ACR Meeting Abstracts

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Abstracts tagged "cytokines"

  • Abstract Number: 1175 • 2014 ACR/ARHP Annual Meeting

    Association of Hand MRI Findings with the Level of Plasma Cytokines in Patients with Newly Diagnosed Rheumatoid Arthritis

    Yasushi Kondo1, Yuko Kaneko1, Hiroaki Sugiura2, Shunsuke Matsumoto2, Naoshi Nishina1, Masataka Kuwana1, Masahiro Jinzaki2 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Radiology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Magnetic resonance imaging (MRI) is a very useful modality that can directly visualize both inflammatory and structural changes of affected joints in patients with…
  • Abstract Number: 2212 • 2014 ACR/ARHP Annual Meeting

    Serum Adipokines in Dermatomyositis: Correlation with Risk Factors Associated to Cardiovascular Diseases and Metabolic Syndrome

    Marilda Guimarães Silva, Suzana Beatriz Veríssimo de Mello and Samuel Katsuyuki Shinjo, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Adipokines are a group of cytokines produced by adipose tissue, which include adiponectin, resistin and leptin. The adiponectin has anti-diabetic, anti-inflammatory and anti-atherogenic effects,…
  • Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting

    Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis

    Trudy McGarry1, Mary Connolly1, Rebecca C. Coll2, Avril A. B. Robertson3, Matthew A. Cooper3, Luke A. O'Neill2, Douglas J. Veale1 and Ursula Fearon1, 1Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 2Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, 3The University of Queensland, Brisbane, Australia

    Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
  • Abstract Number: 2213 • 2014 ACR/ARHP Annual Meeting

    Gene Expression Profiling of T Helper Subsets in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with Juvenile and Adult Dermatomyositis

    Consuelo Lopez de Padilla1, Molly S. Hein1, Cynthia S. Crowson2, Richard S. Pendegraft3, Erik J. Peterson4, Emily Baechler5 and Ann M. Reed1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Biomedical Statistics and informatics, Rochester, MN, 4University of Minnesota, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: The molecular and cellular basis for juvenile and adult dermatomyositis (JDM and ADM) presumably is similar. However, important differences in the clinical features, outcome…
  • Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting

    ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts

    Takeo Isozaki1,2, Sho Ishii2, Shinichiro Nishimi2, Airi Maeoka2, Mayu Saito2, Nao Oguro2, Shinya Seki2, Yoko Miura2, Yusuke Miwa2, Koei Oh3, Yoichi Toyoshima3, Masanori Nakamura3, Katsunori Inagaki3 and Tsuyoshi Kasama2, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, 3Department of Orthopedics, Showa University School of Med, Tokyo, Japan

    Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…
  • Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting

    Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis

    Yingni Li1, Fanlei Hu2, Li Zheng1, Linchong Su3, Lianjie Shi2, Pei Song1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 3Hubei Minzu University, Enshi, China

    Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
  • Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting

    Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity

    Ladislav Senolt1, Klara Prajzlerova1, Hana Hulejova2, David Veigl3, Karel Pavelka1 and Jiri Vencovsky1, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 31st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
  • Abstract Number: 2425 • 2013 ACR/ARHP Annual Meeting

    Impaired TNFá Production By Dendritic Cells From Rheumatoid Arthritis Patients Upon Contact With Porphyromonas Gingivalis

    Kim CM Santegoets1,2, Mark H. Wenink1,2, Wim B van den Berg3 and Timothy RDJ Radstake2,4, 1Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA) and the severity of periodontitis can affect the level of arthritis. Porphyromonas…
  • Abstract Number: 1296 • 2013 ACR/ARHP Annual Meeting

    Deletion Of RBP-J In a Murine Model Of Inflammatory Arthritis Reveals Pro-Inflammatory Cytokine Expression and Immunophenotypic Differences

    Soumya D. Chakravarty1, Karmen Au2, Lionel B. Ivashkiv3 and Xiaoyu Hu4, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 4Arthritis Tissue Degeneration Program, Hospital for Special Surgery, New York, NY

    Background/Purpose: RBP-J, a DNA-binding protein, serves as the central transcriptional regulator of the Notch signaling pathway. Prior in vitro work has demonstrated that RBP-J plays…
  • Abstract Number: 571 • 2013 ACR/ARHP Annual Meeting

    Protective Effect Of Inducible Adeno-Associated Virus Mediated IL-2 Gene Therapy On Tissue Damages In Lupus-Prone Mice

    Masayuki Mizui1, Tomohiro Koga2, Linda Lieberman3, Jessica Beltran3, Mark C. Johnson4, José C. Crispin2, Roland Tisch4 and George C. Tsokos5, 1Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: IL-2 plays critical roles not only in immune responses but also in peripheral tolerance.  Impairment of IL-2 production has been linked to the development…
  • Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting

    Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis

    Emilie Duvallet1, Laure Foulboeuf1, Luca Semerano2, Nadia Belmellat1, Marc Lecouvey3, Eric Assier1, Sylviane Muller4 and Marie-Christophe Boissier5, 1EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 2INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 3CSPBAT Paris 13 University, Bobigny, France, 4Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, 5INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
  • Abstract Number: 1194 • 2013 ACR/ARHP Annual Meeting

    Enhanced IL-1β and IL-6 Production In Gout Patients Upon Stimulation With Mono Sodium Urate Crystals and Synergizing Agents Compared To Healthy Volunteers

    Tania O. Crisan1, Maartje Cleophas1, Mihai G. Netea1, Tim L. Jansen2 and Leo A. Joosten3, 1Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

    Background/Purpose: Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
  • Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting

    Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females

    Neelakshi Jog1 and Roberto Caricchio2, 1Rheumatology, Temple University, Philadelphia, PA, 2Medicine/Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
  • Abstract Number: 2190 • 2013 ACR/ARHP Annual Meeting

    Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)

    Hanna Kim1, Adriana Almeida de Jesus2, Yin Liu3, Yan Huang1, Gina Montealegre4, Dawn Chapelle5, Nicole Plass1, Wanxia Tsai6, Massimo Gadina7, Lisa G. Rider8, Adeline Vanderver9 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 2Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, 3Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, 4Office of the Clinical DIrector, NIAMS / NIH, Bethesda, MD, 5Office of the Clinical Director, NIAMS / NIH, Bethesda, MD, 6Translational Immunology Section, NIAMS / NIH, Bethesda, MD, 7Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 8Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 9Pediatric Neurology, Children's National Medical Center, Washington, DC

    Background/Purpose: Increased interferon (IFN) regulated gene (IRG) expression has been reported in juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis (JDM)2. Recently, two monogenic conditions chronic…
  • Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting

    Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients

    Paulina Chalan1, Johan Bijzet2, Kornelis S.M. van der Geest1, Bart-Jan Kroesen3, Annemieke M.H. Boots4,5 and Elisabeth Brouwer1, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Groningen Research initiative on healthy Ageing and Immune Longevity (GRAIL), Groningen, Netherlands

    Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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