Abstracts tagged "cytokines"

Abstract Number: 2363 • 2014 ACR/ARHP Annual Meeting
Leucine-Rich Alpha-2 Glycoprotein Is a Potential Disease Activity Marker Under IL-6 Suppression in Autoimmune Arthritis
Yusuke Takahashi¹, Minoru Fujimoto², Satoshi Serada³ and Tetsuji Naka², ¹a doctoral student, Osaka university, Suita city, Japan, ²Laboratory for immune signal, National Institute of Biomedical Innovation, Ibaraki, Japan, ³7-6-8, Saito-asagi, National Institute of Biomedical Innovation, Laboratory for immune signal, Japan, Ibaraki, Japan
Background/Purpose C-reactive protein (CRP) is frequently used to evaluate inflammation in patients with rheumatoid arthritis (RA). However, CRP is normalized when IL-6 function is potently…
Abstract Number: 1195 • 2014 ACR/ARHP Annual Meeting
Activation of the nlrp3 Inflammasome By an Endogenous TLR2 Ligand in Rheumatoid Arthritis
Mary Connolly, Trudy McGarry, Monika Biniecka, Douglas J. Veale and Ursula Fearon, Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: The inflammasome is a large multiprotein complex which plays a key role in innate immunity by mediating the production of pro-inflammatory cytokines interleukin-1β (IL-1β)…
Abstract Number: 2350 • 2014 ACR/ARHP Annual Meeting
A Humanized Monoclonal Antibody Raised Against a Heat Shock Protein Epitope Suppresses Autoimmune Inflammatory Diseases By Skewing the Immune System Selectively Towards an Anti-Inflammatory Response
Yaakov Naparstek¹, Rina Ulmansky², Galia Katzavian³, Ronit Meyuhas³, Eli Moallem⁴, Shira Yair³, Dorit Landstein³ and Virginie Loeb³, ¹Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ²Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ³ProtAb Ltd., Jerusalem, Israel, ⁴Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Background/Purpose We have previously shown that resistance to Adjuvant Arthritis (AA) is due to the presence of anti-heat shock protein (HSP) antibodies, directed at peptide-6,…
Abstract Number: 1175 • 2014 ACR/ARHP Annual Meeting
Association of Hand MRI Findings with the Level of Plasma Cytokines in Patients with Newly Diagnosed Rheumatoid Arthritis
Yasushi Kondo¹, Yuko Kaneko¹, Hiroaki Sugiura², Shunsuke Matsumoto², Naoshi Nishina¹, Masataka Kuwana¹, Masahiro Jinzaki² and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Radiology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Magnetic resonance imaging (MRI) is a very useful modality that can directly visualize both inflammatory and structural changes of affected joints in patients with…
Abstract Number: 2212 • 2014 ACR/ARHP Annual Meeting
Serum Adipokines in Dermatomyositis: Correlation with Risk Factors Associated to Cardiovascular Diseases and Metabolic Syndrome
Marilda Guimarães Silva, Suzana Beatriz Veríssimo de Mello and Samuel Katsuyuki Shinjo, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Adipokines are a group of cytokines produced by adipose tissue, which include adiponectin, resistin and leptin. The adiponectin has anti-diabetic, anti-inflammatory and anti-atherogenic effects,…
Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting
Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis
Trudy McGarry¹, Mary Connolly¹, Rebecca C. Coll², Avril A. B. Robertson³, Matthew A. Cooper³, Luke A. O'Neill², Douglas J. Veale¹ and Ursula Fearon¹, ¹Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ²Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, ³The University of Queensland, Brisbane, Australia
Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
Abstract Number: 2213 • 2014 ACR/ARHP Annual Meeting
Gene Expression Profiling of T Helper Subsets in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with Juvenile and Adult Dermatomyositis
Consuelo Lopez de Padilla¹, Molly S. Hein¹, Cynthia S. Crowson², Richard S. Pendegraft³, Erik J. Peterson⁴, Emily Baechler⁵ and Ann M. Reed¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Biomedical Statistics and informatics, Rochester, MN, ⁴University of Minnesota, Minneapolis, MN, ⁵Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: The molecular and cellular basis for juvenile and adult dermatomyositis (JDM and ADM) presumably is similar. However, important differences in the clinical features, outcome…
Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting
ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts
Takeo Isozaki^1,2, Sho Ishii², Shinichiro Nishimi², Airi Maeoka², Mayu Saito², Nao Oguro², Shinya Seki², Yoko Miura², Yusuke Miwa², Koei Oh³, Yoichi Toyoshima³, Masanori Nakamura³, Katsunori Inagaki³ and Tsuyoshi Kasama², ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ³Department of Orthopedics, Showa University School of Med, Tokyo, Japan
Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…
Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting
Class a Scavenger Receptor（SR-a）Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis
Yingni Li¹, Fanlei Hu², Li Zheng¹, Linchong Su³, Lianjie Shi², Pei Song¹ and Zhanguo Li², ¹Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ³Hubei Minzu University, Enshi, China
Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting
Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity
Ladislav Senolt¹, Klara Prajzlerova¹, Hana Hulejova², David Veigl³, Karel Pavelka¹ and Jiri Vencovsky¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
Abstract Number: 2425 • 2013 ACR/ARHP Annual Meeting
Impaired TNFá Production By Dendritic Cells From Rheumatoid Arthritis Patients Upon Contact With Porphyromonas Gingivalis
Kim CM Santegoets^1,2, Mark H. Wenink^1,2, Wim B van den Berg³ and Timothy RDJ Radstake^2,4, ¹Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA) and the severity of periodontitis can affect the level of arthritis. Porphyromonas…
Abstract Number: 1296 • 2013 ACR/ARHP Annual Meeting
Deletion Of RBP-J In a Murine Model Of Inflammatory Arthritis Reveals Pro-Inflammatory Cytokine Expression and Immunophenotypic Differences
Soumya D. Chakravarty¹, Karmen Au², Lionel B. Ivashkiv³ and Xiaoyu Hu⁴, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁴Arthritis Tissue Degeneration Program, Hospital for Special Surgery, New York, NY
Background/Purpose: RBP-J, a DNA-binding protein, serves as the central transcriptional regulator of the Notch signaling pathway. Prior in vitro work has demonstrated that RBP-J plays…
Abstract Number: 571 • 2013 ACR/ARHP Annual Meeting
Protective Effect Of Inducible Adeno-Associated Virus Mediated IL-2 Gene Therapy On Tissue Damages In Lupus-Prone Mice
Masayuki Mizui¹, Tomohiro Koga², Linda Lieberman³, Jessica Beltran³, Mark C. Johnson⁴, José C. Crispin², Roland Tisch⁴ and George C. Tsokos⁵, ¹Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-2 plays critical roles not only in immune responses but also in peripheral tolerance. Impairment of IL-2 production has been linked to the development…
Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting
Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis
Emilie Duvallet¹, Laure Foulboeuf¹, Luca Semerano², Nadia Belmellat¹, Marc Lecouvey³, Eric Assier¹, Sylviane Muller⁴ and Marie-Christophe Boissier⁵, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³CSPBAT Paris 13 University, Bobigny, France, ⁴Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, ⁵INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
Abstract Number: 1194 • 2013 ACR/ARHP Annual Meeting
Enhanced IL-1β and IL-6 Production In Gout Patients Upon Stimulation With Mono Sodium Urate Crystals and Synergizing Agents Compared To Healthy Volunteers
Tania O. Crisan¹, Maartje Cleophas¹, Mihai G. Netea¹, Tim L. Jansen² and Leo A. Joosten³, ¹Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…

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