Abstracts tagged "cytokines"

Abstract Number: 1156 • 2015 ACR/ARHP Annual Meeting
Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
MIN-YOUNG JUNG¹, Hae-Rim Kim², HYUN-SOOK KIM³, HO-YOUN KIM¹ and Sang Heon Lee⁴, ¹Konkuk university hospital, Seoul, South Korea, ²Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ³Soonchenhyang university school of medicine, Seoul, South Korea, ⁴Konkuk University Hospital, Seoul, South Korea
Background/Purpose: This study aimed to determine the regulatory effect of Th17 cytokines on osteoclastogenesis in rheumatoid arthritis (RA). Methods: The expression of interleukin (IL)-17 and…
Abstract Number: 2518 • 2015 ACR/ARHP Annual Meeting
Does the Cytokine Pattern, Including the IL23 – IL17 Immune Axis, Change in Pregnant Women with Psoriatic Arthritis?
Andrea Pluma-Sanjurjo¹, Peter M. Villiger² and Frauke Förger³, ¹Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain, ²Professor & Head, Bern, Switzerland, ³Rheumatology, Clinical Immunology and Allergology, Inselspital-University Hospital, Bern, Switzerland
Background/Purpose: During pregnancy, most patients with Psoriatic Arthritis (PsA) experience a natural improvement of their symptoms. This might be due to the immunological changes that…
Abstract Number: 13 • 2015 ACR/ARHP Annual Meeting
Altered Soluble Mediators, Autoantibodies, and Lupus-Specific Connective Tissue Disease Questionnaire Scores Distinguish Blood Relatives with Incomplete Lupus from Unaffected Relatives and Relatives with Classified SLE
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris³, Teresa Aberle¹, Virginia C. Roberts¹, Joel M. Guthridge¹, Diane L. Kamen⁴, Gary S. Gilkeson⁵, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J Wallace⁷, David R. Karp⁸, Kathy L. Sivils⁹, John B. Harley¹⁰ and Judith A. James¹¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO, ⁴Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Blood relatives (Rel) of lupus patients have increased risk of SLE. Some have autoantibodies and SLE clinical features, but do not meet ≥ 4…
Abstract Number: 1161 • 2015 ACR/ARHP Annual Meeting
Synovial Th9 Cells Prolong Neutrophil Survival and Functionally Enhance the Infiltrating T Cells in Rheumatoid Arthritis
Dipendra Kumar Mitra¹ and Kaustav Chowdhury², ¹Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, ²TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India
Background/Purpose: Th-9 cells are distinct T cell subset secreting IL-9 and associated with allergic and parasitic diseases and produced by Th9 cells. Contribution of these…
Abstract Number: 2611 • 2015 ACR/ARHP Annual Meeting
Circulating Monocyte Count Is Significantly Associated with Interstitial Pneumonia in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Cohort Study (Keio First-Bio Cohort Study)
Keisuke Izumi¹, Misato Hashizume², Yuko Kaneko³, Keiko Yoshimoto¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Interstitial pneumonia (IP) is one of the most critical complications in rheumatoid arthritis (RA). Severe IP is developed in zymosan-treated SKG mice, and…
Abstract Number: 18 • 2015 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts
Anil Singh^1,2, Mukesh Chourasia³ and Salahuddin Ahmed⁴, ¹Department of Pharmaceutical Science, Washington State University, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: TAK1 is one of the most important proteins in IL-1β signaling cascade that mediates downstream p38/JNK and NF-κB activation. In the present study, we…
Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting
Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota
Mark Asquith¹, Phoebe Lin², Sean Davin³, Patrick Stauffer⁴, Stephen R. Planck⁵ and James T. Rosenbaum⁶, ¹OHSU, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³Oregon Health and Science University, Portland, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute, Oregon Health & Science University, Portland, OR, ⁶Devers Eye Institute, Legacy Hospital system, Portland, OR
Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…
Abstract Number: 2699 • 2015 ACR/ARHP Annual Meeting
Muscle Inflammation Relates to Disease Activity and Disability but Not Insulin Resistance in Rheumatoid Arthritis
Ryan Jessee¹, Rachel Narowski², Monica Hubal³, Janet Huebner⁴, Virginia Kraus⁵, William Kraus⁶ and Kim Huffman^2,7, ¹Internal Medicine, Duke University Medical Center, Durham, NC, ²Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, ³Research and Education, George Washington University School of Medicine and Health Sciences, Washington, DC, ⁴Duke Molecular Physiology Institute,, Duke University Medical Center, Durham, NC, ⁵Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, ⁶Division of Cardiology, Duke University Medical Center, Durham, NC, ⁷Durham Veterans Affairs Medical Center, Durham, NC
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease, insulin resistance, and disability. Our objectives were to analyze levels of skeletal muscle inflammatory cytokines…
Abstract Number: 67 • 2015 ACR/ARHP Annual Meeting
Higher Levels of Pro-Inflammatory and Lower Levels of Anti-Inflammatory Cytokines Are Present in Fibromyalgia Patients
Robert S. Katz¹, Hannah Leavitt² and Daniel Pickrell², ¹Rush University Medical Center, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: Abnormalities in the central processing of pain may play a role in fibromyalgia and cytokines could be targets for new therapies. We measured cytokine levels…
Abstract Number: 1167 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with Adenoviral Overexpression of IL-22 or with Blocking Antibodies Against Endogenous IL-22 Both Reduces Inflammation and Destruction
Marije I. Koenders¹, Debbie M. Roeleveld¹, Loreto Parga¹, Shahla Abdolahi-Roodsaz¹, Fons A.J. van de Loo¹, Jay K. Kolls² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the…
Abstract Number: 2767 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated By Serum Amyloid a
Katja Lakota¹, Dolores Hrušovar², Katjusa Mrak-Poljšak³, Polona Žigon¹, SaÂša Čučnik^1,2, Borut BoÂžiÄ�^2,3, Matija Tomšič¹ and Snezna Sodin Semrl^1,4, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ³University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁴Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia
Background/Purpose: In certain chronic diseases, such as rheumatoid arthritis (RA), atherosclerosis is more prevalent. RA patients have a higher incidence of cardiovascular disease and at…
Abstract Number: 282 • 2015 ACR/ARHP Annual Meeting
Angiogenesis in Fasciitis Associated with Dermatomyositis
Ken Yoshida, Kentaro Noda, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu and Daitaro Kurosaka, Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Background/Purpose: We have previously demonstrated that fasciitis is a common lesion of dermatomyositis (DM) detectable early after disease onset. Furthermore, en bloc biopsy showed that the…
Abstract Number: 1170 • 2015 ACR/ARHP Annual Meeting
The Alarmins S100A8/A9 Induce Canonical Wnt Signaling in Naïve Joints and Experimental OA
Martijn H. van den Bosch¹, Arjen Blom¹, Rik Schelbergen², Thomas Vogl³, Johannes Roth⁴, Wim van den Berg¹, Peter van der Kraan¹ and Peter van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Institute of Immunology, University of Muenster, Munster, Germany, ⁴Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found increased expression of both the…
Abstract Number: 2834 • 2015 ACR/ARHP Annual Meeting
CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis Patients
Anastasiya Muntyanu¹, Fatima Abji², Kun Liang³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, develops in approximately 30% of patients with psoriasis. We previously identified C-X-C motif chemokine 10 (CXCL10) as…
Abstract Number: 298 • 2015 ACR/ARHP Annual Meeting
Investigating the Pathogenic Role of ER Stress Pathway Activation in the Idiopathic Inflammatory Myopathies (IIM): Skeletal Muscle Cells As a Source of Cytokines (Myokines)
Adam P. Lightfoot¹, Katarzyna Goljanek-Whysall², Kate E. Earl², Caroline V. Cotton², Anne McArdle¹ and Robert G. Cooper³, ¹Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Rheumatic Diseaes Center, Salford Royal Foundation Trust, University of Manchester, Salford, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a collection of autoimmune disorders, characterised by the development of debilitating symmetrical skeletal muscle weakness. IIM Patients also…

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