Abstracts tagged "degenerative arthritis"

Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode¹, Rebecca Cleveland ², David Hu ³, Steven George ⁴, Virginia Byers Kraus ⁵, Todd Schwartz ⁶, Richard Gracely ⁷, Louis DeFrate ⁸, Joanne Jordan ⁹ and Yvonne Golightly ¹⁰, ¹Duke University, Department of Orthopedic Surgery, Duke Clinical Research Institute, and Department of Population Health Sciences, Durham, NC, ²Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Duke University, Department of Orthopedic Surgery and Duke Clinical Research Institute, Durham, NC, ⁵Duke University, Department of Orthopedic Surgery, Duke Molecular Physiology Laboratory, Durham, NC, ⁶University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁷Department of Endodontics, Adams School of Dentistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, ⁸Duke University, Department of Orthopedic Surgery, Department of Mechanical Engineering and Materials Science and Department of Biomedical Engineering, Durhham, NC, ⁹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ¹⁰University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka¹ and Shigeki Momohara¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan
Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…

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