R. Landewe³, Vivian P. Bykerk⁴ and Anthony Marotta⁵, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: Serum 14-3-3 eta, a protein biomarker that is differentially expressed in rheumatoid arthritis (RA), has been reported to add incrementally to rheumatoid factor (RF)…
Abstract Number: 199 • 2012 ACR/ARHP Annual Meeting
Joint, Hand and Feet Swelling As a Presenting Symptom of Hereditary Angioedema
Maria J. Gutierrez¹ and Timothy J. Craig², ¹Department of Pediatrics, Division of Pediatric Rheumatology. Department of Medicine, Section of Allergy and Immunology, Penn State College of Medicine Milton S. Hershey Medical Center, Hershey, PA, ²Department of Medicine. Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine Milton S. Hershey Medical Cente, Hershey, PA
Background/Purpose: Hereditary Angioedema (HAE) is a rare disorder caused by deficiency or impaired function of C1 esterase inhibitor. Early and accurate diagnosis of HAE is…
Abstract Number: 2528 • 2012 ACR/ARHP Annual Meeting
Hypertrophic Pachymeningitis: IgG4-Related Disease Is A Common Etiology
Zachary S. Wallace¹, Mollie Carruthers², Arezou Khosroshahi², Robert Carruthers³, Shweta Shinagare⁴, Anat Stemmer-Rachamimov⁴, Vikram Deshpande⁴ and John H. Stone², ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Rheumatology, Massachusetts General Hospital, Boston, MA, ³Department of Neurology, Massachusetts General Hospital, Boston, MA, ⁴Pathology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result…

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