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Abstracts tagged "cytokines"

  • Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting

    Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis

    Yingni Li1, Fanlei Hu2, Li Zheng1, Linchong Su3, Lianjie Shi2, Pei Song1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 3Hubei Minzu University, Enshi, China

    Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
  • Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting

    Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity

    Ladislav Senolt1, Klara Prajzlerova1, Hana Hulejova2, David Veigl3, Karel Pavelka1 and Jiri Vencovsky1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 31st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
  • Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting

    Profiling 14-3-3η in Human Primary Cell Based BioMAP® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology

    Alison O'Mahony1, Ellen L. Berg1, Walter P. Maksymowych2, Yuan Gui3 and Anthony Marotta4, 1BioSeek, South San Francisco, CA, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 41423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions.  The 14-3-3 eta…
  • Abstract Number: 1036 • 2014 ACR/ARHP Annual Meeting

    Synergism Between GM-CSF and IL-17 Causes Enhanced Joint Pathology Via the Production of IL-6 and IL-23

    Annemarie E.M. van Nieuwenhuijze1, Debbie M. Roeleveld2, Birgitte Walgreen2, Miranda Bennink1, Monique M. Helsen1, Liduine van den Bersselaar1, Ian P. Wicks3, Wim B. van den Berg1, Fons A. van de Loo1 and Marije I. Koenders1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
  • Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting

    Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis

    Nataliya Yeremenko1, Raquel Celis2, Leonie M. van Duivenvoorde3, Julio Ramirez4, Iris C. Blijdorp5, Sara Marsal6, Jose L. Pablos7, Raimon Sanmarti4, Juan D. Cañete4 and Dominique L. Baeten1, 1Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 2Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 3Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 4Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 5Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 7Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain

    Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…
  • Abstract Number: 1001 • 2014 ACR/ARHP Annual Meeting

    Fibroblast-like Synoviocytes Inhibit Wnt Signaling Pathway By Secreting Dockcop-1

    Satoshi Yamasaki and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose: There is evidence of osteoclast activation in the inflamed joints of patients with rheumatoid arthritis (RA). Studies that focus on osteoblasts are not sufficient…
  • Abstract Number: 1965 • 2014 ACR/ARHP Annual Meeting

    Characterization of the Thyroid Hormone System in Rheumatoid Arthritis

    Anna-Sophia Pörings1, Torsten Lowin2, Luise Rauch1, Tanja Späth1, Angelika Graeber2 and Rainer Straub3, 1Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Regensburg, Germany, 2Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, 3Internal Medicine, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Chronic inflammation is characterized by an energy appeal reaction supporting high energy demand of the activated immune system. Thyroid hormones are strongly associated with…
  • Abstract Number: 914 • 2014 ACR/ARHP Annual Meeting

    A Predictive Model of Disease Outcome in Rituximab-Treated Myositis Patients Using Clinical Features, Autoantibodies, and Serum Biomarkers

    Jeannette Olazagasti1, Cynthia S. Crowson2, Molly S. Hein1, Consuelo Lopez de Padilla1, Rohit Aggarwal3, Chester V. Oddis4 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Medicine, University of Pittsburgh, Pittsburgh, PA, 4Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Develop predictive models of early (8 week) and late (24 week) disease outcomes using clinical features, autoantibodies, and serum biomarkers in patients with refractory…
  • Abstract Number: 1922 • 2014 ACR/ARHP Annual Meeting

    Hydroxylchloroquine Use Is Associated with Decreased Soluble TNF Receptor Levels in SLE Patient Samples

    Rufei Lu1,2, Adam Przebinda3, Melissa E. Munroe4, Joel M. Guthridge1, Joan T. Merrill5 and Judith A. James6, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disorder with a waxing and waning clinical course. Hydroxychloroquine (HCQ) is a well-tolerated and effective…
  • Abstract Number: 878 • 2014 ACR/ARHP Annual Meeting

    Luminex and Autoantigen Microarray Analysis of Sera from Patients with Diffuse Cutaneous Systemic Sclerosis Reveals Changes Associated with Imatinib Mesylate Treatment

    D. James Haddon1, Hannah Wand2, Paul J. Utz1, Robert F. Spiera3, Jessica K. Gordon3 and Lorinda Chung4, 1Medicine, Stanford University School of Medicine, Stanford, CA, 2Stanford University School of Medicine, Stanford, CA, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose Tyrosine kinase inhibitors (TKIs), including imatinib mesylate, have been studied for the treatment of diffuse cutaneous Systemic Sclerosis (dcSSc). In a previously reported single…
  • Abstract Number: 2075 • 2013 ACR/ARHP Annual Meeting

    Analysis Of The Associations Between Serum Ferritin and Cytokines In Pulmonary Disease Activity With Polymyositis/Dermatomyositis

    Hidenaga Kawasumi, Takahisa Gono, Yasushi Kawaguchi, Yasuhiro Katsumata, Masanori Hanaoka, Sayuri Kataoka, Kae Takagi, Hisae Ichida, Sayumi Baba, Yuko Okamoto, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Polymyositis (PM) / dermatomyositis (DM) is occasionally complicated by interstitial lung disease (ILD), and ILD is a prognostic factor in PM/DM. We previously reported…
  • Abstract Number: 1150 • 2013 ACR/ARHP Annual Meeting

    Differential Regulation Of IL-10 and Dusp1 Production By Kinases In The p38 MAPK Pathway

    Deepa Hammaker1, Katharyn Topolewski2 and G. S. Firestein3, 1MC 0656, UCSD School of Medicine, La Jolla, CA, 2UCSD School of Medicine, La Jolla, CA, 3Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: MAPK kinases MKK3 and MKK6 regulate p38 function in inflammatory diseases like rheumatoid arthritis (RA). Targeting MKK3 or MKK6 might be superior to traditional…
  • Abstract Number: 175 • 2013 ACR/ARHP Annual Meeting

    Dynamics Of The Inflammatory Response In Rheumatoid Arthritis Patients Following Traumatic Injury: Insights From In Vivo,In Silico, and Single Nucleotide Polymorphism Studies

    Rajaie Namas1, Rami Namas2, Harpreet Sagar3, Felix Fernandez-Madrid3, Timothy Billiar2 and Yoram Vodovotz4, 1Rheumatology, Wayne State University/ Henry Ford Health System, Detroit, MI, 2Surgery, University of Pittsburgh, Pittsburgh, PA, 3Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, 4Surgery, Immunology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Both traumatic injury/hemorrhagic shock (T/HS) and rheumatoid arthritis (RA) are inflammatory diseases that are major sources of morbidity worldwide. We hypothesize that RA modifies…
  • Abstract Number: 1869 • 2013 ACR/ARHP Annual Meeting

    Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions Of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients

    Hitoshi Uga1, Takahiro Okazawa1, Yoshiaki Miyamoto1, Takehiro Hasegawa1, Jun Saegusa2, Goh Tsuji3, Sho Sendo4, Akio Morinobu5, Shunichi Kumagai6,7 and Hirokazu Kurata1, 1Sysmex Corporation, Kobe, Japan, 2Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 3Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, 4Center of rheumatic diseases, Shinko Hospital, Kobe, Japan, 5Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 6Center of rheumatic diseases, Shinko hospital, Kobe, Japan, 7Department of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: The diagnosis of anti-CCP antibody (ACPA) negative rheumatoid arthritis (RA) are known to be difficult and delayed as compared with ACPA-positive RA. This study…
  • Abstract Number: 953 • 2013 ACR/ARHP Annual Meeting

    Baseline Serum Interleukin-34 Levels Predict Radiographic Progression In Rheumatoid Arthritis Patients

    Sung Hae Chang1,2, Byoung Youg Choi3, Hyon Joung Cho4, Hye Jin Oh5, Eun Ha Kang3, Yeong Wook Song2,6 and Yun Jong Lee2,7, 1Internal Medicine Rheumatology, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 2Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 3Internal Medicine, Rheumatology, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 4Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 5Internal Medicine, Rheumatology, Seoul National University Hospital, Seoul, South Korea, 6Internal Medicine,Rheumatology, Seoul National University Hospital, Seoul, South Korea, 7Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea

    Background/Purpose: Interleukin-34 (IL-34), a novel cytokine playing a critical role in osteoclastogenesis, recently was reported that its expression increases in the synovial tissue and sera…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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