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Abstracts tagged "cytokines"

  • Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting

    Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota

    Mark Asquith1, Phoebe Lin2, Sean Davin3, Patrick Stauffer4, Stephen R. Planck5 and James T. Rosenbaum6, 1OHSU, Portland, OR, 2Casey Eye Institute, Oregon Health and Science University, Portland, OR, 3Oregon Health and Science University, Portland, OR, 4Oregon Health & Science University, Portland, OR, 5Casey Eye Institute, Oregon Health & Science University, Portland, OR, 6Devers Eye Institute, Legacy Hospital system, Portland, OR

    Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…
  • Abstract Number: 2699 • 2015 ACR/ARHP Annual Meeting

    Muscle Inflammation Relates to Disease Activity and Disability but Not Insulin Resistance in Rheumatoid Arthritis

    Ryan Jessee1, Rachel Narowski2, Monica Hubal3, Janet Huebner4, Virginia Kraus5, William Kraus6 and Kim Huffman2,7, 1Internal Medicine, Duke University Medical Center, Durham, NC, 2Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 3Research and Education, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Duke Molecular Physiology Institute,, Duke University Medical Center, Durham, NC, 5Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 6Division of Cardiology, Duke University Medical Center, Durham, NC, 7Durham Veterans Affairs Medical Center, Durham, NC

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease, insulin resistance, and disability. Our objectives were to analyze levels of skeletal muscle inflammatory cytokines…
  • Abstract Number: 2350 • 2014 ACR/ARHP Annual Meeting

    A Humanized Monoclonal Antibody Raised Against a Heat Shock Protein Epitope Suppresses Autoimmune Inflammatory Diseases By Skewing the Immune System Selectively Towards an Anti-Inflammatory Response

    Yaakov Naparstek1, Rina Ulmansky2, Galia Katzavian3, Ronit Meyuhas3, Eli Moallem4, Shira Yair3, Dorit Landstein3 and Virginie Loeb3, 1Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, 2Hadassah - Hebrew University Medical Center, Jerusalem, Israel, 3ProtAb Ltd., Jerusalem, Israel, 4Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel

    Background/Purpose We have previously shown that resistance to Adjuvant Arthritis (AA) is due to the presence of anti-heat shock protein (HSP) antibodies, directed at peptide-6,…
  • Abstract Number: 1175 • 2014 ACR/ARHP Annual Meeting

    Association of Hand MRI Findings with the Level of Plasma Cytokines in Patients with Newly Diagnosed Rheumatoid Arthritis

    Yasushi Kondo1, Yuko Kaneko1, Hiroaki Sugiura2, Shunsuke Matsumoto2, Naoshi Nishina1, Masataka Kuwana1, Masahiro Jinzaki2 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Radiology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Magnetic resonance imaging (MRI) is a very useful modality that can directly visualize both inflammatory and structural changes of affected joints in patients with…
  • Abstract Number: 2212 • 2014 ACR/ARHP Annual Meeting

    Serum Adipokines in Dermatomyositis: Correlation with Risk Factors Associated to Cardiovascular Diseases and Metabolic Syndrome

    Marilda Guimarães Silva, Suzana Beatriz Veríssimo de Mello and Samuel Katsuyuki Shinjo, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Adipokines are a group of cytokines produced by adipose tissue, which include adiponectin, resistin and leptin. The adiponectin has anti-diabetic, anti-inflammatory and anti-atherogenic effects,…
  • Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting

    Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis

    Trudy McGarry1, Mary Connolly1, Rebecca C. Coll2, Avril A. B. Robertson3, Matthew A. Cooper3, Luke A. O'Neill2, Douglas J. Veale1 and Ursula Fearon1, 1Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 2Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, 3The University of Queensland, Brisbane, Australia

    Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
  • Abstract Number: 2213 • 2014 ACR/ARHP Annual Meeting

    Gene Expression Profiling of T Helper Subsets in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with Juvenile and Adult Dermatomyositis

    Consuelo Lopez de Padilla1, Molly S. Hein1, Cynthia S. Crowson2, Richard S. Pendegraft3, Erik J. Peterson4, Emily Baechler5 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Biomedical Statistics and informatics, Rochester, MN, 4University of Minnesota, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: The molecular and cellular basis for juvenile and adult dermatomyositis (JDM and ADM) presumably is similar. However, important differences in the clinical features, outcome…
  • Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting

    ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts

    Takeo Isozaki1,2, Sho Ishii2, Shinichiro Nishimi2, Airi Maeoka2, Mayu Saito2, Nao Oguro2, Shinya Seki2, Yoko Miura2, Yusuke Miwa2, Koei Oh3, Yoichi Toyoshima3, Masanori Nakamura3, Katsunori Inagaki3 and Tsuyoshi Kasama2, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, 3Department of Orthopedics, Showa University School of Med, Tokyo, Japan

    Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…
  • Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting

    Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis

    Yingni Li1, Fanlei Hu2, Li Zheng1, Linchong Su3, Lianjie Shi2, Pei Song1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 3Hubei Minzu University, Enshi, China

    Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
  • Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting

    Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity

    Ladislav Senolt1, Klara Prajzlerova1, Hana Hulejova2, David Veigl3, Karel Pavelka1 and Jiri Vencovsky1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 31st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
  • Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting

    Profiling 14-3-3η in Human Primary Cell Based BioMAP® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology

    Alison O'Mahony1, Ellen L. Berg1, Walter P. Maksymowych2, Yuan Gui3 and Anthony Marotta4, 1BioSeek, South San Francisco, CA, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 41423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions.  The 14-3-3 eta…
  • Abstract Number: 1036 • 2014 ACR/ARHP Annual Meeting

    Synergism Between GM-CSF and IL-17 Causes Enhanced Joint Pathology Via the Production of IL-6 and IL-23

    Annemarie E.M. van Nieuwenhuijze1, Debbie M. Roeleveld2, Birgitte Walgreen2, Miranda Bennink1, Monique M. Helsen1, Liduine van den Bersselaar1, Ian P. Wicks3, Wim B. van den Berg1, Fons A. van de Loo1 and Marije I. Koenders1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
  • Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting

    Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis

    Nataliya Yeremenko1, Raquel Celis2, Leonie M. van Duivenvoorde3, Julio Ramirez4, Iris C. Blijdorp5, Sara Marsal6, Jose L. Pablos7, Raimon Sanmarti4, Juan D. Cañete4 and Dominique L. Baeten1, 1Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 2Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 3Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 4Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 5Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 7Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain

    Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…
  • Abstract Number: 1001 • 2014 ACR/ARHP Annual Meeting

    Fibroblast-like Synoviocytes Inhibit Wnt Signaling Pathway By Secreting Dockcop-1

    Satoshi Yamasaki and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose: There is evidence of osteoclast activation in the inflamed joints of patients with rheumatoid arthritis (RA). Studies that focus on osteoblasts are not sufficient…
  • Abstract Number: 1965 • 2014 ACR/ARHP Annual Meeting

    Characterization of the Thyroid Hormone System in Rheumatoid Arthritis

    Anna-Sophia Pörings1, Torsten Lowin2, Luise Rauch1, Tanja Späth1, Angelika Graeber2 and Rainer Straub3, 1Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Regensburg, Germany, 2Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, 3Internal Medicine, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Chronic inflammation is characterized by an energy appeal reaction supporting high energy demand of the activated immune system. Thyroid hormones are strongly associated with…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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