Abstract Number: 177 • 2016 ACR/ARHP Annual Meeting
Treatment with Dexamethasone and Monophosphoryl Lipid a Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers the Ability to Modulate CD4+ T Cell Responses
Background/Purpose: Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases such as rheumatoid arthritis (RA). Here we characterise TolDCs from RA patients…Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting
CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice
Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…Abstract Number: 1820 • 2016 ACR/ARHP Annual Meeting
Dectin-1 on Monocytic Cells Mediates Aberrant Innate and Adaptive Immune Responses in Patients with Systemic Lupus Erythematosus
Background/Purpose: Dectin-1 is a c-type lectin like receptor that signals via syk and is involved in anti-fungal immunity. Dectin-1 was found to trigger experimental inflammatory…Abstract Number: 1918 • 2016 ACR/ARHP Annual Meeting
Characterising the Specificity, Function and Behavior of CD4+ T Cells Initiating Inflammation in a Murine Model of Rheumatoid Arthritis
Background/Purpose: CD4+ T cells are important contributors to the pathogenesis of Rheumatoid Arthritis (RA). The presence of activated T cells in the inflamed synovium, strong…Abstract Number: 206 • 2015 ACR/ARHP Annual Meeting
Activation of Non-Canonical NF-Kappa B Signalling in Dendritic Cells Induces Extrathymic Autoimmune Regulator (AIRE) Expression
Background/Purpose: Immune regulation is necessary for limiting excessive immune responses and for preventing autoimmune diseases. Nuclear factor (NF)-κB signalling plays an important role in the…Abstract Number: 807 • 2015 ACR/ARHP Annual Meeting
High Levels of Serum IFN-Alpha Mark a Subgroup of SLE Patients with Distinct Immunophenotypic Features and Hyperresponsiveness to Toll-like Receptor Stimulation
Background/Purpose: IFN-alpha is a pathogenic factor in SLE. High serum interferon activity (IFN-high) marks a subgroup of SLE patients strongly associated with increased disease severity…Abstract Number: 1362 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Dendritic Cell Maturation & T Cell Activation within the Inflamed Synovium in Rheumatoid Arthritis
Background/Purpose: Dendritic cells (DC) are a heterogeneous population of antigen presenting cells which link both innate & adaptive immunity. To date their classification within blood…Abstract Number: 1774 • 2015 ACR/ARHP Annual Meeting
Bone Marrow Derived Dendritic Cells Modified By Lentiviral-Mediated RelB shRNA Possess Tolerogenic Phenotype and Functions on Lupus Splenic Lymphocytes
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by high morbidity and mortality and remains challenging in treatment. Dendritic cells (DCs)…Abstract Number: 3081 • 2015 ACR/ARHP Annual Meeting
IRF5 Deletion Prevents the SLE-like Disease Initiated By Dendritic Cell-Specific Loss of Caspase 8
Background/Purpose: Previous studies implicate dendritic cells (DCs) in the initiation and persistence of systemic lupus erythematosus (SLE). While DCs from SLE patients exhibit elevated activation,…Abstract Number: 950 • 2014 ACR/ARHP Annual Meeting
Multiple Mechanisms of Tolerance Characterize the Immune Response to Autologous Modified Dendritic Cells Exposed to Citrullinated Peptides in Patients with Rheumatoid Arthritis
Background/Purpose We carried out a phase I clinical trial of tolerising autologous peripheral blood DCs exposed to 4 citrullinated self-peptides (“Rheumavax”) in 29 HLA-DR shared…Abstract Number: 946 • 2014 ACR/ARHP Annual Meeting
Phase 1 Study of Immunotherapy Using Autoantigen-Loaded Dendritic Cells in Patients with Anti-Citrullinated Peptide Antigen Positive Rheumatoid Arthritis
Background/Purpose To date, no dendritic cell (DC) immunotherapy has been shown to give a benefit in patients with rheumatoid arthritis (RA). In this prospective phase…Abstract Number: 767 • 2014 ACR/ARHP Annual Meeting
The Impact of Plasmacytoid Dendiritc Cells (pDCs) on Fibrosis in bleomycin–induced Murine Model of Systemic Sclerosis (SSc)
Background/Purpose Pathogenesis of systemic sclerosis (SSc) remains unclear. Alterations in adaptive and innate immune responses, with increased T-cells that produce type 2 cytokines and impaired…Abstract Number: 642 • 2014 ACR/ARHP Annual Meeting
Treatment with a Glycolipid Ameliorates Lupus Dermatitis and Expands Skin ãä T Cells That Promote the Migration of Langerhans Dendritic Cells
Background/Purpose: Self antigens are taken from tissues to local lymphoid organs to acquire ability to avoid self-reactivity. This important immune function is accomplished by dendritic…Abstract Number: 659 • 2014 ACR/ARHP Annual Meeting
Breakdown of Tolerance at the Tissue Level in Systemic Autoimmunity: Role of Tissue-Resident Dendritic Cells
Background/Purpose Systemic autoimmune diseases such as lupus affect multiple organs including skin and kidneys, usually in a diverse fashion where only certain organs are affected…Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis
Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Both myeloid cells and…
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