Abstracts tagged "cytokines"

Abstract Number: 1176 • 2015 ACR/ARHP Annual Meeting
Interleukin-37 Prevents New-Onset Joint Inflammation but Does Not Inhibit Existing Experimental Arthritis
Marije I. Koenders¹, Debbie M. Roeleveld¹, Charles Dinarello², Peter M. van der Kraan¹ and Leo Joosten³, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ³Internal Medicine, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-37 (IL-37) is a recently identified cytokine with potent anti-inflammatory and immunosuppressive functions. This cytokine has been shown to be expressed in synovial tissue…
Abstract Number: 2967 • 2015 ACR/ARHP Annual Meeting
Musculoskeletal Involvement in SSc Correlates with Poor Short Form 36 and SSc Health Assessment Questionnaire Scores As Well As Lower TNF-Alpha Gene Expression in PBMCs
Eliza Pelrine¹, Marie-Dominique Ah-Kioon¹, Meng Zhang², Franck J. Barrat³, Robert F. Spiera³ and Jessica K. Gordon³, ¹Hospital for Special Surgery, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic Sclerosis (SSc) is characterized by a wide variety of symptoms and disease manifestations including joint pain, gastrointestinal dysfunction, interstitial lung disease, and cardiomyopathy. …
Abstract Number: 332 • 2015 ACR/ARHP Annual Meeting
Adipokine SERUM Levels in Patients with EARLY Knee Osteoarthritis with and without Metabolic Syndrome
Istar Guzman¹, Rolando Espinosa-Morales², Ignacio-Alfredo Valerio-Morales³, Austreberto Sanchez¹, Paulina P⁴ and Carlos Lozada¹, ¹Rheumatology, National Institute of Rehabilitation, Mexico, Mexico, ²Mexican Board of Rheumatology, Mexico City, Mexico, ³Rheumatology, National Institute of Rehablitation, Mexico, Mexico, ⁴Rheumatology, National institute of Rehabilitation, Mexico, Mexico
Background/Purpose: Osteoarthritis is a chronic, inflammatory, multifactorial disease. The metabolic syndrome (MS) has been linked to this disease; adipokines levels have been associated in the…
Abstract Number: 1360 • 2015 ACR/ARHP Annual Meeting
Functional Consequences of NOD2 Gene Variants in Patients with NOD2-Associated Autoinflammatory Disease
Christine McDonald¹, Min Shen¹, Amrita Kabi¹, Craig Homer¹ and Qingping Yao², ¹Cleveland Clinic, Cleveland, OH, ²Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Yao Syndrome (YS) is a systemic autoinflammatory disease formerly termed Nucleotide-binding oligomerization domain 2 (NOD2)-associated AutoInflammatory Disease (NAID) due to its association with specific…
Abstract Number: 3020 • 2015 ACR/ARHP Annual Meeting
IL-21 Abrogates CD4+CD25+FOXP3+ Treg Differentiation in Part By Suppressing Treg GATA-3 Expression in SLE
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Previous studies point to qualitative and quantitative Treg insufficiencies underlying aberrant T-cell activation in SLE. GATA-3 is critical in lineage commitment and functions of…
Abstract Number: 544 • 2015 ACR/ARHP Annual Meeting
IL-6 May Have an Important Role in the Resistance to Anti-TNF Therapies of Human T-Lymphotropic Virus Type 1 (HTLV-1) Positive Rheumatoid Arthritis (RA) Patients; HTLV-1 Infected Cells Activate the Inflammatory Responses of RA Synovial Fibroblasts
Kunihiko Umekita¹, Shunichi Miyauchi¹, Kazuyoshi Kubo¹, Kazumi Umeki¹, Hajime Nomura¹, Mao Komura¹, Koushou Iwao¹, Ichiro Takajo¹, Yasuhiro Nagatomo¹, Toshihiko Hidaka² and Akihiko Okayama¹, ¹Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan, ²Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan
Background/Purpose: We reported that human T-lymphotropic virus type 1 (HTLV-1) positive patients with rheumatoid arthritis (RA) had higher inflammation and greater resistance to anti-TNF treatment…
Abstract Number: 1364 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with the Innate Immune Inhibitor IL-37 Reduces Joint and Systemic Inflammation
Giulio Cavalli¹, Marije Koenders², Lorenzo Dagna³, Alberto Mantovani⁴, Cecilia Garlanda⁴, Leo Joosten⁵ and Charles Dinarello¹, ¹Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milano, Italy, ⁴Research Institute Humanitas, Milan, Italy, ⁵Internal Medicine, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Characterized as a fundamental inhibitor of innate inflammation, IL‑1 family member IL‑37 is expressed in the synovia of patients with rheumatoid arthritis. We investigated…
Abstract Number: 3059 • 2015 ACR/ARHP Annual Meeting
Abnormal Body Composition in Takayasu Arteritis Patients: Role of Inflammatory Cytokines and Adipokines
Thiago Ferreira da Silva, Mauricio Levy Neto, Valéria Caparbo, Liliam Takayama and Rosa M R Pereira, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Chronic inflammatory conditions including rheumatic diseases may alter body composition, especially lean and fat mass. In this process, adipokines and inflammatory cytokines appear to…
Abstract Number: 902 • 2015 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Fibroblast Derived Inflammatory Angiogenic Agonist in Rheumatoid Arthritis
Gautam Edhayan¹, Christine M. Ha¹, Ray A. Ohara¹, Takeo Isozaki¹, M. Asif Amin¹, Ali S. Arbab², Phillip L. Campbell¹, Rachel Morgan¹, W. Alexander Stinson³, Sean C. Friday¹, David A. Fox¹ and Jeffrey H. Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Georgia Regents University, Augusta, GA, ³Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and…
Abstract Number: 1367 • 2015 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Shape and Perpetuate the Inflammatory Immune Responses Associated with Antibiotic-Refractory Lyme Arthritis.
Klemen Strle¹, Robert Locchead², Annalisa Pianta³, Jameson T. Crowley³, Sheila Arvikar¹ and John Aversa⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Allery and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Yale Medical Group, Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT
Background/Purpose: Antibiotic-refractory Lyme arthritis is defined as persistent synovitis for months to years after antibiotic therapy for Borrelia burgdorferi, the causative agent of Lyme disease.…
Abstract Number: 3096 • 2015 ACR/ARHP Annual Meeting
Interferon-Gamma (IFNg) in Macrophage Activation Syndrome (MAS): CXCL9 Levels As a Biomarker for IFNg Production in MAS
Claudia Bracaglia¹, Denise Pires Marafon², Ivan Caiello¹, Kathy De Graaf³, Florence Guilhot⁴, Walter Ferlin⁴, Sergio Davì⁵, Grant Schulert⁶, Angelo Ravelli⁵, Alexei A. Grom⁷, Robert Nelson⁴, Cristina de Min⁴ and Fabrizio De Benedetti¹, ¹Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ²Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ³Novimmune S.A., Geneva, Switzerland, ⁴NovImmune S.A., Geneva, Switzerland, ⁵Istituto Giannina Gaslini and University of Genova, Genova, Italy, ⁶Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: A vast body of evidence in animals and humans points to a pivotal pathogenic role of IFNγ, in primary HLH. The role of IFNg…
Abstract Number: 903 • 2015 ACR/ARHP Annual Meeting
CGEN-15001, a Novel B7-like Protein, Controls Inflammation in a Translational Rheumatoid Arthritis (RA) Assay and Induces Treg Driven Long-Term Remission in an Autoimmune Disease Model
Iris Hecht¹, Ashley Gilmour², Clare Tange², Donna McIntyre², Joseph R. Podojil³, Kay McNamee⁴, Galit Rotman⁵, Eyal Neria⁵, Mariola Kurowska-Stolarska², Richard O. Williams⁴, Stephen D. Miller³ and Iain B. McInnes^2,6, ¹Therapeutic Proteins, Compugen Ltd., Tel Aviv, Israel, ²Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Microbiology-Immunology, Northwestern University, Chicago, IL, ⁴Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁵Compugen Ltd., Tel Aviv, Israel, ⁶Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: CGEN-15001 is an Fc fusion protein composed of the extracellular domain of a novel B7-like protein. Therapeutic CGEN-15001 treatment is effective in collagen induced…
Abstract Number: 1391 • 2015 ACR/ARHP Annual Meeting
Differential Expression of Interferon Gamma in Exudate from Hidradenitis Suppurativa Lesions Compared to Chronic Wounds
Anirban Banerjee¹, Victoria K. Shanmugam^1,2, Sean McNish¹ and Kara Couch¹, ¹Division of Rheumatology, The George Washington University, Washington, DC, ²Director, Division of Rheumatology, The George Washington University, Washington, DC
Background/Purpose: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease which affects 1% to 4% of young adults. The purpose of the current study was…
Abstract Number: 3097 • 2015 ACR/ARHP Annual Meeting
Innovative Approach for the Identification of an Appropriate Dose Regimen of a Targeted Treatment, NI-0501, an Anti-Interferon Gamma (IFNg) Antibody, in Patients with Hemophagocytic Lymphohistiocytosis (HLH)
Cristina De Min¹, Philippe Jacqmin², Christian Laveille³, Robert Nelson¹, Florence Guilhot¹, Maureen Deehan¹, Marie Kosco-Vilbois¹, Walter Ferlin¹ and Genevieve Lapeyre¹, ¹NovImmune S.A., Geneva, Switzerland, ²SGS Exprimo, Mechelen, Belgium, ³SGS Exprimo NV, Mechelen, Belgium
Background/Purpose: Based on the growing evidence that IFNg plays a pivotal role in HLH, NI-0501, an anti-IFNg monoclonal antibody, is being developed as the first…
Abstract Number: 932 • 2015 ACR/ARHP Annual Meeting
IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
Michela Manni¹, Sanjay Gupta², Briana G. Nixon³ and Alessandra B. Pernis⁴, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, ⁴Autoimmunity & Inflammation, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Interferon Regulatory Factors (IRFs) play fundamental roles in dendritic cell (DC) differentiation and function. In particular IRFs are critical transducers of Toll-like Receptors (TLR)…

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