ACR Meeting Abstracts

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Abstracts tagged "dermatomyositis and myositis"

  • Abstract Number: 2298 • 2018 ACR/ARHP Annual Meeting

    Developing a Classification Criteria for Cutaneous Dermatomyositis Utilizing the Delphi Technique

    Josef Concha1, Victoria P. Werth1, Joseph F. Merola2, David Fiorentino3, Jan Dutz4, Manabu Fujimoto5, Mark Goodfield6, Chia-Chun Ang7, Filippa Nyberg8 and Beatrix Volc-Platzer9, 1University of Pennsylvania, Philadelphia, PA, 2Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Dermatology, Stanford University School of Medicine, Stanford, CA, 4Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada, 5University of Tsukuba, Faculty of Medicine, Department of Dermatology, Tsukuba, Japan, 6Leeds General Infirmary, Leeds, United Kingdom, 7Changi General Hospital, Singapore, Singapore, 8Karolinska Institute, Solna, Sweden, 9Wiener Krankenanstaltenverbund, Vienna, Austria

    Background/Purpose: The new European League Against Rheumatism / American College of Rheumatology (EULAR / ACR) classification criteria for inflammatory myopathies are able to identify patients…
  • Abstract Number: 849 • 2017 ACR/ARHP Annual Meeting

    Tumor TIF1 Mutations and Loss of Heterozygosity Related to Cancer Associated Myositis

    Iago Pinal-Fernandez1, Berta Ferrer-Fabregas2, Ernesto Trallero-Araguas1, Eva Balada1, Maria Angeles Martinez3, Jose Cesar Milisenda4, Gloria Aparicio-Español5, Moises Labrador-Horrillo1, Vicente Garcia-Patos1, Josep Maria Grau-Junyent4 and Albert Selva O'Callaghan6, 1Internal Medicine, Autoimmune Diseases Unit. Vall d´Hebron Hospital, Barcelona, Spain, 2Pathology, Vall d´Hebron, Barcelona, Spain, 3Immunology, Immunology Department, Barcelona, Spain, 4Muscle Research Group and Ciberer, Hospital Clinic Provincial, Barcelona, Spain, 5Dermatology, Vall d´Hebron Hospital, Barcelona, Spain, 6Internal Medicine, Hospital Universitari General Vall d'Hebron, Barcelona, Spain

    Background/Purpose: To analyze the influence of genetic alterations and differential expression of the TIF1 genes in the pathophysiology of cancer-associated myositis (CAM). Methods: Whole exome…
  • Abstract Number: 853 • 2017 ACR/ARHP Annual Meeting

    Anti-TIF-1 Antibody Positivity Is Associated with a Five-Fold Increase in Cancer Risk in the Idiopathic Inflammatory Myopathies

    Alexander Oldroyd1,2, Jamie C Sergeant1,3, Paul New4, Neil J. McHugh5,6, Zoe Betteridge5, Janine Lamb7, William Ollier7, Robert Cooper4,7,8 and Hector Chinoy2,9, 1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester, United Kingdom, 3Centre for Biostatistics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4MRC/ARUK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, United Kingdom, 5Department of Pharmacy and Pharmacology, The University of Bath, Bath, United Kingdom, 6Royal National Hospital for Rheumatic Diseases, Bath, UK, Bath, United Kingdom, 7Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, 8Department of Rheumatology, Aintree University Hospital, Liverpool, United Kingdom, 9Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom

    Background/Purpose: There is an increased cancer risk associated with the idiopathic inflammatory myopathies (IIM). Studies have identified that positivity for the autoantibody against transcriptional intermediary…
  • Abstract Number: 2155 • 2017 ACR/ARHP Annual Meeting

    Myositis As a Complication of Checkpoint Blockade at a Comprehensive Cancer Center

    Mohsin Shah1, Jean Tayar1, Noha Abdel-Wahab1,2 and Maria Suarez-Almazor1, 1Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX, 2Rheumatology and Rehabilitation Department, Assiut University Hospitals, Assiut, Egypt, Assiut, Egypt

    Background/Purpose: Immune checkpoint inhibitor therapy (ICI) has surfaced as a successful and robust treatment option in the fight to end cancer. As we gain more…
  • Abstract Number: 272 • 2016 ACR/ARHP Annual Meeting

    Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis

    Cynthia S. Crowson1, Jeannette M. Olazagasti Lourido2, Molly S. Hein3, Richard S. Pendegraft4, Michael A. Strausbauch5, Timothy B. Niewold6, Floranne C. Ernste7, Theresa L. Wampler Muskardin3, Erik J. Peterson8, Emily C. Gillespie9 and Ann M Reed10, 1Health Sciences Research, Mayo Clinic, Rochester, MN, 2University of Puerto Rico, San Juan, Puerto Rico, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Biomedical Statistics and informatics, Rochester, MN, 5Surgical Research, Mayo Clinic, Rochester, MN, 6Rheumatology and Immunology, Mayo Clinic, Rochester, MN, 7Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, 8Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN, 9Medicine, University of Minnesota, Minneapolis, MN, 10Rheumatology, Duke University, Durham, NC

    Background/Purpose:   Methods:  Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of IFN-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific…
  • Abstract Number: 2314 • 2016 ACR/ARHP Annual Meeting

    Anti-Mi2 Dermatomyositis Revisited: Pure DM Phenotype with Muscle Fiber Necrosis and High Risk of Malignancy

    Océane Landon-Cardinal1, Grégoire Monseau2, Yoland Schoindre3, Aude Rigolet1, Nicolas Champtiaux1, Baptiste Hervier1, Agathe Masseau4, Eric Hachulla5, Thomas Papo6, Benjamin Terrier7, Alain Meyer8, Jean-Emmanuel Kahn3, François Maurier9, Francis Gaches10, Emmanuelle Salort-Campana11, Thierry Zenone12, Nathalie Costedoat-Chalumeau7, Florian Perez13, Maxime Samson14, Anne-Marie Piette3, Guillaume Moulis10, Sylvain Audia15, Séverine Genot16, Nicolas Schleinitz17, Guillaume Lefevre5, Laurence Verneuil18, Olivier Benveniste19, Yves Allenbach1 and Boris Bienvenu20, 1Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, 2Internal Medicine, Caen University Hospital, Caen, France, 3Internal Medicine, Foch Hospital, Suresnes, France, 4Internal Medicine, Nantes University Hospital, Nantes, France, 5Internal Medicine, Lille University Hospital, Lille, France, 6Bichat University Hospital - Internal Medicine, Paris, France, 7Internal Medicine, Cochin University Hospital, Paris, France, 8Rheumatology, Strasbourg University Hospital, Strasbourg, France, 9Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, 10Internal Medicine, Toulouse University Hospital, Toulouse, France, 11Neurology, La Timone University Hospital, Marseille, France, 12Internal Medicine, Valence Hospital, Valence, France, 13Neurology, Albi Hospital, Albi, France, 14Dijon University Hospital, Dijon, France, 15Internal Medicine, Dijon University Hospital, Dijon, France, 16Internal Medicine, Martigues Hospital, Martigues, France, 17La Timone University Hospital, Marseille, France, 18Dermatology, Caen University Hospital, Caen, France, 19Pitié-Salpêtrière University Hospital, Paris, France, 20Caen University Hospital, Caen, France

    Background/Purpose:  Anti-Mi2 autoantibodies (Aabs) have been proposed to be highly specific for dermatomyositis (DM) and to be associated with a DM classical phenotype consisting of…
  • Abstract Number: 2320 • 2016 ACR/ARHP Annual Meeting

    Oropharyngeal Dysphagia in Autoimmune Myositis

    Jessica Nehme1, Jean-Paul Makhzoum2, Josiane Bourré-Tessier3, Yves Troyanov4, Marianne Landry1, Océane Landon-Cardinal5, Marvin J. Fritzler6, Anne-Marie Mansour7, Eric Rich8, Jean-Richard Goulet9, Tamara Grodzicky10, Edith Villeneuve2, Frédéric Massicotte11, Florence Weber12, Martial Koenig13, Sylvie Desmarais14, José Ferreira2, Benjamin Ellezam15, Ira N. Targoff16 and Jean-Luc Senécal2, 1Université de Montréal, Montreal, QC, Canada, 2Université de Montréal, Montréal, QC, Canada, 3Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 4Rheumatology, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, 5Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, 6Medicine, University of Calgary, Calgary, AB, Canada, 7medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, 8Div of Rheumatology, C H Univ de Montreal, Montreal, QC, Canada, 9246 av Edison, CHUM - H, Saint-Lambert, QC, Canada, 10Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, 11Hôpital Notre-Dame, Montr, QC, Canada, 12Hôpital St-Luc, Montreal, QC, Canada, 13Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 14Centre Hospitalier Pierre-Boucher, Longueuil, QC, Canada, 15Hôpital Ste-Justine, Montreal, QC, Canada, 16University of Oklahoma, Oklahoma City, OK

    Background/Purpose:  Oropharyngeal dysphagia (OPD) is an ominous finding in autoimmune myositis (AIM), yet few studies have evaluated the disease subsets at higher risk for this…
  • Abstract Number: 2213 • 2014 ACR/ARHP Annual Meeting

    Gene Expression Profiling of T Helper Subsets in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with Juvenile and Adult Dermatomyositis

    Consuelo Lopez de Padilla1, Molly S. Hein1, Cynthia S. Crowson2, Richard S. Pendegraft3, Erik J. Peterson4, Emily Baechler5 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Biomedical Statistics and informatics, Rochester, MN, 4University of Minnesota, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: The molecular and cellular basis for juvenile and adult dermatomyositis (JDM and ADM) presumably is similar. However, important differences in the clinical features, outcome…
  • Abstract Number: 2210 • 2014 ACR/ARHP Annual Meeting

    Redefining Dermatomyositis: Description of New Diagnostic Criteria That Differentiate Pure Dermatomyositis from Overlap Myositis with Dermatomyositis Features

    Marie-Pier Payette1, Yves Troyanov1, Ira N. Targoff2, Jean-Pierre Raynauld1, Suzanne Chartier3, Jean-Richard Goulet1, Josiane Bourré-Tessier1, Eric Rich1, Tamara Grodzicky1, Marvin J. Fritzler4, France Joyal5, Martial Koenig5 and Jean-Luc Senécal1, 1Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Division of Dermatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Mitogen Advanced Diagnostics Laboratory, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, 5Department of Medicine, Division of Internal Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada

    Background/Purpose: Dermatomyositis (DM) is a major form of autoimmune myositis (AIM). The characteristic DM rash (Gottron's papules, heliotrope rash) and perifascicular atrophy (PFA) at muscle…
  • Abstract Number: 2086 • 2013 ACR/ARHP Annual Meeting

    Defining The Prevalence and Associated Risk Factors For Calcinosis In Adult Dermatomyositis Patients

    Jessie Werner1, Jason Liebowitz2, Andrew L. Mammen3 and Lisa Christopher-Stine4, 1Medicine, University of Maryland School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3NIAMS, NIH, Bethesda, MD, 4Medicine and Neurology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Calcinosis is known to be associated with junvenile dermatomyositis, but the prevalence and risk factors associated with the development of calcinosis in adult dermatomyositis…
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