Abstracts tagged "cytokines"

Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting
Polyclonal CD4⁺Foxp3⁺treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome
Qin Lan¹ and Song G. Zheng², ¹Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting
Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se
Gregor Bauer¹, Constantin Aschauer¹, Birgit Niederreiter², Josef S. Smolen³, Kurt Redlich² and Silvia Hayer², ¹Dep. of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…
Abstract Number: 2415 • 2012 ACR/ARHP Annual Meeting
Does Interleukin-6 Mediate the Relation Between Estrogen and Bone? an Epidemiologic Approach in the Framingham Osteoporosis Study
Robert R. McLean¹, Xiaochun Zhang², Andrea D. Coviello³, Joao D.T. Fontes⁴, L. Adrienne Cupples⁵, Douglas P. Kiel⁶ and Marian T. Hannan¹, ¹Institute for Aging Research, Hebrew SeniorLife & Harvard Medical School, Boston, MA, ²Institute for Aging Research, Hebrew Senior Life, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Framingham Heart Study and Boston University, Framingham, MA, ⁵Department of Biostatistics, Boston University School of Public Health, Boston, MA, ⁶Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Laboratory and animal studies suggest that lower sex hormone levels promote production and activity of pro-inflammatory cytokines that trigger bone resorption. This paradigm is…
Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E₂ Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar³, Patrick S. Asmawidjaja³, Johanna M.W. Hazes⁴ and Erik Lubberts³, ¹Immunology, Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…
Abstract Number: 1058 • 2012 ACR/ARHP Annual Meeting
Fulminant Toll-Like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis Occur Independently of Interferon Gamma
Scott W. Canna¹, Julia Wrobel², Portia A. Kreiger³, Michele E. Paessler⁴ and Edward M. Behrens⁵, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ⁴Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁵Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Macrophage Activation Syndrome (MAS) is a potentially lethal cytokine storm syndrome that complicates various rheumatic diseases. We have previously shown that Toll-like Receptor (TLR9)…
Abstract Number: 314 • 2012 ACR/ARHP Annual Meeting
Transcriptome and Surface Phenotype Analyses Suggest an Alternatively Activated (M2) Function for Hemophagocytes
Scott W. Canna¹, Ana Patrícia Costa Reis², William E. Bernal³, Kathleen E. Sullivan⁴, Michele E. Paessler⁵ and Edward M. Behrens⁶, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁶Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytes (HPCs) are activated macrophages identified in situ by having engulfed other hematopoietic cells. HPCs are rarely seen in normal bone marrow, but are…

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