Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting
Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients
Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…Abstract Number: 367 • 2013 ACR/ARHP Annual Meeting
Cytomegalovirus-Related Immunity Correlates With Myocardial Disease In Rheumatoid Arthritis
Background/Purpose: We recently discovered correlations between a profile of cytokines produced in response to human cytomegalovirus (CMV), poor treatment outcome, and erosive joint damage. The…Abstract Number: 2207 • 2013 ACR/ARHP Annual Meeting
Plasma Cytokine Concentrations Are Associated With Folate Perturbations and Methotrexate Polyglutamate Accumulation In The Peripheral Blood Of Juvenile Idiopathic Arthritis Patients Treated With Low-Dose Methotrexate
Background/Purpose: Methotrexate inhibits the production of inflammatory cytokines, but is also an antifolate. The activity of MTX is thought to depend on the formation of…Abstract Number: 1147 • 2013 ACR/ARHP Annual Meeting
Human Dendritic Cells Produce Thymic Stromal Lymphopoietin In Response To Pattern Recognition Receptor Ligation and This Secretion Is Augmented By Endoplasmic Reticulum Stress
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is a cytokine that has an important role in inducing Th2 cell differentiation and has also been implicated as a…Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting
Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis
Background/Purpose: Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting
Elevated Frequency of Synovial Interleukin-21+ CD4+ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…Abstract Number: 1492 • 2012 ACR/ARHP Annual Meeting
IL-13 Receptors and Signaling in the Dermal Fibroblasts From Patients with Systemic Sclerosis
Background/Purpose: Interleukin (IL)-13 is a pleiotropic cytokine involved in T helper type 2 cell immune response and in the development of fibrotic conditions such as…Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…Abstract Number: 3 • 2012 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Differentiate Into Osteoblasts in Response to Inflammation
Background/Purpose: Bone destruction due to enhanced osteoclast differentiation is a common observation in rheumatoid arthritis. It is well known that inflammatory cytokines cause osteoclatogenesis, however,…Abstract Number: 2338 • 2012 ACR/ARHP Annual Meeting
1,25(OH)2D3 Modulates the Migration Pattern of Th17 Cells From Patients with Rheumatoid Arthritis
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, T-helper-17 (Th17) cells have been implicated to play…Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting
Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease
Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…Abstract Number: 883 • 2012 ACR/ARHP Annual Meeting
Role of Phospholipase D1 (PLD1) in the Expression of Proinflammatory Genes in Rheumatoid Arthritis Synovial Fibroblasts (RASF)
Background/Purpose: Interleukin-17 (IL-17) and Tumor Necrosis Factor alpha (TNFa), when co-applied to RASF, induce synergistic expression of proinflammatory genes such as IL-6 and IL-8. Work…Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…Abstract Number: 1448 • 2012 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice. Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with abnormal…Abstract Number: 872 • 2012 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 and Eotaxin Are Associated with Parameters of Cardiac Dysfunction in Juvenile Dermatomyositis
Background/Purpose : Juvenile dermatomyositis (JDM) is a vasculopathic disease affecting not only skeletal muscle and skin, but other organs as well. Previously we have shown…
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