Abstracts tagged "cytokines"

Abstract Number: 1296 • 2013 ACR/ARHP Annual Meeting
Deletion Of RBP-J In a Murine Model Of Inflammatory Arthritis Reveals Pro-Inflammatory Cytokine Expression and Immunophenotypic Differences
Soumya D. Chakravarty¹, Karmen Au², Lionel B. Ivashkiv³ and Xiaoyu Hu⁴, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁴Arthritis Tissue Degeneration Program, Hospital for Special Surgery, New York, NY
Background/Purpose: RBP-J, a DNA-binding protein, serves as the central transcriptional regulator of the Notch signaling pathway. Prior in vitro work has demonstrated that RBP-J plays…
Abstract Number: 571 • 2013 ACR/ARHP Annual Meeting
Protective Effect Of Inducible Adeno-Associated Virus Mediated IL-2 Gene Therapy On Tissue Damages In Lupus-Prone Mice
Masayuki Mizui¹, Tomohiro Koga², Linda Lieberman³, Jessica Beltran³, Mark C. Johnson⁴, José C. Crispin², Roland Tisch⁴ and George C. Tsokos⁵, ¹Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-2 plays critical roles not only in immune responses but also in peripheral tolerance. Impairment of IL-2 production has been linked to the development…
Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting
Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis
Emilie Duvallet¹, Laure Foulboeuf¹, Luca Semerano², Nadia Belmellat¹, Marc Lecouvey³, Eric Assier¹, Sylviane Muller⁴ and Marie-Christophe Boissier⁵, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³CSPBAT Paris 13 University, Bobigny, France, ⁴Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, ⁵INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
Abstract Number: 1194 • 2013 ACR/ARHP Annual Meeting
Enhanced IL-1β and IL-6 Production In Gout Patients Upon Stimulation With Mono Sodium Urate Crystals and Synergizing Agents Compared To Healthy Volunteers
Tania O. Crisan¹, Maartje Cleophas¹, Mihai G. Netea¹, Tim L. Jansen² and Leo A. Joosten³, ¹Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
Abstract Number: 2190 • 2013 ACR/ARHP Annual Meeting
Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)
Hanna Kim¹, Adriana Almeida de Jesus², Yin Liu³, Yan Huang¹, Gina Montealegre⁴, Dawn Chapelle⁵, Nicole Plass¹, Wanxia Tsai⁶, Massimo Gadina⁷, Lisa G. Rider⁸, Adeline Vanderver⁹ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ³Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁴Office of the Clinical DIrector, NIAMS / NIH, Bethesda, MD, ⁵Office of the Clinical Director, NIAMS / NIH, Bethesda, MD, ⁶Translational Immunology Section, NIAMS / NIH, Bethesda, MD, ⁷Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁸Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁹Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: Increased interferon (IFN) regulated gene (IRG) expression has been reported in juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis (JDM)2. Recently, two monogenic conditions chronic…
Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting
Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients
Paulina Chalan¹, Johan Bijzet², Kornelis S.M. van der Geest¹, Bart-Jan Kroesen³, Annemieke M.H. Boots^4,5 and Elisabeth Brouwer¹, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Groningen Research initiative on healthy Ageing and Immune Longevity (GRAIL), Groningen, Netherlands
Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…
Abstract Number: 367 • 2013 ACR/ARHP Annual Meeting
Cytomegalovirus-Related Immunity Correlates With Myocardial Disease In Rheumatoid Arthritis
John M. Davis III¹, Cynthia S. Crowson², Michael A. Strausbauch³, Terry M. Therneau², Eric L. Matteson¹, Keith L. Knutson³ and Sherine E. Gabriel⁴, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Immunology, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: We recently discovered correlations between a profile of cytokines produced in response to human cytomegalovirus (CMV), poor treatment outcome, and erosive joint damage. The…
Abstract Number: 2207 • 2013 ACR/ARHP Annual Meeting
Plasma Cytokine Concentrations Are Associated With Folate Perturbations and Methotrexate Polyglutamate Accumulation In The Peripheral Blood Of Juvenile Idiopathic Arthritis Patients Treated With Low-Dose Methotrexate
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, J.S. Leeder¹ and Mara L Becker⁶, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Methotrexate inhibits the production of inflammatory cytokines, but is also an antifolate. The activity of MTX is thought to depend on the formation of…
Abstract Number: 1147 • 2013 ACR/ARHP Annual Meeting
Human Dendritic Cells Produce Thymic Stromal Lymphopoietin In Response To Pattern Recognition Receptor Ligation and This Secretion Is Augmented By Endoplasmic Reticulum Stress
Matthew J Elder¹, Anthony YKC Ng², Steven J Webster³, Michael J Bacon¹, JS Hill Gaston⁴ and Jane C Goodall¹, ¹Medicine, University of Cambridge, Cambridge, United Kingdom, ²Medicine, Level 5, University of Cambridge, Cambridge, United Kingdom, ³Dept Medicine Level 5 Box 157, University of Cambridge, Cambridge, United Kingdom, ⁴Dept Medicine Level 5 Box 157, University of Cambridge/Clin Med, Cambridge, United Kingdom
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is a cytokine that has an important role in inducing Th2 cell differentiation and has also been implicated as a…
Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting
Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, S.Q. Ye⁶, J.S. Leeder¹ and Mara L Becker⁷, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Medical Genetic Research, Children's Mercy Hospital, Kansas City, MO, ⁷Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…
Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting
Elevated Frequency of Synovial Interleukin-21⁺ CD4⁺ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis
Maria C. Lebre¹, Pedro L. Vieira², Saïda Aarrass³, Thomas Newsom-Davis², Paul P. Tak⁴ and Gavin R. Screaton², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ²Department of Immunology, Imperial College London, London, United Kingdom, ³Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…
Abstract Number: 1492 • 2012 ACR/ARHP Annual Meeting
IL-13 Receptors and Signaling in the Dermal Fibroblasts From Patients with Systemic Sclerosis
Yuko Ota¹, Yasushi Kawaguchi¹, Atsushi Kitani², Kae Takagi¹, Hisae Ichida¹, Yasuhiro Katsumata¹, Takahisa Gono¹, Masanori Hanaoka¹, Yuko Okamoto¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Mucosal Immunity Section, NIAID/NIH, Bethesda, MD
Background/Purpose: Interleukin (IL)-13 is a pleiotropic cytokine involved in T helper type 2 cell immune response and in the development of fibrotic conditions such as…
Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Steven E. Domino³, G. Kenneth Haines III⁴ and Alisa E. Koch⁵, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, ⁴Department of Pathology, Yale University, New Haven, CT, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…
Abstract Number: 3 • 2012 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Differentiate Into Osteoblasts in Response to Inflammation
Koshiro Sonomoto¹, Kunihiro Yamaoka¹, Koichi Oshita¹, Shunsuke Fukuyo¹, Xiangmei Zhang², Kazuhisa Nakano³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Bone destruction due to enhanced osteoclast differentiation is a common observation in rheumatoid arthritis. It is well known that inflammatory cytokines cause osteoclatogenesis, however,…

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