Abstracts tagged "cytokines"

Abstract Number: 883 • 2012 ACR/ARHP Annual Meeting
Role of Phospholipase D1 (PLD1) in the Expression of Proinflammatory Genes in Rheumatoid Arthritis Synovial Fibroblasts (RASF)
Sean C. Friday¹ and David A. Fox², ¹Rheumatology, The University of Michigan, Ann Arbor, MI, ²Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI
Background/Purpose: Interleukin-17 (IL-17) and Tumor Necrosis Factor alpha (TNFa), when co-applied to RASF, induce synergistic expression of proinflammatory genes such as IL-6 and IL-8. Work…
Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Ningli Li¹ and JP Lin², ¹Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Shanghai Institute of Immunology, Institute of medical sciences,Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
Abstract Number: 1448 • 2012 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice
Kunihiro Ichinose¹, Atsushi Kawakami² and George C. Tsokos³, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice. Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with abnormal…
Abstract Number: 872 • 2012 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 and Eotaxin Are Associated with Parameters of Cardiac Dysfunction in Juvenile Dermatomyositis
Thomas Schwartz¹, Ivar Sjaastad², Berit Flatø³, Maria Vistnes¹, Geir Christensen¹ and Helga Sanner³, ¹Institute for Experimental Medical Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ²Institute for Clinical Medicine, University of Oslo, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, ³Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway
Background/Purpose : Juvenile dermatomyositis (JDM) is a vasculopathic disease affecting not only skeletal muscle and skin, but other organs as well. Previously we have shown…
Abstract Number: 2291 • 2012 ACR/ARHP Annual Meeting
Enhanced Release of S100A9 and Hepatocyte Growth Factor by the Epidermis in Systemic Sclerosis
Joanna Nikitorowicz Buniak¹, Christopher P. Denton¹, David J. Abraham² and Richard J. Stratton¹, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²UCL Medical School, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a severe disease of unknown aetiology characterised by cellular injury and activation in early stage, followed by autoimmunity and fibrosis.…
Abstract Number: 1307 • 2012 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Nanobody (ALX-0061) Seamless “First-in-Human” Phase I/II POC Study in Patients with Active RA On Stable MTX Treatment
Steven De Bruyn¹, Béla Gachályi², Bernadette Rojkovich³, Slavomir Bruk⁴, Petr Sramek⁵, Mariusz Korkosz⁶, Krzysztof Krause⁷, Pieter Schoen⁸, Laura Sargentini-Maier⁹, Joke D'Artois¹⁰, Katrien Verschueren¹⁰, Katelijne De Swert¹⁰, Gerhard Arold¹¹ and Josefin-Beate Holz¹², ¹Clinical Development, Ablynx N.V., Zwijnaarde, Belgium, ²Fázis I-es Klinikai Farmakológiai Vizsgálóhely, Péterfy Sándor Utcai Kórház, Budapest, Hungary, ³II. sz. Reumatológiai Osztály, Budai Irgalmasrendi Kórház Kht., Budapest, Hungary, ⁴Interni oddeleni, Nemocnice Trinec, Trinec, Czech Republic, ⁵Pharmaceutical Research Associates CZ, Praha, Czech Republic, ⁶Malopolskie Centrum Medyczne, Krakow, Poland, ⁷Specjalistyczny im. J. Gromkowskiego, Wojewodzki Szpital, Wroclaw, Poland, ⁸Project Management, Ablynx N.V., Zwijnaarde, Belgium, ⁹Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, ¹⁰Clinical Development, Ablynx nv, Zwijnaarde, Belgium, ¹¹Medical Affairs, PRA International GmbH, Berlin, Germany, ¹²Chief Medical Officer, Ablynx N.V., Zwijnaarde, Belgium
Background/Purpose: ALX-0061 is a 26kD bispecific IL-6R targeting Nanobody® with monovalent binding to IL-6R and serum albumin. It effectively neutralizes IL-6 pathway activity in-vitro and…
Abstract Number: 740 • 2012 ACR/ARHP Annual Meeting
Select Soluble Inflammatory Mediators Are Detected Prior to and Increase At Systemic Lupus Erythematosus Classification
Melissa E. Munroe¹, Jourdan R. Anderson², Julie M. Robertson³, Timothy B. Niewold⁴, George C. Tsokos⁵, Michael P. Keith⁶, John B. Harley⁷ and Judith A. James⁸, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ⁵Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ⁶Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ⁷Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁸Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation; Oklahoma University Health Sciences Center, Oklahoma City, OK
Background/Purpose: The processes that lead to clinical illness in systemic lupus erythematosus (SLE) years before diagnosis are not well characterized. Several cytokines have been associated…
Abstract Number: 2679 • 2012 ACR/ARHP Annual Meeting
Loss of Caspase 8 in Dendritic Cells Induces a Systemic Lupus Erythematosus-Like Disease That Is Independent of the Necroptosome
Carla M. Cuda¹, Alexander V. Misharin², Rana Saber², G. Kenneth Haines III³, Jack Hutcheson⁴, Chandra Mohan⁵ and Harris R. Perlman⁶, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ, destructive autoimmune disease characterized by pathogenic autoantibodies. Though it is accepted that dendritic cells (DCs) play an…
Abstract Number: 2273 • 2012 ACR/ARHP Annual Meeting
Functional Genetic Polymorphisms in Immunoglobulin-Like Transcript 3 Are Associated with Decreased Surface Expression On Dendritic Cells and Increased Serum Cytokines in Lupus Patients
Mark A. Jensen, Karen C. Patterson, Akaash A. Kumar, Marissa Kumabe, Beverly S. Franek and Timothy B. Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an…
Abstract Number: 1237 • 2012 ACR/ARHP Annual Meeting
Baseline Evaluation of Insulin Resistance in Patients with early Non-Treated Rheumatoid Arthritis
Sara Manrique-Arija¹, María América López-Lasanta², Pilar Espiño- Lorenzo², Pedro Valdivielso³, José Rioja³, Inmaculada Ureña¹, Francisco Gabriel Jimenez- Núñez¹, Carmen M. Romero-Barco¹, Veronica Rodríguez-García¹, Laura Nieves², Mari Carmen Ordoñez-Cañizares², Laura Cano², Maria Victoria Irigoyen² and Antonio Fernández-Nebro⁴, ¹Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain, ²Hospital Carlos Haya. University of Malaga, Malaga, Spain, ³Department of Medicine. University of Malaga, Malaga, Spain, ⁴Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain
Background/Purpose: High levels of inflammatory cytokines are associated with insulin resistance syndrome in long-standing AR. The aim was to analyze insulin resistance (IR), adipokines, inflammatory…
Abstract Number: 752 • 2012 ACR/ARHP Annual Meeting
IFNg Production Is Intimately Associated with Clinical and Laboratory Features of CpG-Induced Secondary Hemophagocytic Lymphohistiocytosis (sHLH)/Macrophage Activating Syndrome (MAS) in Mice
Vanessa Buatois¹, Laurence Chatel¹, Laura Cons¹, Maureen Deehan¹, Cristina de Min², Marie Kosco-Vilbois¹ and Walter Ferlin¹, ¹NovImmune S.A., Geneva, Switzerland, ²Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland
Background/Purpose: Repeated TLR9 stimulation with CpG DNA has been found to result in a sHLH/MAS-like disease in mice (1). CpG-administered mice present with cytopenia, anemia,…
Abstract Number: 2116 • 2012 ACR/ARHP Annual Meeting
The Associations of HLA-DR Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis
Mehret Birru Talabi¹, Rachel Mackey², Larry W. Moreland³, Jan Dorman⁴, Kevin D. Deane⁵, Jeremy Sokolove⁶, V. Michael Holers⁷, William H. Robinson⁸, Brian Wallitt⁹ and Lewis Kuller¹⁰, ¹Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴School of Nursing, University of Pittsburgh School of Nursing, Pittsburgh, PA, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁹Washington Hospital Center, Baltimore, MD, ¹⁰Epidemiology, University of Pittsburgh, Pittsburgh, PA
Title: The Associations of HLA-DRβ1 Shared Epitope Alleles and Serum Cytokines Among Postmenopausal Women with Rheumatoid Factor and Anti-Citrullinated Protein Antibody-Positive Rheumatoid ArthritisBackground/Purpose: This study…
Abstract Number: 1212 • 2012 ACR/ARHP Annual Meeting
Elevated Fecal Secretory Immunoglobulin A, Anti-Cyclic Citrullinated Peptide Antibodies, and Cytokine Levels in Rheumatoid Arthritis Patients
Sam Dalvi¹, Jose U. Scher*¹, Mukundan Attur², Jyoti Patel³ and Steven B. Abramson⁴, ¹Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ²Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, ³Rheumatology, NYU Langone Medical Center, New York, NY, ⁴Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disease with genetic and environmental contributions. There has been increasing interest in the microbiome and its potential…
Abstract Number: 691 • 2012 ACR/ARHP Annual Meeting
Characterization of Pro-Inflammatory Cytokines and Vitamin D Levels in a Lupus Cohort and Correlation with Disease Activity
Rohan Willis¹, Praveen Jajoria¹, Brock E. Harper², Emilio B. Gonzalez³, Michelle Petri⁴, Ehtisham Akhter⁵, Hong Fang⁴ and Silvia S. Pierangeli¹, ¹Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Int Med/Rheumatology, University of Texas Medical Branch, Galveston, TX, ³Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Multiple cytokines play a role in the immune dysregulation seen in systemic lupus erythematosus (SLE) and the local inflammatory responses that ultimately lead to…
Abstract Number: 1910 • 2012 ACR/ARHP Annual Meeting
Regulation of Microrna 223 Expression in a Gouty Arthritis
Gianina Statache¹, Ashleigh-Ann Rainey¹, Seth Masters², Andra Balanescu³, Iain B. McInnes⁴ and Mariola Kurowska-Stolarska⁵, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Immunology Research Centre, Trinity College Dublin, Dublin, United Kingdom, ³Internal Medicine and Rheumatology, University of Medicine and Pharmacy, Bucharest, Romania, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Gout is an inflammatory chronic disease caused by deposition of uric acid crystals in the joint and connective tissues causing pain and disability. Current…

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