ACR Meeting Abstracts

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Abstracts tagged "cytokines"

  • Abstract Number: 1824 • 2013 ACR/ARHP Annual Meeting

    ONO-4059 – A Novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase- Suppresses Osteoclastic Bone Resorption and Inflammation

    Yuko Ariza1, Toshio Yoshizawa1, Yoshiko Ueda1, Shingo Hotta1, Tomoko Yasuhiro1, Masami Narita1, Yutaka Shichino2 and Kazuhito Kawabata1, 1Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 2Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, leading to erosion of the joints and cartilage,…
  • Abstract Number: 941 • 2013 ACR/ARHP Annual Meeting

    Mir-34a In Rheumatoid Arthritis: Characterisation Of Elevated Synovial Expression and Association With Treatment Resistance

    Clare E Tange1, Stefano Alivernini2, Derek S. Gilchrist3, Lynn Crawford3, Ashleigh-Ann Rainey1, Derek Baxter3, Iain B. Mcinnes4 and Mariola Kurowska-Stolarska5, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 3Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 4Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 5Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Cells of the monocyte/macrophage lineage are critical to RA pathogenesis: unravelling mechanisms underlying macrophage inflammatory gene expression should elucidate novel disease-associated pathways and thereby…
  • Abstract Number: 2657 • 2013 ACR/ARHP Annual Meeting

    Interactions Between Cigarette Smoking, Body Mass Index and Inflammatory Cytokine Levels In Determining The Risk Of Developing Rheumatoid Arthritis

    Elizabeth V. Arkema1, Susan Malspeis2, Bing Lu3, Linda T. Hiraki4, Elizabeth W. Karlson2 and Karen H. Costenbader2, 1Epidemiology, Harvard School of Public Health, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Rheumatology, Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA

    Background/Purpose:  Smoking and high body mass index (BMI) are risk factors for RA. Both are associated with increased systemic inflammation, with elevated C-reactive protein, interleukin…
  • Abstract Number: 1763 • 2013 ACR/ARHP Annual Meeting

    IL4-10 Synerkine: A Novel Immunoregulatory Drug To Prevent Immunopathology In Rheumatic Diseases

    Sarita Hartgring1, Cristine Steen-louws2, C.E. Hack3, Martin De Smet4, Floris Lafeber5 and J.A.G. van Roon6, 1Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology & Clinical Immunology/Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 3Immunology, UMC Utrecht, Utrecht, Netherlands, 4Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 5Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, 6Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: A considerable percentage of patients shows a limited response to biologics targeting one specific inflammatory mediator, largely because of redundancy of these mediators. An…
  • Abstract Number: 944 • 2013 ACR/ARHP Annual Meeting

    Mir-125a: A Novel Regulator Of IL-6 and TLR Driven Pathways In RA Pathogenesis

    Ashleigh-Ann Rainey1, Derek S. Gilchrist2, Clare E Tange1, Marina Frleta3, Lynn Crawford2, Derek Baxter2, Iain B. Mcinnes4 and Mariola Kurowska-Stolarska5, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Institute of infection, immunity and inflammation, University of Glasgow, Glasgow, United Kingdom, 4University of Glasgow, Glasgow, United Kingdom, 5Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Molecular mechanisms driving disease initiation and chronicity in RA are incompletely understood. There is increasing interest in the role played therein by microRNAs –…
  • Abstract Number: 2573 • 2013 ACR/ARHP Annual Meeting

    The Role Of STAT-3 In The Development Of Pulmonary and Dermal Fibrosis

    Mesias Pedroza1, Sarah To1, Anuh T. George1, David J. Tweardy2 and Sandeep K. Agarwal1, 1Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 2Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibrosis is the accumulation of excessive extra-cellular matrix in tissues, leading to tissue damage.  In systemic sclerosis, the trigger is postulated to be an…
  • Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting

    Role Of IL33 In The Inflammation Of Takayasu Arteritis

    David Saadoun1, Marlène Garrido2, Julien Gaudric3, Cloé Comarmond4, Michele Rosenzwacjg5 and Patrice Cacoub6, 1Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 2I3 laboratory, Pitié-Salpétrière, Paris, France, 3Department of Vascular surgery GHPS, Paris, France, 4Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, 5Department of Immunology GHPS, Paris, France, 6Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France

    Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
  • Abstract Number: 881 • 2013 ACR/ARHP Annual Meeting

    Time To Renal Flare and Renal Disease Activity Over a 1 Year Period Is  associated With Urinary TWEAK Levels In Patients With Systemic Lupus Erythematosus

    Nicolas Wisniacki1, Chris Stebbins2, Jadwiga Bienkowska3, Susan Gawlak2, Donald Bennett4, Yuhong Xiang5, Andrea Dearth6, Linda C. Burkly7, Ann Ranger6, Carrie Wager5, Laurence S. Magder8 and Michelle Petri9, 1Medical Research, Biogen Idec, Maidenhead, United Kingdom, 2Translational Medicine, Biogen Idec, Cambridge, MA, 3Translational Medicine, Biogen Idec Inc., Cambridge, MA, 4Biostatistics, Biogen idec, Cambridge, MA, 5Biostatistics, Biogen Idec, Cambridge, MA, 6Biogen Idec Inc, Cambridge, MA, 7Biogen Idec, Cambridge, MA, 8Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 9Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily that signals through its distinct, highly inducible receptor, FGF-inducible molecule 14…
  • Abstract Number: 2523 • 2012 ACR/ARHP Annual Meeting

    Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a Toll-Like Receptor 2 and Interleukin-1 Driven Th17 Response

    Shahla Abdollahi-Roodsaz1, Sabrina Garcia de Aquino2, Marije I. Koenders3, Fons A. van de Loo4, Ger J. Pruijn5, Mario J. Avila Campos6, Fernando Q. Cunha7, Joni A. Cirelli2 and Wim B. van den Berg1, 1Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Department of Diagnosis and Oral Surgery, Periodontic Division, Araraquara Dental School, Sao Paolo, Brazil, 3Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, 6Department of Microbiology, Institute of Biomedical Sciences—ICB/USP, Sao Paulo, Brazil, 7Department of Pharmacology, School of Medicine of Ribeirao Preto, Sao Paolo, Brazil

    Background/Purpose: The periodontal pathogen Porphyromonas gingivalishas been associated with the pathogenesis of rheumatoid arthritis (RA) because of its ability to citrullinate mammalian proteins and to…
  • Abstract Number: 1810 • 2012 ACR/ARHP Annual Meeting

    Identification and Characterization of Synthetic Small Molecule Macrocycle Antagonists of Human IL17A

    David Livingston, Sethu Alexander, Julian Bond, Timothy Briggs, Andrew Fraley, Stephen Hale, Tanya Landsman, Richard Martinelli, Kelley Shortsleeves, Nick Terrett and Nathan Walsh, Ensemble Therapeutics, Cambridge, MA

    Background/Purpose: :  IL17A has been demonstrated to be a key pro-inflammatory cytokine in human rheumatoid arthritis and in several rodent models of arthritis.  Synthetic macrocycles…
  • Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting

    Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?

    Catriona Cramb1, Jeremy Sokolove2, Geoffrey M. Thiele3, Gail S. Kerr4, Grant W. Cannon5, Andreas M. Reimold6, Ted R. Mikuls7 and William H. Robinson8, 1VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 2Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 4Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 5Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission.   We…
  • Abstract Number: 413 • 2012 ACR/ARHP Annual Meeting

    α(1,2)-Linked Fucosylated Cytokines Are Upregulated in Rheumatoid Arthritis

    Takeo Isozaki1, Jeffrey H. Ruth2, M. Asif Amin1, Phillip L. Campbell1, Christine M. Ha2 and Alisa E. Koch3, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Glycosylation is a common post-translational modification of proteins in eukaryotes. Fucosylated glycans are synthesized by fucosyltransferases (futs). We previously reported that sialyl Lewisx, synthesized…
  • Abstract Number: 2525 • 2012 ACR/ARHP Annual Meeting

    Bruton’s Tyrosine Kinase Inhibition Suppresses Inflammatory Cytokine Production and Affects Gene Expression in Human Macrophages and RA Synovial Tissue Explants

    Linda M. Hartkamp1, Inge E. van Es1, Jay S. Fine2, Michael Smith2, John Woods2, Satwant Narula3, Julie DeMartino2, Paul P. Tak4 and Kris A. Reedquist1, 1Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Inflammation Discovery, Hoffmann-La Roche, Nutley, NJ, 3Inflammatory Discovery, Hoffmann-La Roche, Nutley, NJ, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic and progressive autoinflammatory disorder characterized by the infiltration of inflammatory cells, including B-cells, T-cells and macrophages, in the…
  • Abstract Number: 1787 • 2012 ACR/ARHP Annual Meeting

    Evolution of the Cytokine and Chemokine Profile in Patients Receiving Oral Daily Vitamin D: Results From a Randomized Controlled Trial

    Benjamin Terrier1, Marlène Garrido2 and Patrice Cacoub Sr.3, 1Internal Medicine, Cochin University Hospital, Paris, France, 2I3 laboratory, Pitié-Salpétrière, Paris, France, 3Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France

    Background/Purpose: Immunomodulatory effects of vitamin D were recently described in vitro, notably the expansion of regulatory T cells able to suppress inflammatory responses and the…
  • Abstract Number: 1131 • 2012 ACR/ARHP Annual Meeting

    Intraarticular Infliximab for Knee Osteoarthritis: High Baseline Levels of Synovial Cellularity and High MRI Cartilage Injury At the Lateral Tibial Plateau Predict Improvement in Total WOMAC Score

    Jeremy R. Schue1, Ossama Tawfik2, Rebecca Bolce3, Donald D. Smith1, Gary Hinson4, Jo A. Wick5 and Herbert B. Lindsley6, 1Internal Medicine, Kansas University Med Ctr, Kansas City, KS, 2Pathology, Kansas University Med Ctr, Kansas City, KS, 3Crescendo Bioscience Inc., South San Francisco, CA, 4Radiology, Kansas University Med Ctr, Kansas City, KS, 5Biostatistics, Kansas University Med Ctr, Kansas City, KS, 6Medicine, Kansas University Med Ctr, Kansas City, KS

    Background/Purpose: Synovial tissue from patients with OA often demonstrates inflammation. We hypothesized that a single intraarticular (IA) injection of an anti-TNF drug would decrease inflammatory…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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