ACR Meeting Abstracts

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Abstracts tagged "dermatomyositis"

  • Abstract Number: 912 • 2014 ACR/ARHP Annual Meeting

    A Consensus Hybrid Definition Using a Conjoint Analysis Is the Proposed As Response Criteria for Minimal and Moderate Improvement for Adult Polymyositis and Dermatomyositis Clincal Trials

    Rohit Aggarwal1, Lisa G. Rider2, Nicolino Ruperto3, Nastaran Bayat2, Brian Erman4, Brian M. Feldman5, Adam M. Huber6, Chester V. Oddis7, Ingrid E. Lundberg8, Anthony A. Amato, MD9,10, Robert G. Cooper, MD, FRCP11, Hector Chinoy12, Maryam Dastmalchi13, David Fiorentino14, David Isenberg15, James D. Katz16, Andrew L. Mammen17, Marianne de Visser18, Steven R. Ytterberg19, Katalin Danko20, Luca Villa21, Mariangela Rinaldi21, Howard Rockette22, Peter A. Lachenbruch2, Frederick W. Miller2 and Jiri Vencovsky, MD, DSc23, 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 3Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, 4Social and Scientific Systems, Inc., Durham, NC, 5Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 6IWK Health Centre, Halifax, NS, Canada, 7Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 9Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 11MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, 12Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 13Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, 14Dermatology, Stanford University, Redwood City, CA, 15Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 16NIAMS, NIH, Bethesda, MD, 17Neurology and Medicine, Johns Hopkins University, Baltimore, MD, 18Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands, 19Rheumatology Division, Mayo Clinic, Rochester, MN, 20Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, 21Pediatria II, Reumatologia, PRINTO, IRCCS Istituto G. Gaslini, Genova, Italy, 22University of Pittsburgh, Pittsburgh, PA, 23Institute of Rheumatology, Charles University, Prague, Czech Republic

    Background/Purpose: To develop consensus on definitions of improvement (DOIs) for minimal and moderate improvement (and draft preliminary criteria for major improvement) in adult dermatomyositis (DM)…
  • Abstract Number: 2539 • 2014 ACR/ARHP Annual Meeting

    Antibodies to Human Interferon-Inducible Protein-16 Are Present in Primary Sjögren’s Syndrome and Systemic Lupus, but Are Rare in Dermatomyositis

    Alan N. Baer1, Michelle Petri2, David Fiorentino3, Tao Wang4, Jungsan Sohn4, Antony Rosen1 and Livia Casciola-Rosen5, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, 4Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 5Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Interferon inducible protein-16 (IFI16) is an intracellular DNA receptor involved in innate immunity. We evaluated the frequency and clinical significance of anti-IFI16 antibodies in…
  • Abstract Number: 2211 • 2014 ACR/ARHP Annual Meeting

    Epidemiologic and Clinical Features of Patients with Adult and Juvenile Dermatomyositis, Polymyositis and Inclusion Body Myositis from Myovision, a National Myositis Patient Registry

    Abdullah Faiq1, Payam Noroozi Farhadi1, Nastaran Bayat1, Mikaela Chase1, Anna Jansen1, Karen Malley2, Jesse Wilkerson3, Kathryn Rose4, Caroll Co4, Lukasz Itert5, Anne Johnson6, Richard Morris4, Christine Parks7, Edward H. Giannini8, Hermine I. Brunner8, Frederick W. Miller1, Bob Goldberg9 and Lisa G. Rider1, 1Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 2Malley Research Programming, Inc, Bethesda, MD, 3Social and Scientific Systems, Inc., Research Triangle Park, NC, 4Social and Scientific Systems, Inc., Durham, NC, 5Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Epidemiology Branch, NIEHS, NIH, Research Triangle Park, NC, 8Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9The Myositis Association, Alexandria, VA

    Background/Purpose: The myositis syndromes are rare systemic autoimmune diseases, little is known about their epidemiology.  We describe the demographics and comorbidities of patients in a…
  • Abstract Number: 2214 • 2014 ACR/ARHP Annual Meeting

    Power Doppler Ultrasonography for Detection of Abnormal Fascial Vascularity: A Potential Early Diagnostic Tool in Fasciitis of Dermatomyositis

    Ken Yoshida1, Makiko Nishioka2, Satoshi Matsushima2, Kensuke Joh3, Yosuke Oto1, Yoshiga Masayuki1, Kazuhiro Otani1, Haruyash Ito1, Kenichiro Hirai1, Kazuhiro Furuya1, Taro Ukichi1, Kentaro Noda1, Isamu Kingetsu1 and Daitaro Kurosaka1, 1Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 2Rheumatology, Jikei University School of Medicine, Tokyo, Japan, 3Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose We have previously demonstrated that fasciitis is a common lesion of dermatomyositis (DM) detectable early after disease onset by en bloc biopsy combined with…
  • Abstract Number: 2083 • 2013 ACR/ARHP Annual Meeting

    Environmental Factors Associated With Disease Flare In Juvenile and Adult Dermatomyositis

    Gulnara Mamyrova1, Lisa G. Rider2, Olcay Jones3, Alison Ehrlich4, Lauren M. Pachman5, Robert Nickeson6, Lisa G. Criscione-Schreiber7, Frederick W. Miller2, Lawrence K. Jung8 and James D. Katz1, 1Rheumatology, George Washington University, Washington, DC, 2Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 3Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 4Dermatology, The George Washington University, Washington, DC, 5Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Pediatrics, All Children's Hospital, St Petersburg, FL, 7Dept of Med/Rheum Div, Duke University School of Medicine, Durham, NC, 8Pediatric Rheumatology, Children's National Medical Center, Washington, DC

    Background/Purpose: To assess environmental factors in relationship to increased disease activity (flare) in juvenile and adult dermatomyositis (DM). Methods: An online survey was conducted for…
  • Abstract Number: 1981 • 2013 ACR/ARHP Annual Meeting

    Developing International Consensus Definitions Of Improvement For Adult and Juvenile Dermatomyositis and Polymyositis

    Saad Feroz1, Nicolino. Ruperto2, Jiri Vencovsky3, Peter A. Lachenbruch1, Brian Erman4, Adam Huber5, Brian M. Feldman6, Ingrid E. Lundberg7, Angela Pistorio8, Howard Rockette9, Frederick W. Miller1, Rohit Aggarwal10, Lisa G. Rider1, for The ACR-EULAR Myositis Response Criteria Project Group11, Angelo Ravelli12, Clarissa Pilkington13 and Sheila K. Oliveira14, 1Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 2PRINTO, IRCCS G. Gaslini, Genoa, Italy, 3Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 4SRA International, Research Triangle Park, NC, 5IWK Health Centre, Halifax, NS, Canada, 6Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 7Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 8PRINTO, Genoa, Italy, 9University of Pittsburgh, Pittsburgh, PA, 10Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, 11NIEHS, NIH, Bethesda, MD, 12Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, 13Rheumatology Department, Great Ormond Street Hospital, London, United Kingdom, 14Pediatric Rheumatology, Instituto de Pediatria e Puericultura Martagão Gesteira (IPPMG) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

    Background/Purpose: IMACS and PRINTO have developed preliminary core set activity measures and definitions of improvement (DOIs). However, these were developed from small and partially retrospective…
  • Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting

    A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops:  Brachial Artery Reactivity and Oxidized Lipids

    Lauren M. Pachman1,2, Maureen A. McMahon3, Tamar Polonsky4, Gabrielle A. Morgan1, Maria Amoruso5 and Chiang-Ching Huang6, 1Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, 2Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 4Cardiology, University of Chicago Medicine, Chicago, IL, 5Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, 6Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI

    Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…
  • Abstract Number: 1271 • 2013 ACR/ARHP Annual Meeting

    Longitudinal Disease Trajectory Of Juvenile Dermatomyositis

    Lily Siok Hoon Lim1,2, Eleanor Pullenayegum3, Dafna D. Gladman4, Earl D. Silverman5 and Brian M. Feldman6, 1Pediatric Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, 2Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada, 3Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 6Rheumatology, Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: 1) To determine the longitudinal disease activity trajectory of an inception cohort of Juvenile Dermatomyositis (JDM) patients, 2) To identify predictor(s) for longitudinal disease…
  • Abstract Number: 853 • 2013 ACR/ARHP Annual Meeting

    Capillaroscopy Compared With Color Doppler Ultrasound Of Digital Arteries For Distinguishing Primary From Secondary Raynaud’s Phenomenon

    Wolfgang A. Schmidt1, Katharina Pagel2, Bernd Schicke3 and Andreas Krause4, 1Med Ctr Rheumatology Berlin Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 2Medical Ctr Rheumatol Berlin Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 3Tumorzentrum Berlin, Berlin, Germany, 4Immanuel Krankenhaus Berlin, Berlin, Germany

    Background/Purpose: Raynaud’s phenomenon (RP) is commonly seen in rheumatology practice. Differentiating primary from secondary RP is important for disease management and prognosis. How does capillaroscopy…
  • Abstract Number: 222 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Whole Body Versus Targeted Magnetic Resonance Imaging For Assessing Disease Activity and Damage In Idiopathic Inflammatory Myopathies

    Adam Schiffenbauer1, Evrim Turkbey2, Lisa G. Rider1, Suvimol Hill2, Irene Z. Whitt3, Songtao Liu2, David A. Bluemke2 and Frederick W. Miller1, 1Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 2NIH, Bethesda, MD, 3Rheumatology and Immunology, Duke, Durham, NC

    Background/Purpose: In the idiopathic inflammatory myopathies (IIM) MRI imaging is traditionally focused on the proximal upper or lower extremities.  Whole body MRI (WBMRI) is a…
  • Abstract Number: 228 • 2013 ACR/ARHP Annual Meeting

    The Composition and Structure Of Calcifications In Juvenile Dermatomyositis Differs From Calcified Aortic Valves Removed From Adults Without JDM

    Lauren M. Pachman1,2, Gabrielle A. Morgan1, Patrick M. McCarthy3, Anna Huskin3, S. Chris Malaisrie3, Lyudmila Spevak4, Stephen Doty4 and Adele Boskey4, 1Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, 2Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University Feinberg School of Medicine Bluhm Cardiovascular Institute, Chicago, IL, 4Hospital for Special Surgery, New York, NY

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a systemic vasculopathy, primarily involving the micro vasculature. Soft tissue calcification occurs in 15-30% of cases, and is associated with…
  • Abstract Number: 1955 • 2012 ACR/ARHP Annual Meeting

    Is the Pattern of Capillary Deposition of Complement Membrane Attack COPMLEX  Useful in the Differential Diagnosis of Inflammatory?

    Patrick Gordon1, Nuria Villagra2, Istvan Bodi2, Andrew King2, Stefan Buk2, Tibor Hortobagyi2 and Safa Al-Sarraj2, 1Department of Rheumatology, King's College London, London, United Kingdom, 2Department of Clinical Neuropathology, King's College Hospital, London, United Kingdom

    Background/Purpose: Inflammatory myopathies are a heterogeneous group of diseases. We investigated if the location and pattern of deposition of complement membrane attack complex (MAC) can…
  • Abstract Number: 1937 • 2012 ACR/ARHP Annual Meeting

    HLA-DRB1*0101/*0405 Is Associated with Susceptibility to Anti-MDA5 Antibody-Positive Dermatomyositis in the Japanese Population

    Takahisa Gono1, Yasushi Kawaguchi1, Masataka Kuwana2, Tomoko Sugiura1, Takefumi Furuya1, Kae Takagi1, Hisae Ichida1, Yasuhiro Katsumata1, Masanori Hanaoka1, Yuko Okamoto1, Yuko Ota1, Sayuri Kataoka1 and Hisashi Yamanaka1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: The complication of interstitial lung disease (ILD) is associated with the anti-aminoacyl tRNA synthetase antibody (ARS ab) or the anti-melanoma differentiation-associated gene 5 antibody…
  • Abstract Number: 1037 • 2012 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging (MRI) Assessment of Inflammatory Myopathy: Quantitative Fat-Corrected Muscle T2 and Conventional T2 Measurement Versus Standard MRI and Clinical Metrics

    Lawrence Yao1, Adrienne L. Yip2, Sepehr Mesdaghinia2, Ashkan Shademan2, Joseph A. Shrader3, Anna V. Jansen4, Frederick W. Miller4 and Lisa G. Rider4, 1Diagnostic Radiology, NIH Clinical Center, Bethesda, MD, 2NIEHS, NIH, Bethesda, MD, 3Rehabilitation Medicine, Clinical Center, NIH, Bethesda, MD, 4Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD

    Background/Purpose: Active muscle disease in patients with idiopathic inflammatory myopathies (IIM) is characterized by prolonged muscle T2 relaxation on MRI. We examined the utility of…
  • Abstract Number: 1041 • 2012 ACR/ARHP Annual Meeting

    Whole-Body Magnetic Resonance Imaging – A New Diagnostic Tool in the Assessment of Activity in Juvenile Dermatomyositis Patients?

    Tania Monteiro de Castro1, Henrique Lederman1, Maria Teresa Terreri2, Wanda I. Caldana1, Edmar Zanoteli3 and Maria Odete Hilario1, 1Federal University of São Paulo, São Paulo, Brazil, 2Universidade Federal de São Paulo/UNIFESP, São Paulo, Brazil, 3University of São Paulo, São Paulo, Brazil

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare autoimmune disorder, but remains the most commonly chronic inflammatory myopathy among children. A redefinition of the diagnostic criteria…
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