Abstracts tagged "cytokines"

Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Nathan D. Chamberlain¹, Seung-jae Kim², Michael Volin³, Anjali Mehta², Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…
Abstract Number: 2352 • 2012 ACR/ARHP Annual Meeting
Temporal Artery Biopsy Culture in Tridimensional Matrix. an in Vitro Model for Functional Studies in Giant-Cell Arteritis
Marc Corbera Bellalta¹, Ester Planas Rigol¹, Ester Lozano¹, Marco A. Alba², Itziar Tavera-Bahillo¹, Sergio Prieto-González¹, Georgina Espígol Frigolé¹, Montserrat Butjosa¹, José Hernández-Rodríguez¹, Ana García-Martínez³ and Maria C. Cid⁴, ¹Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, ²Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Department of Emergency Medicine, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁴Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Background/Purpose: GCA is the most frequent systemic vasculitis in Europe and North America. In spite of the initial response to glucocorticoid treatment more than 60%…
Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Samuel Garcia¹, Sarah Krausz², Carmen A. Ambarus³, Bea Malvar Fernandez², Dominique L. Baeten⁴, Paul P. Tak⁵ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…
Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Samuel Garcia¹, Linda M. Hartkamp², Inge E. van Es², Haishan Lin³, Li Long³, Emma L. Masteller³, Brian R. Wong³, Paul P. Tak⁴ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Five Prime Therapeutics, Inc., South San Francisco, CA, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…
Abstract Number: 218 • 2012 ACR/ARHP Annual Meeting
Proteomics Study of a Phase 1b Trial with an Anti-IFN-α Monoclonal Antibody Indicates Association of Soluble Interleukin 2 Receptor with Type I Interferon Activity in Patients with Dermatomyositis or Polymyositis
Xiang Guo¹, Brandon W. Higgs¹, Wei Zhu², Yihong Yao¹ and Wendy White³, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Translational Science, MedImmune, LLC, Gaithersburg, MD, ³Translational Sciences, MedImmune, Gaithersburg, MD
Background/Purpose: To evaluate downstream effects of an anti-IFN-α monoclonal antibody (mAb) in adult dermatomyositis (DM) and polymyositis (PM) patients using serum proteomics and gene expression…
Abstract Number: 2335 • 2012 ACR/ARHP Annual Meeting
Increased TSLP Expression in Joints of Rheumatoid Arthritis Patients Causes Increased Activation of Intra-Articular Myeloid Dendritic Cells with Enhanced Th1 and Th17 Cell Activity
F.M. Moret¹, C.E. Hack², T.R.D.J. Radstake³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Administration of TSLP…
Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Swati Bhattacharyya¹, Zenshiro Tamaki², Wenxia Wang³, Paul Hoover⁴, Adam Booth⁵, Alyssa Dreffs⁶, Monique E. Hinchcliff⁷, Feng Fang⁸, Spiro Getsios⁴, Hang Yin⁹, Eric S. White⁶ and John Varga¹⁰, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Rheumatology, Northwestern Univ Med School, Chicago, IL, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Ann Arbor, MI, ⁶Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁷Division of Rheumatology, Northwestern Univ Med School, Chicago, IL, ⁸Rheumatology Division, Northwestern University, Chicago, IL, ⁹University of Colorado at Boulder, Boulder, CO, ¹⁰Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…
Abstract Number: 878 • 2012 ACR/ARHP Annual Meeting
Differential Regulation of Cytokines by Extracellular-Signal Regulated Kinase and c-Jun N-Terminal Kinase in Map Kinase Kinase-3 and -6 Deficiency
Deepa Hammaker¹, Katharyn Topolewski², Monica Guma³, David L. Boyle⁴ and Gary S. Firestein⁵, ¹MC 0656, UCSD School of Medicine, La Jolla, CA, ²UCSD School of Medicine, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: p38 inhibitors have limited efficacy in rheumatoid arthritis (RA), possibly because p38 blockade suppresses IL-10 production and increases JNK and ERK phosphorylation in…
Abstract Number: 87 • 2012 ACR/ARHP Annual Meeting
Prediction of Mortality in Rheumatoid Arthritis Using a Serum Cytokine Profile
Agustin Escalante¹, Roy W. Haas¹, Daniel F. Battafarano² and Inmaculada Del Rincon³, ¹Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ³Rheumatology, University of Texas Health Science Center, San Antonio, TX
Background/Purpose: Cytokines are important in the pathogenesis of RA. Their concentration in the serum rises immediately prior to RA onset, and may be associated with…

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